Class 546/158 - Single bond between 3,4-positions

Subclass of Class 546 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which there is a single bond between positions
No. of patents: 315
Last issue date: 05/08/2012

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Number	Title	Issue Date
8173813	Quinolone and tetrahydroquinolone and related compounds having NOS inhibitory activity The present invention features quinolones, tetrahydroquinolines, and related compounds that inhibit nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors...	05/08/2012
7678913	Ureas as factor Xa inhibitors The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such...	03/16/2010
7595402	Prodrugs of selective androgen receptor modulators and methods of use thereof The present invention provides prodrugs of selective androgen receptor modulators (SARMs), and their use in treating or reducing the incidence of osteoporosis, a variety of hormone-related conditions, conditions associated with Androgen Decline in Aging Male (ADAM);...	09/29/2009
7524960	Highly pure cilostazol and an improved process for obtaining same A novel process for preparing highly pure cilostazol, effected by reacting 6-hydroxy-3,4-dihydroquinolinone and 5-(4-chlorobutyl)-1-cyclohexyl-1H-tetrazole in the presence of a hydrated inorganic base, is disclosed. Further disclosed is highly pure cilostazol, and p...	04/28/2009
7456288	Heterocyclic compounds and methods of making and using thereof Compounds of formula (I), and methods and/or compositions comprising compounds that are effective in modulating inflammatory responses, such as those resulting from AGE and glycated protein accumulation are provided. Methods and/or compositions comprising compounds ...	11/25/2008
7432374	Inhibitors of macrophage migration inhibitory factor and methods for identifying the same Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures:	10/07/2008
7429583	Betamimetics for the treatment of respiratory complaints The present invention relates to compounds of formula 1 wherein the groups n, m, B, X and R1 may have the meanings given in the claims and specification, processes for preparing them and their use as pharmaceutic...	09/30/2008
7423036	Long-acting betamimetics for the treatment of respiratory complaints The present invention relates to compounds of formula 1, wherein n, A, R1, R2 and R3 may have the meanings specified in the description and claims, processes for preparing them and their use...	09/09/2008
7402598	Arylethanolamine β-adrenoreceptor agonist compounds The present invention relates to compounds of formula (I) as defined herein and salts or solvates thereof. Processes for preparing these compounds and pharmaceutical formulations containing them are also disclosed, as well as methods for the prophylaxis of treatment...	07/22/2008
7399864	Process for producing carbostyril derivatives The present invention provides a process for producing carbostyril derivatives (I) which are known to be useful as medical drug such as antithrombotic agent, cerebral circulation improver, anti-inflammatory agent, antiulcer agent, etc. in a high yield and a high pur...	07/15/2008
7361756	Method of making 7-(4-bromobutoxy)-3,4-dihydrocarbostyril The invention encompasses synthesizing 7-(4-bromobutoxy)-3,4-dihydrocarbostyril by mixing 7-hydroxy-tetrahydroquinolinone, dibromobutane, and at least one base to form a reaction mixture; heating the reaction mixture; cooling the reaction mixture; and isolating the ...	04/22/2008
7361666	Heterocyclic analgesic compounds and methods of use thereof One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, including opiate receptors, other G-protein-couple...	04/22/2008
7339061	3-(4-oxo-4H-chromen-2-yl)-(1H)-quinolin-4-one derivatives, method for preparing same and pharmaceutical compositions containing same Compound of formula (I): wherein: R1, R2, R3, R4, R6, R8, R9 and R10, which may be the same or diffe...	03/04/2008
7294650	Benzothiophen and thiochrone containing phenethanolamine derivatives for the treatment of respiratory disorders Compounds of formula (I): and salts, solvates, and physiologically functional derivatives thereof, useful for the prophylaxis or treatment of a clinical condition for which a selective β2-adrenorecept...	11/13/2007
7241777	Benzylimidazolyl substituted 2-quinoline and quinazoline derivatives for use as farnesyl transferase inhibitors This invention comprises the novel compounds of formula (I) wherein r, t, Y1, Y2, R1, R2, R3, R5, R6and R7 have defined mean...	07/10/2007
7179805	7-amino alkylidenyl-heterocyclic quinolones and naphthyridones The present invention relates to compounds having a structure according to Formula I wherein n, m, z, R, R2, R3, R4, R5, R6, A, E, X, Y, a and b are as defin...	02/20/2007
7173036	Inhibitors of macrophage migration inhibitory factor and methods for identifying the same Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures:	02/06/2007
7169927	Indole-amide derivatives and their use as glycogen phosphorylase inhibitors Heterocyclic amides of formula (1) wherein: is a single or double bond; A is phenylene or heteroarylene; m is 0, 1 or 2;	01/30/2007
7169951	Quinazoline derivatives and pharmaceutical applications thereof A quianazoline derivative having the formula (1): or a pharmaceutically acceptable salt thereof, which has a chymase inhibitory activity and suppresses the exacerbation of vascular permeability induced by chymase...	01/30/2007
7166720	Process for the preparation of α-aminosubstituted carboxylic acid amides Hydroxy-imino derivatives of formula IIb are disclosed, in which R and R1 have the meanings given in the description. ...	01/23/2007
7166726	Aryl substituted 3,4-dihydroanthracene derivatives having retinoid antagonist or retinoid inverse agonist type biological activity Disclosed herein are compounds of the formula wherein R1 is independently H or alkyl of 1 to 6 carbons; R2 is optional and is defined as lower alkyl of 1 to 6 carbons, F, Cl, Br...	01/23/2007
7166617	Cyclic amide derivatives Novel compounds represented by the following formula (I) that act as a ligand to sigma receptor/binding cite and a medicament comprising the same as an active ingredient: wherein X represents an alkyl group, an a...	01/23/2007
7160882	Long acting β-2-agonists and their use as medicaments The present invention relates to compounds of formula 1 wherein the groups X, Ra, Rb, R1, R1′, R2, R2′, R2″, R2′″,...	01/09/2007
7136036	Method and apparatus for uniform brightness in displays An analog display driver comprises a matrix array of flatness correction values used to compensate for variations in liquid crystal gap dimensions and at least a first digital-to-analog converter (DAC), wherein a variable voltage transfer function is applied to the ...	11/14/2006
7125893	6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula I in which R1a, R1b, R2a, R3a, R3b, R4, R...	10/24/2006
7115640	Heterocyclic modulators of nuclear receptors Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of farnesoid X receptor (FXR), liver X receptor (LXR) and/or orphan nuclear receptors. I...	10/03/2006
7115744	Method for producing 8-methoxy-quinolinecarboxylic acids The present invention relates to a novel process for preparing 8-methoxy-3-quinolonecarboxylic acids which are antibiotics having potent antibacterial action. ...	10/03/2006
7105519	Inhibitors of macrophage migration inhibitory factor and methods for identifying the same Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: ...	09/12/2006
RE39265	Heteroarylpiperidines, and their use as antipsychotics and analgetics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compound...	09/05/2006
7102000	Heterocyclic amide derivatives for the treatment of diabetes and other diseases The present invention relates to certain substituted heterocycles of Formula (200), wherein B, H, I, J and K together with the Ar5 form a ring containing at least one amide residue, and W, X, Y and Z t...	09/05/2006
7098340	Benzyl sulfonamide derivatives The present invention is directed to a new class of 6-benzylsulfonamido-quinoline/chromene derivatives, to their use as androgen antagonists, and to formulations containing these androgen antagonists. ...	08/29/2006
7081457	Cyclothiocarbamate derivatives as progesterone receptor modulators Methods of using compounds which are progesterone receptor agonists for contraception and the treatment of progesterone-related maladies alone or in combination with an estrogen receptor agonist or progesterone receptor antagonist are provided. These compounds have ...	07/25/2006
7074796	4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives The present invention relates to substituted 4-phenyl-1-piperazinyl derivatives having the formula I wherein W is C, CH or N, and the dotted line emanating from W indicates a bond when W is C and no bond when W i...	07/11/2006
7067669	Substantially pure cilostazol and processes for making same The present invention provides substantially pure cilostazol. The present invention also provides cilostazol particles that have reduced particle size. ...	06/27/2006
7064208	Substantially pure cilostazol and processes for making same The present invention provides substantially pure cilostazol. The present invention also provides cilostazol particles that have reduced particle size. ...	06/20/2006
7060833	Substantially pure cilostazol and processing for making same The present invention provides substantially pure cilostazol. The present invention also provides cilostazol particles that have reduced particle size. ...	06/13/2006
7026486	Process for production cilostazol The present invention provides a process for producing cilostazol [I] in a high yield and a high purity, by reacting a carbostyril derivative [II] with a tetrazole derivative [III] in the presence of an inorganic basic compound in a solvent of water, wherein water i...	04/11/2006
7019139	Quinolinones and uses thereof The invention relates to compounds of the general formula (and pharmaceutically acceptable derivatives thereof): in which RA, RB, RC, RD, R5, R7, R9...	03/28/2006
7012145	Method Process for preparing 3-[(4S)-5-oxo-2-(trifluoromethyl)-1,4,5,6,7,8-hexahydroquinolin-4-yl]benzonitrile, pharmaceutical compositions containing the compound and methods of treatment using the same. ...	03/14/2006
6998415	Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation. ...	02/14/2006

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Class 546/158 - Single bond between 3,4-positions