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| Number | Title | Issue Date |
| 7432284 | Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v... | 10/07/2008 |
| 7320985 | Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid A method for stabilizing an arylcarboxylic acid, which comprises adding a heterocyclic base to the arylcarboxylic acid or a pharmacologically acceptable salt thereof, a stabilizer thereof and an aqueous solution containing a stabilized arylcarboxylic acid. According... | 01/22/2008 |
| 7314875 | Tricyclic aromatic and bis-phenyl sulfinyl derivatives The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith. ... | 01/01/2008 |
| 7192969 | Ester derivatives This invention relates to compounds which exhibit selective muscarinic M3 receptor antagonism, have little side effects, are suitable for inhalation therapy and are useful as treating agents of respiratory system diseases, of the general formula (I); ... | 03/20/2007 |
| 7087599 | Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v... | 08/08/2006 |
| 7052863 | Alizarin-based chromogenic substrates, their uses and composition containing same An alizarin-based chromogenic substrate, a composition containing the substrate, and its use to detect the presence of an enzymatic activity are disclosed. The substrate is particularly applicable in the field of biological diagnosis. ... | 05/30/2006 |
| 6569849 | N-Substituted azaheterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, A, R1, R2, r and s are as defined in the detailed part of the present description or salts thereof, to me... | 05/27/2003 |
| 6441244 | Benzophenones and the use thereof as photoinitiators The invention relates to new compounds of the formula (I) ##STR1## in which R is phenyl, C1-4 alkyl-, C1-4 alkoxy- or halogen-substituted phenyl, naphthyl or an aromatic ring containing heteroatoms; X is O or S; R1 and R2 | 08/27/2002 |
| 6288234 | Multibinding inhibitors of microsomal triglyceride transferase protein Disclosed are multibinding compounds which inhibit microsomal triglyceride transferase protein (MTP), a protein which mediates the transfer of lipids during the assembly of lipoproteins and related biomolecules. The multibinding compounds contain from 2 t... | 09/11/2001 |
| 6288123 | Therapeutic guanidines The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.... | 09/11/2001 |
| 6239148 | N-substituted azaheterocyclic carboxylic acids and esters thereof The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them... | 05/29/2001 |
| 6174924 | Therapeutic guanidines The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.... | 01/16/2001 |
| 6172085 | Cyclic ether compounds as sodium channel modulators A compound of the formula: ##STR1## wherein R1 and R2 each represents hydrogen, lower alkyl which may be substituted or acyl; R3, R4 and R5 each represents lower alkyl which may be substituted or lowe... | 01/09/2001 |
| 6143791 | Therapeutic guanidines The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.... | 11/07/2000 |
| 6140338 | Chemokine receptor antagonists The present invention relates to a compound of the general formula: ##STR1## wherein each of R1 and R2 which may be the same or different, is e.g. a hydrogen atom, a halogen atom or a lower alkyl group, X is an oxygen atom, a su... | 10/31/2000 |
| 6121281 | Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use Compounds of formula (3), and pharmaceutically acceptable salts and derivatives thereof, in which R1 is vinyl or ethyl; and R2 is a group R3, R4 CH2 --, or R5 R6 C.dbd.CH--; wherein ... | 09/19/2000 |
| 6100253 | Tricycle substituted with azaheterocyclic carboxylic acids The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the present description, or salts thereof, to me... | 08/08/2000 |
| 6040318 | Tricycle substituted with azaheterocyclic carboxylic acids The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the present description, or salts thereof, to methods for thei... | 03/21/2000 |
| 6015900 | N-aminoalkylfluorenecarboxamides Disclosed are compounds of formula (I) or the pharmaceutically acceptable salts thereof wherein: ##STR1## G represents a group of the formula (a), (b) or (c) where Ra and Rb represent hydrogen, or organic or inorganic substituen... | 01/18/2000 |
| 6004959 | Alkyloxyamino substituted fluorenones and their use as protein kinase-C inhibitors The present invention describes certain alkyloxyamino-substituted fluorenones which inhibit protein kinase C, as well as pharmaceutical compositions including these compounds and methods of using these compounds to control protein kinase C activity in mam... | 12/21/1999 |
| 5968954 | 2-aminoindan compounds as 5HT1B antagonists New 2-aminoindan compounds of formula: ##STR1## wherein: n, Ar, R, E, X1, X2, X3, and X4 are as defined in the description, in the form of a racemic mixture and in the form of optical isomers, and physiolog... | 10/19/1999 |
| 5955632 | Seco-d steroids active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them New seco-D steroid derivatives, processes for their preparation and pharmaceutical compositions are provided, which are active on the cardiovascular system. The seco-D steroid derivatives have the following general formula (I): ##STR1##... | 09/21/1999 |
| 5935951 | 1-acyl-4-aliphatylaminopiperidine compounds The invention relates to novel 1-acyl-4-aliphatylaminopiperidine compounds of ##STR1## formula (I), in which R1 is a benzoyl, naphthoyl or cycloalkanoyl radical which is unsubstituted or substituted by lower alkyl, lower alkoxy, halog... | 08/10/1999 |
| 5932734 | N-aminoalkylfluorenecarboxamides Disclosed are compounds of the formula ##STR1## or the pharmaceutically acceptable salts thereof wherein: G represents a group of the formula ##STR2## where Ra and Rb represent hydrogen, or organic or inorganic substi... | 08/03/1999 |
| 5922879 | N-aminoalkyl-2-anthraquinonecarboxamides: new dopamine receptor subtype specific ligands Disclosed are compounds of the formula: or the pharmaceutically acceptable acid addition salts thereof wherein: R1, R2, R3, R4, R5, R6, and R7 are the same or different and represent ... | 07/13/1999 |
| 5883257 | N-piperidinyl- and N-tetrahydropyridinyl-2-anthracenecarboxamides: dopamine receptor subtype specific ligands Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R1, R2, R3, R4, R5, R6, R7, R8 and R | 03/16/1999 |
| 5834459 | Alkyl-substituted compounds having dopamine receptor affinity Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein: A and B are independently selected, optionally substituted, unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is selected from CH | 11/10/1998 |
| 5739135 | Inhibitors of microsomal triglyceride transfer protein and method Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure ##STR1## wherein R1 to R7 | 04/14/1998 |
| 5716949 | Heterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them... | 02/10/1998 |
| 5712292 | N-substituted azaheterocyclic carboxylic acids and esters thereof The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them... | 01/27/1998 |
| 5712269 | M2 receptor ligand for the treatment of neurological disorders Muscarinic M2 receptor ligands are described which are suitable for the treatment of neurological disorders, and which may be administered with minimal side-effects. A method of synthesis of these compounds is also described.... | 01/27/1998 |
| 5703235 | N-Aminoalkyl-2-anthracenecarboxamides; new dopamine receptor subtype specific ligands Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R1, R2, R3, R4, R5, R6, R7, R8 and R | 12/30/1997 |
| 5693649 | N-substituted azaheterocyclic carboxylic acids and esters thereof The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them... | 12/02/1997 |
| 5688788 | N-substituted azaheterocyclic carboxylic acids and esters thereof The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them... | 11/18/1997 |
| 5686586 | Polycyclic aromatic derivatives, process for preparing the same and pharmaceutical and cosmetic compositions containing the same A polycyclic aromatic compound having the formula ##STR1## and its salts have useful therapeutic and cosmetic action particularly in psoriasis. In the formula, X represents --CH.dbd.CH--, O or S, R1 represents hydrogen, branched alkyl having 3-... | 11/11/1997 |
| 5668129 | N-substituted azaheterocyclic carboxylic acids and esters thereof The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them... | 09/16/1997 |
| 5659033 | N-aminoalkylfluorenecarboxamides; a new class of dopamine receptor subtype specific ligands Disclosed are compounds of the formula ##STR1## or the pharmaceutically acceptable salts thereof wherein: G represents a group of the formula ##STR2## where Ra and Rb represent hydrogen, or organic or inorganic substit... | 08/19/1997 |
| 5605896 | Bicyclic heterocyclic derivatives having 1 adrenergic and 5HT1A activities This invention provides bicyclic heterocyclic derivatives and their pharmaceutically acceptable salts useful for the treatment of hypertension, urethral and lower urinary tract contractions, and other disorders. The compounds are also useful for binding &... | 02/25/1997 |
| 5523387 | Mass dyeing of synthetic polymers with dyes in salt form This invention relates to dyes in salt form which are useful for mass dyeing of synthetic polymers. In particular, this invention relates to ammonium or immonium salt-containing dyes that display good polymer affinity, and the methods for using those dyes... | 06/04/1996 |
| 5474994 | Bicyclic heterocyclic derivatives having 1 -adrenergic and 5HT1A This invention provides bicyclic heterocyclic derivatives and their pharmaceutically acceptable salts useful for the treatment of hypertension, urethral and lower urinary tract contractions, and other disorders. The compounds are also useful for binding &... | 12/12/1995 |
