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| Number | Title | Issue Date |
| 8093393 | Cationic ceramides, and analogs thereof, and their use for preventing or treating cancer The present invention relates to cationic ceramides, their dihydro-analogs and aromatic analogs and their derivatives, comprising a pyridinium group. Also provided are methods for making cationic ceramides comprising a pyridinium group, and their use for treating or... | 01/10/2012 |
| 7902368 | Cationic substituted 2,2,6,6-tetraalkylpiperidinyl alkoxyamines Cationic 2,2,6,6-tetraalkylpiperidinyl alkoxyamines of, for example, formula (1a) and (1b) are useful as polymerization initiators/regulators in a controlled stable free radical polymerization process to produce intercalated and/or exfoliated nanoparticles from natu... | 03/08/2011 |
| 7692019 | Methods for the stereoselective synthesis of substituted piperidines One aspect of the present invention relates to methods of synthesizing substituted piperidines. A second aspect of the present invention relates to stereoselective methods of synthesizing substituted piperidines. The methods of the present invention will find use in... | 04/06/2010 |
| 7557215 | Anthraquinone compounds as anti cancer compounds Anthraquinone compounds of the general formula (I) or a salt thereof (Formula I) in which R1 to R4 are each selected from the group consisting of H, C1-4 alkyl, X1, —NHR0N (R5)2 in which ... | 07/07/2009 |
| 7381721 | Substituted piperidine compounds 3,4-Disubstituted-4-aryl-piperidine compounds are disclosed. Pharmaceutical compositions containing the 3,4-disubstituted-4-aryl-piperidine compounds and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, inter alia, as anta... | 06/03/2008 |
| 7351718 | Substituted pyrrolidine and related compounds This invention is directed to compounds of formula I: wherein R1-R5 and a-e are as defined in the specification; or pharmaceutically-acceptable salt or solvate or stereoisomer ... | 04/01/2008 |
| 7351717 | Substituted pyrrolidine and related compounds This invention is directed to compounds of formula I: wherein R1-R5 and a-e are as defined in the specification; or pharmaceutically-acceptable salt or solvate or stereoisomer ... | 04/01/2008 |
| 7348435 | Process for producing cyanopiperidine The present invention relates to an improved and single step process for producing cyanopiperidine by dehydrating respective piperidine carboxamide employing a suitable dehydrating agent. ... | 03/25/2008 |
| 7271161 | Platinum complexes as antitumor agents in combination with biochemical modulation The present invention concerns the use of methods and compositions for the treatment of cancer and other hyperproliferative diseases. In certain embodiments, methods are described for the treatment of cancer and/or hyperproliferative diseases by administration of co... | 09/18/2007 |
| 7253185 | Amino ceramide-like compounds and therapeutic methods of use The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer sy... | 08/07/2007 |
| 7227032 | 3,3-dialkoxy-2-hydroxyiminopropionitriles, process for preparation thereof and process of preparing 5-amino-4-nitrosopyrazoles or salts thereof by the use of the same The present invention is to provide a 3,3-dialkoxy-2-hydroxyiminopropionitrile represented by the formula (1): wherein R1 and R2 may be the same or different from ea... | 06/05/2007 |
| 7217707 | Amide of R-2-(aminoaryl)-propionic acid for use in the prevention of leucocyte activation N-(2-aminoaryl-propionyl)-amides of formula (1) are described. The process for their preparation and pharmaceutical preparations thereof are also described. The amides of the invention are useful in the prev... | 05/15/2007 |
| 7183292 | Substituted pyrrolidine and related compounds This invention is directed to compounds of formula I: wherein R1–R5 and a-e are as defined in the specification; or pharmaceutically-acceptable salt or solvate or ... | 02/27/2007 |
| 7166601 | Substituted diamine derivatives useful as motilin antagonists The present invention relates to novel substituted diamine derivatives for the formula wherein R1, R2, R3, R4, X1, X2, X | 01/23/2007 |
| 7148239 | Method of enhancing cellular production of molecular chaperon, hydroxylamine derivatives useful for enhancing the chaperon production and the preparation thereof A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular cha... | 12/12/2006 |
| 7132422 | Sodium channel modulators The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of the pr... | 11/07/2006 |
| 7112586 | Substituted diamine derivatives useful as motilin antagonists The present invention relates to novel substituted diamine derivatives for the formula wherein R1, R2, R3, R4, X1, X2, X | 09/26/2006 |
| 7005524 | Methods for the stereoselective synthesis of substituted piperidines One aspect of the present invention relates to methods of synthesizing substituted piperidines. A second aspect of the present invention relates to stereoselective methods of synthesizing substituted piperidines. The methods of the present invention will find use in... | 02/28/2006 |
| 6967199 | Substituted diamine derivatives useful as motilin antagonists The present invention relates to novel substituted diamine derivatives for the formula wherein R1, R2, R3, R4, X1, X2, X3, X4, A, ... | 11/22/2005 |
| 6887887 | Asymmetric synthesis of (S,S,R)-(-)-actinonin and its analogs and uses therefor The present invention provides methods for the asymmetric synthesis of (S,S,R)-(−)-actinonin and its analogs and the compounds thereby synthesized having a structural formula: where R1 is an optionally sub... | 05/03/2005 |
| 6867217 | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade The invention relates to substituted polycyclic aryl and heteroaryl pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety... | 03/15/2005 |
| 6815458 | Azacyclic compounds Compounds and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In the method, an effective amount of a compound is adminstered to a patient in need of such treatment. ... | 11/09/2004 |
| 6809207 | Amino acid derivatives The present invention provides certain alpha-amino acids and derivatives thereof, such as, but not limited to, esters, amides and salts. These derivatives may comprise such representative side groups as a phenyl, pyridyl, piperidinyl, tetrahydropyranyl, tetrahydroth... | 10/26/2004 |
| 6800619 | Caspase inhibitors and uses thereof Described herein are compounds that are useful as caspase inhibitors having the formula: wherein Ring A is an optionally substituted piperidine, tetrahydroquinoline or tetrahydroisoquinoline ring; R1 is hydrog... | 10/05/2004 |
| 6784193 | Mutilin derivatives and their use as antibacterials A compound of formula (I) wherein R2 is arylene or heterocyclene; or R and R2 together with the nitrogen atom to which they are attached form non-aromatic heterocyclene; and the other residues have various meanings, useful as pharmaceuticals, e... | 08/31/2004 |
| 6756393 | Azacyclic compounds Compounds and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In the method, an effective amount of a compound is adminstered to a patient in need of such treatment. ... | 06/29/2004 |
| 6743564 | Amine compounds, resist compositions and patterning process Amine compounds having a cyano group are useful in resist compositions for preventing a resist film from thinning and also for enhancing the resolution and focus margin of resist. ... | 06/01/2004 |
| 6723866 | Liquid-crystalline compounds The invention relates to liquid-crystalline compounds of the formula I in which R1, A1, A2, Z1, Z2, a, b, L1, L2 and L3 are a... | 04/20/2004 |
| 6703425 | Sulfonamide derivatives The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such as psychiatric and neurological disorders ##STR1##... | 03/09/2004 |
| 6673934 | Primary intermediates for oxidative coloration of hair Primary intermediates for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): ##STR1## wherein R is hydrogen, hydroxy, nitro, amino, halogen, C1 to C5 alkyl or haloalkyl, C1 to C5... | 01/06/2004 |
| 6670477 | Synthesis of enantiomerically enriched 4-piperidinylglycine A process for making enantiomerically enriched 4-piperidinylglycine having the formula (I), ##STR1## said process comprising (a) combining N-protected glycine ester with 4-piperidone to form didehydroamino acid ester; (b) reducing the didehydroamino ... | 12/30/2003 |
| 6653321 | Naphthylsulfonic acids and related compounds as glucose uptake agonists Methods for treating conditions associated with hyperglycemia, especially Type II diabetes, with novel naphthylsulfonic acids and related compounds. These compounds, as single stereoisomers or mixtures of stereoisomers, or their pharmaceutically acceptabl... | 11/25/2003 |
| 6653326 | Hydroxylamine derivatives useful for enhancing the molecular chaperon production and the preparation thereof A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a mo... | 11/25/2003 |
| 6613769 | Tryptase inhibitors The invention relates to bifunctional tryptase inhibitors of formula (I) ##STR1## wherein H1 and H2 comprise a Q group and L is a linker of formula ##STR2## and the conformation of the H1, H2 and L groups is such that the groups are separated by a distanc... | 09/02/2003 |
| 6608196 | Process for solid supported synthesis of pyruvate-derived compounds Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis.... | 08/19/2003 |
| 6566375 | Elevation of HDL cholesterol by 4-[(aminothioxomethyl)-hydrazono]-N-(substituted)-4-arylbutanamides Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the "good" cholesterol and as such may be useful for treating diseases such as atherosclerosis. These compounds are represented by the formula ##STR1## wherein: R | 05/20/2003 |
| 6562080 | Primary intermediates for oxidative coloration of hair Primary intermediates useful hair coloring systems comprise 2-arylaminomethyl-4-aminophenols. The invention provides new 2-arylaminomethyl-4-aminophenol compounds of Formula (1): ##STR1## wherein R is a moiety selected from formulae (2), (3) or (4) #... | 05/13/2003 |
| 6545022 | 4(3)substituted-4(3)-aminomethyl-(thio)pyran or piperidine derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders Novel amines of formulas 1D and 1E ##STR1## are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders,... | 04/08/2003 |
| 6541632 | Process for producing heterocyclic nitriles A carbocyclic or heterocyclic compound, ammonia and an oxygen-containing gas are subjected to fluid catalytic reaction in vapor phase in the presence of a catalyst containing alkali metal to produce an aromatic or heterocyclic nitrile. The use of the cata... | 04/01/2003 |
| 6525222 | Process for preparing amines Amines are prepared by reacting aldehydes or ketones at elevated temperature under elevated pressure with nitrogen compounds selected from the group of ammonia, primary and secondary amines, and with hydrogen in the presence of a catalyst, wherein the cat... | 02/25/2003 |
