Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| RE40558 | Therapeutic uses of di-aryl acid derivatives The use of diaryl acid derivatives of formula (I) or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and their pharmaceutical compositions as P... | 10/28/2008 |
| 7349144 | Exterior electrochromic reflective mirror element for a vehicular rearview mirror assembly An exterior electrochromic reflective mirror element for a vehicular exterior rearview mirror assembly comprises an electrochromic cross-linked polymeric solid film disposed between a first substrate and a second substrate. The electrochromic cross-linked polymeric ... | 03/25/2008 |
| 7202987 | Electrochromic polymeric solid films, manufacturing electrochromic devices using such solid films, and processes for making such solid films and devices An electrochromic mirror device suitable for use in a vehicle comprises a first transparent substrate having a transparent conductive layer on a surface thereof and a second substrate having a conductive layer on a surface thereof. The conductive layer of the first ... | 04/10/2007 |
| 7138406 | Modulators of the glucocorticoid receptor The present invention provides compounds of the formula wherein A is of the formula and X, Y, n, R1–R25 are as described in the speci... | 11/21/2006 |
| 7004592 | Electrochromic mirrors and devices An electrochromic rearview mirror suitable for a motor vehicle is disclosed. The mirror includes a display device disposed behind the rear substrate. ... | 02/28/2006 |
| 6954300 | Electrochromic polymeric solid films, manufacturing electrochromic devices using such sold films, and processes for making such solid films and devices The present invention relates to electrochromic polymeric solid films, manufacturing electrochromic devices using such solid films and processes for making such solid films and devices. The electrochromic polymeric solid films of the present invention exhibit benefi... | 10/11/2005 |
| 6844366 | Sulfonamide hydroxamates This invention relates to certain sulfonamide derivatives that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds. ... | 01/18/2005 |
| 6833378 | Corticotropin releasing factor antagonists Corticotropin-releasing factor (CRF) antagonists having the formulae wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 and R17 are as defined... | 12/21/2004 |
| 6794380 | Amide derivatives The invention concerns amide derivatives of the Formula I wherein X is CH or N; Y is CH or N; m is 0-3; R1 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and carb... | 09/21/2004 |
| 6709642 | Calixarene acetamido derivatives, preparation and use thereof for extracting strontium The invention concerns derivatives of calixarene having the formula: in which: R1 represents various hydrocarbon groups, R2 and R3 represent an alkyl, cycloalkyl or aryl gro... | 03/23/2004 |
| 6693123 | Inhibitors of protein isoprenyl transferases Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R1 is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L2 --, and (i) heterocyclic-L | 02/17/2004 |
| 6548514 | Amide derivatives The invention concerns amide derivatives of the Formula I ##STR1## wherein X is CH or N; Y is CH or N; m is 0-3; R1 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and carbamoyl; n is 0-3; R2 | 04/15/2003 |
| 6531495 | 2'-Substituted 1,1'-biphenyl-2-carboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them Compounds of the formula I, ##STR1## in which R(1), R(2), R(3), R(4), R(5), R(6), R(7), R(8), R(30) and R(31) have the meanings indicated in the claims, are very particularly suitable as novel and antiarrythmic active compounds, in particular for the ... | 03/11/2003 |
| 6436963 | 2-methoxyimino-2-(pyridinyloxymethyl) phenyl acetamides with (derivatised) hydroxyalkyl derivatives on the pyridine ring The present invention provides novel 2-methoxyimino-2-(pyridinyloxymethyl)phenyl acetamide compounds with (derivatised) hydroxyalkyl substituents on the pyridine ring, their use as fungicidal compounds, and their use in fungicidal compositions comprising ... | 08/20/2002 |
| 6245774 | Tri-substituted phenyl or pyridine derivatives Compounds of general formula (1) are described: ##STR1## wherein .dbd.W-- is (1) .dbd.C(Y)-- where Y is a halogen atom, or an alkyl or --XRa group where X is --O--, --S(O)m -- [where m is zero or an integer of value 1 or 2], or --N(R... | 06/12/2001 |
| 6221871 | Certain aminomethyl biphenyl, aminomethyl phenyl pyridine and aminomethyl phenyl pyrimidine derivatives; novel dopamine receptor subtype selective ligands Disclosed are compounds of the formula: ##STR1## where S and V are various organic or inorganic substituents; G and K are the same or different and represent N or CR' where R' is an organic or inorganic substituent; R is hydrogen or an alkyl group; R1 | 04/24/2001 |
| 6204275 | PDE IV inhibiting compounds, compositions and methods of treatment The invention encompasses compounds of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). ##STR1## The inventio... | 03/20/2001 |
| 6194575 | Method for producing 1,3-di-substituted 2-nitroguanidines The present invention relates to a process for the preparation of compounds of the formula (I) ##STR1## by reacting compounds of the formula (II) ##STR2## in which Het, R1, R2 and R4 are as defined in the description, with... | 02/27/2001 |
| 6184237 | Substituted pyridine compounds and methods of use Selected novel substituted pyridine compounds are effective for prophylaxis and treatment of diseases, such as TNF-, IL-1ଲ, IL-6 and/or IL-8 mediated diseases, and other maladies, suchas pain and diabetes. The inventin encompasses novel compo... | 02/06/2001 |
| 6143751 | Pyridine derivatives and pharmaceutical compositions containing them Compounds of the formula (I) wherein X, R1, R2, and Ar1 as defined in the specification. The compounds are useful medicaments, particularly in the treatment of asthma or rhinitis.... | 11/07/2000 |
| 6127529 | Metal-chelating 2,6-disubstituted pyridine compounds and their use Bifuncitonal chelating pyridine compound and its use for conferring chelating properties on organic compounds. The pyridine compound has the structure ##STR1## where (i) n is an integer 1 or 2, (ii) R1, R2 and R3 repr... | 10/03/2000 |
| 6090808 | Dimeric piperidine, tetrahydropyridine and piperazine derivatives This subject invention relates to dimeric 4-phenylpiperidine, 4-phenyl-1,2,3,6-tetrahydropyridine, or 4-phenylpiperazine compounds or dimeric spirocyclic piperidine compounds having general formula (I), ##STR1## wherein n is 1-5; R1 to R | 07/18/2000 |
| 6013802 | Fluorescent conjugates of metal-chelating nitrogen heterocycles The present invention describes a family of fluorescent indicators for metal cations. The indicators are fluorophore conjugates of pyridyl-based metal ion chelators. The indicators are very sensitive detection as quantification reagents for a variety of m... | 01/11/2000 |
| 5962479 | Corticotropin releasing factor antagonists Corticotropin-releasing factor (CRF) antagonists having formulae (I), (II) or (III) wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 and R17 are as defined in the description, a... | 10/05/1999 |
| 5958983 | Polyaromatic antiviral compositions The present invention relates to polyaromatic compounds having useful antiviral activity against viruses of the herpes family, to a composition containing them, and to a method of using them for the treatment of herpes viruses infections.... | 09/28/1999 |
| 5925653 | Substituted pyridines and pyrimidines processes for their preparation and their use as pesticides and fungicides Substituted pyridines and pyrimidines, processes for their preparation and their use as pesticides and fungicides. The invention relates to compounds of the formula ##STR1## in which A is N or CH, R is H, halogen, alkyl or cycloalkyl, R2 and ... | 07/20/1999 |
| 5912350 | Certain aminomethyl biphenyl, aminomethyl phenyl pyridine and aminomethyl phenyl pyrimidine derivatives; novel dopamine receptor subtype selective ligands Disclosed are compounds of the formula: ##STR1## where S and V are various organic or inorganic substituents; G and K are the same or different and represent N or CR' where R' is an organic or inorganic substituent; R is hydrogen or an alkyl group; R... | 06/15/1999 |
| 5908931 | Preorganized hexadentate ligands useful in radiographic imaging agents The present invention relates particularly to novel preorganized hexadentate ligands that are suitable for completing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.... | 06/01/1999 |
| 5900418 | Method for treatment of obesity A method is provided for the control of obesity comprising administering to a mammal including humans suffering from obesity an acetylcholine esterase reactivator or prodrug derivative thereof optionally in association with an acetylcholine receptor antag... | 05/04/1999 |
| 5874467 | Phenylacetic acid derivatives and use as fungicides The present invention relates to phenylacetic acid derivatives of the formula I ##STR1## and their salts. The invention additionally relates to processes and intermediates for preparing these compounds and compositions containing them for contro... | 02/23/1999 |
| 5861407 | Tetrahydropyridine derivatives as dopamine receptor subtype ligands A class of substituted 1,2,3,6-tetrahydropyridine derivatives are disclosed that are ligands for dopamine receptor subtypes within the body. These compounds are therefore useful in the treatment and/or prevention of disorders of the dopamine system, in pa... | 01/19/1999 |
| 5847218 | Sulfonium salts and chemically amplified positive resist compositions The invention provides a novel sulfonium salt having a substituted or unsubstituted arylsulfonate anion. The novel sulfonium salt minimizes the influence of deactivation by basic compounds not only at a resist surface, but also at a resist-substrate inter... | 12/08/1998 |
| 5814645 | Arylor hetaryl substituted nitrogen heterocycles and their use as pesticides The present invention pertains to new substituted nitrogen heterocycles of general formula (I) ##STR1## in which R1 and R2 independently of each other, stand for hydrogen or alkyl, X stands for oxygen, sulfur or an NR3 | 09/29/1998 |
| 5739340 | Indolizine derivatives with pharmaceutical activity The invention relates to indolizine derivatives of general formula: ##STR1## in which: X denotes an --S or --SO2 -- group, each of R1 and R2, which are identical or different, denotes hydrogen, the methyl or ethyl radical ... | 04/14/1998 |
| 5714488 | Bis-heteroarylylmethoxyphenyl ketone derivatives as inhibitors of leukotriene biosynthesis Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein W is selected from the group consisting of optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, o... | 02/03/1998 |
| 5710160 | Diphenyl pyridyl ethane derivatives as PDE IV inhibitors The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). ##STR1## ... | 01/20/1998 |
| 5710170 | Tri-aryl ethane derivatives as PDE IV inhibitors The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). ##STR1## ... | 01/20/1998 |
| 5677454 | Certain methylpiperazinyl and methylpiperidinyl substituted biphenyl derivatives; novel dopamine receptor subtype selective ligands Disclosed are compounds of the formula: ##STR1## where S and V are various organic or inorganic substituents; G and K are the same or different and represent N or CR' where R' is an organic or inorganic substituent; R is hydrogen or an alkyl group; R... | 10/14/1997 |
| 5622977 | Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same Compounds of the general formula (1) ##STR1## are described wherein Y is halogen or --OR1, where R1 is a substituted or unsubstituted alkyl; X is --O--, --S-- or --N(R8)--, where R8 is hydrogen or alkyl; R | 04/22/1997 |
| 5618821 | Therapeutic phenoxyalkylheterocycles Compounds of the formula ##STR1## wherein Q is chosen from the group consisting of pyridyl, pyrazyl, pyrimidyl, quinolyl, indolyl and 7-azaindolyl or any of these substituted with one or two substituents; Y is an alkylene bridge of 3-9 carbon atoms; ... | 04/08/1997 |
