Did You Know...
...that it was melting ice cream that inspired the invention of the outboard motor? It was a lovely August day and Ole Evinrude was rowing his boat to his favorite island picnic spot. As he rowed, he watched his ice cream melt and wished he had a faster way to get to the island. At that moment the idea for the outboard motor was born!
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| Number | Title | Issue Date |
| 7317103 | Imaging agents for diagnosis of Parkinson's disease Generally, the present invention is directed to central nervous system dopamine transporter-imaging agents and methods of use thereof. In certain embodiments, the present invention relates to radiolabeled piperidine derivatives for use as imaging agents in the diagn... | 01/08/2008 |
| 7230017 | Dihydropyridinone derivatives The invention relates to novel dihydropyridinone derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failur... | 06/12/2007 |
| 7074813 | Substituted N′-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted N′-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs thereof, represented by the Formulae I and II: wherein Ar1, A... | 07/11/2006 |
| 7009058 | Method for preparing pyridine-2,3-dicarboxylic acid esters A method for preparing pyridine-2,3-dicarboxylic acid esters of the general formula: wherein R is C1-6-alkyl, C3-6-cycloalkyl, aryl or arylalkyl, and R1 to R3, independently o... | 03/07/2006 |
| 6846819 | Fab I inhibitors Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections. ... | 01/25/2005 |
| 6716859 | Substituted N′-(Arylcarbonyl)-benzhydrazides, N′(Arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted N′-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs thereof, represented by the Formulae I and II: wherein Ar1, Ar2 | 04/06/2004 |
| 6713492 | N-acyloxylated cycloalkyl compounds, composition containing the same and methods of use therefor Drugs or reagents containing as the active ingredient N-acyloxylated cycloalkyl compounds represented by general formula (I): wherein A is optionally substituted C4 or C5 cycloalkyl which may have o... | 03/30/2004 |
| 6673625 | Saccharide sensing molecules having enhanced fluorescent properties The present invention provides formulae for fluorescent compounds that have a number of properties which make them uniquely suited for use in sensors of analytes such as saccharides. The advantageous fluorescent properties include favorable excitation wav... | 01/06/2004 |
| 6583154 | Compounds and methods which modulate feeding behavior and related diseases There are provided compounds, compositions and methods of use thereof in the modulation of feeding behavior, obesity, diabetes, cancer (tumor), inflammatory disorders, depression, stress related disorders, Alzheimer's disease and other disease conditions.... | 06/24/2003 |
| 6492405 | Nitric oxide donors and pharmaceutical compositions containing them The present invention provides a compound containing at least one sulfhydryl group and at least one NO donor group, wherein said compound is a) a compound containing one or more sulfhydryl groups linked to at least one aromatic ring or a heteroaromatic ri... | 12/10/2002 |
| 6362009 | Solid phase synthesis of heterocycles Methods for solid phase and combinatorial synthesis using a resin activation/capture approach are provided. In particular, methods for the production of dihydropyridones, N-acyidihydropyridones, tetrahydropyridones, pyridines, aminopyridines, N-acyltetrah... | 03/26/2002 |
| 6121451 | Intermediates and process for the manufacture of camptothecin derivatives (CPT-11) and related compounds This invention relates to intermediates and processes for the synthesis of camtothecin derivatives, such as irinotecan. Related procedures and compounds are disclosed, such as a method of making mappicine.... | 09/19/2000 |
| 6046221 | Immunotherapeutic aryl amides Novel aryl amides are inhibitors of tumor necrosis factor and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is N-benzoyl-3-amino-3-(3',4'-dimethoxyphenyl)propanamide.... | 04/04/2000 |
| 5919792 | Integrin antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are v댣 antagonists, ... | 07/06/1999 |
| 5861428 | Substituted 4-biarylbutyric acid derivatives as matrix metalloprotease inhibitors Inhibitors for matrix metalloproteases, pharmaueutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each T... | 01/19/1999 |
| 5654298 | Amine derivatives This invention concerns novel aminopyridinium compounds of the formula I wherein R1, R2, R3, R5 and R6 are selected from the following combinations: ##STR1## (a) one of R2 and R6 | 08/05/1997 |
| 5643914 | Pharmaceutical pyridine compounds This invention relates to a compound of formula 1 ##STR1## or an N-oxide, or a pharmaceutically acceptable salt, where A is CH2 and Z is S(O)q where q is 0, 1 or 2, CH2, CHOH, CO, NRx, or O, or A is C.dbd.O... | 07/01/1997 |
| 5610172 | Sulfonamidocarbonylpyridine-2-carboxamides and pyridine-n-oxides which are useful as pharmaceuticals Sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation, and their use as pharmaceuticals The invention relates to sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-N-oxides according to the formula I ... | 03/11/1997 |
| 5492923 | Substituted pyridines and 2-oxo-1,2-dihydropyridines Substituted pyridines and 2-oxo-1,2-dihydropyridines are prepared by reaction of correspondingly substituted halogenobenzenes with tetrazolylboronic acids. The substituted pyridines and 2-oxo-1,2-dihydropyridines according to the invention can be employed... | 02/20/1996 |
| 5428046 | Acylsulfonamido- and sulfonamidopyridine-2-carboxylic acid esters and their pyridine N-oxides, processes for their preparation and their use as medicaments The invention relates to acylsulfonamido- and sulfonamidopyridine-2-carboxylic acid esters and their pyridine N-oxides of the formula I ##STR1## in which ______________________________________ A = R3 and ... | 06/27/1995 |
| 5420275 | Pyridopyridazine compounds and their use An assay method which comprises utilizing chemiluminescence of a pyridopyridazine compound of the formula ##STR1## wherein R1 is a hydrocarbon group or a heterocyclic group each of which may be substituted and R2 is hydroxy grou... | 05/30/1995 |
| 5418245 | Styryl-substituted monocyclic and bicyclic heteroaryl compounds which inhibit EGF receptor tyrosine kinase Methods of inhibiting cell proliferation in a patient suffering from such disorder comprising the use of a styryl-substituted heteroaryl compound wherein the heteroaryl group is a monocyclic ring with 1 or 2 heteroatoms, or a bicyclic ring with 1 to about... | 05/23/1995 |
| 5366982 | Substituted bicyclic bis-aryl compounds exhibiting selective leukotriene B4 antagonist activity, their preparation and use in pharmaceutical compositions This invention relates to compounds having selective LTB4 antagonist properties, compositions comprising said compounds and methods for the treatment of disorders involving LTB4 agonist-mediated activity utilizing said compositions w... | 11/22/1994 |
| 5356909 | Substituted pyridine-2,4-dicarboxylic acid compounds and the use thereof and medicaments The invention relates to substituted pyridine-2,4-dicarboxylic acid derivatives of the formula I ##STR1## in which R1 and R2 have the meanings given. The invention also relates to a process for the preparation of the abovementio... | 10/18/1994 |
| 5296483 | Brain-specific analogues of centrally acting amines The subject compounds, which are adapted for the site-specific/sustained delivery of centrally acting drug species to the brain, are compounds of the formula ##STR1## and the non-toxic pharmaceutically acceptable salts thereof, wherein D is the ... | 03/22/1994 |
| 5238908 | Herbicidal glutaramic acids and derivatives This invention relates to glutaramic acids and derivatives exhibiting herbicidal activity having the structure ##STR1## wherein A is a carboxylic acid or a derivative thereof, D is CH or N, and R, R1, R2, T, X, Y, and Z are as d... | 08/24/1993 |
| 5228897 | Substituted pyridine compounds Disclosed herein are herbicidal pyridine compounds substituted at the 2- or 6-position with an OR2 moiety where R2 is hydrogen, lower alkyl, halomethyl, lower cyanoalkyl, alkenyl or alkynyl, as well as herbicidal compositions and her... | 07/20/1993 |
| 5225564 | 5-heterocyclic 2-(2-imidazolin-2-yl)pyridines, useful as herbicidal agents and methods for the preparation thereof 5-Heterocyclic 2-(2-imidazolin-2-yl)pyridine compounds which are effective for the control of undesirable plant species are described. Also described are a method for the herbicidal use of said compounds and a method for their preparation.... | 07/06/1993 |
| 5225560 | Process for the preparation of dialkyl pyridine-2,3-dicarboxylate and derivatives thereof from dialkyl dichlorosuccinate There is provided a process for the preparation of substituted and unsubstituted-2,3-pyridinedicarboxylate compounds by reacting a dialkyl dichlorosuccinate with a dehydrohalogenating agent, an ammonia source and an appropriately substituted , ... | 07/06/1993 |
| 5216169 | 3-hydroxypyridineazomethine dye A 3-hydroxypyridineazomethine dye represented by general formula (I) ##STR1## wherein R1 represents an aliphatic group, an aromatic group, or a heterocyclic group; R2 represents an aliphatic group, an aromatic group, a heterocyc... | 06/01/1993 |
| 5204357 | Renin-inhibiting amino acid derivatives The invention relates to compounds of the formula I ##STR1## in which A represents a substituted thio-, sulfinyl- or sulfonyl-alkanoyl radical or a four- to eleven-membered heterocycle, B is an amino acid residue, R1 denotes hydrogen (subs... | 04/20/1993 |
| 5198439 | Angiotension II antagonizing pyridine derivatives The invention concerns pharmaceutically useful novel compounds of the formula I, in which R1, R2, R3, R4, R5, R6, R7, X and Z have the various meanings defined herein, and their ... | 03/30/1993 |
| 5164506 | Substituted 2-pyridones and pyrid-2-thiones compounds For inhibiting HMG-CoA reductase and cholesterol synthesis, the novel 2-pyridones and pyrid-2-thiones of the formula ##STR1## in which A is optionally substituted aryl or heterocyclic, B is optionally substituted alkyl, cycloalkyl or aryl, D and E indepen... | 11/17/1992 |
| 5149359 | Derivatives from 3,4-dehydro-piperidin-5-one exhibiting a herbicidal activity The present invention relates to derivatives of 3,4-dehydropiperidin-5-one having herbicidal activity. The derivatives have the formula ##STR1## as defined in the claims. The present invention further relates to a herbicidal composition and a method ... | 09/22/1992 |
| 5125956 | Substituted pyridine compounds Disclosed herein are herbicidal pyridine compounds substituted at the 2- or 6-position with an OR2 moiety where R2 is hydrogen, lower alkyl, halomethyl, lower cyanoalkyl, alkenyl or alkynyl, as well as herbicidal compositions and her... | 06/30/1992 |
| 5114465 | Substituted pyridine compounds and herbicidal compositions and methods 2- or 6-fluoromethyl-3-pyridinecarboxylate derivatives with 5-(haloalkyl) carboxamide or 5-(haloalkyl)carbamate substitution, useful as herbicides and herbicide intermediates.... | 05/19/1992 |
| 5112386 | Fungicides Acrylic acid derivatives having the formula (I): ##STR1## and stereoisomers thereof, wherein W is R1 O2 C--C.dbd.CH--ZR2, R1 and R2 are alkyl or fluoroalkyl groups, and Z is oxygen or sulphur, A,... | 05/12/1992 |
| 5089168 | Nitrogen-containing heterocycles Optically active nitrogen-containing heterocycles of the formula I according to claim 1 are suitable as components for ferroelectric liquid crystalline materials.... | 02/18/1992 |
| 5082853 | Brain-specific analogues of centrally acting amines The subject compounds, which are adapted for the site-specific/sustained delivery of centrally acting drug species to the brain, are compounds of the formula ##STR1## and the non-toxic pharmaceutically acceptable salts thereof, wherein D is the ... | 01/21/1992 |
| 5079366 | Quarternary pyridinium salts The invention provides novel amino acids and peptides containing them which comprise a dihydropyridine.revreaction.pyridinium salt-type redox system and which provide site-specific and sustained delivery of pharmacologically active peptides to the brain. ... | 01/07/1992 |
