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| Number | Title | Issue Date |
| 8163928 | Heteroaryl substituted benzothiazoles The present invention relates to novel heteroaryl substituted benzothiazole derivatives, precursors thereof, and therapeutic uses for such compounds, having the structural formula (I) below: [Chemical formula should be inserted here. Please see paper copy] and to th... | 04/24/2012 |
| 7737281 | Purine based fluorescent dyes The present invention provides novel purine-based fluorescent dyes that may be used for staining, localizing and otherwise labeling target molecules, such as nucleic acids, for detection, amplification and quantification. ... | 06/15/2010 |
| 7569695 | Dyes for the detection or quantification of desirable target molecules The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of th... | 08/04/2009 |
| 7393866 | Amide compounds and medications containing the same The present invention provides to a novel compound having an ACAT inhibiting activity. The present invention relates to compounds represented by formula (I) wherein represents an optionally s... | 07/01/2008 |
| 7390907 | Vanilloid receptor ligands and their use in treatments Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascu... | 06/24/2008 |
| 7378240 | Synthesis and evaluation of new cyanine dyes as minor groove of [POLY(dA-dT)]binders The present invention relates to new cyanine dyes according to the formula (I), wherein A1 and A2 are each independently O, S, or N, and R is H or a carbohydrate that may contain a hetero atom, and m is 0 to 5, and n is 0 to 5. ... | 05/27/2008 |
| 7371748 | Benzothiazole derivatives This invention relates to compounds of formula I wherein R1 and R2 are defined herein, or a pharmaceutically acceptable salt thereof. | 05/13/2008 |
| 7361671 | Substituted heteroarylalkanoic acids Disclosed are substituted heteroarylalkanoic acids acids of the following formula D-A-C(O)R′, where D, A, and R′ are defined herein. These compounds are useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceu... | 04/22/2008 |
| 7358263 | Fused bicyclic-substituted amines as histamine-3 receptor ligands Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands... | 04/15/2008 |
| 7351807 | Cyanine-sulfenates for dual phototherapy Dye-sulfenate derivatives and their bioconjugates for dual phototherapy of tumors and other lesions. The compounds comprise sulfenates having the formula, t,0080 where E is selected from the group consisting of somatostatin receptor binding molecules, heat se... | 04/01/2008 |
| 7338956 | Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals The present invention relates to acylamino-substituted heteroaromatic compounds of formula I, wherein R1, R2, R3, R4 and R5 and X are as defined herein, to pharmaceutic... | 03/04/2008 |
| 7326403 | Radioactive iodine-labeled compound A radioactive iodine-labeled compound represented by the following formula (I): wherein X represents a radioactive iodine atom which may substitute at an arbitrary position on the benzene ring (preferably 12... | 02/05/2008 |
| 7226740 | Aza-benzazolium containing cyanine dyes Unsymmetrical cyanine dyes that incorporate an aza-benzazolium ring moiety are described, including cyanine dyes substituted by a cationic side chain, monomeric and dimeric cyanine dyes, chemically reactive cyanine dyes, and conjugates of cyanine dyes. The subject d... | 06/05/2007 |
| 7189743 | Prodrugs of 1-methyl-2-(4-amidinophenylaminomethyl)-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amide The present invention relates to new compounds of general formula having thrombin-inhibiting activity. Exemplary are: 1-Methyl-2-[4-(N-hydroxyamidino)-phenylaminomethyl]-benzimidazol-5-yl-carboxylic ... | 03/13/2007 |
| 7189854 | Cyclic protein tyrosine kinase inhibitors Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders. ... | 03/13/2007 |
| 7183293 | Ether derivatives useful as inhibitors of PDE4 isozymes This application is directed to compounds of the formula wherein j is 1; k is 0 or 1; m is 1, 2 or 3; n is 1 or 2; W1 and W2 are independently —O— or —S(═O)t—, where t i... | 02/27/2007 |
| 7153815 | Insecticide containing hydrazone derivative as the active ingredient and novel hydrazone derivative A insecticide characterized by containing as active ingredient a hydrazone derivative of formula (I) wherein A and Q are an aryl or a heterocyclic group, W is oxygen atom, an aminylene, an alkylene group, an oxya... | 12/26/2006 |
| 7153873 | Salts of bicyclic, N-acylated imidazo-3-amines and imidazo-5-amines Salts of a bicyclic, N-acylated imidazo-3-amine or an imidazo-5-amine of the formula: addition products thereof with acids, and methods for preparing the salts and addition products. Also disclosed are pharmaceut... | 12/26/2006 |
| 7112413 | Heteroaryl substituted benzothiazole dioxetanes Chemiluminescent heteroaryl substituted benzothiazole 1,2-dioxetane compounds capable of producing light energy when decomposed are provided. These chemiluminescent compounds are represented by the general formula: The... | 09/26/2006 |
| 7105533 | Fused heterobicyclo substituted phenyl metabotropic glutamate-5 modulators Phenyl compounds substituted with a fused-heterobicyclo moiety, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, and panic, as well as in the treatment of pain and other disease... | 09/12/2006 |
| 7094790 | Fused bicyclic-substituted amines as histamine-3 receptor ligands Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 recep... | 08/22/2006 |
| 7091219 | Bis-sulfonamide hydroxyethyl-amino retroviral protease inhibitors Bis-sulfonamido hydroxyethylamino compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to retroviral protease inhibiting compounds of the formula: | 08/15/2006 |
| RE39198 | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgesics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amounts of one of the compounds. The compoun... | 07/18/2006 |
| 7067516 | Serine protease inhibitors Compounds of formula (I) where R5, R6a, each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents. ... | 06/27/2006 |
| 7057042 | Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction, wherei... | 06/06/2006 |
| 7049271 | Phenyl-substituted 2-enamino-ketonitriles The present invention relates to novel phenyl-substituted 2-enamino-ketonitriles of the formula (I): in which Ar, X, Z, Y and K are each as defined in the description, to a plurality of pro... | 05/23/2006 |
| 7034035 | Fungicidal mono-, bi-, and tri-cycloheteroalkyl amides and their compositions, methods of use and preparation The present invention relates to compounds of Formula I: wherein: a) represents a 6-membered heterocyclic aromatic ring in w... | 04/25/2006 |
| 7026321 | Substituted heterocyclic compounds Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, ... | 04/11/2006 |
| 7008957 | Bicyclic cyanoheterocycles, process for their preparation and their use as medicaments The invention relates to compounds of the formula I in which the radicals have the stated meanings, their stereoisomeric forms and their physiologically tolerated salts and process for their preparation. The com... | 03/07/2006 |
| 6963000 | Benzothiazole derivatives with activity as adenosine receptor ligands The present invention relates to substituted benzothiazole derivitives and to their pharmaceutically acceptable salts useful for the treatment of diseases related to the adenosine receptor. ... | 11/08/2005 |
| 6960599 | Heterocyclic aminoalkylpyridine derivatives as psychopharmaceuticals The invention relates to heterocyclic aminoalkylpyridine derivatives of the formula I: where R1 is the radical of a heterocycle having 1 to 3 ring structures, where each ring structure is satura... | 11/01/2005 |
| 6916930 | Radioactive iodine-labeled compound A radioactive iodine-labeled compound represented by the following formula wherein X represents a radioactive iodine atom which may substitute at an arbitrary position on the benzene ring (preferably 123I, | 07/12/2005 |
| 6911448 | Piperazine and piperidine compounds The invention relates to a group of novel piperazine and piperidine derivatives of the formula wherein Y is hydrogen, halogen, alkyl (1-3C), or CN, CF3, OCF3, SCF3, alkoxy(1-3C), amino or mono- or dialkyl(1-3C) substituted amino or h... | 06/28/2005 |
| 6900229 | Prodrugs of 1-methyl-2-(4-amidinophenylaminomethyl)-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amide The present invention relates to new compounds of general formula having thrombin-inhibiting activity. Exemplary are: 1-Methyl-2-[4-(N-hydroxyamidino)-phenylaminomethyl]-benzimidazol-5-yl-carboxylic acid-(... | 05/31/2005 |
| 6878728 | Inhibitors of aspartyl protease The invention provides novel compounds of formula (I) wherein all variables are as defined in the specification, that are useful as inhibitors of aspartyl proteases. ... | 04/12/2005 |
| 6867211 | 4-Pyridyl-and 2,4-pyrimidinyl-substituted pyrrole derivatives and their use in pharmacy The present invention relates to 4-pyridyl- and 2,4-pyrimidinyl-substituted pyrrole derivatives and their use in pharmacy, of the formula 1: in which the variables have the meanings indicated in the description. The co... | 03/15/2005 |
| 6844295 | Benzoxazole compound, process for producing the same, and herbicide The present invention relates to benzoxazole compounds represented by the following formula (I): wherein R1 to R4 may be the same or different from each other, and each re... | 01/18/2005 |
| 6838462 | Insecticidal azoles The present invention relates to novel heterocyclic compounds of formula (I) where A, R1, R2, Y, Z, and n are defined in the disclosure, to processes for their preparation, and to their use as crop protection agents, i... | 01/04/2005 |
| 6828333 | Ether derivatives useful as inhibitors of PDE4 isozymes This application is directed to compounds of the formula wherein j is 1; k is 0 or 1; m is 1, 2 or 3; n is 1 or 2; W1 and W2 are independently —O— or —S(═O)t—, where t is 0, 1... | 12/07/2004 |
| 6800760 | Quinolinone derivatives Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and... | 10/05/2004 |
