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| Number | Title | Issue Date |
| 7368461 | Compounds and method for the treatment of overactive bladder NK2R binding compounds in accord with structural diagram I useful for the treatment or prevention of OAB or UI in mammals, particularly humans are disclosed: wherein in said compounds D, A, R1, R3 and ... | 05/06/2008 |
| 7361755 | Transition-metal-catalyzed process for the conversion of alkenes to sterically hindered substituted n-alkoxyamines This invention pertains to a novel process for preparing sterically hindered N-substituted alkyloxyamines from alkenes by the transition-metal-catalyzed reaction of a intermediate alkylborane with a sterically hindered nitroxyl radical. ... | 04/22/2008 |
| 7312222 | Heterocyclic piperidines as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases. ... | 12/25/2007 |
| 7238811 | Chemical compounds The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine ... | 07/03/2007 |
| 7199243 | Piperidine compounds useful as PPAR activators PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol ... | 04/03/2007 |
| 7186732 | Non-imidazole aryloxyalkylamines Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions. ... | 03/06/2007 |
| 7122675 | Gamma secretase inhibitors Novel aryl and heteroaryl sulfonamides are disclosed. The sulfonamides, which are gamma secretase inhibitors, are represented by the formula: wherein Ar1 and Ar2 independently represent aryl or he... | 10/17/2006 |
| 7005436 | Heterocyclo inhibitors of potassium channel function Novel heterocyclo compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activatin... | 02/28/2006 |
| 6974872 | Process for production of piperidine derivatives The present invention discloses processes for preparing piperidine derivative compounds of the formulae: wherein n is 0 or 1; R1 is hydrogen or hydroxy; | 12/13/2005 |
| 6919458 | Process for production of piperidine derivatives The present invention relates to a process for preparing piperidine derivative compounds of the formulae: wherein n is 0 or 1; R1 is hydrogen or hydroxy; ... | 07/19/2005 |
| 6900326 | Method of producing N-alkoxycarbonylpiperidine derivative, new compound as raw material therefor, and method of producing the compound A method of producing an N-alkoxycarbonylpiperidine derivative, comprising reacting an N-aralkylpiperidine derivative represented by the following general formula (1): wherein R1 represents an aralkyl group ... | 05/31/2005 |
| 6878723 | LTA4 hydrolase inhibitors The invention concerns compounds inhibiting LTA4 hydrolase of formula (I). The invention also concerns their therapeutic, in particular anti-inflammatory, applications. ... | 04/12/2005 |
| 6841668 | Polyoxometalate catalysts for the preparation of sterically hindered N-substituted aryloxyamines Sterically hindered N-substituted aryloxyamines are prepared by the Keggin polyoxometalate or the transition metal substituted polyoxometalate (TMS-POM) catalyzed decomposition of diazonium salts in the presence of a sterically hindered nitoxyl radical. These compou... | 01/11/2005 |
| 6831089 | Muscarinic antagonists The present invention discloses compounds, which are novel muscarinic receptor antagonists, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such muscarinic receptor antagonists as... | 12/14/2004 |
| 6780863 | Bis-basic compounds with tryptase-inhibitory activity Compounds of which the following are exemplary: These have tryptase-inhibiting activity and are useful for the treatment of inflammatory and allergic disease conditions. ... | 08/24/2004 |
| 6743808 | 4-aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) tetrahydropyridines or piperazines 4-Aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl)piperidine, -tetrahydropyridine or -piperazine compounds of general formula (I), wherein one of X and Y is CH2 and the other one is... | 06/01/2004 |
| 6737527 | 4-formylamino-N-methylpiperidine derivatives, the use thereof as stabilizers and organic material stabilized therewith The present invention relates to 4-formylamino-N-methylpiperidine derivatives of the formula (I) where the variables are as defined in the Description, to a process for preparing these piperidine derivatives, to the use ... | 05/18/2004 |
| 6723729 | Compounds useful in preparing camptothecin derivatives Novel compounds are provided having the formula and salt thereof, where R1 is hydrogen, an alkyl, aralkyl, hydroxymethyl, carboxymethyl acyloxymethyl or trialkylsilyl group, or a group —CH2NR... | 04/20/2004 |
| 6693202 | Muscarinic receptor antagonists Disclosed are multibinding compounds which are muscarinic receptor antagonists. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a muscari... | 02/17/2004 |
| 6642228 | -adrenergic receptor antagonists There are provided compounds represented by the general formula (I): ##STR1## [wherein Ar is indole etc., R1 is hydrogen etc., B is bond, or B--N--R1 forms a ring structure and is piperidine etc., n is 0, 1, etc., A is trimethylene, ... | 11/04/2003 |
| 6627629 | N-ureidoheterocycloalkyl-piperidines as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): ##STR1## or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.... | 09/30/2003 |
| 6613769 | Tryptase inhibitors The invention relates to bifunctional tryptase inhibitors of formula (I) ##STR1## wherein H1 and H2 comprise a Q group and L is a linker of formula ##STR2## and the conformation of the H1, H2 and L groups is such that the groups are separated by a distanc... | 09/02/2003 |
| 6605642 | Inhibitors of formation of advanced glycation endproducts (AGES) The nonenzymatic glycation and crosslinking of proteins is a part of the aging process with the glycation endproducts and crosslinking of long-lived proteins increasing with age. This process is increased at elevated concentrations of reducing sugars in t... | 08/12/2003 |
| 6605635 | N-substituted benzyl or phenyl aromatic sulfamides compounds and the use thereof N-(3,5-bis-disubstituted aminomethyl-4-hydroxy)benzyl aromatic sulfonamides and N-(3,5-bis-disubstituted aminomethyl-4-hydroxy)phenyl aromatic sulfonamides compounds in accordance with the animal test, are active in the prevention and the treatment of car... | 08/12/2003 |
| 6602886 | 3-alkyl-3-phenyl-piperidines The small nonpeptides of the instant invention are tachykinin antagonists. The compounds are highly selective and functional NK3 antagonists expected to be useful in the treatment of pain, depression, anxiety, panic, schizophrenia, neuralgia, a... | 08/05/2003 |
| 6602885 | Piperidine derivatives useful as CCR5 antagonists The use of CCR5 antagonists of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein ##STR2## R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R1 is H, alkyl or alkenyl; R2 is optionally substitut... | 08/05/2003 |
| 6552046 | Materials and methods for the treatment of gastroesophageal reflux disease The subject invention provides novel compounds and compositions for the safe and effective treatment of gastroesophageal reflux and related conditions. In a preferred embodiment, the compositions of the subject invention comprise esterified cisapride deri... | 04/22/2003 |
| 6545156 | Oligomeric hindered amine light stabilizers based on multi-functional carbonyl compounds and methods of making same Oligomeric compounds and methods of making the compounds having the formula: T.paren open-st.M--F.paren close-st.i.paren open-st.M--F'.paren close-st.j M (III) wherein i and j are integers from about 0 to 300 and the sum of i and j is ... | 04/08/2003 |
| 6525070 | Bipiperidine derivatives as modulators of CCR3 activity and as H1 antagonists The present invention provides a compound of a formula (I): ##STR1## wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated dise... | 02/25/2003 |
| 6518283 | Squaric acid derivatives Squaric acid Derivatives of formula (1) are described: ##STR1## wherein R1 is an integrin binding group; R2 is a hydrogen atom or a C1-6 alkyl group; L1 is a covalent bond or a linker atom or group; n is zero or the integ... | 02/11/2003 |
| 6511993 | Metalloprotease inhibitors ##STR1## Compounds of formula (I) and pharmaceutically-acceptable derivatives thereof, are matrix metalloprotease inhibitors, useful in treatment of conditions mediated by matrix metalloproteases, such as chronic dermal ulcers.... | 01/28/2003 |
| 6495568 | Hydroxamic acid derivatives as matrix metalloprotease (MMP) inhibitors Compounds of formula (I): ##STR1## or pharmaceutically or veterinarily acceptable salts thereof, or pharmaceutically or veterinarily acceptable solvates of either entity, wherein the broken line represents an optional bond; A is C or CH; B is CH... | 12/17/2002 |
| 6455529 | Adhesion receptor antagonists Compounds of the formula I ##STR1## in which R1, R2 and R3 have the stated meanings, and their physiologically acceptable salts, inhibit the binding of fibrinogen to the corresponding receptor and can be used for the treat... | 09/24/2002 |
| 6444821 | Crystals of piperidine derivatives, intermediates for production of the same, and process for producing the same Monohydrate and trihydrate crystals of N-(2-(4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidino) ethyl)-1-formyl-4-piperidinecarboxamide hydrochloride having excellent stability.... | 09/03/2002 |
| 6440440 | Biocidal benzylbiphenyl derivatives This invention concerns compounds of formula. ##STR1## stereochemically isomeric forms thereof, acid or base addition salts thereof, N-oxides thereof, or quaternary ammonium derivatives thereof, wherein the dotted line is an optional bond; X is a direct b... | 08/27/2002 |
| 6441244 | Benzophenones and the use thereof as photoinitiators The invention relates to new compounds of the formula (I) ##STR1## in which R is phenyl, C1-4 alkyl-, C1-4 alkoxy- or halogen-substituted phenyl, naphthyl or an aromatic ring containing heteroatoms; X is O or S; R1 and R2 | 08/27/2002 |
| 6440996 | Monomeric and dimeric heterocycles, and therapeutic uses thereof The invention provides compounds of formula (I): X--L--X1 (I) wherein X and X1 are substituted piperidine, cyclohexane, or tetrahydropyran rings, and L is a linking group between X and X1 ; as well a pharmaceutical composition... | 08/27/2002 |
| 6433178 | 3-alkyl-3-phenyl-piperidines The small nonpeptides of the instant invention are tachykinin antagonists. The compounds are highly selective and functional NK3 antagonists expected to be useful in the treatment of pain, depression, anxiety, panic, schizophrenia, neuralgia, a... | 08/13/2002 |
| 6387930 | Piperidine derivatives useful as CCR5 antagonists The use of CCR5 antagonists of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein X is --C(R13)2 --, --C(R13)(R19)--, --C(O)--, --O--, --NH--, --N(alkyl)--, ##STR2## R is optionally subs... | 05/14/2002 |
| 6376584 | Hydroxy-substituted N-alkoxy hindered amines and compositions stabilized therewith Hindered amines substituted on the N-atom with an hydroxy-substituted alkoxy moiety are particularly effective in stabilizing organic polymer compositions against the deleterious effects of oxidative, thermal and actinic radiation where the presence of th... | 04/23/2002 |
