Famous Patents
British merchant Peter Durand invented the tin can in 1810.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8039624 | Azaspiro derivatives The present invention is concerned with novel indol-3-yl-carbonyl-azaspiropiperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use for the treatment of anxiety and depressive disorders and other... | 10/18/2011 |
| 7973162 | Modulators of muscarinic receptors The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases. ... | 07/05/2011 |
| 7589204 | Indane compounds as CCR5 antagonists The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an... | 09/15/2009 |
| 7351713 | Spirohydantoin compounds and methods for the modulation of chemokine receptor activity Compounds of formula I wherein R1, R2, R3, R4 and R5 are as defined herein, or pharmaceutically acceptable salts, hydrates or solvates thereof, are useful for the modul... | 04/01/2008 |
| 7335373 | Biocidal siloxane coating material containing N-halogenated amine and amide functional groups N-halamine compounds which contain hindered amine and amide functional groups. Compounds include wherein X, X′, and X″ independently are H, Cl, or Br, wherein no more than two of X, X′, and X″ are H and | 02/26/2008 |
| 7312332 | Chlorohydrin and cationic compounds having high affinity for pulp or paper Selected chlorohydrin and cationic compounds containing nitroxide or hydroxylamine moieties are effective in stabilizing pulp or paper, especially pulp or paper containing lignin, against yellowing and discoloration due to the adverse effects of light. These compoun... | 12/25/2007 |
| 7291731 | N-aryl diazaspiracyclic compounds and methods of preparation and use thereof Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are N-aryl diazaspirocyclic compounds, bridged analogs of N-heteroaryl diazaspirocyclic compounds, or prodrugs or metabolites of t... | 11/06/2007 |
| 7271176 | Chemokine receptor antagonists and methods of use thereof Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologicall... | 09/18/2007 |
| 7241770 | Hydronopol derivatives as agonists on human ORL1 receptors The invention relates to a group of hydronopol derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at le... | 07/10/2007 |
| 7192964 | 4-oxoimidazolidine-2-spiropiperidine derivatives The invention relates to 4-oxoimidazolidine-2-spiropiperidine derivatives represented by a general formula [I] [in which A1, A2, A3, A4 and A5 stand for option... | 03/20/2007 |
| 7189850 | Triaza-spiropiperidine derivatives The invention relates to compounds of the general formula wherein A-A is —CH2—CH2—, —CH2—CH2—CH2—, —CH2—O— or —... | 03/13/2007 |
| 7186729 | Chemokine receptor antagonists and methods of use thereof Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologicall... | 03/06/2007 |
| 7122677 | NK1 antagonists A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5... | 10/17/2006 |
| 7081463 | Hydroxy alkyl substituted 1,3,8-Triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1receptor mediated disorders The present invention is directed to novel hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formula wherein all variables are as defined herein, usef... | 07/25/2006 |
| 7071195 | Amine and amide derivatives as ligands for the neuropeptide Y Y5 receptor useful in the treatment of obesity and other disorders Amine and amide derivatives of the formula: which are ligands for the neuropeptide Y Y5 (NPY5) receptor, methods of preparation and pharmaceutical compositions containing amines and amides of formula A as the act... | 07/04/2006 |
| 7060105 | Copper complex monazo dyes and their preparation and use Copper complex monoazo dyes of general formula (V) and of general formula (VI) wherein R1, R2, R3, R4, R5 | 06/13/2006 |
| 7053101 | 1,3,8-triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders The present invention is directed to novel 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formula wherein all variables are as defined herein, useful in the treatment of dis... | 05/30/2006 |
| 7012078 | 2-aminopyridines containing fused ring substituents The present invention relates to 2-aminopyridine derivatives of the formula wherein G, R1 and R2 are defined as in the specification, that exhibit activity as nitric oxide synthase (NOS) inhibitor... | 03/14/2006 |
| 6995168 | Triazaspiro compounds useful for treating or preventing pain Triazaspiro Compounds, compositions comprising a Triazaspiro Compound, methods for treating or preventing pain in an animal comprising administering to an animal in need thereof an effective amount of a Triazaspiro Compound and methods for stimulating opioid-recepto... | 02/07/2006 |
| 6919349 | Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient Disclosed are novel spiro derivatives and their medical uses, especially as adhesion molecule inhibitors useful for therapies of inflammatory diseases. The spiro derivative according to the present invention has the chemical structure, for example, represented by th... | 07/19/2005 |
| 6821981 | Azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]-quinoline as 5-HT1A antagonists Compounds of the formula useful for the treatment of disorders, such as anxiety, aggression and stress, and for the control of various physiological phenomena, such as appetite, thermoregulation, sleep and sexual behav... | 11/23/2004 |
| 6815448 | Azaheterocyclylmethyl derivatives of 7,8-dihydro-1,6,9-trioxa-3-aza-cyclopenta[a]naphthalene as 5-HT1A antagonists Compounds of the formula are useful for treating the cognitive deficits due to aging, stroke, head trauma, Alzheimer's disease or other neurodegenerative diseases, or schizophrenia. The compounds of the invention are a... | 11/09/2004 |
| 6790854 | Diphenylalkylamine derivatives useful as opioid receptor agonists A substance having affinity for an opioid δ receptor, which is represented by the following general formula (I): wherein, X represents a group of the general formula: —CO—N(R5)(R6) (II) and the... | 09/14/2004 |
| 6780875 | Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists A compound, or a solvate or a salt thereof, of formula (I): wherein, Ar is an optionally substituted aryl or a C5-7 cycloalkdienyl group, or an optionally substituted C5-7 cycloalkyl group, or an op... | 08/24/2004 |
| 6777421 | 1,3,8-Triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders The present invention is directed to novel 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formula wherein all variables are as defined herein, useful in the treatment of disorders and conditions mediated by... | 08/17/2004 |
| 6716846 | High affinity ligands for nociceptin receptor ORL-1 Novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein: the dotted line represents an optional double bond; X1 is optionally substituted alkyl, cycloalky... | 04/06/2004 |
| 6686370 | Triazospiro compounds having nociceptin receptor affinity Disclosed are compounds of the formula (I) ##STR1## wherein A, R1, R2, R3, R4 and X1 are as disclosed herein. The compounds have affinity for the ORL1 receptor and are useful in the treatment of chron... | 02/03/2004 |
| 6683142 | 1-alkoxy-polyalkyl-piperidine derivatives and their use as polymerization regulators The present invention relates to 1-alkoxy-polyalkyl-piperidine derivatives containing a structural element of formula (I) ##STR1## wherein G1, G2, G3, G4 are independently C1 -C6 alkyl ... | 01/27/2004 |
| 6683141 | Polymerization catalysts A complex suitable for the polymerization of l-olefins is disclosed, having the Formula A ##STR1## wherein M is a transition metal, lanthanide or actinide; X represents an atom or group covalently or ionically bonded to the transition metal M; b is t... | 01/27/2004 |
| 6635653 | Spiropyrazole compounds A compound of the formula (I): ##STR1## wherein Z, W, A, B, C, R1, R2, Q and n are as disclosed herein.... | 10/21/2003 |
| 6620820 | Inhibitors of bone reabsorption and antagonists of vitronectin receptors The present invention relates to 5-membered ring heterocycles of the formula I, ##STR1## in which E, F, G, W, Y and Z have the meaning given in the patent claims, to their preparation and to their use as medicaments. The novel compounds are used as vitron... | 09/16/2003 |
| 6521623 | N,N'-disubstituted benzimidazolone derivatives with affinity at the serotonin and dopamine receptors A compound of formula (I) ##STR1## wherein: R1 is C1 -C6 -alkyl substituted by a group selected from OH, C1 -C6 -alkoxy, --OCONHC1 -C6 -alkyl, --OCONHC1 -C6... | 02/18/2003 |
| 6509346 | Chemokine receptor antagonists and methods of use therefor Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: ##STR1## and ... | 01/21/2003 |
| 6482829 | Substituted heterocyclic siprodecane compound active as an antagonist of neurokinin 1 receptor The invention relates to compounds of the formula ##STR1## as described herein and pharmaceutically acceptable acid addition salts thereof. The described compounds have a good affinity to the NK1 receptor.... | 11/19/2002 |
| 6469047 | Tyrosine derivatives The compounds of the invention are inhibitors of alpha4 containing integrin-mediated binding to ligands such as VCAM-1 and MAdCAM.... | 10/22/2002 |
| 6465478 | 1,3,8-Triuazaspiro(4,5)decanone compounds as ORL1-receptor agonists A compound of formula: ##STR1## R1 and R2 are independently C1 -C4 alkyl; or R1 and R2, taken together with the carbon atom to which they are attached, form a mono-, bi-, tri- or spiro-cycl... | 10/15/2002 |
| 6353107 | 1-alkoxy-polyallkyl-piperidine derivatives and their use as polymerization regulators The present invention relates to 1-alkoxy-polyalkyl-piperidine derivatives containing a structural element of formula (I) ##STR1## wherein G1, G2, G3, G4 are independently C1 -C6 alkyl with... | 03/05/2002 |
| 6329390 | 5-Bicycloindole compounds Disclosed herein are compounds selective for a 5-HT1D receptor, the compounds having the general formula (I): ##STR1## Also disclosed is the use of these compounds as pharmaceuticals to treat indications where stimulation of a 5-HT1D... | 12/11/2001 |
| 6329385 | Chemokine receptor antagonists and methods of use therefor Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by the following struc... | 12/11/2001 |
| 6326379 | Fused pyridine inhibitors of cGMP phosphodiesterase Compounds of the formulas ##STR1## are useful as inhibitors of cGMP PDE, especially type V.... | 12/04/2001 |
