Class 546/203 - The polycyclo ring system is tricyclo-carbocyclic

Subclass of Class 546 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which the polycyclo ring system consists of
No. of patents: 218
Last issue date: 05/29/2012

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Number	Title	Issue Date
8188288	2-adamantylurea derivatives as selective 11beta-HSD1 inhibitors The present invention relates to 2-adamantylurea derivatives of formula I as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, in...	05/29/2012
7432284	Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v...	10/07/2008
7365196	Sulphonamido-substituted bridged bicycloalkyl derivatives A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease. ...	04/29/2008
7351720	N-ureidoalkyl-piperidines as modulators of chemokine receptor activity The present application describes modulators of chemokine receptor activity of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases, as well as auto...	04/01/2008
7282587	Process for the preparation of 10,11-dihydro-5h-dibenzo[a,d]cyclohept-5-enes and derivatives thereof A process for preparing 10,11-dihydro-5H-dibenzo[a,d]cyclohept-5-enes (e.g. loratadine) by reacting a dibenzozuberone with an aliphatic ketone in the presence of low valent titanium. ...	10/16/2007
7250519	Method for the production of arylamines The invention relates to a method for the production of tertiary amines by reaction of secondary amines with aromatics or heteroaromatics in the presence of a base, a nickel or palladium compound and one or several phosphines, dialkoxy-, and/or diaryloxyphosphines i...	07/31/2007
7164025	Manufacture of single isomer methylphenidate The present invention pertains to a process for obtaining a single enantiomer, d or l, of threo-methylphenidate, comprising resolution of a mixture of the enantiomers; racemisation of the unwanted enantiomer, to give a mixture of all four stereoisomers; and separati...	01/16/2007
7053071	Induction of apoptosis in cancer cells The present invention provides compounds that are inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals with leukemia or other forms of...	05/30/2006
6969724	Compounds Compounds of formula I, or a salt thereof or a hydrate thereof, as follows: wherein X and Y are selected independently from hydrogen and aryl, which aryl is unsubstituted or substituted one or more times b...	11/29/2005
6800636	Farnesyl protein transferase inhibitors Disclosed are compounds of the formula: wherein R8 represents a cyclic moiety to which is bound an imodazolylalkyl group; R9 represents a carbamate, urea, amide or sulfonamide group; and the remaini...	10/05/2004
6767915	Substituted piperidines as melanocortin receptor agonists Certain novel 4-substituted piperidine compounds are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseas...	07/27/2004
6700025	Process for stereoselective synthesis of prostacyclin derivatives An improved method is described for making 9-deoxy-PGF1 -type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds....	03/02/2004
6673815	Substituted acid derivatives useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure ##STR1## wherein Q is C or N, X1 is CH or N and, A, E, M, G, X2, X3, X4, R1, R2, R2a, R2b, R2c, R3, Y,...	01/06/2004
6613905	Chemokine receptor antagonists and methods of use therefor Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by the following struc...	09/02/2003
6599921	Non-steroidal estrogen receptor ligands Novel non-steroidal estrogen receptor ligands and methods of synthesis are disclosed. The novel molecules are intended for use in therapeutic preparations for the treatment of estrogen receptor related disease states. The compounds specified are tetra-cyc...	07/29/2003
6569849	N-Substituted azaheterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, A, R1, R2, r and s are as defined in the detailed part of the present description or salts thereof, to me...	05/27/2003
6492355	Adamantane derivatives The invention provides compounds of general formula ##STR1## in which m, A, R1 and Ar have the meanings defined in the specification; a process for their preparation; pharmaceutical compositions containing them; a process for preparing the phar...	12/10/2002
6451801	Compounds and methods for treatment of asthma, allergy and inflammatory disorders The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl peperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well...	09/17/2002
6444821	Crystals of piperidine derivatives, intermediates for production of the same, and process for producing the same Monohydrate and trihydrate crystals of N-(2-(4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidino) ethyl)-1-formyl-4-piperidinecarboxamide hydrochloride having excellent stability....	09/03/2002
6391890	Heterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R1, R2 and m are as defined in the detailed part of the present description, or salts thereof, to methods...	05/21/2002
6355804	Process for producing piperidinecarboxylic acid amide derivatives A process for producing piperidinecarboylic acid amide derivatives useful as serotonin antagonists, antithrombocytic agents or intermediates for them, which comprises the step of reacting a 2-oxazoline compound with a piperidine derivative in the presence...	03/12/2002
6323206	Chemokine receptor antagonists and methods of use therefor Disclosed is a method of treating a subject with a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to the subject a therapeutically effective amount of a compound represented by the following st...	11/27/2001
6288234	Multibinding inhibitors of microsomal triglyceride transferase protein Disclosed are multibinding compounds which inhibit microsomal triglyceride transferase protein (MTP), a protein which mediates the transfer of lipids during the assembly of lipoproteins and related biomolecules. The multibinding compounds contain from 2 t...	09/11/2001
6288123	Therapeutic guanidines The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines....	09/11/2001
6281228	Heterocyclic inhibitors of microsomal triglyceride transfer protein and method Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure ##STR1## including pharmaceutically acceptable salts thereof, or prodrug ester...	08/28/2001
6268383	Substituted aromatic compounds for treatment of antibiotic-resistant infections This invention relates to compounds of the general formula: ##STR1## wherein A is a aromatic hydrocarbon ring system and R1 is a carbon bound directly to an oxygen and is also bound to a nitrogen through a saturated carbon and wherein at least ...	07/31/2001
6262060	Azacycloalkane derivatives, preparation and therapeutic application The invention relates to azacycloalkane derivatives, to pharmaceutical compositions containing them, to processes for preparing them, and to methods for the treatment of hyperglycaemia, diabetes, obesity or inflammation utilizing them....	07/17/2001
6239148	N-substituted azaheterocyclic carboxylic acids and esters thereof The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them...	05/29/2001
6214827	Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the above formula to a biological system. In ...	04/10/2001
6207834	Process for producing piperidinecarboxylic acid amide derivatives A process for producing piperidinecarboylic acid amide derivatives useful as serotonin antagonists, antithrombocytic agents or intermediates for them, which comprises the step of reacting a 2-oxazoline compound with a piperidine derivative in the presence...	03/27/2001
6184233	Crystals of piperidine derivatives, intermediates for production of the same, and process for producing the same Monohydrate and trihydrate crystals of N-(2-(4-(5H dibenzo [a,d]cyclohepten-5-ylidene)-piperidino)ethyl)-1-formyl-4-piperidinecarboxa mide hydrochloride having excellent stability....	02/06/2001
6174924	Therapeutic guanidines The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines....	01/16/2001
6150355	Phenylpiperidine derivative A phenylpiperidine derivative or pharmaceutical acceptable salt thereof represented by formula (I): ##STR1## wherein X represents CH or N; Y--Z represents CH2 --O, CH2 --S, CH2 --CH2, CH.dbd.CH or CONR...	11/21/2000
6143791	Therapeutic guanidines The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines....	11/07/2000
6100253	Tricycle substituted with azaheterocyclic carboxylic acids The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the present description, or salts thereof, to me...	08/08/2000
6093827	Process for the preparation of 10,11-dihydro-5H-dibenzo[A,D]cyclohept-5-enes and derivatives thereof 5,6-Dihydro-11H-dibenzo[a,d]cyclohept-11-enes are prepared by reacting a dibenzosuberone or an aza derivative thereof with an aliphatic ketone in the presence of low valent titanium....	07/25/2000
6048877	Tetralone derivatives as antiarrhythmic agents Tetralone derivatives of the formula ##STR1## where R1 is halo, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, (aryl)alkenyl, (aryl)alkynyl, alkoxy, O-alkenyl, O-aryl, O-alkyl(heterocyclo), COO-alkyl,alkanoyl, CO-amino, CO-substituted amino, ...	04/11/2000
6048856	Heterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic compounds of the formula ##STR1## wherein X, Y, R1, R1a, R2, R2a, R12, R13, A, r and s are as defined in the detail...	04/11/2000
6040318	Tricycle substituted with azaheterocyclic carboxylic acids The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the present description, or salts thereof, to methods for thei...	03/21/2000
6015900	N-aminoalkylfluorenecarboxamides Disclosed are compounds of formula (I) or the pharmaceutically acceptable salts thereof wherein: ##STR1## G represents a group of the formula (a), (b) or (c) where Ra and Rb represent hydrogen, or organic or inorganic substituen...	01/18/2000

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Class 546/203 - The polycyclo ring system is tricyclo-carbocyclic