Class 546/198 - Ring nitrogen in the polycyclo ring system

Subclass of Class 546 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which the polycyclo ring system contains a
No. of patents: 573
Last issue date: 12/20/2011

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Number	Title	Issue Date
8080665	Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The...	12/20/2011
7435744	Piperidine derivatives as NMDA receptor antagonists The present invention relates to a compound of formula (I): wherein: V and U are hydrogen, halogen, C1-C4 alkylamino, or together form a group that contains one or more heteroatoms, and that taken toge...	10/14/2008
7419986	Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, pre...	09/02/2008
7408067	Aza-cyclic compounds as modulators of acetylcholine receptors Compounds comprising an aza-cyclic portion and an aromatic portion linked via a sulphur atom are disclosed. The compounds disclosed are selective modulators of beta 4 subtype nicotinic acetylcholine receptors and are useful for the treatment of dysfunctions of the c...	08/05/2008
7402579	Quinobenzoxazine analogs and compositions The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, W, X, Z, B, ...	07/22/2008
7371748	Benzothiazole derivatives This invention relates to compounds of formula I wherein R1 and R2 are defined herein, or a pharmaceutically acceptable salt thereof.	05/13/2008
7335653	Bis-aryl sulfonamides Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls i...	02/26/2008
7335666	Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, pre...	02/26/2008
7314883	Anti-migraine treatments The present invention relates to methods of treating neurogenic vasodilation, neurogenic inflammaton, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstru...	01/01/2008
7312218	Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula Ia-If: or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic carbocycle or hetero...	12/25/2007
7273857	Benzimidazolidinone derivatives as muscarinic agents Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the s...	09/25/2007
7265103	Substituted amino isoxazoline derivatives and their use as anti-depressants The invention concerns substituted amino isoxazoline derivatives, more in particular tricyclic dihydrobenzopyranoisoxazoline, dihydroquinolinoisozazoline, dihydronaphthalenoisoxazoline and dihydrobenzothiopyranoisoxazoline derivatives substituted on the phenylpart o...	09/04/2007
7259157	N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain. ...	08/21/2007
7238713	Muscarinic agonists Compounds and methods are provided for the treatment of disease conditions in which modification of cholinergic, especially muscarinic m1, m4, or both m1 and m4, receptor activity has a beneficial effect. In the method, an effective amount of a compound is administe...	07/03/2007
7238712	Indole-type derivatives as inhibitors of p38 kinase The invention is directed to methods to inhibit p38-α kinase using compounds of the formula and the pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof, wh...	07/03/2007
7220862	Calcitonin gene related peptide receptor antagonists The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying th...	05/22/2007
7214691	2-substituted benzimidazole derivatives as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders The present invention discloses compounds of formula I wherein Ar, X, R1 and R11 are herein defined, said compounds being novel antagonists for melanin-concentrating hormone (MCH), as well a...	05/08/2007
7208496	Substituted heterocyclic compounds Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, inte...	04/24/2007
7205405	Process for preparing 3-(2-(4-(6-fluorobenzo(d)isoxazol-3-yl)-piperidin-1-yl)-ethyl)-2-methyl- 6,7,8,9-tetrahydro-4h-pyrido-(1,2-a)pyrimidin-4-one The process consists in condensing (2-methyl-6,7,8,9-tetrahydro-4 H-pyrido-[1,2-a]pyrimidin-3-yl)-acetaldehyd with 6-fluoro-3-piperidinyl)-1,2-benzisoxazole to yield the intermediate enamine, 3-{2-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]vinyl}-2-methyl-6,...	04/17/2007
7189739	Compounds and methods to treat cardiac failure and other disorders The invention is directed to compounds of the formula and the pharmaceutically acceptable salts thereof wherein Ar1 is indole, benzimidazole, or benzotriazole, optionally substituted with ...	03/13/2007
7186724	Heterocyclic substituted carbonyl derivatives and their use as dopamine Dreceptor ligands The invention relates to heterocyclic substituted carbonyl derivatives that display selective binding to dopamine D3 receptors. In another aspect, the invention relates to a method for treating central nervous system disorders associated with the dopamine...	03/06/2007
7183290	Fluoropyrrolidines as dipeptidyl peptidase inhibitors The present invention relates to novel compounds, their use for inhibiting post prolin/analine-cleaving proteases, such as serine proteases, such as dipeptidyl peptidases, such as dipeptidyl peptidase IV (DPP-IV), and to methods for their production and their therap...	02/27/2007
7173043	Heteroaromate OSC inhibitors The present invention relates to heteroaromate OSC inhibitors. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vasc...	02/06/2007
7169786	Isoxazoline derivatives as anti-depressants The invention concerns substituted isoxazolines derivatives according to Formula (I): wherein X=CH?2#191, N—R7, S or O, R1, R2 and R3 are certain specific substituents, Pir is an optionally substituted piperidyl or piper...	01/30/2007
7166616	Substituted alkanoic acids The invention is directed to physiologically active compounds of general formula (I): wherein: represents (i) a saturated 3 to 6 membered carbocycle, optiona...	01/23/2007
7166617	Cyclic amide derivatives Novel compounds represented by the following formula (I) that act as a ligand to sigma receptor/binding cite and a medicament comprising the same as an active ingredient: wherein X represents an alkyl group, an a...	01/23/2007
7144883	Bicyclic sulfonamide compounds The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obe...	12/05/2006
7141595	Amino benzothiazole compounds with NOS inhibitory activity The present invention provides novel amino benzothiazole compounds, compositions comprising these compounds and methods of using these compounds as neuroprotectants. In particular, the compounds described in the present invention are useful for treating stroke and n...	11/28/2006
7135479	Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress di...	11/14/2006
7125887	Pyrrolidine modulators of CCR5 chemokine receptor activity Pyrrolidine compounds of Formula (I), (wherein R1, R2, R3, R4, R5, R6a, R6b, R7 and R8 are defined herein) are described. The compounds are modulators of CCR5 chemokin...	10/24/2006
7115610	Substituted heterocyclic compounds Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atri...	10/03/2006
RE39265	Heteroarylpiperidines, and their use as antipsychotics and analgetics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compound...	09/05/2006
7091219	Bis-sulfonamide hydroxyethyl-amino retroviral protease inhibitors Bis-sulfonamido hydroxyethylamino compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to retroviral protease inhibiting compounds of the formula:	08/15/2006
7087593	Benzimidazolidinone derivatives as muscarinic agents Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the s...	08/08/2006
7087610	Benzothiazole antiviral agents The invention encompasses a series of benzothiazole compounds which inhibit HIV entry and are useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for using these compounds. ...	08/08/2006
7081466	2-aroylimidazole compounds for treating cancer Disclosed is a compound represented by Structural Formula (I): R1 is a substituted or unsubstituted 2-imidazolyl group which is optionally fused to a substituted or unsubstitut...	07/25/2006
RE39198	Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgesics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amounts of one of the compounds. The compoun...	07/18/2006
7071201	Quinoline derivatives A novel compound of the formula: wherein A, B, C, D, T, Y, and Z represent each methine or nitrogen; R1, R2, R3, R4, and R5 represent each a substituent; n represe...	07/04/2006
7067656	Sulfamoyl compounds and agricultural and horticultural fungicides A sulfamoyl compound of the general formulae (1): wherein R1 and R2 are each independently C1-4 alkyl, or R1 and R2 togeth...	06/27/2006
7045518	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, rela...	05/16/2006

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Class 546/198 - Ring nitrogen in the polycyclo ring system