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| Number | Title | Issue Date |
| 8158792 | Spiropiperidines for use as tryptase inhibitors The present invention is directed to a compound of Formula (I): or a form thereof, wherein X1, X2, X3, X4, R1, R2 and R3 are as defined herein, us... | 04/17/2012 |
| 8134001 | Spiroindolinone derivatives There are provided compounds of the formula and pharmaceutically acceptable salts and esters thereof wherein W, V, X, Y, A, R and R′ are as described herein. The compounds are useful as ant... | 03/13/2012 |
| 8084609 | Spiropiperidine derivatives The present invention is concerned with novel spiro-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use for the treatment of anxiety and depressive disorders and other diseases. The compoun... | 12/27/2011 |
| 7897765 | Therapeutic compounds and uses thereof Compounds of formula (I) are described herein The compounds can be used, for example, to modulate growth hormone secretagogue receptor (GHS-R). In some instances, the compounds can be used to treat obesity. ... | 03/01/2011 |
| 7855293 | 3-spiro-cyanin fluorochromes and their use in bioassays The invention concerns sterically shielded, stabilized fluorescent dyes based on symmetrical or unsymmetrical 3-spirocyanines and their utilization as marker-molecules in analytical procedures. The fluorescent dyes according to the invention are characterized by a s... | 12/21/2010 |
| 7855294 | Cycloalkanopyridine derivative Provided are cycloalkanopyridine derivatives of formula [I]: [wherein the symbols are the same as those stated in the description]. The compounds act as a nociceptin receptor antagonist, and are useful as medicines for dise... | 12/21/2010 |
| 7812164 | Cyclopamine analogs The invention provides novel derivatives of cyclopamine having the following formula: ... | 10/12/2010 |
| 7709642 | Spirohydantoin compounds and methods for the modulation of chemokine receptor activity Novel compounds represented by formula (I): wherein R1, R2, R3 and R4 are as defined herein, and pharmaceutically acceptable salts, hydrates and solvates thereof, are useful for t... | 05/04/2010 |
| 7576207 | Spirocyclic heterocyclic derivatives and methods of their use Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ-opioid receptor and may be us... | 08/18/2009 |
| 7435816 | Synthesis of solanum glycosides The present invention relates to the chemical synthesis of solanum glycosides, in particular to the synthesis of solasonine as well as to novel β-monosaccharide intermediate compounds, of Formula (2), where R1 is a benzylidene, 4-nitrobenzylidene or 4-me... | 10/14/2008 |
| 7410976 | Spirochromanone derivatives The invention relates to a compound of a formula (I): or a pharmaceutically acceptable salt or ester thereof, useful as a therapeutic agent for various ACC-related disorders. ... | 08/12/2008 |
| 7396930 | Process for producing cyclic thioether and synthetic intermediate thereof A process for producing cyclic thioether compounds and their synthetic intermediates. The process produces a compound represented by formula (5): wherein G1 is an alkylene group, R1 is a thiol protecti... | 07/08/2008 |
| 7365067 | Indanol derivative The present invention provides a compound having the following general formula (I) which is useful as a neurokinin receptor antagonist: (wherein, R1, R2: optionally s... | 04/29/2008 |
| 7354925 | Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as ORL1-receptor antagonists This invention provides the compounds of formula (I): or a pharmaceutically acceptable ester of such compound, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 independently represent a... | 04/08/2008 |
| 7351706 | Indol-3-yl-carbonyl-spiro-piperidine derivatives This invention relates to indol-3-yl-carbonyl-spiro-piperidine derivatives which act as V1a receptor antagonists and which are represented by Formula I: wherein the spiropiperidine-head group A and the residues R1 | 04/01/2008 |
| 7351831 | Process for asymmetric intramolecular [3+2] cyclo-addition of hydrazones An intramolecular [3+2] cycloaddition reaction of a hydrazone is carried out under a mild condition with a high stereoselectivity and yield by reacting a hydrazone derivative in the presence of an asymmetric catalyst system obtained by mixing a zirconium alkoxide re... | 04/01/2008 |
| 7338962 | Spirocyclic heterocyclic derivatives and methods of their use Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be us... | 03/04/2008 |
| 7335665 | Spirocyclic piperidines as MCH1 antagonists and uses thereof This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pha... | 02/26/2008 |
| 7332501 | Indol-3-yl-carbonyl-spiro-piperidine derivatives as V1a receptor antagonists The invention relates to indol-3-yl-carbonyl-spiro-piperidine derivatives which act as V1a receptor antagonists and which are represented by Formula I: wherein the spiro-piperidine head group A and the residues R... | 02/19/2008 |
| 7329673 | Acylated spiropiperidine derivatives as melanocortin-4 receptor agonists Certain novel N-acylated spiropiperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of di... | 02/12/2008 |
| 7288613 | N-alkoxy-4,4-dioxy-polyalkyl-piperidine compounds, their corresponding N-oxides and controlled radical polymerization therewith The present invention relates to selected 1-alkoxy-2,2,6,6 tetramethyl piperidine, 1-alkoxy-2,2 diethyl-6,6 dimethyl piperidine and 1-alkoxy-2,6 diethyl-2,3,6 dimethyl piperidine derivatives which are substituted in the 4 position by two oxygen atoms forming an open... | 10/30/2007 |
| 7288559 | Carboxamide spirohydantoin CGRP receptor antagonists The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pha... | 10/30/2007 |
| 7279486 | Alpha aryl or heteroaryl methyl beta piperidino propanoic acid compounds as ORL1-receptor antagonists This invention provides the compounds of formula (I): or a pharmaceutically acceptable ester of such compound, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 independently ... | 10/09/2007 |
| 7276511 | Benzylamine derivative The invention provides a compound which exhibits satisfactory peroral absorbability and excellent antagonistic activity against NK-1 receptor or NK-2 receptor. The compound is a benzylamine derivative represented by formula (1) or a salt thereof | 10/02/2007 |
| 7262212 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: wherein R1 represents a hydrogen atom or C1-C6 alkyl group, n represents... | 08/28/2007 |
| 7247725 | Gamma-aminoamide modulators of chemokine receptor activity The present invention is directed to compounds of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R11, R12, W, X, and n are defined herein, which a... | 07/24/2007 |
| 7217719 | Spiroazacyclic compounds as monoamine receptor modulators The present invention relates to 1,3,8-triara-spiro[4.5]decan-2-one compounds as monoamine receptor modulators; compositions comprising the same; methods of inhibiting an activity of a monoamine receptor with said compounds; methods of treating a disease condition a... | 05/15/2007 |
| 7202251 | Bicyclic anilide spirohydantoin CGRP receptor antagonists The present invention is directed to compounds of the formula: that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache... | 04/10/2007 |
| 7115644 | Heterocyclic compounds Disclosed are benzimidazolone compounds of formulas (I) & (II): wherein R1, R2, R3, R4, R5, X, L, m, n and t are defined herein. The compounds inhibit production of cytokines involved in inflammatory proc... | 10/03/2006 |
| 7109207 | Spirosubstituted piperidines as selective melanin concentrating hormone receptor antagonists for the treatment of obesity The present invention discloses compounds which, are novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonist... | 09/19/2006 |
| 7014925 | Heterogeneous spiro compounds in organic light emitting device elements A family of non-polymeric heterogeneous spiro compounds having visible light emissive, hole-transport, electron transport or bipolar-transport properties may be used in organic light emitting devices (OLEDs), as an emissive layer in the OLEDs and/or in one or more o... | 03/21/2006 |
| 6939867 | β3 agonists and uses thereof Sulfamide compounds having formula (I) are described as well as their use in the treatment of diseases dependent on the signaling pathways associated with β-adrenergic receptors, such as obesity, diabetes, hypertension, gastrointestinal hypo- or hyper-motility and ... | 09/06/2005 |
| 6936614 | Piperidine-piperazine ligands for neurotransmitter receptors One aspect of the present invention relates to piperidine-piperazine compounds. A second aspect of the present invention relates to the use of the piperidine-piperazine compounds as ligands for various mammalian cellular receptors or transporters or both, including ... | 08/30/2005 |
| 6916822 | Phenoxyalkylamine derivatives useful as opioid δ receptor agonists A medicament useful for preventive and/or therapeutic treatment of nerve system diseases which comprises, as an active ingredient, a compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof: | 07/12/2005 |
| 6869960 | N-substituted spiropiperidine compounds as ligands for ORL-1 receptor A compound of the formula: or a pharmaceutically acceptable salt, ester or ether thereof, wherein R1 through R12 are independently hydrogen or the like; X1 and X2 are indepen... | 03/22/2005 |
| 6828440 | Spiroindene and spiroindane compounds A compound of the formula (I): wherein Z, A, B, C, R1, R2, X1, X2, Q and n are as disclosed herein. ... | 12/07/2004 |
| 6774132 | Spirooxindole derivatives that act as analgesics The present invention relates to certain spirooxindole derivatives and to pharmaceutically acceptable salts thereof, which exhibit good analgesic properties and are effective in the treatment of chronic pain. The derivatives have the structure of formula I: | 08/10/2004 |
| 6713487 | Compounds useful as modulators of melanocortin receptors and pharmaceutical compositions comprising same Compounds having the formula (I), —NR11R12; G is a novel side chain selected from C2-6alkenyl, A3-aryl, —OR18, heteroaryl, A1-cyano, A2—O... | 03/30/2004 |
| 6673625 | Saccharide sensing molecules having enhanced fluorescent properties The present invention provides formulae for fluorescent compounds that have a number of properties which make them uniquely suited for use in sensors of analytes such as saccharides. The advantageous fluorescent properties include favorable excitation wav... | 01/06/2004 |
| 6566367 | Spiro[isobenzofuran-1,4'-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4'-piperidines Substituted spiro[isobenzofuran-1,4'-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4'-piperidines capable of modulating NPY5 receptor activity are provided. Such compounds may be used to modulate ligand binding to NPY5 receptors in vivo or in vitro, and a... | 05/20/2003 |
