Did You Know...
...that a workman who left the soap mixing machine on too long was responsible for making Ivory Soap? He was so embarrassed by his mistake that he threw the mess in a stream. Imagine his dismay when the evidence of his error floated to the surface! Result: Ivory soap, the soap that floats.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8084613 | Tetrazoyloxime derivative and plant disease control agent The present invention provides a tetrazoyloxime derivative or salt thereof, represented by the following formula (1): [wherein, R1 represents an optionally substituted C1-C6 alkyl group etc., q represents an inte... | 12/27/2011 |
| 7902369 | Diaryl-substituted five-membered heterocycle derivative The present invention provides the compounds represented by formula (I): (I) or pharmaceutical salts thereof, wherein: X1 represents oxygen atoms and the like, X2 | 03/08/2011 |
| 7696352 | Factor Xa inhibitors The present invention is directed to compounds represented by Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, p... | 04/13/2010 |
| 7442716 | 2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to t... | 10/28/2008 |
| 7439260 | 7-(1,3-thiazol-2-YL)thio-coumarin derivatives and their use as leukotriene biosynthesis inhibitors The instant invention provides compounds of Formula (I) which are leukotriene biosynthesis inhibitors. Compounds of formula (I) are useful as anti-asthmatic, anti-allergic, anti-inflammatory, cytoprotective and anti-artherosclerotic agents. | 10/21/2008 |
| 7429605 | Phenylpyridine derivatives The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical comp... | 09/30/2008 |
| 7425570 | Pyridoxine and pyridoxal analogues: new uses The invention provides pyridoxal and pyridoxine analogues, pharmaceutical compositions containing pyridoxine and pyridoxal analogues, and methods of administering pharmaceutical compositions containing a therapeutically effective amount of at least one of these anal... | 09/16/2008 |
| 7414055 | Inhibitors of Akt activity The present invention is directed to compounds which contain a substituted pyridine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this inven... | 08/19/2008 |
| 7390907 | Vanilloid receptor ligands and their use in treatments Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascu... | 06/24/2008 |
| 7375122 | Compounds useful as pesticides Compounds useful to control pests are provided. ... | 05/20/2008 |
| 7361672 | Heteroarylacetamide inhibitors of factor Xa The invention is concerned with novel heteroarylacetamides of formula (I) Rd—C(O)—N(Re)—Rc—CH2—C(O)—N(Ra)(Rb) (I) wherein Ra to Re are as def... | 04/22/2008 |
| 7361654 | Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory- and immune-associated disea... | 04/22/2008 |
| 7323570 | Farnesyltransferase inhibitors Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase ... | 01/29/2008 |
| 7309800 | Biphenylcarboxylic amide derivatives as p38 kinase inhibitors Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ... | 12/18/2007 |
| 7273936 | Oxazole and thiazole compounds as transforming growth factor (TGF) inhibitors Novel oxazole and thiazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of tran... | 09/25/2007 |
| 7268229 | Compounds to co-localize luminophores with luminescent proteins A method of measuring the enzymatic activity of a luciferase includes contacting a luminogenic protein, such as a luciferase, with a protected luminophore to form a composition; and detecting light produced from the composition. The protected luminophore provides in... | 09/11/2007 |
| 7253190 | Heteroaryl substituted tetrazole modulators of metabotrophic glutamate receptor-5 Tetrazole compounds substituted directly, or by a bridge, with a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia... | 08/07/2007 |
| 7250518 | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes Compounds of the formula: useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils. ... | 07/31/2007 |
| 7238714 | Aryl or heteroaryl amide compounds This invention provides a compound of the formula (I): wherein A represents a phenyl group or the like: B represents an aryl or the like: E represents a 1,4-phenylene group; R1 and R2 indepe... | 07/03/2007 |
| 7217714 | CCR5 modulators Compounds of Formula 1 [Region α]−[Region β]−[Region γ]−[Region δ] (I) which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and m... | 05/15/2007 |
| 7211595 | Farnesyltransferase inhibitors Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a p... | 05/01/2007 |
| 7208169 | Biphenyl carboxamides The invention relates to novel biphenylcarboxamides of the formula (I) in which R1, R2, m, n, R3, Y and A are as defined in the disclosure, to a plurality... | 04/24/2007 |
| 7205312 | N-[4-(heteroarylmethyl)phenyl]-heteroarylamines The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen, hydrox... | 04/17/2007 |
| 7205318 | Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors The present application describes lactam-containing cyclic diamines and derivatives thereof of Formula I: P4-M-M4I or pharmaceutically acceptable salt forms thereof, wherein M is a non-aromatic carbocycle or heterocycle. Com... | 04/17/2007 |
| 7205320 | Phosphodiesterase 4 inhibitors PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3 ... | 04/17/2007 |
| 7179822 | Hetero biaryl derivatives as matrix metalloproteinase inhibitors This invention provides compounds defined by Formula I and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising a compound of Formula I, or a pharmaceutically acceptable... | 02/20/2007 |
| 7169798 | Inhibitors of c-Jun N terminal kinases (JNK) and other protein kinases The present invention provides compounds of formula I: where R1 is H, CONH2, T(n)-R, or T(n)-Ar2, n may be zero or one, and G, XYZ, and Q are as described be... | 01/30/2007 |
| 7157580 | Aminopyrimidine and aminopyridine anti-inflammation agents Aminopyrimidine and aminopyridine (I) compounds, compositions and methods useful in the treatment of inflammatory, metabolic or malignant conditions, are provided herein ... | 01/02/2007 |
| 7153871 | Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs PDE4 inhibition is achieved by novel compounds, e.g., aminoindazole and aminobenzofuran analogs. The compounds of the present invention are of Formulas I and II: wherein R1, R2, R3 | 12/26/2006 |
| 7151118 | Biphenylcarboxylic amide derivatives as p38-kinase inhibitors Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ... | 12/19/2006 |
| 7125887 | Pyrrolidine modulators of CCR5 chemokine receptor activity Pyrrolidine compounds of Formula (I), (wherein R1, R2, R3, R4, R5, R6a, R6b, R7 and R8 are defined herein) are described. The compounds are modulators of CCR5 chemokin... | 10/24/2006 |
| 7112599 | Oxazole compounds for the treatment of neurodegenerative disorders The present invention relates to compounds of the Formula wherein R3, R5, R6, R7, and Z, and other variables enumerated under one or more of R3, R5 | 09/26/2006 |
| 7105548 | Heteroaryl substituted triazole modulators of metabotropic glutamate receptor-5 Triazole compounds substituted directly, or by a bridge, with a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl which are metabotropic glutamate receptor—subtype 5 (“mGluR5”) modulators useful in the treatment of psychiatri... | 09/12/2006 |
| 7105556 | Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure wherein Q is C or N, X1 is C or N, and R1, R2, R2a, R2b, R2c, R3, Y, A, m, n, X2 | 09/12/2006 |
| 7078419 | Cytokine inhibitors Disclosed are compounds of formula (I) Where Ar1, X, Y, Q, W, R3, R4, R5, R6 and Ry are defined herein. The compounds of the invention inhibit pro... | 07/18/2006 |
| 7071175 | Pyridine mercapto carboxylic acids as carboxypeptidase U inhibitors The present invention relates to compounds of Formula I, and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and thus can be used in the prev... | 07/04/2006 |
| RE39113 | Utilization of derivatives of tetrahydropyridines(or 4-hydroxypiperidines)-butylazols in the preparation of a medicament for the treatment of pain Derivatives of tetrahydropyridines (or 4-hydroxypiperidines)-butylazols of formula (I), wherein R1, R2 and R3, which are similar or different, represent each of them hydrogen, halogen, alkyl C1-C4, trifluorometh... | 05/30/2006 |
| 7038057 | Substituted 1-dihydropyrazoles, their preparation and use This invention provides compounds of Formula (I), methods for their preparation and use for preparing compounds of Formula (II) wherein R1, R2, R3, R5, R6, X and n are as defined in the disclosure. This inventio... | 05/02/2006 |
| 7026324 | Thrombin inhibitors Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, wherein R2 is R3 is selected from the group consisting of 1) hydrogen, 2) halogen, 3) C1... | 04/11/2006 |
| 7026321 | Substituted heterocyclic compounds Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, ... | 04/11/2006 |
