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| Number | Title | Issue Date |
| 8288552 | Dihydropyridone amidesas P2Xmodulators Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4, R5 and Ra are as defined herein. Also disclosed are m... | 10/16/2012 |
| 7994330 | Method for producing organic compound and method for decomposing compound having dicarboximide skeleton It is desirable to provide a method for easily removing catalyst-derived impurities from a product of a reaction by the catalysis of a compound having a dicarboximide skeleton and thereby efficiently yielding a target compound with high purity. Disclosed is a... | 08/09/2011 |
| 7662967 | Anti-inflammatory compounds and compositions The invention relates to the use of 3-(2′,2′-dimethylpropanoylamino)-tetrahydropyridin-2-one for preparing a medicament intended to prevent or treat inflammatory disorders. ... | 02/16/2010 |
| 7375230 | Fermentation and purification of migrastatin and analog Migrastatin and a migrastatin analog can be produced by fermentation of Streptomyces platensis NRRL 18993 and used in pharmaceutical formulations to treat cancer and/or inhibit metastasis of cancer cells. ... | 05/20/2008 |
| 7326789 | Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them The present invention relates to compounds of the formula I wherein A1, A2, R1, R2, R3, X and n are as defined in the claims, which are valuable pharmaceutic... | 02/05/2008 |
| 7220869 | Brønsted acidic room temperature ionic liquids each having a -protonated lactam cation and method for preparing the same The invention relates to a class of novel Brønsted acidic ionic liquids each having a lactam cation, and to a method for preparing the same through simple neutralization reaction of a lactam, which is available in large scale from industry, with a Brønsted inorgan... | 05/22/2007 |
| 7053085 | EP receptor agonist, compositions and methods thereof This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which are related to elevated intraocular pressure in the eye of a ... | 05/30/2006 |
| 6992103 | Benzamide derivatives, processes for their preparation, and their pharmaceutical use The present invention relates to novel hydroxyethylene compounds having Asp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevat... | 01/31/2006 |
| RE38934 | Method and reagents for N-alkylating ureides A method of N-alkoxyalkylating ureides according to the invention comprises reacting a ureide of structure I with an alkylating agent of structure III in the presence of a basic catalyst in an... | 01/10/2006 |
| 6977260 | Piperidinyl prostaglandin E analogs The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; | 12/20/2005 |
| 6831176 | Process for the preparation of 1, 5-dideoxy-1,5-imino hexitols from oximes or imines A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs. ... | 12/14/2004 |
| 6770658 | Substituted γ-phenyl-Δ-lactams and uses related thereto γ-Phenyl-substituted Δ-lactams are disclosed. They may be formulated into pharmaceutical compositions, and/or used in the treatment or prevention of inflammation or other conditions or disease states. ... | 08/03/2004 |
| 6723711 | Propanoic acid derivatives that inhibit the binding of integrins to their receptors A compound of the structure A method for the inhibition of the binding of α4β1 integrin to its receptors, for example VCAM-1(vascular cell adhesion molecule-1) and fibronectin; pharmaceutically ac... | 04/20/2004 |
| 6683185 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines A process for the preparation of 1,5-dideoxy -1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.... | 01/27/2004 |
| 6673920 | Method for the production of N-alkenyl-amides A process for preparing N-alkenyl-amides by reacting the corresponding NH-amides with acetylenes in the liquid phase in the presence of basic alkali metal compounds and of a cocatalyst comprises using as the cocatalyst diols of the general formula (I) ... | 01/06/2004 |
| 6653272 | Detergent composition A detergent composition that contains inorganic powder and a soap such as a soda soap, wherein the inorganic powder is zeolite powder, calcium carbonate powder, silica powder, ceramic powder, alga fossil powder, seashell powder or the like, and pineapple ... | 11/25/2003 |
| 6653480 | Process for the preparation of 1,5-dideoxy-1, 5-imino hexitols from oximes or imines A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.... | 11/25/2003 |
| 6624303 | Method for producing N-alkenyl amides A process for preparing N-alkenyl-amides by reacting the corresponding NH-amides with acetylenes in the liquid phase in the presence of basic alkali metal compounds and of a cocatalyst comprises using as the cocatalyst compounds of the general formulae (I... | 09/23/2003 |
| 6605724 | Process for the preparation of 1,5-dideoxy-1, 5-imino hexitols from oximes or imines A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.... | 08/12/2003 |
| 6537948 | Uracil compounds and use thereof The present invention relates to an uracil compound of the formula [I]: ##STR1## [wherein, Q--R3 represents a R3 -substituted group of a 5-membered or 6-membered heterocyclic ring having one or two nitrogen selected from the group co... | 03/25/2003 |
| 6509354 | 3-arylphenyl sulfide derivative and insecticide and miticide 3-Arylphenyl sulfide derivatives represented by general formula (I): ##STR1## (wherein R is a C2 -C6 alkyl group, a C2 -C6 alkenyl group, a C2 -C6 alkynyl group or the like, B0 to B | 01/21/2003 |
| 6509359 | Pyrrolidin-2-one compounds and their use as neuraminidase inhibitors A compound having the formula: ##STR1## wherein all variables are as defined in the specification, for use as a neuramninidase inhibitor.... | 01/21/2003 |
| 6472529 | Retroviral protease inhibiting compounds A compound of the formula: ##STR1## is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.... | 10/29/2002 |
| 6462197 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.... | 10/08/2002 |
| 6362332 | Coproduction of a cyclic lactam and a cyclic amine A cyclic lactam and a cyclic amine are coproduced by reacting an aliphatic alpha, omega-diamine with water in the gas phase in the presence of a heterogeneous catalyst.... | 03/26/2002 |
| 6362333 | Method for simultaneously producing a cyclic lactam and a cyclic amine A cyclic lactam and a cyclic amine are coproduced by coreacting an aliphatic alpha, omega-diamine and an aliphatic alpha, omega-aminonitrile with water in the gas phase in the presence of a heterogeneous catalyst.... | 03/26/2002 |
| 6353001 | 2-nitromethylidene/2-cyanimino/2-nitro-imino-pyrrolidines and piperidines, intermediates, and their use as pesticides Compounds of formula: ##STR1## wherein A is an unsubstituted or substituted aromatic or non-aromatic, monocyclic or bicyclic heterocyclic radical wherein a ring nitrogen atom may have been replaced by a group ##STR2## R1 is hydrogen or C | 03/05/2002 |
| 6274580 | Aminoguanidine carboxylate lactams for the treatment of non-insulin-dependent diabetes mellitus Compounds selected from the group consisting of formulae I, II, III, IV, VI, VII, and VIII ##STR1## wherein R is H or NH2, and pharmacologically acceptable salts thereof, are suitable for use in methods for treating non-insulin-dependent d... | 08/14/2001 |
| 6262222 | Copolymers containing N-vinyllactam derivatives, preparation methods thereof and photoresists therefrom Copolymers containing N-vinyllactam derivatives protected at 3-position are provided and represented by the following formula. The copolymers are used as a photoresist material suitable for deep uv process so that high sensitivity and resolution can be ob... | 07/17/2001 |
| 6255479 | Process for the preparation of -oxolactams A method for preparing an -oxolactam comprising, reacting a corresponding -diazolactam with an oxygen donor, in the presence of a transition metal catalyst, to yield the corresponding -oxolactam.... | 07/03/2001 |
| 6214857 | Substituted alkanohydroxamic acids and method of reducing TNF levels Imido and amido substituted alkanohydroxamic acids reduce the levels of TNF and inhibit phosphodiesterase in a mammal. A typical embodiment is 3-(3-cyclopentyloxy-4-methoxyphenyl)-N-hydroxy-3-phthalimidopropionamide.... | 04/10/2001 |
| 6169200 | Method for producing -hydroxy-ଲ-aminocarboxylic acids The present invention provides a simple and inexpensive method for producing -hydroxy-ଲ-aminocarboxylic acids and their esters. An ester of an N-protected -amino acid ester is converted into a ଲ-ketosulfoxide, which is then processed ... | 01/02/2001 |
| 6160126 | Synthetic Intermediates for the preparation of N, N'-Di-substituted isothiourea derivatives and N-cyclic(methyl)-N'-Substituted isothiourea derivatives Novel Intermediates ##STR1## wherein R is a substituted or unsubstituted hydrocarbon residue or acyl group; X is an electron withdrawing group; Y1 and Y2, which are the same or different, are each independently oxygen or sulfur;... | 12/12/2000 |
| 6100396 | Method for purifying lactams A method for purifying lactams by liquid-liquid extraction and/or processing with an ion exchange resin is disclosed. The method is useful for purifying lactams produced by the cyclising vapour-phase hydrolysis of an aliphatic aminonitrile, and comprises ... | 08/08/2000 |
| 6093820 | Method and reagents for N-alkylating ureides A method of N-alkoxyalkylating ureides according to the invention comprises reacting a ureide of structure I ##STR1## with an alkylating agent of structure III ##STR2## in the presence of a basic catalyst in an aprotic reaction medium. The ... | 07/25/2000 |
| 6080857 | Method of preparation of ଲ-amino acids A method for the preparation of ଲ-amino acid compounds is provided. The method includes contacting an amine nucleophile with an ,ଲ-unsaturated amide compound in the presence of a chiral Lewis acid complex. The chiral Lewis acid complex ... | 06/27/2000 |
| 6069144 | N-heterocyclic compounds, intermediate products used to prepare them, agents containing them and their use in antifungal applications N-heterocyclic compounds I ##STR1## or their salts or N-oxides, wherein A is an N-heterocycle selected from the group consisting of ##STR2## R1 -R6, R24 -R26 are hydrogen, cyano, nitro, halogen, a... | 05/30/2000 |
| 6066642 | Dihydropyridine-, pyridine-, benzopyran-4-one- and triazoloquinazoline derivative, their preparation and their use as adenosine receptor antagonists The present invention provides certain novel compounds, compositions, and a method of treating a mammal by blocking its adenosine receptors comprising administering at least one compound of the present invention. Examples of the present inventive compound... | 05/23/2000 |
| 6051678 | Copolymers containing N-vinyllactam derivatives, preparation methods thereof and photoresists therefrom Copolymers containing N-vinyllactam derivatives protected at 3-position are provided and represented by the following formula. The copolymers are used as a photoresist material suitable for deep uv process so that high sensitivity and resolution can be ob... | 04/18/2000 |
| 6034215 | 3-amino-2-oxo-1-piperidnercetic derivatives as enzyme inhibitors The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease ... | 03/07/2000 |
