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3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Number | Title | Issue Date |
| 8153795 | Substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one-compounds and the use thereof for producing drugs The present invention relates to substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one compounds, to methods for the production thereof, to medicaments containing these compounds and to the use of these compounds for producing medicaments. ... | 04/10/2012 |
| 8071774 | Heterocyclic spiro-compounds as aldosterone synthase inhibitors The patent application relates to new heterocyclic compounds of the general formula (I) in which A, R, R1, R2, U, V, W, X, Y, Z, n and p have the definitions elucidated in more detail in the description, to a process for preparing them and to t... | 12/06/2011 |
| 8034937 | Azaspiro derivatives The present invention is concerned with novel indol-3-yl-carbonyl-azaspiropiperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use for the treatment of anxiety and depressive disorders and other... | 10/11/2011 |
| 7687627 | Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy The present invention provides agents having antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel substituted piperidino phenyloxazolidinone derivatives, processes for making compounds as well as antimicr... | 03/30/2010 |
| 7439251 | Methods and compositions for treatment of central and peripheral nervous system disorders and novel compounds useful therefor There are provided methods for the treatment of diseases involving dysfunction of the peripheral and central nervous system comprising administering one or more spiro compounds. Also provided are pharmaceutical compositions useful in such methods, compounds for use ... | 10/21/2008 |
| 7361666 | Heterocyclic analgesic compounds and methods of use thereof One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, including opiate receptors, other G-protein-couple... | 04/22/2008 |
| 7312332 | Chlorohydrin and cationic compounds having high affinity for pulp or paper Selected chlorohydrin and cationic compounds containing nitroxide or hydroxylamine moieties are effective in stabilizing pulp or paper, especially pulp or paper containing lignin, against yellowing and discoloration due to the adverse effects of light. These compoun... | 12/25/2007 |
| 7262294 | Photochromatic pyrano-1,3-oxazinonaphthalene derivatives Photochromatic compounds belonging to the groups of chromenes and spiro-pyrans having general formula (I) ... | 08/28/2007 |
| 7214714 | 20-hydroxyeicosatetraenoic acid production inhibitors A hydroxyformamidine compound represented by the following formula or a pharmaceutically acceptable salt thereof [wherein R1 represents a substituted morpholino group, a substituted piperidino group, a... | 05/08/2007 |
| 7132540 | Hindered spiro-ketal nitroxides The present invention discloses a series of novel hindered spiro-ketal nitroxides prepared by the ketalization reaction of 1,3-propanediols with triacetoneamine followed by oxidation. These novel spiro-ketals have unexpected advantages in hydrocarbon and monomer sol... | 11/07/2006 |
| 7122677 | NK1 antagonists A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5... | 10/17/2006 |
| 7105507 | Cyclohexane derivatives and their use as therapeutic agents The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and (e); and R1, R2, R3, R4, R | 09/12/2006 |
| 7091345 | Amino-substituted dihydropyrimido[4,5-D]pyrimidinone derivatives Compounds of formula I are described. These compounds are protein kinase inhibitors, in particular they inhibit the src family tyrosine kinases. Thus, these compounds are useful for the treatment of diseases medi... | 08/15/2006 |
| 7049307 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in repro... | 05/23/2006 |
| 7049320 | NKantagonists A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R... | 05/23/2006 |
| 6946517 | Stabilizer mixtures A stabilizer mixture containing (A) for example a compound of the formula (A-I) wherein R1 is hydrogen or C1-C4alkyl, R2 is a direct bond or C1 | 09/20/2005 |
| 6878707 | Carboxamides useful as inhibitors of microsomal triglyceride transfer protein and of apolipoprotein b secretion Compounds of formula (I) wherein R2—C, R3—C, R4—C or R5—C may be replaced by N; and wherein n is 1, 2 or 3; R1 is aryl, heteroaryl or (aryl or heteroaryl)-lo... | 04/12/2005 |
| 6852860 | Method for making piperidone ketals using polyphosphoric acid A method for making piperidone ketals by condensing a suitable alcohol with a piperidone in the presence of polyphosphoric acid. ... | 02/08/2005 |
| 6803368 | Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diaza-cyclopenta[a]naphthalene Compounds of the formula useful for treatment of disorders of the dopaminergic system, such as schizophrenia, schizoaffective disorder, bipolar disorder, Parkinson's disease, L-DOPA induced pychoses and dyskinesias, To... | 10/12/2004 |
| 6784173 | Aromatic dicarboxylic acid derivatives Compounds of formula I wherein A, R1 and R2 are defined in the specification. These compounds are useful as HDAC inhibitors. Also disclosed are methods of making and using said compounds. ... | 08/31/2004 |
| 6774132 | Spirooxindole derivatives that act as analgesics The present invention relates to certain spirooxindole derivatives and to pharmaceutically acceptable salts thereof, which exhibit good analgesic properties and are effective in the treatment of chronic pain. The derivatives have the structure of formula I: | 08/10/2004 |
| 6723753 | Substituted n-benzyl-n-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atheroscle... | 04/20/2004 |
| 6693109 | Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.... | 02/17/2004 |
| 6683142 | 1-alkoxy-polyalkyl-piperidine derivatives and their use as polymerization regulators The present invention relates to 1-alkoxy-polyalkyl-piperidine derivatives containing a structural element of formula (I) ##STR1## wherein G1, G2, G3, G4 are independently C1 -C6 alkyl ... | 01/27/2004 |
| 6656954 | Sulfonyl divalent aryl or heteroaryl hydroxamic acid compounds A sulfonyl divalent aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated sulfonyl divalent aromatic or heteroa... | 12/02/2003 |
| 6642247 | Di-or triaza-spiro [4,5] decane derivatives The present invention relates to compounds of the general formula ##STR1## wherein R1 is C6-10 -cycloalkyl, optionally substituted by lower alkyl or --C(O)O-lower alkyl; decahydro-naphthalen-1-yl; decahydro-naphthalen-2-yl; indan... | 11/04/2003 |
| 6635653 | Spiropyrazole compounds A compound of the formula (I): ##STR1## wherein Z, W, A, B, C, R1, R2, Q and n are as disclosed herein.... | 10/21/2003 |
| 6627624 | Aryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein the A, B, C, D, X, R1, R2, R3, R4, R5, and R6, are variables defined here... | 09/30/2003 |
| 6617339 | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them Compounds of formula (I) as defined herein, or a pharmaceutically acceptable salt, or an in-vivo-hydrolysable ester thereof, are useful as antibacterial agents. Processes for their manufacture and pharmaceutical compositions containing them are described.... | 09/09/2003 |
| 6512112 | Aminoaryl oxazolidinone N-oxides The present invention provides for aminoaryl oxazolidinone N-oxide compounds of Formula I ##STR1## wherein the variables are as defined herein. These compounds are exceedingly water soluble which is useful in preparing pharmaceutical formulations of ... | 01/28/2003 |
| 6486153 | Phenylindole derivatives as 5-HT2A receptor ligands A class of tryptamine analogues bearing an optionally substituted phenyl nucleus at the 2-position are selective antagonists of the human 5-HT2A receptor and are therefore useful as pharmaceutical agents, especially in the treatment and/or prev... | 11/26/2002 |
| 6410557 | Dry skin remedies Novel dry skin remedies useful for treatment dry skin, containing as the active ingredient spiro [oxathiolane-quinuclidine] derivatives represented by general formula (I) or acid addition salts thereof, desirably cis-2-methylspiro [1,3-oxathiolane-5,3'-qu... | 06/25/2002 |
| 6388072 | Hydroxy-substituted N-alkoxy hindered amines and compositions stabilized therewith Hindered amines substituted on the N-atom with an --O--E--OH moiety are particularly effective in stabilizing polyolefin and automotive coating compositions against the deleterious effects of oxidative, thermal and actinic radiation where the presence of ... | 05/14/2002 |
| 6380258 | Sulfonyl divalent aryl or heteroaryl hydroxamic acid compounds A sulfonyl divalent aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated sulfonyl divalent aromatic or heteroa... | 04/30/2002 |
| 6369053 | 2-Aminoquinolinecarboxamides: neurokinin receptor ligands Disclosed are compounds of the formula: ##STR1## or pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof, wherein R1, R2, R3, X, Q1 and Q2 are defined herein, which compou... | 04/09/2002 |
| 6362195 | Branched alkoxy-substituted 2-aminopyridines as NOS inhibitors The present invention relates to 6-phenyl-pyridin-2-ylamine derivatives of the formula ##STR1## wherein R1, R2, R3 and R4 are defined as in the specification, that exhibit activity as nitric oxide synthase (NOS)... | 03/26/2002 |
| 6358946 | C-6 ring-substituted pyrido[1,2-a]benzimidazole derivatives useful in treating central nervous system disorders A C-6 ring-substituted pyrido[1,2-a]benzimidazole derivative of the formula: ##STR1## methods of preparation and pharmaceutical compositions containing a substituted pyrido[1,2-a]benzimidzole derivative as the active ingredient are disclosed. The sub... | 03/19/2002 |
| 6353107 | 1-alkoxy-polyallkyl-piperidine derivatives and their use as polymerization regulators The present invention relates to 1-alkoxy-polyalkyl-piperidine derivatives containing a structural element of formula (I) ##STR1## wherein G1, G2, G3, G4 are independently C1 -C6 alkyl with... | 03/05/2002 |
| 6297258 | Substituted 3-cyanoquinolines This invention provides compounds of formula I having the structure ##STR1## wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as... | 10/02/2001 |
| 6291469 | Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, as shown by formula (I): ##STR1## wherein Q, L, Ai, Bj, R0, R3, R10, m, n, p and q are as ... | 09/18/2001 |
