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...that Kleenex tissue was originally designed to be a gas mask filter? It was developed at the beginning of World War I to replace cotton, which was then in short supply as a surgical dressing.
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| Number | Title | Issue Date |
| 8129535 | Alkyl ether derivatives or salts thereof An alkyl ether derivative represented by the general formula: wherein each of R1 and R2 represents one or more groups selected from a hydrogen atom, a halogen atom, an alkyl group, an aryl group, an ar... | 03/06/2012 |
| 8124776 | Process and intermediates for preparing arzoxifene The present invention provides for novel compounds of formula I wherein X is S or S(O); R1 and R2 are each independently selected from the group consisting of —CH2CH3 and phenyl; or R1 and R2 combin... | 02/28/2012 |
| 8084612 | Proline analogs as ligands for cannabinoid receptors The invention relates to compounds of Formulae I(a) to XI and pharmaceutically acceptable salts and solvates thereof (Proline Analog Compounds), ... | 12/27/2011 |
| 7375229 | Dihydro-dibenzo[B,E]oxepine based selective estrogen receptor modulators, compositions and methods The present invention provides a compound of the formula (I) wherein R1 is —H, —OH, —O(C1-C4 alkyl), —OCOC6H5, —OCO(C1-C6 alkyl), or —OSO2(C2-C6 | 05/20/2008 |
| 7351735 | Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders This invention relates to novel benzofuran and benzothiophene derivatives of the general table formula and their use for the treatment of hyper-proliferative disorders ... | 04/01/2008 |
| 7345060 | Compounds having βadrenergic receptor agonist and muscarinic receptor antagonist activity The invention is directed to compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7a, R7b, W, G1 | 03/18/2008 |
| 7326716 | Treatment of inflammatory bowel disease The present invention provides a method of treating inflammatory bowel disease which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a piperidinyl prostaglandin E analog. ... | 02/05/2008 |
| 7282497 | Pyrrolidin-2-one derivatives as inhibitors of factor xa The invention relates to compounds of formula (Ic) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical con... | 10/16/2007 |
| 7271264 | Pentacyclic oxepines and derivatives thereof, compositions and methods The present invention provides a compound of the formula (I) wherein R1 is —H, —OH, —O(C1-C4 alkyl), —OCOC6H5, —OCO(C1-C6 alkyl), or —OSO2(C2-C6 | 09/18/2007 |
| 7238713 | Muscarinic agonists Compounds and methods are provided for the treatment of disease conditions in which modification of cholinergic, especially muscarinic m1, m4, or both m1 and m4, receptor activity has a beneficial effect. In the method, an effective amount of a compound is administe... | 07/03/2007 |
| 7226934 | Optically active isomers of ketotifen and therapeutically active metabolites thereof Racemic norketotifen, racemic 10-hydroxy-ketotifen, racemic 10-hydroxy-nor-ketotifen and optically active isomers of ketotifen, norketotifen, 10-hydroxy-ketotifen and 10-hydroxy-norketotifen were found to have antiallergic and anti-inflammatory effects while being d... | 06/05/2007 |
| 7208491 | N-monoacylated o-phenylenediamines Mono-acylated o-phenylendiamines derivatives of formula I wherein X and R are as described herein, have been found useful for the treatment of diseases mediated by the inhibition of histone deacetylase, such as c... | 04/24/2007 |
| 7186726 | Preferentially substituted calcium channel blockers Certain piperazine substituted compounds are described which are useful in altering calcium channel activity. ... | 03/06/2007 |
| 7157454 | Derivatives of n-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same The invention relates to compounds of formula: These compounds show affinity for the bradykinin receptors with selectivity towards the B1 receptors; they may be used for the preparation of medicinal pr... | 01/02/2007 |
| 7148240 | Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same The invention relates to benzofuran or benzothiophene derivatives of general formula: These compounds are of use as medicinal products, in particular in the treatment of pathological syndromes of the cardiovascular... | 12/12/2006 |
| 7144898 | Indole derivatives for the treatment of depression and anxiety The present invention provides compounds of formula (I): which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine. | 12/05/2006 |
| 7144885 | Fused tricyclic heterocycles useful for treating hyper-proliferative disorders This invention relates to a novel fused tricyclic heterocycle of the formula (Ia, Ib) and its use for the treatment of hyper-proliferative disorders ... | 12/05/2006 |
| 7144883 | Bicyclic sulfonamide compounds The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obe... | 12/05/2006 |
| 7122203 | Stabilized formulations of 6-hydroxy-3-(-4-[2-(piperidin-1-yl) ethoxy]phenoxy)-2-(4-methoxyphenyl) benzo[b]thiophene and salts thereof The present invention is directed to pharmaceutical formulations containing 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxypheny)benzo[b]thiophene or a salt thereof; stabilized to oxidation or other forms of decomposition by incorporation of a stabili... | 10/17/2006 |
| 7112594 | Fused bicyclic amide compounds and medicinal use thereof Compounds represented by the following general formula (I) wherein ring A is benzene, cyclohexane, pyridine, piperidine, a derivative thereof, imidazole, a derivative thereof, etc.; the ring B represents benzene, cyclohexane, pyrrole or a derivative thereof, furan, ... | 09/26/2006 |
| 7084171 | Compounds and therapies for the prevention of vascular and non-vascular pathologies The invention provides a method of treating a mammal having, or at risk of, an indication associated with a TGF-beta deficiency comprising administering one or more agents that is effective to elevate the level of TGF-beta. The invention also provides novel compound... | 08/01/2006 |
| 7071201 | Quinoline derivatives A novel compound of the formula: wherein A, B, C, D, T, Y, and Z represent each methine or nitrogen; R1, R2, R3, R4, and R5 represent each a substituent; n represe... | 07/04/2006 |
| 7060711 | Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HTreceptor antagonist The present invention relates to derivatives of 4-(Thio- or Selenoxanthene-9-ylidene)-piperidine or acridine and pharmaceutically acceptable salts thereof, use of these compounds as a medicament and for the manufacture of a medicament for treatment of a disease stat... | 06/13/2006 |
| 6984637 | Cyclic amine derivatives-CCR-3 receptor antagonists This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compound... | 01/10/2006 |
| 6977260 | Piperidinyl prostaglandin E analogs The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; | 12/20/2005 |
| 6977263 | Chemical compounds Provided herein are novel and useful compounds having a tryptase inhibition activity, pharmaceutical compositions comprising such compounds, and methods treating subjects suffering from a condition, disease, or disorder that can be ameliorated by the administration ... | 12/20/2005 |
| 6977265 | Piperidine CCR-3 receptor antagonists The invention provides compounds of Formula (I): wherein: R1-R5, A, L, and X have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical compositions co... | 12/20/2005 |
| 6969718 | 17-β hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases There are disclosed compounds of the formula (I): prodrugs thereof, or pharmaceutically acceptable salts of the compounds or of said prodrugs which are useful as inhibitors of Type 3 17β-Hydroxysteroid Dehydrogenase. ... | 11/29/2005 |
| 6949540 | Substituted pyrazoles Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described. ... | 09/27/2005 |
| 6921827 | Process for preparing 3-aryl-benzo{b} thiophenes The present invention relates to a process for preparing a compound of formula (I): which includes cyclodehydrating a compound of formula (II): in the presence of an acid activated clay or acid activated zeolite catalyst and in the presence of a suitable solvent | 07/26/2005 |
| 6916831 | Flavone acetic acid analogs and methods of use thereof Compounds are described having a structure according to Formula I or Formula II: wherein: X is selected from the group consisting of O, NH, and S; Y is selected from the group consisting of O and S; m is from 1 to 3; n... | 07/12/2005 |
| 6911456 | Use of estrogen antagonists and estrogen agonists in inhibiting pathological conditions The present invention provides novel methods of inhibiting pathological conditions related to organ systems which respond to estrogen agonists comprising administering to a mammal in need of such treatment an effective amount of a compound of formula I ... | 06/28/2005 |
| 6908922 | Linear cyclic ureas Compound of formula (I): wherein: V represents a single bond or an alkylene chain, M represents a single bond or an alkylene chain, A and E each repr... | 06/21/2005 |
| 6903102 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases There are disclosed compounds of the formula (I): prodrugs thereof, or pharmaceutically acceptable salts of the compounds or of said prodrugs which are useful as inhibitors of Type 3 17β-Hydroxysteroid Dehydrogenase. ... | 06/07/2005 |
| 6903085 | Substituted piperidine compounds useful as modulators of chemokine receptor activity The invention provides compounds of formula (I) wherein R1, R2, R3, R6, Z, Q, m, n, X1, X2, X3, X4 and T are as defined in the specification, processes for their preparation, pha... | 06/07/2005 |
| 6897211 | Thienodibenzoazulene compounds as tumor necrosis factor inhibitors The present invention relates to the dibenzoazulene compounds represented by formula I as well as to their pharmaceutical preparations for the inhibition of tumor necrosis factor alpha (TNF-α) and interleukine 1 (IL-1) in mammals at all diseases and conditions wher... | 05/24/2005 |
| 6894064 | Benzothiophenes, formulations containing same, and methods This invention provides compounds of formula I and pharmaceutically acceptable salts and solvates thereof, characterized that the compound is in particulate form and having a specific size range. The present in... | 05/17/2005 |
| 6878725 | Serine protease inhibitors Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardi... | 04/12/2005 |
| 6861530 | Piperidine derivatives This invention relates to substituted piperidine derivatives having at least one six-membered ring substituent. The piperidine derivatives exhibit antitumor activity and are useful as pharmaceuticals such as an antitumor agent. ... | 03/01/2005 |
| 6849658 | Biaromatic compounds and pharmaceutical and cosmetic compositions comprising them The invention concerns bi-aromatic compounds of formula (I) in which Ar represents (a), Z being O or S, R1 is CH3, —CH2—O—R6, —OR6 or —COR7; R2 is —OR8, —SR8 | 02/01/2005 |
