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...that Kleenex tissue was originally designed to be a gas mask filter? It was developed at the beginning of World War I to replace cotton, which was then in short supply as a surgical dressing.
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| Number | Title | Issue Date |
| 7393846 | Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs, their pharmaceutically acceptable salts, their appropriate N-oxides, the... | 07/01/2008 |
| 7371777 | Cyclic compound and PPAR agonist The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them. ... | 05/13/2008 |
| 7297693 | Nitrogen-containing heterocyclic compounds and their use as Raf inhibitors Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy. ... | 11/20/2007 |
| 7253187 | Heterocyclic inhibitors of ERK2 and uses thereof Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein Z1 and Z2 are each independently nitrogen or CH and Ring A, TmR1... | 08/07/2007 |
| 7238725 | Tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel tricyclic compounds useful for the treatment of inflammatory conditions, diseases of the central nervous and insulin resistant diabetes. ... | 07/03/2007 |
| 7223789 | Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs, their pharmaceutically acceptable salts, their appropriate N-oxides, the... | 05/29/2007 |
| 7196089 | EPreceptor antagonists Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O... | 03/27/2007 |
| 7101878 | Non-peptide GNRH agents, methods and intermediates for their preparation Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, multimers, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorde... | 09/05/2006 |
| 6972292 | Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors The present invention relates to certain substituted polyketides of formula I, wherein A, B, C, D, E, F and m are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds ... | 12/06/2005 |
| 6900210 | Pyridinyl, pyrimidinyl and pyrazinyl amides as potassium channel openers The present invention provides novel heterocyclic amides and related derivatives having the general Formula I wherein R1, R2, R3, R4, R5, R6, A, B and Z... | 05/31/2005 |
| 6844358 | Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds of Formula I having the structure wherein: A is O, S, or N; B is —(CH2)m—, —CH(OH)—, or carbonyl;... | 01/18/2005 |
| 6797712 | Substituted amino-furan-2-yl-acetic acid and amino-thien-2-yl-acetic acid derivatives and their use in the treatment of migraine and pain Compounds of formula I, or a pharmaceutically acceptable salt thereof, The compounds of the present invention are suitable for the treatment of pain and migraine. Also disclosed are method for preparing the compounds, an... | 09/28/2004 |
| 6706882 | Process for the preparation of (pyridinylidene)-phthalides A process for the preparation of (pyridinylidene)-phthalides starting from 3-oxo-1,3-dihydro-isobenzofuran-1-carboxylic acids and pyridinecarbaldehydes, is described. ... | 03/16/2004 |
| 6645987 | Nor-seco himbacine derivatives useful as thrombin receptor antagonists Heterocyclic-substituted compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof, are disclosed.... | 11/11/2003 |
| 6566375 | Elevation of HDL cholesterol by 4-[(aminothioxomethyl)-hydrazono]-N-(substituted)-4-arylbutanamides Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the "good" cholesterol and as such may be useful for treating diseases such as atherosclerosis. These compounds are represented by the formula ##STR1## wherein: R | 05/20/2003 |
| 6566373 | Protease inhibitors The invention relates to 3-hydroxy-and 3-keto-cyclohetero-substituted leucine compounds that are inhibitors of cysteine proteases, particularly cathepsin K, and are useful in the treatment of diseases in which inhibition of bone loss is a factor. The 3-hy... | 05/20/2003 |
| 6498172 | Prostaglandin agonists and their use to treat bone disorders This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for t... | 12/24/2002 |
| 6399606 | Neuroprotective agents and methods related thereto Neuroprotective agents are disclosed having the following structure: ##STR1## wherein R1, R2, R3, R4 and R5 are as defined herein. Such compounds have utility in the treatment of conditions which bene... | 06/04/2002 |
| 6384058 | 2,4,6-trisubstituted pryridines with estrogenic activity and methods for the solid phase synthesis thereof The present invention relates to novel substituted pyridine compounds of Formula (I) ##STR1## wherein the moiety Z, R1, R2 and R3 are as herein defined, having estrogenic activity, to processes for their preparation, to a ... | 05/07/2002 |
| 6271236 | Diaminopyridine-containing thiourea inhibitors of herpes virus Compounds of the formula ##STR1## wherein R1 -R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl ... | 08/07/2001 |
| 6258822 | Urokinase inhibitors Compounds having the formula ##STR1## are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and a method of inhibiting urokinase in a mammal.... | 07/10/2001 |
| 6255340 | Pesticidal composition A pesticidal composition comprising prallethrin and a neonicotinoid compound given in the following formula (1), (2) or (3), as an active ingredient ##STR1## wherein, A represents a 6-chloro-3-pyridyl, 2-chloro-5-thiazolyl, tetrahydrofuran-2-yl, tetr... | 07/03/2001 |
| 6121202 | Thienyloxypyridines and-pyrimidines useful as herbicidal agents The present invention provides a herbicidal compound of formula I, methods for the preparation thereof and intermediates useful therefor. ##STR1## wherein X and Y are each independently O or S; Z is N or CR4.... | 09/19/2000 |
| 6087505 | Benzo[1,2-G]-chrom-3-ene, and benzo[1,2-G]-thiochrom-3-ene derivatives Compounds of the formula ##STR1## where the symbols have the meaning defined in the specification, have retinoid, retinoid antagonist and/or retinoid inverse-agonist-like biological activity.... | 07/11/2000 |
| 6005113 | Long wavelength dyes for infrared tracing The invention relates to fluorescent dyes that are substituted or unsubstituted derivatives of 1-(isoindolyl)methylene-isoindole that are bound through both isoindole nitrogens to a boron difluoride moiety, forming a fluorescent dibenzopyrrometheneboron d... | 12/21/1999 |
| 5824625 | Substituted pyridine compounds Disclosed herein are herbicidal pyridine compounds substituted at the 2- or 6-position with an OR2 moiety where R2 is hydrogen, lower alkyl, halomethyl, lower cyanoalkyl, alkenyl or alkynyl, as well as herbicidal compositions and her... | 10/20/1998 |
| 5705513 | Fungicides for the control of take-all disease of plants A compound, composition, and method for controlling Take-all disease of plants by applying to the seed prior to planting, a fungicide of the formula: ##STR1## wherein Z1 and Z2 are C and are part of an aromatic ring which i... | 01/06/1998 |
| 5698581 | Substituted N-heteroaroylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and a medicament containing them The invention relates to heteroaroylguanidines of the formula I ##STR1## in which the substituents HA and R(1) to R(5) have the meanings given in the specification. These compounds exhibit very good antiarrhythmic properties and are outstandingly sui... | 12/16/1997 |
| 5684198 | Method of preparing therapeutic amides Amides having formula I: ##STR1## wherein E, X, R2 and R3 have the meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable in vivo hydrolysable esters thereof, which are useful ... | 11/04/1997 |
| 5635527 | Carboxylic acid compound having condensed ring, salt thereof and pharmaceutical use thereof A novel carboxylic acid compound having a condensed ring, which is represented by the formula (I) ##STR1## wherein each symbol is as defined in the specification, a pharmacologically acceptable salt thereof, a pharmaceutical composition thereof ... | 06/03/1997 |
| 5629432 | Preparation of -aryl γ-butyrolactones This appliciation discloses a process for preparing a lactone of general formula (I), where R is an optionally substituted phenyl group or an optionally substituted mono- or bicyclic heteroaryl radical which process comprises reacting an anion of a malona... | 05/13/1997 |
| 5599820 | Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (IV) ##STR1## ... | 02/04/1997 |
| 5580871 | 4-Heteroaryl- 1,4-dihydropyridine compounds with calcium agonist and alpha1 -antagonist activity There are provided novel 1,4-dihydropyridine compounds, compositions containing them and methods of using them to treat congestive heart failure.... | 12/03/1996 |
| 5580983 | Process for the preparation of N-acylated 2-chloro-5-aminomethylpyridines 2-Chloro-5-(N-acyl-aminomethyl)pyridines can be prepared by hydrogenation of 2-chloro-5-cyanopyridine with hydrogen in an acylating agent using a hydrogenation catalyst.... | 12/03/1996 |
| 5563115 | Herbicidal compounds A compound of formula (I): ##STR1## or a salt, enamine or the like, acylate, sulphonate, carbamate or ether derivative thereof; wherein X, X1 and X2 are independently oxygen or sulphur, R1 is an optionally substituted... | 10/08/1996 |
| 5521179 | Heterocyclic amides The present invention relates to certain novel heterocyclic amides which are 1-pyridylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them usef... | 05/28/1996 |
| 5506259 | ଲ-mercapto-propanamide derivatives useful in the treatment of cardiovascular diseases Compounds of formula ##STR1## wherein R, R1, R2, Het and n have the meanings reported in the description, processes for their preparation and pharmaceutical compositions which contain them as active ingredients are described. Th... | 04/09/1996 |
| 5491152 | Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis The present invention provides compounds of Formula I, ##STR1## or a pharmaceutically acceptable salt forms thereof, which are inhibitors of acyl-Coenzyme A: cholesterol O-acyltransferase (ACAT), pharmaceutical compositions containing such compounds,... | 02/13/1996 |
| 5491149 | Dihydroxypropylamine containing retroviral protease inhibitors This invention relates to substituted dihydroxypropylamines, a process to prepare intermediates useful for the synthesis of these compounds, compositions comprising such compounds, and a method of treating retroviral infection.... | 02/13/1996 |
| 5489601 | Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them Taxane derivatives having a 3' pyridyl substituted C13 side chain.... | 02/06/1996 |
