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| Number | Title | Issue Date |
| 7960553 | Reagent for synthesis of para-methoxbenzyl (PMB) ethers and associated methods A newly synthesized compound designated lepidine ether 2-(4-Methoxybenzyloxy)-4-methylquinoline reacts with methyl triflate in the presence of alcohols to generate a neutral organic salt that transfers the para-methoxybenzyl (PMB) protecting group onto alcohols in h... | 06/14/2011 |
| 7312222 | Heterocyclic piperidines as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases. ... | 12/25/2007 |
| 7265115 | Diazabicyclic CNS active agents Compounds of formula I: or pharmaceutically acceptable salts thereof, are useful for controlling synaptic transmission in mammals. ... | 09/04/2007 |
| 7226913 | Pharmaceutical compositions having Aadenosine receptor agonist activity The present invention provides compositions for oral administration of compounds having A2A adenosine receptor agonist activity. These compositions are useful for treatment of inflammatory conditions. ... | 06/05/2007 |
| 7214665 | 2-propynyl adenosine analogs having Aagonist activity and compositions thereof The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described here. ... | 05/08/2007 |
| 7102008 | Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein the variables A, R1, R2, R3, R4, Z,... | 09/05/2006 |
| 6887996 | Compounds and their use This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP. ... | 05/03/2005 |
| 6635641 | Amide compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use Amide compounds represented by the formula: ##STR1## wherein: R1 is a moiety represented by the formula ##STR2## where X is selected from the group consisting of CH2, O, S, and NH; and Y is selected from the group consisting... | 10/21/2003 |
| 6566372 | Bicyclic androgen and progesterone receptor modulator compounds and methods The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high speci... | 05/20/2003 |
| 6399820 | Process and reagent useful for the synthesis of sulphanilide which is perhalogenated on the carbon borne by the sulphur atom of the sulphanilide function The present invention relates to a process and a reagent useful for the synthesis of sulphanilide which is perhalogenated on the carbon borne by the sulphur atom of the sulphanilide function. This persulphonylation process is characterized in that it comp... | 06/04/2002 |
| 6399821 | Process for the synthesis of perfluorosulphonamides, of perfluorosulphonimides and of their salts, and a sulphonylation reagent The invention concerns a method of sulphonation characterised in that it consists in contacting a nucleophile whose nucleophilic atom is a nitrogen atom with a reagent comprising by successive or simultaneous addition: a heavy sulphonyl halide (i.e. whose... | 06/04/2002 |
| 6388081 | 4-substituted-quinoline derivatives and 4-substituted-quinoline combinatorial libraries The present invention relates to novel 4-substituted quinoline compounds of the following formula, libraries containing such compounds, and to the generation of such combinatorial libraries composed of such compounds: ##STR1## wherein R1, R | 05/14/2002 |
| 6380213 | Compounds useful as neuro-protective agents This invention relates to novel phenyl oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents.... | 04/30/2002 |
| 6365738 | Preparation of heterocycles using 1,3-dihalopropenes Described are preferred processes for preparing heterocycles having one or more nitrogen and/or oxygen heteroatoms, utilizing a 1,3-dihalopropene as an effective 3-carbon fragment. Preferred processes yield pyridines, quinolines, oxazoles, pyrimidines and... | 04/02/2002 |
| 6323366 | Arylamine synthesis The present invention provides a method for the preparation of a wide range of primary arylamines. The arylamines are prepared in two efficient, straightforward transformations: 1) an activated aryl group and an imine group are combined, in the presence o... | 11/27/2001 |
| 6303627 | Inhibitors of serotonin reuptake This invention provides compounds and a method for the inhibition of serotonin reuptake in mammals.... | 10/16/2001 |
| 6156748 | Compounds useful as neuro-protective agents This invention relates to novel phenyl oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents.... | 12/05/2000 |
| 6114350 | Cyanine dyes and synthesis methods thereof A cyanine dye having the formula ##STR1## wherein R1 -R8 are each independently selected from a group consisting of hydrogen, C1 -C6 alkyl group, and C0 -C4 alkyl group having a hydrop... | 09/05/2000 |
| 6103904 | Skraup reaction process for synthesizing quinolones The present invention relates to an improved Skraup reaction process wherein pressure is applied during the reaction and the number of equivalents of sulfuric acid utilized is reduced.... | 08/15/2000 |
| 6093825 | Methods for preparation of 1,2-dihydroquinolines Methods for conversion of anilines to 1,2-dihydroquinolines. 1,2-dihydroquinoliiies are generated from combining an aniline, a silylating agent, and further condensing with a ketone in the presence of a catalyst. In one aspect, the silylation of the anili... | 07/25/2000 |
| 6063784 | Heteroaryloxyethylamines, method of preparation, application as medicine and pharmaceutical compositions containing them A compound selected from the group consisting of a compound of the formula ##STR1## wherein the substituents are defined as in the application and its non-toxic, pharmaceutically acceptable acid addition salts which are useful for treating hypertensi... | 05/16/2000 |
| 6020494 | Method of purifying quinaldine In a method of purifying quinaldine prepared from coal tar, a phenol, cresol and xylenol-type mononuclear aromatic compound is added to the quinaldine fraction, said aromatic compound is crystallized out forming an adduct with quinaldine and the quinaldin... | 02/01/2000 |
| 5939268 | Combinatorial libraries of molecules and methods for producing same This invention features methods of synthesizing combinatorial libraries of chemical compounds, and combinatorial libraries of chemical compounds formed by the methods of this invention. Specifically, Diels-Alder chemistry is utilized to generate libraries... | 08/17/1999 |
| 5780634 | Process for producing 2-(carboxyphenyl)-4-quinolinecarboxylic acid compounds Quinolin-2-yl benzoic acid compounds which are useful as intermediates of quinoline compounds having angiotensin II antagonist activity prepared by decarboxylating 2-(carboxyphenyl)-4-quinolinecarboxylic acid compounds in which a carboxyl group bonded to ... | 07/14/1998 |
| 5753676 | 6-aryl-(methyl - or methylidone)-quinoline derivatives as voltage-gated potassium channel blockers This invention concerns a compound of generic formula: ##STR1## or a pharmaceutically acceptable salt thereof, where the dotted lines represent optional bonds, R3 is an optionally substituted C6 -C10 aryl or heteroaryl ... | 05/19/1998 |
| 5714488 | Bis-heteroarylylmethoxyphenyl ketone derivatives as inhibitors of leukotriene biosynthesis Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein W is selected from the group consisting of optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, o... | 02/03/1998 |
| 5700942 | Process for preparing quinoline bases There are provided processes for preparing quinolines by vapor phase reaction of a substituted or unsubstituted aniline base, formaldehyde and a C2 -C4 aldehyde wherein the aldehydes:aniline base molar ratio is at least 2:1. More pre... | 12/23/1997 |
| 5695684 | Mesomorphic compound, liquid crystal composition containing the compound, liquid crystal device using the composition, liquid crystal apparatus and display method A mesomorphic compound represented by a formula (I) containing a quinoline-2,6-diyl skeleton is suitable as a component for a liquid crystal composition providing improved response characteristics and a high contrast. A liquid crystal device is constitute... | 12/09/1997 |
| 5691363 | Fungicidal azole derivatives Compounds having the formula ##STR1## wherein Q is ##STR2## R1 is C1 -C8 alkyl; R2 is C4 -C17 heterocyclic aryl, unsubstituted or substituted with one or more C1 -... | 11/25/1997 |
| 5677458 | Method of preparing azatetralones Compounds of the formula ##STR1## which are intermediates in the preparation of hydantoin aldose reductase inhibitors and methods of preparing these intermediates.... | 10/14/1997 |
| 5552549 | Process for the dechlorination of chlorinated aromatic compounds Chlorinated aromatic compounds are dechlorinated in a simple and inexpensive manner by heating them to 300° to 450° C. in a salt melt in the presence of water and/or water vapor and carbon.... | 09/03/1996 |
| 5541196 | 2-substituted quinolines for the treatment of leishmaniasis Substituted quinolines having formula (1), wherein R1, R3, R4, R5, R6, and R7 each independently represent a hydrogen atom, a linear or branched C1-7 alkyl, alkenyl, epoxy-alkyl ... | 07/30/1996 |
| 5491164 | Inhibitors of farnesyl-protein transferase The present invention comprises dipeptide analogs that inhibit the farnesylation of Ras. These farnesyl-protein transferase inhibitors are characterized by the inclusion of a cyclic amine in the backbone of the dipeptide. Further contained in this inventi... | 02/13/1996 |
| 5486613 | Vulcanization accelerators The present invention relates to vulcanization accelerators constituted by compounds, derived from secondary amines, belonging to the class of enamines and to a process for their preparation.... | 01/23/1996 |
| 5478832 | Quinoline compounds A quinoline compound represented by the formula (1) or a salt thereof: ##STR1## wherein the definition of each substituents are described in the specification, which have angiotensin II antagonism and hypotensive action and are useful as an agent for... | 12/26/1995 |
| 5474994 | Bicyclic heterocyclic derivatives having 1 -adrenergic and 5HT1A This invention provides bicyclic heterocyclic derivatives and their pharmaceutically acceptable salts useful for the treatment of hypertension, urethral and lower urinary tract contractions, and other disorders. The compounds are also useful for binding &... | 12/12/1995 |
| 5457103 | 3',5'-di-tert.-butyl-4'-hydroxy flavones Compounds of the general formula (I): ##STR1## in which R represents: a hydrogen atom, or a radical --OR' in which R' is as defined in the description.... | 10/10/1995 |
| 5438140 | Production of nickelized shaped articles Nickelized shaped articles are produced by electrodeposition of nickel from aqueous acidic baths containing as essential constituents one or more nickel salts, one or more inorganic acids and one or more brighteners, the brighteners used being cyclic ammo... | 08/01/1995 |
| 5411969 | Antihyperlipidemic/antioxidant dihydroquinolines The present invention relates to novel dihydroquinolines which are useful for cholesterol lowering and as antioxidant agents. Also provided is a process for preparing the dihydroquinolines of the present invention, pharmaceutical compositions, and a metho... | 05/02/1995 |
| 5410052 | Symmetrical and unsymmetrical polyalkylamine metal complexes for ligand extraction and generation Mthods and apparatus for the extraction of a ligand such as molecular oxygen from a first fluid environment and for release of a ligand such as molecular oxygen, as well as ligand carrier compounds therefore comprising linear, pentadentate polyalkylamines... | 04/25/1995 |
