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| Number | Title | Issue Date |
| 7592460 | Colorant compositions Disclosed are colorant compounds of the formula wherein R is an alkyl group, an aryl group, an arylalkyl group, or an alkylaryl group, and wherein R can be joined to the phenyl moiety to form a ring, each R′, independentl... | 09/22/2009 |
| 7425567 | Piperidine derivative compounds and drugs containing the compounds as the active ingredient A piperidine derivative of formula (I) (wherein all symbols are as described in the specification.) and an intermediate for the preparation thereof. The compound of formula (I) has phosphodiesterase 4 inhibitory activity, a... | 09/16/2008 |
| 7265132 | Compounds useful as reversible inhibitors of cysteine proteases Disclosed are cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds | 09/04/2007 |
| 7109342 | Piperidine derivatives and agent comprising the derivative as active ingredient Piperidine derivatives represented by formula (I) or nontoxic salts thereof (wherein symbols are defined in the description): Since the compound represented by formula (I) has a PDE4 inhibitory activity, it is usef... | 09/19/2006 |
| 7053101 | 1,3,8-triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders The present invention is directed to novel 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formula wherein all variables are as defined herein, useful in the treatment of dis... | 05/30/2006 |
| 7045630 | Method for preparing 4-amino-4-phenylpiperidines The invention relates to a process for preparing a 4-amino-4-phenylpiperidine (I): in which R is hydrogen or a (C1–C3)alkyl group, characterized in that a 1-protected 4-piperidone (II): | 05/16/2006 |
| 6982263 | Nitriles useful as reversible inhibitors of cysteine proteases Disclosed are novel nitrile compounds of formula (I) further defined herein, which compounds are useful as reversible inhibitors of cysteine proteases such as cathepsin K, S, F, L and B. These compounds are useful for treating diseases and pathological conditions ex... | 01/03/2006 |
| 6982272 | Compounds useful as reversible inhibitors of cysteine proteases Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds. ... | 01/03/2006 |
| 6962998 | Processes for producing racemic piperidine derivative and for producing optically active piperidine derivative Disclosed are a method for producing racemic piperidine derivatives by processing optically-active piperidine derivatives in a hydrogen atmosphere in the presence of a reducing catalyst; and a method for producing optically-active piperidine derivatives or their aci... | 11/08/2005 |
| 6858623 | Compounds useful as reversible inhibitors of cysteine proteases Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R2, R3, R4, R5, R6, R7, R8, Het and X are defined herein. The compounds are... | 02/22/2005 |
| 6756389 | Pharmaceutically active compounds and methods of use The present invention relates to certain imine-substituted heterocyclic compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment or p... | 06/29/2004 |
| 6753336 | Melanin concentrating hormone receptor ligands Disclosed are compounds of the formula: and the pharmaceutically acceptable salts thereof wherein Q, X, Y, Z, and R1 R9, and R12-R19 are defined herein. These compounds ... | 06/22/2004 |
| 6750219 | Ω-amino-α-hydroxycarboxylic acid derivatives having integrin ανβ3 antagonistic activity An objective of the present invention is to provide highly water-soluble compounds having integrin αvβ3 antagonistic activity. The compounds according to the present invention are compounds represented by formula (I) and pharmaceutically acce... | 06/15/2004 |
| 6638955 | Antibiotic oxazolidinone derivatives The present application discloses a class of antibiotic compounds containing an oxazolidinone ring. These compounds have useful activity against Gram-positive pathogens including MRSA and MRCNS and, in particular, against various strains exhibiting resist... | 10/28/2003 |
| 6586441 | Adenosine receptor ligands and their use in the treatment of disease The invention relates to cyclic heteroaromatic compounds, containing at least one nitrogen atom, and to their use in the manufacture of medicaments for the treatment of diseases, related to adenosine receptor modulators, such as Alzheimer's disease, Parki... | 07/01/2003 |
| 6506733 | Compounds and compositions as protease inhibitors Compounds of the formula: ##STR1## are provided, and are useful as cysteine protease inhibitors, particularly in the treatment of diseases such as osteoporosis or autoimmune disorders in which cathepsins K or S contribute to the pathology or symptomatolgy... | 01/14/2003 |
| 6436962 | Arylhydantoin derivatives and uses thereof Arylhydantoin derivatives and their pharmaceutically acceptable salts are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also described. One application of these compounds is in the treatment of be... | 08/20/2002 |
| 6303782 | Process for preparing benzylnitriles A process is described for preparing an aromatic compound substituted by a tertiary nitrile of Formula (1.0.0): ##STR1## comprising treating a substituted aromatic compound of Formula (2.0.0): ##STR2## with a secondary nitrile of Formula (3.0.0): ##S... | 10/16/2001 |
| 6294556 | Arylglycinamide derivatives, methods of producing these substances and pharmaceutical compositions containing such compounds The invention relates to new arylglycinamide derivatives of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein R1 and R2 together with the N to which they are bound form a ring of the formula #... | 09/25/2001 |
| 6271383 | Antibiotic oxazolidinone derivatives The present invention relates to antibiotic compounds and in particular to antibiotic compounds containing an oxazolidinone ring. This invention further relates to processes for their preparation, to intermediates useful in their preparation, to their use... | 08/07/2001 |
| 6231786 | Fluorinated azoles, and their use in liquid-crystalline mixtures In the fluorinated azoles of the formula (I) R1 (--A1)a --T--(A2 --)b (M--A3 --)c R2 (I) the symbols and indices have -the following meanings: T is undirected and is 4-fluorot... | 05/15/2001 |
| 6229011 | N-aroylphenylalanine derivative VCAM-1 inhibitors Compounds of the formula: ##STR1## are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 ... | 05/08/2001 |
| 6180648 | Analogs of cocaine The invention provides a compound of formula (I): ##STR1## wherein R1, R2, R3, and Y have any of the meanings defined in the specification; as well a pharmaceutical composition comprising a compound of formula I; intermedi... | 01/30/2001 |
| 6043366 | 1,3,8,-triaza spiro (4,5)decan-4-on derivatives The present invention relates to compounds of formula I and pharmaceutically acceptable acid addition salts thereof.... | 03/28/2000 |
| 5922738 | Heteroarylpyridine herbicides The novel heteroaryloxypyridines of formula I: ##STR1## (A, B, R1 and R2 are defined in the specification) show excellent selective herbicidal activity. The new compounds can be prepared according to known methods and can be use... | 07/13/1999 |
| 5831114 | Carbamate herbicides Substituted N-phenyl- and N-heteroarylalkylcarbamates of formula (I), in which Q is a group (1), (2) or (3); R is halogen, trifluoromethyl, cyano, nitro or C1 -C3 haloalkoxy; Z is hydrogen or halogen; or Z and R together in the 2- an... | 11/03/1998 |
| 5756748 | Process for the preparation of sameridine The present invention discloses a new and improved process for the preparation of sameridine and its pharmaceutically acceptable salt.... | 05/26/1998 |
| 5661163 | Alpha-1a adrenergic receptor antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as selective alpha-1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These ... | 08/26/1997 |
| 5622971 | Endothelin antagonists A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.... | 04/22/1997 |
| 5621107 | Sulfopyridones and a process of making therefor Azo dyes of the formula ##STR1## where D is the radical of a diazo component, and X is substituted or unsubstituted C2 -C8 -alkylene, in the form of the free acid or its salts, the use thereof for dyeing or printing natural or synthe... | 04/15/1997 |
| 5620993 | Alpha-1a adrenergic receptor antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as selective alpha-1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These ... | 04/15/1997 |
| 5576334 | Acylurea derivatives The invention concerns chemical compounds of formula I R1 --CON(R2)--CON(R3)--X1 --Q--X2 --GI and pharmaceutically acceptable metabolically labile esters or amides thereof, and pharmaceutically acceptable salts... | 11/19/1996 |
| 5424319 | Piperidinyl-terminated non-peptidyl -succinamidoacyl aminodiols as anti-hypertensive agents Non-peptidyl compounds characterized generally as -succinamidoacyl aminodiols having a piperidinyl-type group at the N-terminus are useful as renin inhibitors for the treatment of hypertension.... | 06/13/1995 |
| 5371086 | Aminopyridine compounds An aminopyridine compound represented by the formula: ##STR1## wherein n represents 0 or 1; Z represents .dbd.S, .dbd.NCN or .dbd.CHNO2 ; R1 represents --NR3 R4, --NHNR3 R4, --NHCONHR | 12/06/1994 |
| 5324723 | Oxazoles and thiazoles for the treatment of senile dementia 1,3-Oxazole and 1,3-thiazole compounds of formula I, and their pharmaceutically acceptable salts and prodrugs: ##STR1## wherein X represents oxygen or sulphur; R1 represents a non-aromatic azacyclic or azabicyclic ring system.... | 06/28/1994 |
| 5310902 | Alkylenediamine derivatives Novel alkylenediamine derivatives effectively employable glutamate blockers have the formula (I) or (II): ##STR1## wherein each of R1 and R6 is an aliphatic hydrocarbon group, an alicyclic hydrocarbon group, an aryl group, or an... | 05/10/1994 |
| 5283355 | Benzoquinone compounds Compounds of the Formula (5) and processes for their preparation and use, particularly in the manufacture of unsymmetrical triphenodioxazine dyes: ##STR1## wherein: Y is H, alkyl, substituted alkyl, alkoxy, Cl or Br; R is a group of Formula (3) ##STR... | 02/01/1994 |
| 5262415 | Aminopyridine compounds An aminopyridine compound represented by the formula: ##STR1## wherein n represents 0 or 1; Z represents .dbd.S, .dbd.O, .dbd.NCN or .dbd.CHNO2 ; R1 represents --CN, --NR3 R4, --CONR3 R4 | 11/16/1993 |
| 5231105 | Ethylamine derivatives and antihypertensives containing the same An ethylamine derivative of formula (I): ##STR1## wherein A represents a carbon atom or a nitrogen atom; B represents a substituted or unsubstituted aralkyl or aryl group; C represents hydrogen, alkyl, aralkyl, or aryl, each of which may optionally be sub... | 07/27/1993 |
| 5212185 | Piperidinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension Compounds characterized generally as piperidinyl-terminated alkylamino ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of Formula I ##STR1## wher... | 05/18/1993 |
