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| Number | Title | Issue Date |
| 8143405 | Piperidine and pyrrolidine beta-secretase inhibitors for the treatment of alzheimer's disease The present invention is directed to compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzhei... | 03/27/2012 |
| 7923563 | Amorphous object of cinnamide compound An amorphous object of (3E)-1-[l(s)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4methyl-1H-imidazol-1-yl)benzylidene]piperidine-2-one, which is represented by the formula (1) and has Aβ-production inhibitory activity. The amorphous object has such satisfactory propert... | 04/12/2011 |
| 7880009 | Cinnamide compound The present invention relates to a compound represented by Formula (I): (wherein Ar1 represents an imidazolyl group which may be substituted with 1 to 3 substituents; Ar2 represents a pyridinyl group, ... | 02/01/2011 |
| 7807837 | Scalable synthesis of imidazole derivatives Imidazole derivatives, compositions containing them, methods of preparing them, including regioselective scale-up synthetic methods, and methods of using them. ... | 10/05/2010 |
| 7799924 | Substituted homopiperidine, piperidine or pyrrolidine derivatives A novel class of substituted homopiperidine, piperidine and pyrrolidine derivatives, methods for their preparation, pharmaceutical compositions comprising them and use thereof in the treatment of disorders related to the histamine H3 receptor. More particularly, the... | 09/21/2010 |
| 7745630 | Triazolyl piperidine arginine vasopressin receptor modulators Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: Z, O, A, V, Y and Y′ are as defined herein; are useful for treating dysmenorreah. ... | 06/29/2010 |
| 7667041 | Cinnamide compound The present invention relates to a compound represented by Formula (I): (wherein Ar1 represents an imidazolyl group which may be substituted with 1 to 3 substituents; Ar2 represents a pyridinyl group, ... | 02/23/2010 |
| 7534893 | Imidazol-2-one compounds useful in the treatment of various disorders A compound of formula (I) wherein: R is a group selected from: A-B is a bivalent radical of formula (v), (vi) or (vii) —CH═C(R11 | 05/19/2009 |
| 7442795 | Triazole compounds useful in therapy A compound of formula (I), or a pharmaceutically acceptable derivative, wherein A, B, V, W, X, Y, and Z are as defined herein; pharmaceutical compositions thereof; and uses thereof. ... | 10/28/2008 |
| 7425633 | Pyrrolidine compounds A compound of the following formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, T, X, Y, and Z are as defined herein. Also disclosed is a ... | 09/16/2008 |
| 7423012 | Phosphinyloxy, oxime and carboxylic acid derivatives which are useful as carboxypeptidase U inhibitors The present invention relates to compounds of Formula I, and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and thus can be used in the preventio... | 09/09/2008 |
| 7423052 | Piperidine compounds for use as orexin receptor antagoinst A invention relates to N aroyl cyclic amine derivatives and their use as pharmaceuticals, specifically as orexin receptor antagonists. ... | 09/09/2008 |
| 7390822 | Substituted 4-phenyl-4-[1-imidazol-2-yl]-piperidine derivatives for reducing ischaemic damage The present invention relates to an agent for reducing ischaemic damage to an organ, in particular to a heart and a brain, pharmaceutical compositions comprising said agent and the use of said agent for the treatment of ischaemic diseases to the heart and the brain.... | 06/24/2008 |
| 7381721 | Substituted piperidine compounds 3,4-Disubstituted-4-aryl-piperidine compounds are disclosed. Pharmaceutical compositions containing the 3,4-disubstituted-4-aryl-piperidine compounds and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, inter alia, as anta... | 06/03/2008 |
| 7361666 | Heterocyclic analgesic compounds and methods of use thereof One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, including opiate receptors, other G-protein-couple... | 04/22/2008 |
| 7354895 | Phosphinyloxy, oxime and carboxylic acid derivatives which are useful as carboxypeptidase U inhibitors The present invention relates to compounds of Formula I, and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and thus can be used in the preventio... | 04/08/2008 |
| 7351720 | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity The present application describes modulators of chemokine receptor activity of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases, as well as auto... | 04/01/2008 |
| 7332508 | Substituted homopiperidine, piperidine or pyrrolidine derivatives A novel class of substituted homopiperidine, piperidine and pyrrolidine derivatives, methods for their preparation, pharmaceutical compositions comprising them and use thereof in the treatment of disorders related to the histamine H3 receptor. More particularly, the... | 02/19/2008 |
| 7329652 | Diaminotriazole compounds useful as protein kinase inhibitors The present invention relates to inhibitors of protein kinases, particularly to inhibitors of JAK2 and JAK3. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using... | 02/12/2008 |
| 7326705 | Heterocyclic sodium/proton exchange inhibitors and method Heterocyclic are provided which are sodium/proton exchange (NHE) inhibitors which have the structure wherein n is 1 to 5; X is N or C—R5 wherein R5 is H, halo, alkenyl, alkynyl, alkoxy, al... | 02/05/2008 |
| 7326716 | Treatment of inflammatory bowel disease The present invention provides a method of treating inflammatory bowel disease which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a piperidinyl prostaglandin E analog. ... | 02/05/2008 |
| 7326720 | Phenyl- and pyridylpiperidines with TNF activity The present invention relates to compounds of formula (I): in which X represents N or CH; R1 represents a hydrogen or halogen atom or a CF3 group; R2 and R3 independent... | 02/05/2008 |
| 7294636 | Chemical compounds Compounds of formula (I): compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal) ... | 11/13/2007 |
| 7291642 | Bradykinin-B1 antagonists, process for their preparation and their use as medicaments The present invention provides bradykinin-B1 antagonists of the formula in which A, Ar, G, Q, R1 and R4 are as defined in claim 1, their enantiomers, their diastereomers, their mixtures and ... | 11/06/2007 |
| 7282508 | Substituted 4-phenyl-4-(1-imidazol-2-yl)-piperidine derivatives and their use as selective non-peptide delta opioid agonists The present invention relates to novel 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives according to Formula (I) the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isome... | 10/16/2007 |
| 7268154 | Substituted triazole compounds The present invention relates to compounds of formula (I) wherein R1, R2 and R3 are as defined in the specification and to pharmaceutically suitable acid addition sal... | 09/11/2007 |
| 7265135 | 2-oxy, 2-amino, and 2-thio-imidazole compounds The invention relates to novel 2-Oxy, 2-Amino, and 2-Thio-imidazole compounds of formula (I): wherein all variables are as herein defined, pharmaceutical compositions containing the compo... | 09/04/2007 |
| 7262208 | Hydroxypropyl amides for the treatment of Alzheimer's disease The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the... | 08/28/2007 |
| 7259157 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain. ... | 08/21/2007 |
| 7253186 | N-substituted piperidine derivatives as serotonin receptor agents Disclosed herein are compounds of Formula I, or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof. Also disclosed are methods of inhibiting an activity of a monoamine receptor comprising contac... | 08/07/2007 |
| 7244692 | Substituted benzoylcyclohexane diones for use as herbicides The invention relates to novel substituted benzoylcyclohexanediones of formula (I) in which A1 represents a single bond or represents alkanediyl (alkylene) hav... | 07/17/2007 |
| 7241787 | Substituted N-cycloexylimidazolinones, process for their preparation and their use as medicaments The invention relates to substituted N-cyclohexylheterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof, to processes for their preparation and to their use as medicaments. Compounds of the formula I, | 07/10/2007 |
| 7241760 | Heteroaryl-substituted imidazole derivatives The present invention relates to imidazole derivatives of the general formula wherein R1, R2, R3 and R4 are described hereinbelow. These compounds can be used in the tr... | 07/10/2007 |
| 7230001 | Arylalkane, arylalkene and aryl azaalkane, medicaments containing said compounds and method for the production thereof The present invention relates to compounds of general formula R—Z1—Z2—Z3—R1, (I) wherein R, R1 and Z1 to Z3 are defined as in claim 1, ... | 06/12/2007 |
| 7226929 | Pyrrolidin-2-one derivatives as inhibitors of factor xa The invention relates to compounds of formula (Ic) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical con... | 06/05/2007 |
| 7223780 | Triazole-derivatives as blood clotting enzyme factor Xa inhibitors The present invention is directed to the compound of formula I which is useful for inhibiting the activity of blood clotting enzyme Factor Xa. The present invention is also directed to compositions containing said compounds, processes for their preparation, their us... | 05/29/2007 |
| 7217714 | CCR5 modulators Compounds of Formula 1 [Region α]−[Region β]−[Region γ]−[Region δ] (I) which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and m... | 05/15/2007 |
| 7208504 | Bicyclic inhibitors of hormone sensitive lipase Benzotriazoles of formula I in which R1 to R8 have the abovementioned meanings and process for their preparation are described. The compounds show an inhibitory effect on hormone-sensitive lipase. ... | 04/24/2007 |
| 7202259 | Therapeutic agents useful for treating pain 4-Tetrazolyl-4-phenylpiperidine Compounds, compositions comprising an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound, methods for treating or preventing pain or diarrhea in an animal comprising administering to an animal in need thereof an effective ... | 04/10/2007 |
| 7202254 | Antibacterial compounds: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel triazole compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotamers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutic... | 04/10/2007 |
