|8404850||Bis-quaternary pyridinium-aldoxime salts and treatment of exposure to cholinesterase inhibitors|
Bis-quaternary pyridinium-aldoxime salts are disclosed, and their associated polymorphic character, along with their methods of preparation. Such polymorphic salts may then be used for treatment of exposure to cholinesterase inhibitors, such as a phosphorous contain...
|8067607||Potassium channel inhibitors|
The present invention relates to pyridin-3-yl pyridin-3-amine compounds and derivatives thereof having the structure formula (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like. ...
|8058445||Substituted pyridinecarboxamides for the treatment of cancer|
Selected pyridine carboxamide compounds of Formula XI are effective for treatment of diseases and other maladies or conditions involving, cancer and the like. ...
|7977487||Method for producing N,N-bis(pyridin-2ylmethyl)-1,1-bis(pyridin-2-yl)-1-aminoalkane compounds and metal complex salts containing these compounds|
The invention relates to a method for producing the compositions cited in the title. According to this method: dipyridyl ketone is reacted with hydroxylamine; the oxime obtained thereby is reduced without intermediate isolation to form 1,1-di-(2-pyridyl)-methylamine...
|7968723||Compounds, their preparation and use|
Novel compounds of the general formula (I), in which the variables are as defined in claim 1, the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds an...
|7402683||Cinnamic acid amides|
The present invention relates to compounds, to processes for preparing them, to pharmaceutical compositions comprising them, and to their use in the therapy and/or prophylaxis in illnesses in people or animals, especially diseases of bacterial infection. ...
|7270700||Magenta dyes and inks for use in ink-jet printing|
A composition comprising: (a) a compound of Formula (1) wherein: R1, R2, R3 and R4 independently are substituents; ...
|7227034||Process for arylamine production|
Forming a 4-aminobiphenyl derivative arylamine compound, includes (i) providing a first disubstituted 4-aminobiphenyl compound; (ii) optionally formylating the first disubstituted 4-aminobiphenyl compound to form a bisformyl substituted compound where the first disu...
A bis(5-aryl-2-pyridyl) compound represented by formula (1) or a salt thereof: wherein A is a substituted or unsubstituted aromatic hydrocarbyl group or a substituted or unsubstituted aromatic heterocyclic group,...
|7176223||Method for synthesis of 5-(3-pyridylmethylene-)imidazolidine-2,4-dione|
Process for the synthesis of 5-(3-pyridylmethyl)imidazolidine-2,4-dione, according to which 5-(3-pyridylmethylene)imidazolidine-2,4-dione is subjected to a hydrogenation reaction. ...
Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro...
|7166710||Cationic dimeric dyes|
The present invention relates to novel cationic dye of formula (1) and (1a) wherein A is an organic radical of formula (2) or (3) wherein ...
|7161008||Optically active β-aminoketones, optically active 1,3-amino alcohols and processes for preparing them|
The invention relates to chiral Mannich bases of formula (I), chiral 1,3-amino alcohols of formula (II) derived therefrom, wherein R1, R2, R3, R4 and R5 are as defined herein, and to processes for preparing Mann...
|7074742||Pyridinyl amides and imides for use as fungicides|
Compounds of Formula (I), their N-oxides and agriculturally suitable salts are disclosed which are useful as fungicides formula (I), (II) wherein A is a substituted pyridinyl ring; B is a substituted pyridinyl ring; W is C=L or SOn is O or S; R1
|7045632||Composition and method for a hexadentate ligand and bimetallic complex for polymerization of olefins|
A hexadentate ligand for polymerization of olefins including chemical structure I is provided: R1, R2, and R3 of chemical structure I are each independently hydrogen, hydrocarbyl, substituted hydrocarbyl, or an i...
|7022858||Unsymmetrical methine and polymethine dye-molecules for fluorescent intracellular applications|
A new class of alpha-cyanomethine and alpha-cyanopolymethine dyes is provided having moieties which serve for the covalent attachment to biological substrates and resulting in the fluorescent labeling of the substrates. The labeled substrates are useful in analytica...
|6949567||Compounds for the treatment of protozoal diseases|
The invention relates to new diphenylurea having the formula (I) or a salt thereof, where Y is C═O, C═S, C═NH, (C═O)2 or SO2; and to pro...
|6939855||Anti-inflammatory compositions and method|
The disclosed invention includes pharmaceutical compositions and methods for treating inflammatory conditions, particularly those that are characterized by increased binding of alpha-9 integrin to one or more of its ligands. Also disclosed are methods for selecting ...
|6906195||Pyridone dyes, a process for the preparation and their use in the production of colored plastics or polymeric color particles|
The present invention relates to pyridone dyes of formula (1), wherein R is a radical —(CR′H)n—W, R′ is hydrogen, C1-C2alkyl or phenyl, Y is cyano, —CONH2 or —CH2SO3H, W is hydrogen, a rad...
|6900329||MCH antagonists and their use in the treatment of obesity|
The present invention discloses compounds which, are novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonist...
A bis(2-aryl-5-pyridyl) compound having formula (1) or a salt thereof: wherein A is a substituted or unsubstituted aromatic hydrocarbon group, and X is a substituent having one of the following formulas (2) to (4):
|6867217||Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade|
The invention relates to substituted polycyclic aryl and heteroaryl pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety...
|6833378||Corticotropin releasing factor antagonists|
Corticotropin-releasing factor (CRF) antagonists having the formulae wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 and R17 are as defined...
|6809109||2, 4-disubstituted-pyridine N-oxides useful as HIV reverse transcriptase inhibitors|
The present invention relates to 2,4-disubstituted pyridine-N-oxide compounds of formula (I): or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhib...
The invention concerns amide derivatives of the Formula I wherein X is CH or N; Y is CH or N; m is 0-3; R1 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and carb...
|6794398||Preventive/remedies for liver diseases|
The invention provides an agent for the prophylaxis and treatment of liver disease and an activation inhibitor of hepatic stellate cells, which contains a compound having a Rho kinase inhibitory activity. The compound having a Rho kinase inhibitory activity, such as...
|6787546||Heterocycle derivatives and drugs|
The object of the invention is to provide an excellent compound as a drug. The invention relates to a heterocyclic compound shown by the following formula: A—B—D—E  wherein A is heteroaryl or its oxi...
|6693123||Inhibitors of protein isoprenyl transferases|
Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R1 is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L2 --, and (i) heterocyclic-L
Phenylalanine derivatives of formula (1) are described: ##STR1## in which: Ar1 is an aromatic or heteroaromatic group; L1 is a linker atom or group; R is a carboxylic acid or a derivative thereof; Ar2 is an optionall...
|6677341||(R)-Chiral halogenated substituted heteroaryl benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity|
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and m...
|6656958||Substituted pyridine compounds useful for controlling chemical synaptic transmission|
The present invention is directed to a series of substituted pyridine compounds, a method for selectively controlling neurotransmitter release in mammals using these compounds, and pharmaceutical compositions containing these compounds. Preferred compound...
|6657063||Combinations of 댣 agonists and growth hormone secretagogues|
This invention is directed to pharmaceutical compositions comprising 댣 adrenergic agonists including (4-(2-(2-(6-aminopyridin-3-yl)-2(R)-hydroxyethylamino)ethoxy)phenyl)acetic acid and growth hormone or growth hormone secretagogues, prod...
Diacylhydrazine derivatives of general formula (I) ##STR1## wherein X, Y, Z, R1, 2 and R3 are as defined herein, and their physiologically acceptable salts or solvates thereof, are integrin inhibitors and can be used to co...
|6617458||Alpha cyano methine and polymethine dyes for the labeling of biological subtrates|
A new class of alpha-cyanomethine and alpha-cyanopolymethine dyes is provided having moieties which serve for the covalent attachment to biological substrates and resulting in the fluorescent labeling of the substrates. The labeled substrates are useful i...
|6608060||Inhibitors of p38|
The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides...
|6596728||Substituted 1,3-diaryl-2-pyrid-2-yl-3-(pyrid-2-ylamino)propanol derivatives, process for their preparation, pharmaceuticals comprising these compounds and their use|
Substituted 1,3-diaryl-2-pyridin-2-yl-3-(pyridin-2-ylamino)propanol derivatives of the formula (I), and salts thereof, ##STR1## in which the radicals have the meanings given in the specification, and physiologically tolerated salts thereof and processes f...
|6589966||Cytotoxic metal chelators and methods for making and using same|
A family of hexadentate Fe(II) chelators having marked antiproliferative activity against tumor cells is disclosed. The cytotoxic metal chelators and complexes of the present invention are represented by the general formula below: ##STR1## wherein: X...
|6583182||Compounds with chelation affinity and selectivity for first transition series elements: use in medical therapy and diagnosis|
This invention involves synthesis and use of a class of compounds with chelation affinity and selectivity for first transition series elements. Administration of the free or conjugated compound, or physiological salts of the free or conjugated compound, r...
|6548523||Process for the preparation of arylethanolamine derivatives having an anti-obesity and anti-diabetic properties|
The present invention is a process for the preparation of a compound of Formula (IA) or a pharmaceutically acceptable salt thereof: ##STR1## that includes preparing a diamide of Formula (II) or a pharmaceutically acceptable salt thereof: ##STR2##...
The invention concerns amide derivatives of the Formula I ##STR1## wherein X is CH or N; Y is CH or N; m is 0-3; R1 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and carbamoyl; n is 0-3; R2