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| Number | Title | Issue Date |
| 8173815 | Biphenyl compounds useful as muscarinic receptor antagonists This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as define... | 05/08/2012 |
| 8034946 | Biphenyl compounds useful as muscarinic receptor antagonists This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as define... | 10/11/2011 |
| 8013162 | Water compatible sterically hindered alkoxyamines and hydroxy substituted alkoxyamines Sterically hindered hydroxy substituted alkoxyamine stabilizer compounds are made water compatible via certain backbones with affinity towards water. The sterically hindered amines are for example of formulae (5)-(7) These ... | 09/06/2011 |
| 7683173 | Biphenyl compounds useful as muscarinic receptor antagonists The invention provides compounds of formula I: wherein a, b, c, d, f, W, Q, Y, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagoni... | 03/23/2010 |
| 7524962 | Biphenyl compounds useful as muscarinic receptor antagonists This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, r, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the specificat... | 04/28/2009 |
| 7482459 | [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone hydrochloride as an inhibitor of mast cell tryptase The present invention extends to the compound of formula I: or a prodrug, pharmaceutically acceptable salt, or solvate of said compound. Furthermore, the present invention is directed to a pharmaceutical composition... | 01/27/2009 |
| 7479562 | Biphenyl compounds useful as muscarinic receptor antagonists The invention provides compounds of formula I: wherein a, b, c, d, f, W, Q, Y, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagoni... | 01/20/2009 |
| 7399771 | Piperidine derivatives as CCR5 inhibitors Disclosed are compounds of formula I: wherein R1, R2, R3 and X are as defined herein, in free or salt form, which are useful as CCR5 inhibitors, e.g. in the prevention or treatment of disord... | 07/15/2008 |
| 7385059 | 3,4-disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinase and glycogen synthase kinase-3 modulators The invention provides compounds of the formula (0) or salts or tautomers or N-oxides or solvates thereof for use in the prophylaxis or treatment of disease states and conditions such as cancers mediated by cyclin-dependent kinase and glycogen synthase kinase-3.... | 06/10/2008 |
| 7348324 | Cyclic amine compounds as CCR5 antagonists A compound of formula (I) (wherein R1 is a hydrogen atom, a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, R2 is a hydrocarbon group which may be substituted, a non-aromatic heterocyclic ... | 03/25/2008 |
| 7323502 | Flame retardant compositions Organic polymeric substrates, for example polyolefins such as polypropylene, can be made flame retardant by the incorporation of a synergistic mixture of (i) at least one compound selected from the group consisting of the (a) sterically hindered nitroxyl stabilizers... | 01/29/2008 |
| 7297706 | Certain glycine derivatives as factor Xa inhibitors for use in the treatment of thrombotic disorders Compounds of formula (I) in which R, R1, R2, n and X1 have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders. ... | 11/20/2007 |
| 7288657 | Biphenyl compounds useful as muscarinic receptor antagonists This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 ar... | 10/30/2007 |
| 7276609 | Process for preparing 4-(hydroxy)-[1,4′]bipiperidinyl-l'carboxylic acid tert-butyl ester The present invention concerns a process for preparing 4-(hydroxy)-[1,4′]bipiperidinyl-1′-carboxylic acid tert-butyl ester, comprising hydrogenating a mixture of 4-hydroxypiperidine and 1-tert-butoxycarbonyl-4-piperidone in a suitable solvent, in the presence of... | 10/02/2007 |
| 7241778 | Non-imidazole aryloxypiperidines Substituted non-imidazole aryloxypiperidine compounds, compositions containing them, and methods of making and using them to treat or prevent histamine-mediated conditions. ... | 07/10/2007 |
| 7238811 | Chemical compounds The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine ... | 07/03/2007 |
| 7214729 | Flame retardant polymeric electrical parts Disclosed is a flame retardant lighting assembly comprising thermoplastic insulation, plugs and sockets. The thermoplastic resin is for example polypropylene homopolymer and comprises a synergistic combination of an N-alkoxyoxy hindered amine and a conventional orga... | 05/08/2007 |
| 7211675 | Antiozonant based on functionalized benzotriazole UV absorbers and the process thereof A process for the preparation of a novel antiozonant and antioxidant, based on functionalized benzotriazole UV absorbers, and the process for the preparation thereof having a general Formula I: wherein R1 | 05/01/2007 |
| 7186719 | Antibacterial agents Compounds of formula (II) are antibacterial agents wherein Q represents a radical of the formula: —N(OH)CH(═O) or the formula: —C(═O)NH(OH); R1 represents hydrogen, C1–C6 alkyl or C1–C6 alkyl substit... | 03/06/2007 |
| 7166586 | Sulfonamide lactam inhibitors of FXa and method Sulfonamide lactams of the following formula wherein X, R1, R2, R3, R4, R4a, R5, R5a, R6, R6a, R7 and ... | 01/23/2007 |
| 7078415 | Certain glycine derivatives as factor Xa inhibitors for use in the treatment of thrombotic disorders Compounds of formula (I) in which R, R1, R2, n and X1 have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders. ... | 07/18/2006 |
| 7074795 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases In its many embodiments, the present invention provides a novel class of compounds as inhibitors of type 3 17 β-hydroxysteroid dehydrogenase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparin... | 07/11/2006 |
| 7067670 | Sulfamato hydroxamic acid metalloprotease inhibitor A sulfamato hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a process for preparing the same, intermediate compounds useful in those syntheses, and a treatment process that comprises administering a contemplated ... | 06/27/2006 |
| 7064136 | Compounds A compound having the general formula and methods of using such compounds for the treatment of diseases and pharmaceutical composition comprising such compounds. ... | 06/20/2006 |
| 7064210 | Light resistant colorant and composition containing the same A light resistant colorant is obtained by coupling a dye or a pigment with a light resistant material. A light resistant colorant-containing composition has no additional light stabilizer. Therefore, side effects caused by the addition of a light stabilizer, such as... | 06/20/2006 |
| 7041679 | Crystalline forms of osanetant The invention relates to crystalline forms of (R)-(+)-N-[[3-[1-benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]prop-1-yl]-4-phenylpiperidin-4-yl]-N-methylacetamide and to processes for preparing them. ... | 05/09/2006 |
| 7005436 | Heterocyclo inhibitors of potassium channel function Novel heterocyclo compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activatin... | 02/28/2006 |
| 6989449 | Chlorohydrin and cationic compounds having high affinity for pulp or paper Selected chlorohydrin and cationic compounds containing nitroxide or hydroxylamine moieties are effective in stabilizing pulp or paper, especially pulp or paper containing lignin, against yellowing and discoloration due to the adverse effects of light. These compoun... | 01/24/2006 |
| 6949594 | Molecular weight modification of thermoplastic polymers The invention relates to a process for the molecular weight increase/crosslinking of non-halogen-containing thermoplastic polymers, in which process a composition comprising a) a non-halogen-containing thermoplastic polymer; b) a functional compound having at least ... | 09/27/2005 |
| 6946517 | Stabilizer mixtures A stabilizer mixture containing (A) for example a compound of the formula (A-I) wherein R1 is hydrogen or C1-C4alkyl, R2 is a direct bond or C1 | 09/20/2005 |
| 6936718 | Preparation of rotamer mixtures of pharmaceutical salts In one embodiment, the present invention discloses a process to directly prepare an unequal ratio of specific, preferred rotamer or rotameric pair of an acid salt from a basic compound, by creative choice of a solvent medium. The process is particularly useful in pr... | 08/30/2005 |
| 6900326 | Method of producing N-alkoxycarbonylpiperidine derivative, new compound as raw material therefor, and method of producing the compound A method of producing an N-alkoxycarbonylpiperidine derivative, comprising reacting an N-aralkylpiperidine derivative represented by the following general formula (1): wherein R1 represents an aralkyl group ... | 05/31/2005 |
| 6894041 | Oxazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructuive pulmonary disease, of the formula: | 05/17/2005 |
| 6881846 | Antiproliferative agents This invention relates to certain dioxodihydropyridine derivatives and certain methacrylic acid and furan derivative precursors thereof, processes for their preparation, pharmaceutical compositions containing such compounds and their use as anti-proliferative agents... | 04/19/2005 |
| 6878723 | LTA4 hydrolase inhibitors The invention concerns compounds inhibiting LTA4 hydrolase of formula (I). The invention also concerns their therapeutic, in particular anti-inflammatory, applications. ... | 04/12/2005 |
| 6864266 | 4-piperidinyl alkyl amine derivatives as muscarinic receptor antagonists This invention relates to the (R)-isomers of compounds which are generally muscarinic receptor antagonists and which are represented by Formula I: wherein p, R1, R2, R3 and A are as def... | 03/08/2005 |
| 6846825 | Antibacterial agents Compounds of formula (II) are antibacterial agents wherein Q represents a radical of the formula: —N(OH)CH(═O) or the formula: —C(═O)NH(OH); R1 represents hydrogen, C1-C6 alkyl or C1-C6 alkyl substituted... | 01/25/2005 |
| 6812235 | Beta-alanine derivatives and their use as receptor anatgonists A beta-alanine derivative of the formula (I) wherein R1 is hydrogen atom or an amino protective group; A is a lower alkylene group or a lower alkenylene group; R2 is hydrogen atom or an amino group which may be substituted with an acyl group; R... | 11/02/2004 |
| 6800646 | Sulfamato hydroxamic acid metalloprotease inhibitor A sulfamato hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a process for preparing the same, intermediate compounds useful in those syntheses, and a treatment process that comprises administering a contemplated ... | 10/05/2004 |
| 6787650 | Urea compounds, process for producing the same and use thereof A compound of the formula: [wherein R1 is a hydrocarbon group which may be substituted; R2 is a cyclic hydrocarbon group which may be substituted or a heterocyclic group which may be substitu... | 09/07/2004 |
