Did You Know...
...that when IBM conducted a market study of Chester Carlson's invention in 1959, the company concluded that it would take only 5000 units of his new product to saturate the market? IBM therefore declined to be part of the new product introduction. Too bad for IBM. Carlson's invention was the xerography process, and his new product was the beginning of the Xerox Corporation. It is estimated that every day, worldwide, 3,000,000,000 copies are made!!
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| Number | Title | Issue Date |
| 8119810 | Process for the preparation of a benzimidazole derivative The invention relates to a process for preparing the compound of formula 1, a valuable intermediate product in the synthesis of the pharmaceutical active substance dabigatran etexilate. ... | 02/21/2012 |
| 7994332 | Process for producing crystal The present invention relates to a production method of a crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole.n′H2O (wherein n′ is about 0 to about 0.1) or a salt thereof, which characteristically includes cr... | 08/09/2011 |
| 7956190 | Benzimidazole amido derivatives as kinase inhibitors Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as wel... | 06/07/2011 |
| 7932394 | Aryloxy-substituted benzimidazole derivatives A glucokinase activator is provided; and a treatment and/or a preventive for diabetes, or a treatment and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a treatment and/or a preventive for... | 04/26/2011 |
| 7767820 | Substituted benzimidazoles and methods of preparation Methods for preparing new substituted benzimidazole compounds having formula (I) useful for treating kinase mediated disorders are provided wherein R1, R2, R3, R4, a, b, and c are defined herein | 08/03/2010 |
| 7737282 | Benzimidazole compound crystal A novel crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole or a salt thereof of the present invention is useful for an excellent antiulcer agent. ... | 06/15/2010 |
| 7569696 | Process for producing crystal The present invention relates to a production method of a crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole.n′H2O (wherein n′ is about 0 to about 0.1) or a salt thereof, which characteristically includes cr... | 08/04/2009 |
| 7439258 | Viral polymerase inhibitors A compound of the formula I: wherein: X is CH or N; Y is O or S; Z is OH, NH2, NMeR3, NHR3; OR3 or 5- or 6-membered heterocycle, having 1 to 4 heteroatoms selected from O, N and S... | 10/21/2008 |
| 7423150 | Substituted benzazoles and methods of their use as inhibitors of Raf kinase New substituted benzazole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatme... | 09/09/2008 |
| 7414046 | Gyrase inhibitors and uses thereof The present invention relates to compounds of the formula I: or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also re... | 08/19/2008 |
| 7390907 | Vanilloid receptor ligands and their use in treatments Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascu... | 06/24/2008 |
| 7378240 | Synthesis and evaluation of new cyanine dyes as minor groove of [POLY(dA-dT)]binders The present invention relates to new cyanine dyes according to the formula (I), wherein A1 and A2 are each independently O, S, or N, and R is H or a carbohydrate that may contain a hetero atom, and m is 0 to 5, and n is 0 to 5. ... | 05/27/2008 |
| RE40245 | Gyrase inhibitors and uses thereof The present invention relates to compounds of the formula I: or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates ... | 04/15/2008 |
| 7329678 | Chemical compounds Benzimidazolyl-pyridine derivatives, which are useful as SGK-1 inhibitors are described herein. The described invention also includes methods of making such benzimidazolyl-pyridine derivatives as well as methods of using the same in the treatment of diseases mediate... | 02/12/2008 |
| 7288541 | Propylcarbamate derivatives as inhibitors of serine and cysteine proteases The present invention includes ketone derivatives (I) and (II), which are useful as cathepsin K inhibitors. The described invention also includes methods of making such ketone derivatives as well as methods of using the same in the treatment of disorders, including ... | 10/30/2007 |
| 7285560 | Indole derivatives or benzimidazole derivatives for modulating IκB kinase The present invention relates to indole derivatives or benzimidazole derivatives, to processes for preparing such compounds, to pharmaceutical compositions comprising such compounds, and methods for the prophylaxis and therapy of a disease associated with an increas... | 10/23/2007 |
| 7285551 | Fused-ring compounds and use thereof as drugs The present invention provides a fused ring compound of the following formula [I] wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, and a therapeutic agent for he... | 10/23/2007 |
| 7271261 | Substituted benzimidazoles and imidazo-[4,5]-pyridines 2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer. ... | 09/18/2007 |
| 7252925 | Nitrogen-containing organic compound, resist composition and patterning process Resist compositions comprising nitrogen-containing organic compounds having a benzimidazole structure and a specific ether chain moiety have an excellent resolution, form precisely configured patterns with minimized roughness of sidewalls and are useful in microfabr... | 08/07/2007 |
| 7244747 | Imidazole derivatives, processes for preparing them and their uses The present invention relates to imidazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals. ... | 07/17/2007 |
| 7241758 | Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds of the formula (I) wherein G, X, Ar, L and Q are defined herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory disease... | 07/10/2007 |
| 7235570 | 1,4-dihydropyridine and pyridine compounds as calcium channel blockers The present invention is directed in part towards methods of modulating the function of calcium channels with pyridine- or 1,4-dihydropyridine-based compounds. In addition, the invention describes methods of preventing and treating protein kinase-related abnormal co... | 06/26/2007 |
| 7220762 | Methods for stabilizing benzimidazole compounds The present invention provides a method for stabilizing an oral solid formulation containing a benzimidazole-based compound or a physiologically acceptable salt thereof. That is, it provides a method for stabilizing a benzimidazole-based compound or a physiologicall... | 05/22/2007 |
| 7186720 | Tetrahydropyridyl-alkyl-heterocycles, method for preparing the same and pharmaceutical compositions containing the same The present invention relates to compounds of formula (I): in which X represents N or CH; R1 represents a hydrogen or halogen atom or a CF3 group; R2 and R3 independent... | 03/06/2007 |
| 7183295 | PPAR-activating compound and pharmaceutical composition comprising the compound A compound represented by the following formula (1): (wherein each of R1 and R2, which may be identical to or different from each other, represents a hydrogen atom, a methyl group, or an eth... | 02/27/2007 |
| 7169793 | Process for preparation of optically pure or optically enriched sulfoxide compounds, including amorphous esomeprazole and salts thereof A process of preparation of optically pure or optically enriched isomers of omeprazole and structurally related sulfoxides is provided. Also provided are an amorphous form of esomeprazole, as well a pharmaceutical composition containing it and a method of using it f... | 01/30/2007 |
| 7148234 | Use of EP4 receptor ligands in the treatment of IL-6 involved diseases Methods of treating IL-6 involved diseases with EP4 receptor ligands, including EP4 receptor antagonists. Assays to determine the effect of test compounds on PGE2-induced whole blood cells activation. ... | 12/12/2006 |
| 7138420 | Substituted benzimidazole compounds Disclosed are substituted benzimidazole compounds of formula (I): wherein R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention inhibit It... | 11/21/2006 |
| 7132435 | Compounds This invention relates to nicotinamide derivatives of general formula (I): in which R1, X, Y, Z and R2 have the meanings defined herein, and to processes for the preparation of, intermediate... | 11/07/2006 |
| 7129358 | Processes for the production of substituted 2-(2-pyridylmethyl) sulfinyl-1H-benzimidazoles Improved processes for preparing substituted 2-(2-pyridylmethyl)sulfinyl-1H-benzimidazoles are disclosed. ... | 10/31/2006 |
| 7081534 | Process for the preparation of pantoprazole and salts thereof A process for the preparation of pantoprazole and the salts thereof, comprising the reaction of a mercaptoimidazole with a picoline, to give a 2-pyridinyl-methylsulfinyl-2-benzimidazole intermediate, the oxidation thereof with ε-phthalimidoperhexanoic acid and the ... | 07/25/2006 |
| 7071216 | Substituted benz-azoles and methods of their use as inhibitors of Raf kinase New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatm... | 07/04/2006 |
| 7030139 | Compounds Compounds of general formula (I), are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain | 04/18/2006 |
| 7030150 | Benzimidazole compounds and antiviral uses thereof The present invention relates to novel benzimidazole compounds that have useful antiviral activity. More specifically, the invention encompasses benzimidazole compounds that inhibit membrane fusion associated events such as viral transmission, reduce viral load or o... | 04/18/2006 |
| 7019018 | Methods for stabilizing benzimidazole compounds The present invention provides a method for stabilizing an oral solid formulation containing a benzimidazole-based compound or a physiologically acceptable salt thereof. That is, it provides a method for stabilizing a benzimidazole-based compound or a physiologicall... | 03/28/2006 |
| 7008953 | 3, 5 Disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation 3,5 disubstituted indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating CDK dependent diseases to modulate a... | 03/07/2006 |
| 6989398 | Benzanilides as potassium channel openers Benzanilides are provided which are voltage-dependent potassium channel openers. Methods of using the benzanilides of the invention are also provided. ... | 01/24/2006 |
| 6982275 | Process for producing optically active sulfoxide derivative The present invention relates to a production method of an optically active form of a compound represented by formula (II) wherein ring A is a benzene ring optionally having substituent(s); R1 is H, a hydroca... | 01/03/2006 |
| 6974808 | CRF receptor antagonists and methods relating thereto CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke. ... | 12/13/2005 |
| 6962932 | 1-phenyl-2-heteroaryl-substituted benzimdazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as ph... | 11/08/2005 |
