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| Number | Title | Issue Date |
| 8058441 | Tetrahydroquinoline derivatives The present invention relates to tetrahydroquinoline derivatives having general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 is formyl, (1-6C)alkylcarbonyl or (1-6C)alkylsulfonyl; R2 and R3 are H or (1-4C)alk... | 11/15/2011 |
| 8034944 | Benzofluoranthene compound and organic light-emitting device using the compound There are provided a novel benzofluoranthene compound and an organic light-emitting device which uses the benzofluoranthene compound, gives a blue emission hue with extremely good purity, and has an optical output with a high efficiency, a high luminance, and a long... | 10/11/2011 |
| 7964729 | Sox-based kinase sensor Peptidyl sensors comprise a metal-binding peptide and one or two kinase recognition sequences with a hydroxyamino acid that can be phosphorylated in the presence of a kinase. ... | 06/21/2011 |
| 7928239 | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions in such therapy. ... | 04/19/2011 |
| 7888509 | Chiral 1,8-diarylnaphthalenes, methods of making them, and their use as sensors One aspect of the invention relates to 1,8-diarylnaphthalene compounds. In certain embodiments, a compound of the invention is an N-oxide of a 1,8-diarylnaphthalene. In certain embodiments, the aryl group is an optionally substituted acridyl group. In certain embodi... | 02/15/2011 |
| 7790892 | Aromatic compound and organic electroluminescent element containing the same A novel aromatic compound having an anthracene skeleton structure and an asymmetric molecular structure; and an organic electroluminescence device which comprises a cathode, an anode and an organic thin film layer comprising at least one layer containing a light emi... | 09/07/2010 |
| 7767817 | Water soluble boronic acid fluorescent reporter compounds and methods of use thereof Described herein are boronic acid fluorescent compounds and methods of use thereof. ... | 08/03/2010 |
| 7692016 | Process for the synthesis of quinoline derivatives The present invention provides an improved process for the synthesis of quinoline derivatives. More particularly the present invention provides an improved and economical process for the synthesis of quinoline derivatives by the reaction of aniline/substituted anili... | 04/06/2010 |
| 7629467 | Diphenyl substituted cycloalkanes, compositions containing such compounds and methods of use The instant invention provides compounds of formula: (I) which are 5-lipoxygenase activating protein inhibitors: formula (I). Compounds of formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cyto-protective agents. | 12/08/2009 |
| RE40558 | Therapeutic uses of di-aryl acid derivatives The use of diaryl acid derivatives of formula (I) or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and their pharmaceutical compositions as P... | 10/28/2008 |
| 7439257 | Aryloxyalkylcarbamate-type derivatives, preparation method thereof and use of same in therapeutics The invention relates to a compound of formula (I): Wherein m, n, X, Y, R1, R2, R3 and R4 are as defined herein. The invention also relates to the use of same in therapeutics. | 10/21/2008 |
| 7429592 | Cyanoanthranilamide derivatives and the use thereof as medicaments Substituted cyanoanthranilamide derivatives, their production and use as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis are described. The compounds according to the invention can be used as or in the case of psoriasis, Kap... | 09/30/2008 |
| 7429665 | Heteroaromatic quinoline compounds The invention pertains to heteroaromatic compounds that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE10. The invention also relates to intermediates for preparation... | 09/30/2008 |
| 7408065 | P2Xreceptor antagonists and their use The invention provides compounds of formula (IA), processes for their preparation, pharmaceutical compositions containing them, and their use in therapy. ... | 08/05/2008 |
| 7405262 | Preparation of functionalized anionic polymerization initiators A process for preparing a functionalized polymerization initiator, the process comprising combining a functionalized styryl compound and an organolithium compound. ... | 07/29/2008 |
| 7399865 | Protein tyrosine kinase enzyme inhibitors This invention provides compounds of formula 1, having the structure wherein R1, R2, R3, R4, and R5 are described within the specification. ... | 07/15/2008 |
| 7378240 | Synthesis and evaluation of new cyanine dyes as minor groove of [POLY(dA-dT)]binders The present invention relates to new cyanine dyes according to the formula (I), wherein A1 and A2 are each independently O, S, or N, and R is H or a carbohydrate that may contain a hetero atom, and m is 0 to 5, and n is 0 to 5. ... | 05/27/2008 |
| 7371865 | Process for the manufacture of HMG-CoA reductase inhibitors The invention relates to a process for the manufacture of a compound of formula or a salt, especially a pharmaceutically acceptable salt with a base, thereof or a lactone thereof wherein the element represents —CH2 | 05/13/2008 |
| 7361796 | Orangic electroluminescence device A compound having a diphenylanthracene structure at the center and a specific structure substituted with an aryl group at end portions. An organic electroluminescence device comprises a plurality of layers of thin films of organic compounds which comprise a light em... | 04/22/2008 |
| 7358222 | Preventing airway mucus production by administration of EGF-R antagonists Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic molecule, an antibody, or portion of an antibody that binds to and blocks th... | 04/15/2008 |
| 7351451 | Anthraquinone compound, liquid crystal composition, cell and display device employing the same A liquid crystal composition comprising at least one liquid crystal compound and at least one anthraquinone compound represented by formula (1) below: Formula (1) (wherein R2 to R8 each independently represents a hydrogen or substituent; Het is... | 04/01/2008 |
| 7339062 | Method for producing a 3,5-dihydroxy-6-heptenoate A method for producing an alkyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate of the formula (1) (wherein R is a C1-4 alkyl group), which is an intermediate for a cholesterol-reducing agent (a HMG-CoA reductase inhib... | 03/04/2008 |
| 7335753 | Bifunctional heterocyclic compounds and methods of making and using same The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using... | 02/26/2008 |
| 7323477 | 7-((1H-imidazol-4-yl)methyl)-5,6,7,8-tetrahydroquinoline A compound having a structure or a pharmaceutically acceptable salt, or a prodrug thereof is disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed. ... | 01/29/2008 |
| 7320992 | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods fo... | 01/22/2008 |
| 7312212 | Aminopiperidine derivatives Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man. ... | 12/25/2007 |
| 7304066 | Pyridyl cyanoguanidine compounds Compounds according to formula (I) wherein R1 represents hydrogen, halogen or one or more straight or branched, saturated or unsaturated C1-6 hydrocarbon radical, optionally substituted with halogen, h... | 12/04/2007 |
| 7279478 | Cathepsin cysteine protease inhibitors This invention relates to class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as o... | 10/09/2007 |
| 7276522 | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones, 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds The compound of the formula wherein the * indicates an asymmetric carbon, is specific to alpha2B adrenergic receptors in preference over alpha2A and alpha2C adrenergic receptors, ... | 10/02/2007 |
| 7268135 | Biaryl sulfonamides and methods for using same The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors. ... | 09/11/2007 |
| 7265115 | Diazabicyclic CNS active agents Compounds of formula I: or pharmaceutically acceptable salts thereof, are useful for controlling synaptic transmission in mammals. ... | 09/04/2007 |
| 7253188 | Aminobenzamide derivative This invention relates to a novel compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 is —S(O)p-A, â... | 08/07/2007 |
| 7241893 | Thiazolinone 2-substituted quinolines Thiazolinone substituted quinoline derivatives where the quinoline ring is substituted at the 2 position which derivatives demonstrates CDK1 antiproliferative activity and are useful as anti-cancer agents. ... | 07/10/2007 |
| 7241776 | Cyanoamidine P2Xantagonists for the treatment of pain Novel cyanoamidines compounds of formula (I) and (II) and their derivatives wherein R1-R12 are as defined in the specification act as antagonists of the P2X7 receptor. These compo... | 07/10/2007 |
| 7232832 | Antibacterial agents Quinoline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans. ... | 06/19/2007 |
| 7230010 | 1,2,4-triazole derivative, method for preparing the same, and pharmaceutical composition containing the same A 1,2,4-triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided: where... | 06/12/2007 |
| 7223759 | Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds The invention relates to antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds and pharmaceutical compositions thereof. This invention also relates to a method of using such compounds in the treatment of bacterial infections in mammal... | 05/29/2007 |
| 7220760 | Quinoline derivatives as CRTH2 antagonists The invetion relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the description... | 05/22/2007 |
| 7217714 | CCR5 modulators Compounds of Formula 1 [Region α]−[Region β]−[Region γ]−[Region δ]   (I) which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and m... | 05/15/2007 |
| 7217706 | Propanolamine derivatives This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which have gut selective sympatho... | 05/15/2007 |
