Class 546/42 - Pentacyclo ring system having the six-membered hetero ring as one of the cyclos

Subclass of Class 546 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which the polycyclo ring system consists of
No. of patents: 40
Last issue date: 02/19/2008

Number	Title	Issue Date
7332502	Phenanthroindolizidine alkaloids A group of novel phenanthroindolizidine alkaloid compounds as shown and their use in treating cancer. Also disclosed are methods of using phenanthroindolizidine alkoid compounds in suppressing NO and TNF-α production, inhibiting MEKK1 activity and cyclooxygenase II...	02/19/2008
7166726	Aryl substituted 3,4-dihydroanthracene derivatives having retinoid antagonist or retinoid inverse agonist type biological activity Disclosed herein are compounds of the formula wherein R1 is independently H or alkyl of 1 to 6 carbons; R2 is optional and is defined as lower alkyl of 1 to 6 carbons, F, Cl, Br...	01/23/2007
6972332	Process for the production of opiates A morphine component, e.g., a concentrate of poppy straw, is converted into codeine in high yield and high purity and in a highly controlled manner. The conversion process involves the following steps: (a) providing a solution or suspension of a morphine component i...	12/06/2005
6784187	8-carboxamido-2,6-methano-3-benzazocines 8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is —CH2—OH, —CH2NH2, —NHSO2CH3, and Y is O, S or NOH are useful as analgesi...	08/31/2004
6242604	Process for preparing a morphinan derivative A process for preparing a morphinan derivative, by providing a dihydrofuranyl bridged tetracycle halide of the formula (19) ##STR1## wherein X is halogen, R is an alkyl group of from 1 to about 10 carbon atoms, and R1 is a protecting group; and...	06/05/2001
6187783	Phenanthridinium derivatives A novel phenanthridinium derivative represented by general formula (A): ##STR1## wherein R1 is a substituted or unsubstituted lower aliphatic hydrocarbon group; R is an aliphatic hydrocarbon chain having 2 to 6 carbon atoms which may optionally...	02/13/2001
6013802	Fluorescent conjugates of metal-chelating nitrogen heterocycles The present invention describes a family of fluorescent indicators for metal cations. The indicators are fluorophore conjugates of pyridyl-based metal ion chelators. The indicators are very sensitive detection as quantification reagents for a variety of m...	01/11/2000
5998594	Self-assembling, chromogenic receptors for the recognition of medically important substrates and their method of use A chromogenic receptor comprises a self-assembled chromogenic compound having at least one intrinsic binding site. The chromogenic compound is characterized by the property of producing a reversible color change responsive to binding a target substrate to...	12/07/1999
5861411	4-Acylaminopyridine derivative A novel 4-acylaminopyridine derivative represented by the following formula (I) is disclosed. ##STR1## The 4-acylaminopyridine derivative of the present invention is useful as a medicine for treating disturbances of memory such as senile dementia and...	01/19/1999
5856487	Application of protoberberine alkaloid, berberine, an immunosuppressive agent A process for isolating berberine from plants is described. An oral formulation of berberine is described....	01/05/1999
5843952	Tricyclic benzazepine vasopressin antagonists Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V1 and/or V2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treati...	12/01/1998
5750409	Pentacyclic compounds and their use as absorption or fluorescent dyes Pentacyclic derivatives having the general formulae (Ia), (Ib) and (Ic) ##STR1## denote: hydrogen, alkyl with 1 to 20 carbon atoms polyoxyhydrocarbyl, phenyl, phenylalkyl with 1 to 3 carbon atoms in the alkyl chain, wherein the alkyl residues or/and ...	05/12/1998
5747502	Process for preparing benzoc!phenanthridinium derivatives, novel compounds prepared by said process, and antitumor agents The present invention relates to benzoc!phenanthridinium derivative of the general formula A: ##STR1## wherein M and N individually represent a hydroxyl or lower alkoxy group, or M and N simultaneously represent a hydrogen atom or together form a ...	05/05/1998
5710162	Condensed-indan derivatives and pharmaceutically acceptable salts thereof A condensed-indan derivative represented by formula (1) and a pharmaceutically acceptable salt thereof: ##STR1## wherein ring A represents an optionally substituted naphthalene ring, ring B represents an optionally substituted benzene ring or a benze...	01/20/1998
5543406	Inhibitors of 5-଱-testosterone reductase The present invention relates to certain substituted 17ଲ-substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I), especially those of formula (IG) ##STR1## wherein R1 and R2 are i) independently hydrogen or lower alky...	08/06/1996
5541322	Synthesis of 6-azaandrostenones A process of providing novel compounds of Formula (I), that are useful as 6-azaandrostenone testosterone 5-alpha-reductase inhibitors, from commercially available compounds of Formula (II) ##STR1## wherein the substituents are as defined in the speci...	07/30/1996
5536728	4-acylaminopyridine derivative A novel 4-acylaminopyridine derivative represented by the following formula (I) is disclosed. ##STR1## The 4-acylaminopyridine derivative of the present invention is useful as a medicine for treating disturbances of memory such as senile dementia and...	07/16/1996
5397785	4-acylaminopyridine derivative A novel 4-acylaminopyridine derivative represented by the following formula (I) is disclosed. ##STR1## The 4-acylaminopyridine derivative of the present invention is useful as a medicine for treating disturbances of memory such as senile dementia and...	03/14/1995
5302589	Heterocyclic inhibitors of 5-଱-testosterone reductase The present invention relates to certain substituted 17 ଲ-substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I): ##STR1## wherein R1 and R2 are i) independently hydrogen or lower alkyl and the bond between the carbons ...	04/12/1994
5276053	Polycyclic amines useful as cerebrovascular agents A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed....	01/04/1994
5071853	Polycyclic amines useful as cerebrovascular agents A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed....	12/10/1991
4959371	Isoquinoline derivatives with anti-tumor activity There are provided compounds of general formula ##STR1## (wherein R1 is a hydrogen atom or a methyl group; R2 is a hydrogen or halogen atom or a methyl group; and one of R3 and R4 is a hydrogen atom and the other is ...	09/25/1990
4933457	Preparation of 5,8,13,14-tetrahydrobenz[5,6]isoindolo[2,1-b]isoquinolin-8,13-dione derivatives A process is described for the preparation of compounds of formula (1) ##STR1## [where OR is hydroxyl, protected hydroxyl or OP(O)(OCH2 Ph)(OR1) (where Ph is phenyl and OR1 is hydroxyl or protected hydroxyl)] and salt...	06/12/1990
4900737	Isoquinoline derivatives Compounds of formula (I) ##STR1## (wherein R1 is a hydrogen atom or a methyl group; R2 is a hydrogen atom or a hydroxyl, C1-4 alkoxy or C2-4 alkanoyloxy group; R3 is a hydrogen atom, or (when R2	02/13/1990
4866070	Acenaphtho[1,2b]quinolinylmethylamino derivatives and pharmaceutical compositions containing them The present invention relates to compounds of formula (I) or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wh...	09/12/1989
4866073	Acridinylmethylamino derivatives and pharmaceutical compositions containing them The present invention relates to compounds of formula (I) or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wh...	09/12/1989
4851399	Isoquinoline derivatives and their use as anti-cancer agents There are provided compounds of the general formula (1) ##STR1## (wherein R1 and R2, which may be the same or different, each represents a hydrogen atom, a hydroxyl group or a group --OP(O) (OH) (OR4) [where R4	07/25/1989
4835158	Isoquinoline derivatives Pharmaceutical compositions for combatting cancer comprising a compound of formula (I) ##STR1## (wherein R1 represents a hydrogen atom or a C1-4 alkyl, C2-4 alkenyl or C2-4 alkynyl group; R2 repr...	05/30/1989
4831039	Isoquinoline compound 5,14-Dihydrobenz[5,6]isoindolo[2,1-b]isoquinoline-8,13-dione ##STR1## exhibits anticancer activity. The compound can be prepared by reaction of 2-formyl-3-carboxyl-1,2,3,4-tetrahydroisoquinoline with 1,4-naphthoquinone and is particularly suitably ad...	05/16/1989
4716162	Fused 5 ring heterocyclic compounds, their preparation, and their anti-arrhythmic and diuretic use Fused ring compounds of formula (I): ##STR1## (where R1 -R4, X1 and X2 represent hydrogen or various substituents, n and m are 1-3 and 2-7 respectively, the dotted lines are double or single bonds and Y is ...	12/29/1987
4591587	Cyclopropyl pyridine compounds useful as calcium channel blockers Novel cyclopropyl pyridine compounds useful as calcium channel blockers, pharmaceutical compositions thereof, and methods of treatment are disclosed....	05/27/1986
4590276	Process for the preparation of cyclopropyl pyridine compounds useful as calcium channel blockers A novel process for the preparation of cyclopropyl pyridine compounds, which are useful as calcium channel blockers, is disclosed....	05/20/1986
4451398	Dyes containing imidazolymethylene groups Dyes of the formula ##STR1## where R1 is hydrogen, C1 -C6 -alkyl or C2 -C6 -alkenyl, R2 and R3 independently of one another are hydrogen, C1 -C5 -alkyl...	05/29/1984
4346090	13-Chloro-benzocycloheptapyridoisoquinolines and use as neuroleptics 13-Chloro-octahydrobanzo[6,7]cyclohepta[1,2,3-de]pyrido[2,1-a]isoquinolin-5 -ols, substituted on the piperidine ring with lower alkyl or a cycloalkyl are disclosed. The compounds are useful CNS depressants. Methods for their preparation and use also are di...	08/24/1982
4108667	Photographic compositions and elements containing benzo[a]quinolizinium methine dyes The invention relates to methine dyes and photographic silver halide compositions and film elements comprising methine dyes which contain 9,9a-dihydropyrido-[1,2-a]indolium nuclei, benzo[a]quinolizinium nuclei or 6,7-dihydrobenzo[a]quinolizinium nuclei....	08/22/1978
4062851	Process for the resolution of certain octahydrobenzocycloheptapyridoisoquinolinols An efficient, commercially feasible process for the resolution of the organic bases, (&#b1;)-(4a,13b-trans)-(3-hydroxy,13b-trans)-3-isopropyl-2,3,4,4a,8,9,13b,1 4-octahydro-1H-benzo[6,7]cyclohepta[1,2,-3-de)pyrido[2,1-a]isoquinolin-3-ol and (&#b1...	12/13/1977
4059585	Process for preparing an intermediate for CNS depressants Disclosed is a process for preparing (4a,13b-trans)-1,2,4,4a,8,9,13b,14-octahydro-3H-benzo[6,7]cyclohepta[1,2,3 -de]-pyrido[2,1-a]isoquinolin-3-one involving a 1,3-cycloaddition of a 4-halo-1-butene to 1,7,8,12b-tetrahydrobenzo[1,2]cyclohepta-[3,4,5-d...	11/22/1977
4054569	Benzocycloheptaisoquinoline derivatives Octahydrobenzo[6,7]-(or [5,6]-)cyclohepta-[1,2,3-de]pyrido-(or pyrrolo-)[2,1-a]isoquinolines, and decahydrobenzo[6,7]-(or[5,6]-)cyclohepta[1,2,3-de]-azepino[2,1-a]isoquinol ines and derivatives thereof, optionally substituted on the pyrrolidine, piper...	10/18/1977
4042591	Naphthoquinone compounds Disclosed are compounds of formula I ##STR1## WHERE R1 is a fused benzene or naphthalene nucleus, m is one or two and R2 and R3 have various significances, their production and use as pigments and disperse dyes....	08/16/1977
3985751	Benzocycloheptaisoquinoline derivatives Octahydrobenzo[6,7]- (or [5,6]-) cyclohepta-[1,2,3-de]pyride- (or pyrrolo-) [2,1-a]isoquinolines, and decahydrobenzo[6,7]- (or [5,6]-) cyclohepta[1,2,3-de]-azepino[2,1-a]isoquinolines and derivatives thereof, optionally substituted on the pyrrolidine, pip...	10/12/1976

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Class 546/42 - Pentacyclo ring system having the six-membered hetero ring as one of the cyclos