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| Number | Title | Issue Date |
| 7790896 | RNA-selective probes for live cell imaging of nuclear structure and function The present invention is directed to fluorescent compounds and methods of making said compounds that selectively bind to cellular RNA. The fluorescent compounds of the present invention are useful for live cell imaging applications. ... | 09/07/2010 |
| 7358261 | Heteroaryl alkylamide derivatives useful as bradykinin receptor modulators This invention is directed towards novel alkylamide derivatives as bradykinin receptor antagonists useful for the treatment of bradykinin modulated disorders such as pain, inflammation, asthma and allergy. Furthermore, the present invention is directed to novel alky... | 04/15/2008 |
| 7321036 | Process for preparing aluminum trisquinoline complex A process for forming the facial isomer of an aluminum trisquinoline complex comprises heating the solid aluminum trisquinoline complex material at a temperature at least 50° C. below the melting point temperature of the solid for a time sufficient to convert the a... | 01/22/2008 |
| 7265115 | Diazabicyclic CNS active agents Compounds of formula I: or pharmaceutically acceptable salts thereof, are useful for controlling synaptic transmission in mammals. ... | 09/04/2007 |
| 7166723 | Process for the synthesis of derivatives of 2,3-dihydro-1,4-dioxino-[2,3-f] quinoline Methods of preparing compounds of Formula I are provided. ... | 01/23/2007 |
| 7141531 | Combinations of phenylsulfonylurea herbicides and safeners The invention relates to combinations of sulfonylurea herbicides (A) and their salts in which R2 is H, OH, aliphatic hydrocarbon radical or hydrocarbon-oxy radical, and R1 is an acyl radical... | 11/28/2006 |
| 7115543 | Aryl sulfonyl amino carbonyl triazole based selective herbicides The invention relates to novel herbicidal synergistic active compound combinations which comprise firstly arylsulphonylaminocarbonyltriazolinones and secondly herbicidally active compounds and/or safeners listed in the description, and which can be used with particu... | 10/03/2006 |
| 7084156 | 2-Aminoquinoline compounds The present invention is concerned with compounds of the general Formula I: and pharmaceutically acceptable salts thereof, which are useful as melanin concentrating hormone receptor antagonists, particularly MCH-... | 08/01/2006 |
| 6982334 | Crystalline form of (3R,4R)-4-[3-(S)-hydroxy-3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(2-thienylthio)ethyl]piperindine-3-carboxylic acid The present invention comprises crystalline forms of 3R,4R)-4-[3-(S)-hydroxy-3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(2-thienylthio)ethyl]piperidine-3-carboxylic acid, represented by the structure: and as characterized h... | 01/03/2006 |
| 6943183 | 5-substituted tetralones as inhibitors of ras farnesyl transferase The present invention provides novel 5-substituted tetralones of Formulas I, II, III, and IV and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, ... | 09/13/2005 |
| 6939970 | Crystalline form of (3R,4R)-4-[3-(S)-hydroxy-3-(6 methoxyquinolin-4-propyl]-1-[2-2-thienylthio)ethyl] piperidine-3-carboxylic acid The present invention comprises monohydrated form C of (3R,4R)-4-[3-(S)-hydroxy-3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(2-thienylthio)ethyl]piperidine-3-carboxylic acid, represented by the structure and as herein defin... | 09/06/2005 |
| 6933301 | 1,2,3,6-tetrahydropyrimidine-2-one compositions, articles and therapeutic methods for upper airway breathing disorders A therapeutic composition is provided that comprises a 1-R1-phenyl, 4-R2-phenyl substituted 1,2,3,6-tetrahydropyrimidine-2-one cold receptor agonist in a therapeutically effective amount. The cold receptor agonist may be represented by the general formula 1-[R1-phen... | 08/23/2005 |
| 6855824 | Processes for preparing quinoline derivatives and intermediates thereof The present invention provides a production method of quinoline derivative (V) wherein each symbol is as defined in the Specification, which includes reacting quinolinecarbaldehyde (I) with any of the compounds (II) to... | 02/15/2005 |
| 6841561 | Dihydroorotate dehydrogenase inhibitors for the treatment of viral-mediated diseases Flavivirus, rhabdovirus and paramyxovirus infections may be treated by administering an inhibitor of the enzyme dihydroorotate dehydrogenase such as 6-fluoro-2-(2′-fluoro-1,1′-biphenyl-4-yl)-3-methyl-4-quinolinearcarboxylic acid sodium salt (Brequinar). A synerg... | 01/11/2005 |
| 6815547 | Quinolylpropylpiperidine derivatives, their preparation, and compositions containing them Quinolylpropylpiperidine derivatives of general formula (I) are described, and are useful as antimicrobial agents. Their preparation is also described. ... | 11/09/2004 |
| 6809097 | Quinoline derivatives inhibiting the effect of growth factors such as VEGF Compounds of the formula (I): wherein: R2 represents hydroxy, halogeno, C1-3alkyl, C1-3alkoxy, C1-3alkanoyloxy, trifluoromethyl, cyano, amino or nitro; n is an integer from 0... | 10/26/2004 |
| 6806277 | Quinolylpropylpiperidine derivatives, preparation process and intermediates, and compositions including them Quinolylpropylpiperidine derivatives of general formula (I) in which: R1 is NH2, alkylamino, dialkylamino, hydroxyamino, alkyl(alkyloxy)amino or alkyloxyamino, R2 is a carboxyl, car... | 10/19/2004 |
| 6777427 | Tetrahydroquinoline compounds Tetrahydroquinoline compounds of general formula (I) or pharmacologically acceptable salts thereof, which have a specific and strong binding affinity for AR, exhibit AR agonism or antagonism, have therapeutic effects on AR-mediated diseases, particularly by not acti... | 08/17/2004 |
| 6774241 | 1-sulfonyl-4-aminoalkoxy indole derivatives and uses thereof The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R1, R2, R3, R4, R5, R6, and n are... | 08/10/2004 |
| 6703384 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof The present invention provides an antiproliferative compound having a structural formula ##STR1## where X and Y independently are oxygen, nitrogen o r sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, ... | 03/09/2004 |
| 6696434 | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56lck tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for trea... | 02/24/2004 |
| 6660865 | Process for the preparation of quinoline derivatives Compounds of formula (I), wherein R1 is hydrogen or chlorine and R2 is hydrogen, C1 -C8 alkyl, or C1 -C8 alkyl substituted by C1 -C6 alkoxy or by C3 -C6 | 12/09/2003 |
| 6602884 | Quinolylpropylpiperidine derivatives, their preparation, and compositions containing them Quinolylpropylpiperidine derivatives of general formula (I) are described, and are useful as antimicrobial agents. Their preparation is also described. ##STR1##... | 08/05/2003 |
| 6573278 | Aryl sulfonamides and analogues thereof and their use in the treatment of neurodegenerative diseases The present invention relates to new aryl ether sulphonamides and analogues, processes for their preparation and their use for the treatment of neurodegenerative disorders, in particular for the prophylaxis and treatment of neurodegenerative disorders, in... | 06/03/2003 |
| 6562750 | Catalyst for the production of olefin polymers A catalyst composition for the polymerization of olefins is provided, comprising a bis(hydroxy aromatic nitrogen ligand) transition metal catalyst precursor and an activating cocatalyst.... | 05/13/2003 |
| 6515127 | Method for preparing quinoline-5,8-diones ##STR1## The invention concerns a method for preparing quinoline-5,8-diones of formula (I) wherein R1, R2 and R3 are as defined in claim 1, by light-induced oxygenation of a 8-hydroxyquinoline.... | 02/04/2003 |
| 6482947 | Substituted (hetero) aryl compounds, process for their preparation, agents containing them and their use as safeners Compounds of the formula I and their salts, as defined in claim 1, are suitable as safeners for protecting crop plants against the phytotoxic side-effects of herbicides.... | 11/19/2002 |
| 6482834 | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56lck tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for trea... | 11/19/2002 |
| 6465486 | Pyridyl/quinolinyl imidazoles Certain imidazo pyridines/quinolines of the formula: ##STR1## where n is 0, 1, 2; X is independently selected from the group consisting of C1-4 alkyl, bromine, chlorine, iodide, trifluoromethyl, C1-4 alkoxy, --SO2 NH2... | 10/15/2002 |
| 6410561 | Amide derivatives and nociceptin antagonists The present invention relates to a compound of the formula [1'] ##STR1## wherein R2 is lower alkyl optionally substituted by hydroxy, amino and the like, ring B is phenyl, thienyl and the like, E is a single bond, --O--, --S-- and the like, rin... | 06/25/2002 |
| 6407242 | Quinoline derivative and use of same Quinoline compound, zinc halogenide complex and zinc complex suited for use in an electro-luminescence (EL) element, a fluorescent material and an ultraviolet absorption material, and a preparation process for these compounds are described. These compound... | 06/18/2002 |
| 6403610 | Quinolylpropylpiperidine derivatives, their preparation and the compositions which comprise them Quinolylpropylpiperidine derivatives of formula (I) ##STR1## which are particularly advantageous antimicrobial agents, their compositions, and their use.... | 06/11/2002 |
| 6387926 | Inhibitors of farnesyl protein transferase Disclosed are quinoline and benzazepine derivatives that inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogenic protein Ras. Thus, the compounds are useful as anti-cancer agents. The compounds are also useful in the treatment ... | 05/14/2002 |
| 6380390 | Catalyst for the production of olefin polymers A catalyst composition for the polymerization of olefins is provided, comprising a bis(hydroxy aromatic nitrogen ligand) transition metal catalyst precursor and an activating cocatalyst.... | 04/30/2002 |
| 6380213 | Compounds useful as neuro-protective agents This invention relates to novel phenyl oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents.... | 04/30/2002 |
| 6326380 | Thrombin receptor antagonists Heterocyclic-substituted tricyclics of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: the single dotted line represents an optional double bond; the double dotted line represents an optional single bond; n is 0-2; Q is optionally subst... | 12/04/2001 |
| 6303627 | Inhibitors of serotonin reuptake This invention provides compounds and a method for the inhibition of serotonin reuptake in mammals.... | 10/16/2001 |
| 6277863 | Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes Novel compounds comprising chemically reactive intermediates which can react with available reactive functionalities on blood components to form covalent linkages, where the resulting covalently-bound conjugates are found to have thrombin inhibition activ... | 08/21/2001 |
| 6214842 | Amino-thiazolidinediones useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds of Formula I having the structure ##STR1## wherein: R is hydrogen or alkyl of 1-6 carbon atoms; A is ##STR2## R1, R2, R3 are each, independently, hydrogen, alkoxy of 1-6 carbon atoms, thio... | 04/10/2001 |
| 6211196 | Benzyloxy-substituted, fused N-heterocycles, processes for their preparation, and their use as bradykinin receptor antagonists Benzyloxy-substituted, fused N-heterocycles, because of their ability to act as bradykinin receptor antagonists, have been found to be useful as therapeutics for the treatment and prevention of liver cirrhosis or Alzheimer's disease. This application desc... | 04/03/2001 |
