"I hate what they've done to my child...I would never let my own children watch it. "
|7863452||Process for production of piperidine derivatives|
Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: The processes involve reacting a compound of formula Ia, IIa or IIIa with isobu...
|7858798||Process for production of carebastine|
Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: ...
|7498443||Process for production of carebastine|
Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: ...
|7435746||5-thiopiperdinyl prostaglandin E analogs|
A compound comprising or a pharmaceutically acceptable salt or a prodrug thereof is disclosed herein. Y and R are described in detail herein A compound having an ω chain comprising ...
|7410971||1,2-di(cyclic)substituted benzene compounds|
A compound represented by the following general formula (1) or (100), a salt thereof or a hydrate of the foregoing has excellent cell adhesion inhibitory action or cell infiltration inhibitory action, and is useful as a therapeutic or prophylactic agent for various ...
|7368443||2,6-disubstituted piperidines and piperazine compounds|
The present invention is directed to 2,6-disubstituted piperidine and piperazine analogs having the following general formula: which are used to treat diseases of the central nervous system, drug abuse, and withdrawal there...
|7361666||Heterocyclic analgesic compounds and methods of use thereof|
One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, including opiate receptors, other G-protein-couple...
|7338965||3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines|
The invention relates to substituted piperidine, piperazine, morpholine and thiomorpholine compounds useful in the treatment of Alzheimer's disease and more specifically to compounds that are capable of inhibiting beta-secretase, an enzyme that cleaves amyloid precu...
|7288552||Piperidine derivatives, process for preparation thereof, and pharmaceutical composition for alzheimer's disease containing the same|
The present invention relates to novel piperidine derivatives having effect of inhibiting acetylcholinesterase and aggregation of β-amyloid, Alzheimer's disease-induced protein, and treatment for Alzheimer's disease containing the same, the piperidine derivatives r...
Novel compounds of the formula I in which W, X, Y, T, R1 and R2 are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders
|7259173||Derivatives of 3-phenyl-n-(2-(4-benzyl)-piperidin-1-yl)-ethyl)-acrylamid with ccr-3-receptor antagonistic activity for use in the treatment of inflammations and allergic conditions|
This invention relates to organic compounds of formula I, in which Ar1 is unsubstituted phenyl substituted by one or more halogen atoms; Ar2 is unsubstituted phenyl or phenyl substituted by ...
|7196100||Opioid receptor antagonists|
A compound of the formula (I) wherein the variables X1 to X5, R1 to R7 including R3′, E, q, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer...
A herbicidal composition that, in addition to comprising customary inert formulation adjuvants, comprises either: a) a compound of formula (I), wherein R is C1–C2alkyl or chlorine, R1 is hydrogen or C1–C4alk...
Compounds of formula (II) are antibacterial agents wherein Q represents a radical of the formula: —N(OH)CH(═O) or the formula: —C(═O)NH(OH); R1 represents hydrogen, C1–C6 alkyl or C1–C6 alkyl substit...
|7166618||Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use|
The present invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitor, and, optionally, at least one compound that don...
|7115632||Sulfonyl aryl or heteroaryl hydroxamic acid compounds|
A sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated sulfonyl aromatic or heteroaromatic ring hydroxamic acid ...
|7105507||Cyclohexane derivatives and their use as therapeutic agents|
The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and (e); and R1, R2, R3, R4, R
|RE39263||Substituted aromatic thiocarboxylic acid amides and their use as herbicides|
There is disclosed substituted thiocarboxamides of the general formula (I) useful as herbicides. ...
|7064124||NF-κB inhibitor containing substituted benzoic acid derivative as active ingredient|
A NF-κB inhibitor represented by the following formula (I) is provided: ...
|RE39128||Pleuromutilin derivatives as antimicrobials|
The present invention relates to pleuromutilin derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medical therapy, particularly antibacterial therapy. ...
|7034042||N-(4-aryloxypiperidin-1-ylalkyl) cinnamic amides as CCR33 receptor antagonists|
Compounds of formula (I) in free or salt form, where Ar1 is phenyl substituted by one or more substituents selected from halogen, cyano, nitro, and C1–C8-alkyl optionally substituted by cyano or halogen, Ar2 is phenyl op...
|7005524||Methods for the stereoselective synthesis of substituted piperidines|
One aspect of the present invention relates to methods of synthesizing substituted piperidines. A second aspect of the present invention relates to stereoselective methods of synthesizing substituted piperidines. The methods of the present invention will find use in...
|6949545||Heterocyclic side chain containing, n-substituted metalloprotease inhibitors|
Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I):
Novel compounds of the formula I in which X, Y, Z, R, R1, R2 and R3 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of tromboembolic diseases and...
|6943177||Cis-2,6-disubstituted piperidines for the treatment of psychostimulant abuse and withdrawal, eating disorders, and central nervous system diseases and pathologies|
Cis-2,6-disubstituted piperdine analogs, or lobeline analogs, having the general formula: are used to treat diseases of the central nervous system, drug abuse and withdrawal therefrom as well as to treating eating diso...
|6900322||Method for stereochemically controlled production of isomerically pure highly substituted azacyclic compounds|
A method for stereochemically controlled production of azacyclic compounds of general formula (I) in which the substituents have the meanings given in the specification. The invention also relates to intermediate produ...
|6890939||Aminopyrrolidine sulfonamides as serine protease inhibitors|
The present invention is directed to compounds useful as selective serine protease or dual-serine protease inhibitors, compositions thereof and methods for treating serine protease or dual-serine protease mediated disorders. ...
|6878712||Amides as inhibitors for pyruvate dehydrogenase|
A compound of formula (I): wherein: Ring A is a nitrogen linked mono or bicyclic heterocyclic ring as defined within; R1 and R2 are independentl...
Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α 4 integrin. They are used as therapeutic agents for various diseases concerning α 4 integrin. ...
Compounds of formula (II) are antibacterial agents wherein Q represents a radical of the formula: —N(OH)CH(═O) or the formula: —C(═O)NH(OH); R1 represents hydrogen, C1-C6 alkyl or C1-C6 alkyl substituted...
|6815548||Process for preparing a piperidine derivative|
A piperidine derivative, which can be used as an intermediate for pharmaceuticals such as paroxetine useful as antidepressants, represented by the general formula (I): wherein R1 is hydrogen atom, benzyloxyc...
|6803468||Process for the synthesis of n-(5-methylnicontinoyl)-4 hydroxypiperidine, a key intermediate of rupatadine|
The present invention relates to an improved and industrially advantageous process for the preparation of N-(5-methylnicotinoyl)-4-hydroxypiperidine of Formula I, as shown in the accompanied drawings. This compound is a key intermediate for the synthesis of rupatadi...
|6753431||Production of mixed acid anhydride and amide compound|
There is disclosed an advantageous mixed acid anhydride production method of formula (1): R1C(O)OY(O)n(R2)p (1) wherein R1, R2 and Y denote the same as defined bel...
|6737528||Vinylic hindered amine light stabilizers|
Vinylic hindered amine light stabilizers as novel polylmerizable light stabilizers are disclosed and have the general formula (I): wherein: R1 is C1 to C8: alkyl, alkoxy, alkyl phe...
|6730783||Process for preparing aminoguanidines and alkoxyguanidines as protease inhibitors|
Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: wherein X is O or NR9 and R1-R4, R6-R9, R11, R12, Ra
|6713492||N-acyloxylated cycloalkyl compounds, composition containing the same and methods of use therefor|
Drugs or reagents containing as the active ingredient N-acyloxylated cycloalkyl compounds represented by general formula (I): wherein A is optionally substituted C4 or C5 cycloalkyl which may have o...
|6699881||Thiol compounds, their production and use|
The present invention provides a compound represented by Formula: ##STR1## wherein ring A and ring B may be same or different and each is an optionally substituted homocyclic or heterocyclic ring and the like, each R1 may be same or different a...
|6699990||3-(2,5-diaminophenyl)-acrylamide derivatives and coloring agents containing said compounds|
The present patent application relates to 3-(2,5-diaminophenyl)acrylamide derivatives of general formula (I) or to physiologically tolerated, water-soluble-salts thereof ##STR1## and to agents containing said compounds and used for oxidative dyeing of ...
|6645980||Heterocyclic analgesic compounds and methods of use thereof|
One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, including opiate receptors, other G-pro...
|6638950||Piperidine amides as modulators of chemokine receptor activity|
The present application describes modulators of CCR3 of formula (I): ##STR1## or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases....