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| Number | Title | Issue Date |
| 7964734 | Raloxifene acid addition salts and/or solvates thereof, improved method for purification of said raloxifene acid addition salts and/or solvates thereof and pharmaceutical compositions comprising these Raloxifene acid addition salts or solvates thereof, having improved dissolution properties in media comprising hydrochloric acid are described, compared with similar preparations based on raloxifene or raloxifene hydrochloride. The disclosed acid addition salts or s... | 06/21/2011 |
| 7667042 | Stable polymorphic forms of an anticonvulsant Stable polymorphic forms III, IV and substantially amorphous form of an anticonvulsant, tiagabine hydrochloride. ... | 02/23/2010 |
| 7423052 | Piperidine compounds for use as orexin receptor antagoinst A invention relates to N aroyl cyclic amine derivatives and their use as pharmaceuticals, specifically as orexin receptor antagonists. ... | 09/09/2008 |
| 7417058 | Pharmaceutically active benzsulfonamide derivatives as inhibitors of protein junkinases The present invention is related to benzsulfonamide derivatives of formula I notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such benzsulfonamide derivatives. Said benzsulfonamide derivatives are ef-ficient ... | 08/26/2008 |
| 7348341 | Chemical compounds The invention concerns compounds of formula (I), and their use in therapy, particularly in the modulation of CCR3 activity. ... | 03/25/2008 |
| 7342027 | 1-phenylpiperidin-3-one derivatives and processes for the preparation thereof Provided are 1-phenylpiperidin-3-one derivatives and pharmaceutically acceptable salts thereof, having cysteine protease inhibitory activity, pharmaceutical compositions containing the same as an active ingredient, and processes for the preparation thereof. ... | 03/11/2008 |
| 7326716 | Treatment of inflammatory bowel disease The present invention provides a method of treating inflammatory bowel disease which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a piperidinyl prostaglandin E analog. ... | 02/05/2008 |
| 7288657 | Biphenyl compounds useful as muscarinic receptor antagonists This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 ar... | 10/30/2007 |
| 7276607 | 5-HTreceptor antagonists Substituted carbocyclic sulphonamide derivatives of formula (I), in which n is 0 or 1 and the other variables are as defined in the claims, are selective 5-HT7 receptor antagonists and are thereby effective in the treatment of a variety of neurological co... | 10/02/2007 |
| 7259157 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain. ... | 08/21/2007 |
| 7223780 | Triazole-derivatives as blood clotting enzyme factor Xa inhibitors The present invention is directed to the compound of formula I which is useful for inhibiting the activity of blood clotting enzyme Factor Xa. The present invention is also directed to compositions containing said compounds, processes for their preparation, their us... | 05/29/2007 |
| 7217823 | 4,4-Disubstituted piperidines, and methods of use thereof One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine transporters. The compounds of th... | 05/15/2007 |
| 7122675 | Gamma secretase inhibitors Novel aryl and heteroaryl sulfonamides are disclosed. The sulfonamides, which are gamma secretase inhibitors, are represented by the formula: wherein Ar1 and Ar2 independently represent aryl or he... | 10/17/2006 |
| 7119203 | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metallop... | 10/10/2006 |
| 7041682 | NKantagonists Disclosed are NK1 antagonists having the formula: Also disclosed are methods for treating a number of physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough, usi... | 05/09/2006 |
| 7034110 | Method of identifying chemical compounds having selected properties for a particular application A method for obtaining compounds having selected properties for a particular application by forming base modules having at least two structural diversity elements from the reaction of a first compound having at least one structural diversity element and a first reac... | 04/25/2006 |
| 7022716 | Cyclic amine phenyl beta-3 adrenergic receptor agonists This invention provides compounds of Formula I having the structure wherein, R1, R2, R3, R4, R5, T, T1, T2,... | 04/04/2006 |
| 7019007 | CCR-3 receptor antagonists (I) The invention provides compounds of Formula (I): wherein: R1–R4, A, D, and L have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical compositions c... | 03/28/2006 |
| 7015235 | Acylated piperidine derivatives as melanocortin-4 receptor agonists Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment... | 03/21/2006 |
| 7012084 | Acylated piperidine derivatives as melanocortin-4 receptor agonists Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevent... | 03/14/2006 |
| 6995268 | N- and O-substituted 4-[2-(diphenylmethoxy)-ethyl]-1- (phenyl) methyl) piperidine analogs and methods of treating CNS disorders therewith N- and O-substituted 4[2-diaromaticmethoxy and methylamino)alkyl]piperidines exhibit high CNS activity with respect to the dopamine transporter (DAT) and serotonin transporter (SERT). Preferred compounds exhibit highly differential behavior as between the DAT and SE... | 02/07/2006 |
| 6977260 | Piperidinyl prostaglandin E analogs The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; | 12/20/2005 |
| 6977265 | Piperidine CCR-3 receptor antagonists The invention provides compounds of Formula (I): wherein: R1-R5, A, L, and X have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical compositions co... | 12/20/2005 |
| 6887870 | Heterocyclic sodium/proton exchange inhibitors and method Heterocyclic are provided which are sodium/proton exchange (NHE) inhibitors which have the structure wherein n is 1 to 5; X is N or C—R5 wherein R5 is H, halo, alkenyl, alkynyl, alkoxy, alkyl, a... | 05/03/2005 |
| 6878723 | LTA4 hydrolase inhibitors The invention concerns compounds inhibiting LTA4 hydrolase of formula (I). The invention also concerns their therapeutic, in particular anti-inflammatory, applications. ... | 04/12/2005 |
| 6864249 | Piperidine and azetidine thrombin inhibitors The present invention relates to a compound having formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I and pharmaceutical compositions containing them are of the class of thrombin inhib... | 03/08/2005 |
| 6861530 | Piperidine derivatives This invention relates to substituted piperidine derivatives having at least one six-membered ring substituent. The piperidine derivatives exhibit antitumor activity and are useful as pharmaceuticals such as an antitumor agent. ... | 03/01/2005 |
| 6828318 | 2-adamantylethylamines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission Compounds of formula (1): wherein R1, R2, R3, R4, R5 and R6 are independently selected from hydrogen, alkyl, aryl and... | 12/07/2004 |
| 6825217 | Carbinols for the treatment of neuropathic dysfunction Compositions and methods are provided for treating neuropathic pain or neuropathic dysfunction that include the administration of an effective amount of a defined carbinol or a pharmaceutically acceptable salt or prodrug thereof. ... | 11/30/2004 |
| 6784173 | Aromatic dicarboxylic acid derivatives Compounds of formula I wherein A, R1 and R2 are defined in the specification. These compounds are useful as HDAC inhibitors. Also disclosed are methods of making and using said compounds. ... | 08/31/2004 |
| 6753337 | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors Compounds of the formula: useful in the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection. ... | 06/22/2004 |
| 6750231 | 4-arylpiperidine derivatives for the treatment of pruritus There is provided a compound of formula I, wherein Het1, R1, R2, R3, X and n have meanings given in the description, which are useful in the prophylaxis and in the treatment of... | 06/15/2004 |
| 6747037 | Piperidinyl prostaglandin E analogs The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; | 06/08/2004 |
| 6740647 | Thrombin inhibitors Novel five-membered heterocyclic amidines, their preparation and use as competitive inhibitors of trypsin-like serine proteases, especially thrombin and kininogenases such as kallikrein. Pharmaceutical compositions which contain the compounds as active ingredients, ... | 05/25/2004 |
| 6720336 | 4,4-biarylpiperidine derivatives The present invention relates to compounds of the formula I, wherein Z1, Z2, R1, R2 and R3 are defined as in the specification, pharmaceutical compositions containin... | 04/13/2004 |
| 6710060 | 4-hydroxypiperidine derivatives having antiarrhythmic activity The present invention relates to a compound represented by the following formula (I) or a salt thereof, or a pharmaceutical composition containing the compound as an effective ingredient: (wherein A represents, for examp... | 03/23/2004 |
| 6696443 | Piperidine/piperazine-type inhibitors of p38 kinase Certain compounds which contain a piperidine moiety flanked by aryl groups are inhibitors of p38- kinase and thus useful in the treatment of a variety of conditions characterized by inappropriate p38- kinase activity.... | 02/24/2004 |
| 6680329 | N-(heterocyclyl)benzene or pyridinesulphonamides as antithrombotic agents and anticoagulants Compounds of formula [I] ##STR1## in which: W may represent a --(CH2)2 --, --(CH2)3 --, --CH2 --C.ident.C-- or --CH2 --CH.dbd.CH-- group, R2 may in particular represent a pipe... | 01/20/2004 |
| 6664271 | Immunopotentiator agents Novel compounds and methods for preparing same, immunopotentiating compositions, and a method for potentiating the immune system of a host animal. The method comprises administering to the animal an effective amount of an immunopotentiating compound of Fo... | 12/16/2003 |
| 6639076 | Growth hormone secretagogues This invention relates to novel compounds of formula I ##STR1## wherein A, B, D, E, G, J, L, X, V are as defined in the specification, and the compounds are useful in the modulation of endogenous growth hormone levels in a mammal.... | 10/28/2003 |
