Class 546/269.1 - Oxadiazoles (including hydrogenated)

Subclass of Class 546 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which the five-membered hetero ring consists
No. of patents: 229
Last issue date: 03/13/2012

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Number	Title	Issue Date
8134007	Pyridine derivatives The present invention relates to compounds of the formula (I): and pharmaceutically acceptable salts thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such c...	03/13/2012
7442795	Triazole compounds useful in therapy A compound of formula (I), or a pharmaceutically acceptable derivative, wherein A, B, V, W, X, Y, and Z are as defined herein; pharmaceutical compositions thereof; and uses thereof. ...	10/28/2008
7390907	Vanilloid receptor ligands and their use in treatments Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascu...	06/24/2008
7390804	N-containing five-membered ring compounds and pharmaceutical agents comprising the same as active ingredient An N-containing five-membered ring compound of formula (I) wherein all symbols are the same as described in the specification, and a non-toxic salt thereof. The compound of formula (I) has an inhibitory activity aga...	06/24/2008
7250518	Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes Compounds of the formula: useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils. ...	07/31/2007
7217714	CCR5 modulators Compounds of Formula 1 [Region α]−[Region β]−[Region γ]−[Region δ] (I) which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and m...	05/15/2007
7157476	Aminofurazan compounds useful as protein kinase inhibitors The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, ...	01/02/2007
7153878	Peroxisome proliferator activated receptor modulators The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts thereof, Formula I. (Formula I); wherein: (a) R5 is selected from the group consisting of (C1–C6)alkyl, (C	12/26/2006
7148219	Biaryl heterocyclic compounds and methods of making and using the same The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety th...	12/12/2006
7144899	Thrombin inhibitors Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure Formula (I): wherein u is CH or N; Q is 1)—N(R25)CH(R30)— wherein the nitrogen atom is attached to R1	12/05/2006
7141672	Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds of Formula I having the structure or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia. ...	11/28/2006
7135472	3-Heterocyclic benzylamide derivatives as potassium channel openers The present invention provides novel 3-heterocyclic benzylamides and related derivatives having the general Formula I wherein R1, R2, R3, R4, R5, R6	11/14/2006
7132425	5-substituted-six-membered heteroaromatic glucokinase activators The present invention provides a compound according to formula I where the substituent designations are provided in the specification. Pharmaceutical compositions comprising a compound according to formula I are ...	11/07/2006
7119098	Heteroarylakanoic acids as intergrin receptor antagonists The present invention relates to a class of compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of Formula (I), and methods of selectively antagonizing the ανβ3 and/or the...	10/10/2006
7112595	Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed. ...	09/26/2006
7105556	Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure wherein Q is C or N, X1 is C or N, and R1, R2, R2a, R2b, R2c, R3, Y, A, m, n, X2	09/12/2006
7037880	Ethylene derivatives and pesticides containing said derivatives Ethylene derivatives of formula (I): where Q is an unsubstituted or substituted phenyl or heterocyclic group, especially a 4-thiazolyl, 1- or 3-pyrazolyl, 1,3-oxazol-4-yl, phenyl or pyridyl group; E is a substituent su...	05/02/2006
7026321	Substituted heterocyclic compounds Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, ...	04/11/2006
7026307	Method for producing 1,3-disubstituted 2-nitroguanidines The present invention relates to a process for the preparation of compounds of the formula (I) by reacting compounds of the formula (II) in which ...	04/11/2006
7022650	4-trifluoromethylpyrazolyl-substituted pyridines and pyrimidines A description is given of 4-trifluoromethylpyrazolyl-substituted pyridines and pyrimidines of formula (I) and of their use as herbicides. In this formula (I) R1, R2, R3 and R4	04/04/2006
6992083	Benzoxazol derivatives The invention relates to compounds of formula wherein R is phenyl, unsubstituted or substituted by halogen or —CH2N(CH3)(CH2)nOCH3	01/31/2006
6953798	β-alanine derivates Alkanoic acid derivatives of formula (1) are described: Ar1(Alka)rL1Ar2CH(R1)C(Ra)(Ra′)R (1) Ar1 is an optionally substituted aromatic or...	10/11/2005
6919359	Azabicyclic-substituted-heteroaryl compounds for the treatment of disease The invention provides compounds of Formula I: Azabicyclo-N(R1)—C(═X)—W Formula I These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Fo...	07/19/2005
6916933	4-pyridinyl-n-acyl-l-phenylalanines Compounds of Formula I have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and are useful for treating disease whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4. ...	07/12/2005
6903085	Substituted piperidine compounds useful as modulators of chemokine receptor activity The invention provides compounds of formula (I) wherein R1, R2, R3, R6, Z, Q, m, n, X1, X2, X3, X4 and T are as defined in the specification, processes for their preparation, pha...	06/07/2005
6875768	Phthalamide derivatives, intermediates in the production thereof, and agricultural/horticultural insecticides and method for using the same Heterocyclic amine derivatives represented by general formula (I): wherein R1, R2 and R3 represent each H, optionally halogenated C3-6 cycloalkyl, etc.; Q represents an optio...	04/05/2005
6852719	Glucocorticoid receptor modulators The present invention provides non-steroidal compounds of Formula I, including prodrugs and pharmaceutically acceptable salts thereof, which are selective modulators (e.g., agonists, partial agonists and antagonists) of a steroid receptor, specifically, the glucocor...	02/08/2005
6803378	HIV integrase inhibitors Novel diketoacid compounds of Formula I are provided which are useful as HIV integrase inhibitors and for the treatment of AIDS or ARC. ...	10/12/2004
6706715	Urea derivatives with antiproteolytic activity The present invention relates to compounds of the formula I, in which R1, R2, R4, R5, D1, D2, X1, X2, X3, A and B have th...	03/16/2004
6699896	Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds having the structure ##STR1## wherein A is OR5, or ##STR2## R1 is alkyl, cycloalkyl of 3-8 carbon atoms, thienyl, furyl, pyridyl, ##STR3## R2 is H, alkyl, or aryl; R3	03/02/2004
6699853	4-HALOALKYL-3-HETEROCYCLYLPYRIDINES, 4-HALOALKYL-5-HETEROCYCLYL-PYRIMIDINES AND 4-TRIFLUOROMETHYL-3-OXADIAZOLYLPYRIDINES, PROCESSES FOR THEIR PREPARATION, COMPOSITIONS COMPRISING THEM, AND THEIR USE AS PESTICIDES The present invention relates to 4-Haloalkyl-3-heterocyclylpyridines, 4-haloalkyl-5-heterocyclyl-pyrimidines and 4-trifluoromethyl-3-oxadiazolylpyridines, Processes for Their Preparation, Compositions Comprising Them, and Their Use as Pesticides More part...	03/02/2004
6660753	Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclos...	12/09/2003
6656911	Serine protease inhibitors The present invention relates to certain substituted oxadiazole, thiadiazoles and triazole peptoids which are useful as inhibitors of serine proteases. Compounds of the invention are useful for treating, for example, adult respiratory distress syndrome, s...	12/02/2003
6656910	Serine protease inhibitors The present invention relates to certain substituted oxadiazole, thiadiazoles and triazole peptoids which are useful as inhibitors of serine proteases. Compounds of the invention are useful for treating, for example, adult respiratory distress syndrome, s...	12/02/2003
6645984	Arylisoxazoline derivatives, processes for their preparation and their use as pesticides Compounds of the formula (I), ##STR1## are described in which X is halogen, cyano, nitro, (C1 -C4)-alkyl, (C1 -C4)-alkoxy, (C1 -C4)-alkylthio or (C1 -C4)-alkylsulf...	11/11/2003
6645993	3-heterocyclylpropanohydroxamic acid PCP inhibitors Compounds of formula (I) ##STR1## and their salts, solvates and prodrugs, wherein the substituents have the values mentioned herein, are Procollagen C-Proteinase (PCP) inhibitors and have utility in conditions mediated by PCP....	11/11/2003
6630592	Processes for production of oxadiazoline derivatives A process as represented by reaction scheme: ##STR1## which permits industrial mass production of Ɗ2 -1,2,4-oxadiazoline derivatives having excellent insecticidal effects or salts thereof in high yield with advantage, [wherein X1 is...	10/07/2003
6617339	Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them Compounds of formula (I) as defined herein, or a pharmaceutically acceptable salt, or an in-vivo-hydrolysable ester thereof, are useful as antibacterial agents. Processes for their manufacture and pharmaceutical compositions containing them are described....	09/09/2003
6583141	4,5-dihydro-isoxazole derivatives and their pharmaceutical use The present invention is concerned with the compounds of formula ##STR1## wherein m, n and p are each independently 0 or 1 and q is 0, 1, 2, 3, 4 or 5; --A1.dbd.A.sup.2 --A3.dbd.A.sup.4 -- is a pyridinylidene, pyridazinylidene, pyrim...	06/24/2003
6566377	댣 adrenergic receptor agonists and uses thereof The instant invention provides 댣 adrenergic receptor agonists of structural Formula (I), ##STR1## the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers and prodrugs, wherein Ar,...	05/20/2003

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Class 546/269.1 - Oxadiazoles (including hydrogenated)