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| Number | Title | Issue Date |
| 8097728 | Iminosugar compounds with antiflavirus activity An anti-viral compounds effective against viruses belonging to the Flaviviridae family, wherein the anti-viral compounds are 1,5-dideoxy-1,5-imino-D-glucitol derivative compounds having the general formula (I) wherein R | 01/17/2012 |
| 8071780 | 2-Hydroxymethyl-3,4,5-trihydroxy-1-benzilpiperidine derivatives as inhibitors of glucosylceramide The present invention provides novel piperidine derivatives of formula (I), wherein R represents a substituted benzyl group, which are useful as inhibitors of glucosylceramide synthase (GCS). The co... | 12/06/2011 |
| 8022219 | 2-hydroxymethy1-3,4,5-trihydroxy-1-(4-pentyloxybenzyl) piperidine as glucosylceramide synthase (Gcs) inhibitor The present invention relates to the compound 3,4,5-piperidinetriol, 2-(hydroxymethyl)-1-[(4-(pentyloxy)phenyl)methyl]-, (2S,3S,4R,5S), or a pharmaceutically acceptable salt or prodrug thereof, which is useful as an inhibitor of glucosylceramide synthase. The compou... | 09/20/2011 |
| 7423155 | N-sulfonyldicarboximide containing tethering compounds Compounds having two reactive functional groups are described that can be used as a tethering compound to immobilize an amine-containing material to a substrate. The first reactive functional group can be used to provide attachment to a surface of a substrate. The s... | 09/09/2008 |
| 7361767 | N-sulfonyldicarboximide containing tethering compounds Compounds having two reactive functional groups are described that can be used as a tethering compound to immobilize an amine-containing material to a substrate. The first reactive functional group can be used to provide attachment to a surface of a substrate. The s... | 04/22/2008 |
| 7288565 | Azasugar compound The present invention provides a compound represented by the formula (I) or a salt thereof: wherein R1 represents a hydrogen atom, a C1-10 alkyl group optionally having a substituent, or a p... | 10/30/2007 |
| 6946269 | Alkyl esters of 3-(3,4-dihalophenyl)-2,6-dioxopiperidine-3-propionic acid of use as intermediates The invention relates to lower-alkyl esters of 3-(3,4-dihalophenyl)-2,6-dioxopiperidine-3-propionic acid derivatives, and to processes for preparing the same. ... | 09/20/2005 |
| 6943177 | Cis-2,6-disubstituted piperidines for the treatment of psychostimulant abuse and withdrawal, eating disorders, and central nervous system diseases and pathologies Cis-2,6-disubstituted piperdine analogs, or lobeline analogs, having the general formula: are used to treat diseases of the central nervous system, drug abuse and withdrawal therefrom as well as to treating eating diso... | 09/13/2005 |
| 6927294 | Nitrogen-containing heterocycles Functionalized nitrogen heterocyclic compounds, including benzodiazepines and azasugars, and synthetic methods for preparing such compounds. Nitrogen-containing heterocycles are prepared by reacting amino-carbonyl compounds that contain an amine moiety connected via... | 08/09/2005 |
| 6864254 | Inhibitor for 20-hete-yielding enzyme An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is useful especially as a remedy for kidney diseases, cerebrovascular dis... | 03/08/2005 |
| 6774135 | Method of enhancing lysosomal α-galactosidase A A method of enhancing the activity of lysosomal α-Galactosidase A (α-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related compounds. ... | 08/10/2004 |
| 6759430 | Piperidine and pyrrolidine derivatives comprising a nitric oxide donor for treating stress The present invention relates to chemical compounds comprising a nitric oxide (NO) donor and a superoxide ion (O2−) scavenger, their preparation and their use in the treatment of conditions associated with oxidative stress or endothelial dysf... | 07/06/2004 |
| 6713492 | N-acyloxylated cycloalkyl compounds, composition containing the same and methods of use therefor Drugs or reagents containing as the active ingredient N-acyloxylated cycloalkyl compounds represented by general formula (I): wherein A is optionally substituted C4 or C5 cycloalkyl which may have o... | 03/30/2004 |
| 6689909 | Substituted N-phenyl 2-hydroxy-2-methyl-3,3,3-trifluoropropanamide derivatives which elevate pyruvate dehydrogenase activity A compound of formula (I) wherein: n is 1 or 2; R1 is chloro, fluoro, bromo, methyl or methoxy; R2 is as defined within; R3 is as defined within; and R4 is hydrogen or fluoro; or a pharmaceutically acceptable sa... | 02/10/2004 |
| 6656937 | Substituted glutarimides and their use as inhibitors of IL-12 production Substituted glutarimides of formula I ##STR1## and their method of making. Also disclosed are pharmaceutical compositions comprising the glutarimidie, particularly as immunomodulators and as inhibitors of angiopathies, or haematological or oncological dis... | 12/02/2003 |
| 6605723 | Process for the preparation of ethanesul fonyl-piperidine derivatives The present invention relates to a new process for the preparation of compounds of the formulae ##STR1## and their pharmaceutically acceptable acid addition salts, which are NMDA (N-methyl-D-aspartate)-receptor-subtype selective blockers.... | 08/12/2003 |
| 6538136 | Preparation of substituted piperidin-4-ones The present invention provides a novel process for the preparation of substituted piperidine-4-ones useful as intermediates in the preparation of pharmaceuticals.... | 03/25/2003 |
| 6531604 | Benzothiepine derivatives, their production and use The invention provides compounds of the formula: ##STR1## wherein the ring A is an optionally substituted benzene ring; R1 is an optionally substituted non-aromatic heterocyclic group; R2 and R3 are independently hydrogen ... | 03/11/2003 |
| 6448267 | Piperidine and pyrrolidine derivatives comprising a nitric oxide donor for treating stress The present invention relates to chemical compounds comprising a nitric oxide (NO) donor and a superoxide ion (O2-) scavenger, their preparation and their use in the treatment of conditions associated with oxidative stress or endothe... | 09/10/2002 |
| 6432985 | Neuroprotective substituted piperidine compounds with activity as NMDA NR2B subtype selective antagonists The invention relates to a compound of the formula ##STR1## its R,R-, S,S-enantiomers and racemic mixtures thereof and to their pharmaceutically acceptable acid addition salts. The compound of formula I and its R,R- and S,S-enantiomers may be used as medi... | 08/13/2002 |
| 6420415 | Thiol compounds, their production and use Compounds represented by general formula (1) or salts thereof which have a matrix metalloprotease inhibitory activity and are useful as drugs, wherein the rings A and B represent each an optionally substituted homocycle or heterocycle, etc.; R1... | 07/16/2002 |
| 6310213 | Ethanesulfonyl-piperidine derivatives The invention relates to compounds of the general formula ##STR1## wherein R1 signifies hydrogen or hydroxy; R2 signifies hydrogen or methyl; and X signifies --O-- or --CH2 -- and their pharmaceutically acceptable acid add... | 10/30/2001 |
| 6046214 | Heterocyclic compounds Novel piperidine compounds are provided, and those compounds are useful in the treatment and/or prevention of diabetes, and especially non-insulin dependent diabetes (NIDDM or type 2 diabetes) including overnight or meal treatment and treatment or prevent... | 04/04/2000 |
| 6022971 | Azetidines The present invention provides compounds of the formula (I): ##STR1## and the pharmaceutically acceptable salts thereof, wherein R is C3 -C7 cycloalkyl, aryl or C1 -C6 alkyl, said C1 -C6 ... | 02/08/2000 |
| 6008360 | Substituted 3-aryl-3-carboxyalkyl glutaramides, method for preparing same by 4-arylo-4-cyanoheptane dicarboxylic acid cyclisation, and use thereof for preparing 3-aryl-3-hydroxyalkylpiperidines The invention relates to glutarimides of formula (I): ##STR1## in which Ar represents a phenyl non substituted or substituted one or more times with one of the substitutents selected from a halogen atom, a hydroxyl, a (C1 -C4)al... | 12/28/1999 |
| 5981539 | Piperidine compounds as calcium channel blockers The present invention discloses compounds of the formula ##STR1## any of its enantiomers or any mixture thereof, or a pharmaceutically-acceptable addition salt thereof, wherein X, Ar, R, R1, R2, n are as defined herein.... | 11/09/1999 |
| 5935951 | 1-acyl-4-aliphatylaminopiperidine compounds The invention relates to novel 1-acyl-4-aliphatylaminopiperidine compounds of ##STR1## formula (I), in which R1 is a benzoyl, naphthoyl or cycloalkanoyl radical which is unsubstituted or substituted by lower alkyl, lower alkoxy, halog... | 08/10/1999 |
| 5908934 | Process for the preparation of chiral ketone intermediates useful for the preparation of flavopiridol and analogs A process for the preparation of compounds of formula I ##STR1## where R1, R2, R3, m, n and q are as defined herein; which comprises the steps of (a)reacting a compound of formula III ##STR2## with a chiral acid ... | 06/01/1999 |
| 5698494 | Substituted N-phenylglutarimides and N-phenylglutaramides, their preparation and use Substituted N-phenylglutarimides I ##STR1## X1, X2 =O, S; R1 =halogen, NO2, CN, CF3 ; R2 =H, halogen; R3, R4, R5 =H, halogen, CN, alkyl, cyctoalkyl, alkenyl... | 12/16/1997 |
| 5693630 | Phenylethyl and phenylpropylamines Compounds of the general formula ##STR1## or pharmaceutically acceptable salts thereof, wherein Z is a saturated or unsaturated 3 to 6 carbon chain, m is 2 or 3, R1 is a hydrogen atom, or a straight or branched C1-4 alkyl group,... | 12/02/1997 |
| 5681962 | Process for preparing aryl-piperidine carbinols A process for the preparation of a compound of formula (I) ##STR1## in which R3 is hydrogen, C1-6 alkyl or C1-6 alkylaryl, by reduction using diborane, of a compound of Formula (II) in which R3 is as define... | 10/28/1997 |
| 5620993 | Alpha-1a adrenergic receptor antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as selective alpha-1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These ... | 04/15/1997 |
| 5610318 | Imidocarboxylic acid activators and sulfimidocarboxylic acid activators processes for their preparation and their use This invention is directed to a process for preparing a compound containing a persalt activators and salts thereof which are derived from imidocarboxylic acids and sulfimidocarboxylic acids of the formula I: ##STR1## in which A is a group of the form... | 03/11/1997 |
| 5596005 | Omega-deoxy-azasugars Omega-deoxy-azapyranose compounds, processes of making and using the same are disclosed, as are a process of making omega-deoxy-azafuranose compounds.... | 01/21/1997 |
| 5507843 | Fuel compositions The present invention is directed to the use of multiple cyclic nitrogen-containing alkoxylate compounds as additives in fuel compositions. The invention is also directed to the use of these multiple cyclic nitrogen-containing alkoxylate compounds for dec... | 04/16/1996 |
| 5459270 | Azacyclic compounds, processes for their preparation and pharmaceutical compositions containing them | 10/17/1995 |
| 5451679 | 2-chloro and 2-bromo derivatives of 1,5-iminosugars Novel 2-chloro and 2-bromo derivatives of 1,5-iminosugars are disclosed, especially such derivatives of 1,5-dideoxy-1,5-imino-D-glucitol. These compounds are useful inhibitors of glucosidase enzymes and also are useful as antiviral agents and as intermedi... | 09/19/1995 |
| 5423998 | Peroxy carboxylic amino-derivatives Amino-derivative (poly)peroxycarboxylic acids which have the formula: ##STR1## wherein the symbols have the following meanings: R, R1, and R2, which may be equal to or different from one another, represent hydrogen atoms, alkyl ... | 06/13/1995 |
| 5393735 | Herbicidal glutarimides This invention relates to glutarimide compounds exhibiting herbicidal activity having the structure ##STR1## wherein A is carbonyl, thiocarbonyl or methylene, A1 is carbonyl or methylene, Q is O or (CH2)n where n is 0... | 02/28/1995 |
| 5359077 | Process for preparation of 2-oxo-1 piperidinyl derivatives The process involves ring opening and ring closure of compounds containing a tetrahydrofuroyl group ##STR1## to provide facile synthesis of compounds containing a piperidin-2-one group of the formula ##STR2##... | 10/25/1994 |
