Did You Know...
...that the first rickshaw was invented in 1869 by an American Baptist minister, the Rev. E. Jonathan Scobie, to transport his invalid wife around the streets of Yokohama?
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8153805 | Biaryl derivatives The invention is concerned with novel biaryl derivatives of formula (I), wherein m, R1, R2, R3, X1, X2 and X3 are... | 04/10/2012 |
| 8153804 | Aryl pyridines and methods of their use Aryl pyridines, compositions comprising them, and methods of their use for the treatment, prevention and management of a variety of diseases and disorders are disclosed. ... | 04/10/2012 |
| 8143404 | Nitrogenous heterocylic derivative and medicine containing the same as an active ingredient A compound represented by formula (I), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof: (wherein each symbol is as defined in the description.) The compounds represented by formula (I) has the ant... | 03/27/2012 |
| 8101768 | Cyclic amine compound and pest control agent A chemical compound represented by the formula [I]: (wherein R1 represents a hydroxyl group or the like, m represents 0 or an integer of 1 to 5, R2 represents a halogen atom or the like, k represents 0... | 01/24/2012 |
| 8071778 | Substituted heterocyclic ethers and their use in CNS disorders The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating CNS disorders. ... | 12/06/2011 |
| 8003796 | Pyridone GPR119 G protein-coupled receptor agonists Novel compounds are provided which are GPR119 G protein-coupled receptor modulators. GPR119 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring GPR119 G protein-coupled receptor modulator therapy... | 08/23/2011 |
| 7910741 | Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient A compound represented by the following general formula (I), its salt, solvates thereof or prodrugs thereof: (wherein each symbol is as defined in the description.) The compounds represented by the general formula (I) are u... | 03/22/2011 |
| 7910742 | Survivin inhibitors Compounds that inhibit survivin, compositions containing the compounds and methods of treating diseases in which survivin is unregulated or overexpressed are disclosed. ... | 03/22/2011 |
| 7863450 | Compounds comprising an oxazoline or thiazoline moiety, processes for making them, and their uses The present invention relates to compounds comprising an oxazoline or thiazoline moiety, processes for preparing them, pharmaceutical compositions comprising said compounds and their uses as H3-receptor ligands, (I), wherein A1 is CH C(CH3... | 01/04/2011 |
| 7601843 | 4-(2-furoyl)aminopiperidine compound useful as therapeutic agent for itching There are provided compounds represented by the following general formula (I): [where R1 is 5-methylpyridin-2-yl, p-tolyl or mesityl, R2 is one of the following general formulas (II)-(IX): | 10/13/2009 |
| 7538223 | Compounds, compositions and methods Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure. ... | 05/26/2009 |
| 7504511 | 2-acylamino-4-phenylthiazole derivatives, preparation thereof and therapeutic application thereof The invention relates to 2-acylamino-4-phenylthiazole derivatives of general formula (I): pharmaceutically acceptable acid-addition salts thereof, hydrates or solvates of such derivatives or such pharmaceutically acceptable... | 03/17/2009 |
| 7491826 | Compounds, compositions and methods Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure. ... | 02/17/2009 |
| 7427632 | Factor Xa inhibitors Compounds of formula (I) in which R1, n, Z, R3 and R4 have any of the meanings given in the specification, are inhibitors of the serine protease Factor Xa and are useful in the treatment of ... | 09/23/2008 |
| 7423051 | 2,6-diaminopyridine derivatives Novel 2,6-diaminopyridine derivatives of formula wherein R1 and R2 are as defined below, are disclosed. These compounds inhibit cyclin-dependent kinases. These compounds and their pharmaceutically acce... | 09/09/2008 |
| 7419990 | Piperidine derivatives as melanocortin-4 receptor agonists Certain novel piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disor... | 09/02/2008 |
| 7408066 | Carbon-linked substituted piperidines and derivatives thereof useful as histamine Hantagonists Disclosed are compounds of the formula or a pharmaceutically acceptable salt thereof, wherein: M1 and M3 are CH or N; M2 is CH, CF or N; | 08/05/2008 |
| 7399866 | Compounds, compositions, and methods Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, are useful in the treatment of systolic heart failure including congestive heart failure. ... | 07/15/2008 |
| 7393845 | Heteroaryl derivates, their preparation and use A heteroaryl derivative having the formula (I). The compounds of the invention are considered useful for the treatment of affective disorders such as general anxiety disorder, panic disorder, obsessive compulsive disorder, depression, social phobia and eating disord... | 07/01/2008 |
| 7375100 | 2-amino-pyridine derivatives useful for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the ... | 05/20/2008 |
| 7375105 | Pyridine substituted furan derivatives as Raf kinase inhibitors Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy. Wherein X is O, CH2 CO, S or NH, or the moiety X—R | 05/20/2008 |
| 7361666 | Heterocyclic analgesic compounds and methods of use thereof One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, including opiate receptors, other G-protein-couple... | 04/22/2008 |
| 7355042 | Treatment of CNS disorders using CNS target modulators The invention is directed to compositions and methods useful for treating Central Nervous System (CNS) disorders. Furthermore, the invention provides compositions and methods of treating sleep disorders. More specifically, the invention is directed to the compositio... | 04/08/2008 |
| 7351720 | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity The present application describes modulators of chemokine receptor activity of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases, as well as auto... | 04/01/2008 |
| 7351719 | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds The present invention relates to amide compounds of general formula I wherein the groups and residues A, B, b, W, X, Y, Z, R1, R2 and R3 have the meanings given in claim 1. Moreover t... | 04/01/2008 |
| 7342014 | Diamine derivatives A compound represented by the general formula (1): Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4 (1) wherein R1 and R2 are hydrogen atoms or the li... | 03/11/2008 |
| 7335670 | Derivatives of N-[heteroaryl(piperidine-2-yl) methyl]benzamide, preparation method thereof and application of same in therapeutics Compounds of formula (I) as defined herein: are useful for treating behavioral disorders associated with dementia, psychoses, in particular schizophrenia (deficient form and productive form) and acute or chronic extrapyrami... | 02/26/2008 |
| 7329656 | Arylthiobenzylpiperidine derivatives This invention is directed to Arylthiobenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically accepta... | 02/12/2008 |
| 7317026 | CNS target modulators The invention is directed to compositions used for treating Central Nervous System (CNS) disorders. More specifically, the invention is directed to derivatized, e.g., ester or carboxylic acid derivatized, doxepins, and analogs thereof, useful for the treatment of sl... | 01/08/2008 |
| 7312235 | Benzamide inhibitors of factor Xa Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian Factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders. ... | 12/25/2007 |
| 7297694 | Pyridylfurans and pyrroles as Raf kinase inhibitors Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy. ... | 11/20/2007 |
| 7294627 | Chemical compounds Compounds of formula (I) in which R1, R2, R3 and R4, have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorde... | 11/13/2007 |
| 7288552 | Piperidine derivatives, process for preparation thereof, and pharmaceutical composition for alzheimer's disease containing the same The present invention relates to novel piperidine derivatives having effect of inhibiting acetylcholinesterase and aggregation of β-amyloid, Alzheimer's disease-induced protein, and treatment for Alzheimer's disease containing the same, the piperidine derivatives r... | 10/30/2007 |
| 7282496 | Allenic aryl sulfonamide hydroxamic acids as matrix metalloproteinase and TACE inhibitors Compounds of the formula are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease, degenera... | 10/16/2007 |
| 7282587 | Process for the preparation of 10,11-dihydro-5h-dibenzo[a,d]cyclohept-5-enes and derivatives thereof A process for preparing 10,11-dihydro-5H-dibenzo[a,d]cyclohept-5-enes (e.g. loratadine) by reacting a dibenzozuberone with an aliphatic ketone in the presence of low valent titanium. ... | 10/16/2007 |
| 7282589 | Acid addition salt of optically active piperidine compound and process for preparing the same (S)-(−)-4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperi-dine represented by the formula (IV): wherein * represents an asymmetric carbon. ... | 10/16/2007 |
| 7279491 | Phenylpiperidines and phenylpyrrolidines Substituted phenylpiperidines and phenylpyrrolidines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions. ... | 10/09/2007 |
| 7276500 | Substituted amides, their preparation and use An amide of the formula I and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meanings:... | 10/02/2007 |
| 7276524 | Pyridyl alkane acid amides as cytostatics and immunosuppressives The invention relates to new pyridyl alkane acid amides according to general formula (I) as well as methods for their production, medicaments containing these compounds as well as their medical use, especially in the treatment of tumors or for immunosuppression ... | 10/02/2007 |
| 7259171 | Di and trifluoro-triazolo-pyridines anti-inflammatory compounds The present invention relates to novel triazolo-pyridines of the formula I wherein R1 is fluoro; s is an integer from two to three; R2 is (C3-C6)cycloalkyl ... | 08/21/2007 |
