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| Number | Title | Issue Date |
| 7361671 | Substituted heteroarylalkanoic acids Disclosed are substituted heteroarylalkanoic acids acids of the following formula D-A-C(O)R′, where D, A, and R′ are defined herein. These compounds are useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceu... | 04/22/2008 |
| 7321044 | Synthesis of oxygen-substituted benzocycloheptenes as valuable intermediate products for the production of tissue-selective estrogens The invention relates to intermediate products and a new process for the production of benzocycloheptene C. The process for the production of its new intermediate products according to the invention starts from eco... | 01/22/2008 |
| 7268135 | Biaryl sulfonamides and methods for using same The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors. ... | 09/11/2007 |
| 7247732 | Method for producing optically active compound The present invention provides a method for producing an optically active β-hydroxy ester compound represented by the general formula: wherein R1 represents an optionally substituted hydrocarb... | 07/24/2007 |
| 7157458 | Bifunctional energy-reversible acyl-compositions Energy-reversible acyl conjugates, intermediates, and related compositions are disclosed. In preferred aspects, examples of such compositions include: ... | 01/02/2007 |
| 7071175 | Pyridine mercapto carboxylic acids as carboxypeptidase U inhibitors The present invention relates to compounds of Formula I, and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and thus can be used in the prev... | 07/04/2006 |
| 7067501 | Aryloxyphenyl and arylsulfanylphenyl derivatives The invention provides compounds of the formula wherein the substituents are as defined in the application. The compounds are valuable glycine transport inhibitors. ... | 06/27/2006 |
| 7037914 | Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as ... | 05/02/2006 |
| 6969768 | Preparation of 4-haloalkylnicotinic esters A process for preparing 4-haloalkylnicotinic esters of the formula (I), where RF is (C1-C4)-haloalkyl and R is (C1-C6)-alkyl; w... | 11/29/2005 |
| 6780997 | Cardioprotective phosphonates and malonates Pharmaceutical compositions including an effective amount of the compound of formula IV in which R1 is hydrogen or alkyl; R2 is —CHO, —CH2OH, —CH3 or —CO | 08/24/2004 |
| 6749988 | Amine compounds, resist compositions and patterning process Novel amine compounds having a nitrogen-containing cyclic structure and a hydrating group such as a hydroxy, ether, ester, carbonyl, carbonate group or lactone ring are useful for use in resist compositions for preventing a resist film from thinning and also for enh... | 06/15/2004 |
| 6703509 | Method for producing 5-aryl nicotinaldehydes The invention relates to a process for the preparation of 5-arylnicotinaldehydes by reduction of the corresponding 5-arylnicotinic acids by catalytic hydrogenation in the presence of carboxylic anhydrides in which the catalyst used is a palladium/ligand c... | 03/09/2004 |
| 6617339 | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them Compounds of formula (I) as defined herein, or a pharmaceutically acceptable salt, or an in-vivo-hydrolysable ester thereof, are useful as antibacterial agents. Processes for their manufacture and pharmaceutical compositions containing them are described.... | 09/09/2003 |
| 6583162 | 2-pyridinylguanidine urokinase inhibitors Compounds of formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, or solvate of either entity, wherein R4 is a guanidinyl moiety and the other substituents are as defined in the text, are urokinase inhibitors.... | 06/24/2003 |
| 6555690 | Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.... | 04/29/2003 |
| 6479659 | Process of making 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic acid derivatives Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentano[b]pyridine derivatives. The most preferred compounds prepared by this inven... | 11/12/2002 |
| 6465486 | Pyridyl/quinolinyl imidazoles Certain imidazo pyridines/quinolines of the formula: ##STR1## where n is 0, 1, 2; X is independently selected from the group consisting of C1-4 alkyl, bromine, chlorine, iodide, trifluoromethyl, C1-4 alkoxy, --SO2 NH2... | 10/15/2002 |
| 6437140 | Process for preparing ethyl 3-(2,5,6-trihalopyridin-3-yl)-3-oxopropionate from 2,5,6-trihalo-3-cyanopyridine The new process for preparing ethyl 3-(2,5,6-trihalopyridin-3-yl)-3-oxopropionate from 2,5,6-trihalo-3-cyanopyridine in accordance with the present invention comprises reacting 2,5,6-trihalo-3-cyanopyridine with ethyl haloacetate at the presence of a... | 08/20/2002 |
| 6420314 | Substituted 2-phenyl pyridines, their manufacture and use as herbicides Substituted 2-phenylpyridines of the formula I ##STR1## in which the substituents and the index m are defined in the specification.... | 07/16/2002 |
| 6392050 | Process for preparing substituted pyridines The invention relates to a process for preparing substituted pyridines in a simple and cost-effective manner in good yields by reacting substituted 1,4-dihydropyridines with methyl nitrite in the presence of an acid that contains less than 20% by weight o... | 05/21/2002 |
| 6372693 | Substituted 2-(3-alkenyl-benzoyl)-cyclohexane-1,3-diones The invention relates to 2-(3-alkenylbenzoyl)cyclohexane-1,3-diones of the formula I ##STR1## where the variables have the following meanings: R1, R2 are hydrogen, nitro, halogen, cyano, thiocyanato, alkyl, haloalkyl, alkoxyalkyl, al... | 04/16/2002 |
| 6369230 | Supernucleophilic 4-substituted-pyridine catalysts, and processes useful for preparing same A process of preparing 4-substituted pyridine compounds via pyridine betaine compounds.... | 04/09/2002 |
| 6353110 | Asymmetric conjugate addition reaction This invention relates to a key intermediate in the synthesis of an endothelin antagonist the synthesis of this key intermediate via an asymmetric conjugate addition reaction.... | 03/05/2002 |
| 6333082 | Liquid crystalline (E,E)-butadiene compounds and mixtures and devices containing such compounds Liquid crystalline compounds useful in super twisted nematic liquid crystal displays are described and have the formula: ##STR1## wherein n is 1-5; m is 0-5; p is 0, 1 or 2; q is 0, 1 or 2 p+q is less than or equal to 3; A1, A2, A3 | 12/25/2001 |
| 6320074 | Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors Compounds, compositions, and methods for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to members of the subclass... | 11/20/2001 |
| 6271386 | Product and process for making quaternized, water soluble vinylpyridine carboxylate polymers This invention relates to stable, quaternized vinlypyridine carboxylate home-, co- and ter-polymers, useful as dye transfer inhibitors and polymers complexable with active agrochemical, pharmaceutical or cosmetic agents for controlled release thereof, and... | 08/07/2001 |
| 6214818 | Cephem compounds and pharmaceutical compositions containing the same A cephem compound, wherein the cephem ring has a substituent at the 3-position, which substituent is shown by the formula II, wherein Het is a mono- or polycyclic heterocyclic group comprising one or more hetero atoms selected from the group consisting of... | 04/10/2001 |
| 6174905 | Cell differentiation inducer The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors,... | 01/16/2001 |
| 6165236 | Poly(oxyalkylene) pyridyl and piperidyl esters and fuel compositions containing the same A poly(oxyalkylene)pyridyl or piperidyl ester having the formula: ##STR1## or a fuel-soluble salt thereof; wherein A is a nitrogen-containing ring selected from the group consisting of 3-pyridyl, 4-pyridyl, 3-piperidyl and 4-piperidyl; R1 ... | 12/26/2000 |
| 6130349 | Catalytic compositions and methods for asymmetric allylic alkylation Complexes of a selected class of chiral ligands with molybdenum, tungsten or chromium, preferably molybdenum, are effective as catalysts in highly enantioselective and regioselective alkylation of allylic substrates. Such compositions provide a versatile ... | 10/10/2000 |
| 6106908 | Liquid crystalline (E, E)-butadiene compounds and mixtures and devices containing such compounds Liquid crystalline compounds useful in super twisted nematic liquid crystal displays are described and have the formula: ##STR1## wherein n is 1-5; m is 0-5; p is 0, 1 or 2; q is 0, 1 or 2 p+q is less than or equal to 3; A1, A2, A | 08/22/2000 |
| 6020368 | Carbamoyloxy derivatives of mutiline and their use as antibacterials Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and derivatives thereof, in which R1 is ethyl or vinyl, Y is a carbamoyloxy group, in which the N-atom is unsubstituted, or mono- or di-substituted, are useful in the... | 02/01/2000 |
| 6013811 | Preparation process of benzodifuranone dyes A process for the preparation of a polycyclic dye of Formula (1) which comprises steps: i) reaction of a compound of formula (2) with a compound of formula (3) or a derivative thereof to form an intermediate of formula (4) and ii) reaction of the intermed... | 01/11/2000 |
| 6010642 | Azine derivative, process for the preparation thereof, nematic liquid crystal composition and liquid crystal display system comprising same Disclosed is to provide an azine derivative as a novel liquid crystal compound, a novel process for the preparation of an asymmetrical azine in a high reaction yield with an extremely small amount of by-products such as symmetrical azines, a nematic liqui... | 01/04/2000 |
| 5998625 | Asymmetric conjugate addition reaction using a chiral additive This invention relates to a process for the preparation of a key intermediate using an chiral additive to effect an asymmetric conjugate addition.... | 12/07/1999 |
| 5990314 | Pharmaceutical pyridine compounds This invention relates to a compound of formula I ##STR1## These compounds are leukotriene antagonists and as such can be used in treating various diseases associated with leukotrienes.... | 11/23/1999 |
| 5977125 | Mono-or polyenic carboxylic acid derivatives Compounds of the formula ##STR1## and compounds of the formula ##STR2## or their salts have the potent ability to bind to retinoic acid receptors thus useful in treating psoriasis and rheumatoid arthritis.... | 11/02/1999 |
| 5972839 | 2-fluoroacrylic acid derivatives, novel mixtures of herbicides and antidotes, and their use The invention relates to novel -fluoroacrylic acid derivatives, to active compound/antidote combinations which comprise -fluoroacrylic acid derivatives and are outstandingly suitable for use in crops of useful plants, to their use and to met... | 10/26/1999 |
| 5908851 | Derivatives of succinamide and their use as metalloproteinase inhibitor Compounds of formula (I), ##STR1## wherein X is a --CO2 H or --CONHOH group; R4 is a group --CHRx Ry wherein Rx and Ry independently represent optionally substituted phenyl or monocycl... | 06/01/1999 |
| 5906989 | Cyclopentane(ENE) heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents The invention relates to 7-5-hydroxy-2-(hydroxyhydrocarbyl or heteroatom-substituted hydroxy hydrocarbyl)-3-hydroxy-cyclopentyl(enyl)! heptanoic or heptenoic acids and derivatives of said acids, wherein one or more of said hydroxy groups are replaced by... | 05/25/1999 |
