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| Number | Title | Issue Date |
| 8008499 | Anabaseine derivatives, pharmaceutical compositions and methods of use thereof Disclosed are novel anabaseine derivatives that act as agonists of the α7 nAChR. Also disclosed are pharmaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian c... | 08/30/2011 |
| 7439363 | Substituted indazoly(indoly)maleimide derivatives as kinase inhibitors The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): R2 is selected from the group consisting of —C1-8alkyl-Z, —C2-8alkenyl-Z and —C | 10/21/2008 |
| 7423049 | Inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceut... | 09/09/2008 |
| 7351737 | 4-[(8-substituted)-6-chromanoyl]-and 4-[8-substituted)-chroman-6-YL-ethynyl]-benzoic and phenylacetic acids, their esters and salts having cytochrome P450RAI inhibitory activity Compounds of the formula where the variables are defined in the specification have cytochrome P450RAI-1 and P450RAI-2 inhibitory activity, and are suitable for treatment of mammals with conditions which are treatable with r... | 04/01/2008 |
| 7304050 | Antibacterial agents Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I a... | 12/04/2007 |
| 7279489 | Compounds and methods for modulation of estrogen receptors Compounds that modulate the estrogen receptor (ER) are disclosed, as well as pharmaceutical compositions containing the same. In a specific embodiment, the compounds are selective for ER-β over ER-α. Methods are disclosed for modulating ER-β in cell and/or tissue... | 10/09/2007 |
| 7265129 | Anti-infective biaryl compounds Compounds represented by the formula (I), where R1, R2, R3, R4, R5, and Q are as defined herein, exhibit activity against infectious pathogens ... | 09/04/2007 |
| 7265125 | Neuropeptide Y antagonists Quinoline and quinazoline derivatives can be used in the form of pharmaceutical preparations as Neuropeptide Y antagonists for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity. ... | 09/04/2007 |
| 7256201 | Selective estrogen receptor-β ligands The invention relates to novel compounds having the general formula: (I) and arc useful as selective ER-β ligands in the treatment or prophylaxis of Alzheimer's disease, anxiety disorders, depressive disorders, osteoporosis cardiovascular disease, rheumatoid arthri... | 08/14/2007 |
| 7250526 | Transfer hydrogenation process and catalyst A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal hydrocarbyl complex which is coordinated to defined bidentate ligands substituted with at least one group selected from an optionally substituted sulphonated hydr... | 07/31/2007 |
| 7238685 | Benzo-fused heterocycles as endothelin antagonists The invention relates to novel benzo-fused heterocycles and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compos... | 07/03/2007 |
| 7232906 | Substituted pyrrolines as kinase inhibitors The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder. ... | 06/19/2007 |
| 7226951 | Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme. ... | 06/05/2007 |
| RE39663 | Electron-deficient nitrogen heterocycle-substituted fluorescein dyes The invention provides compositions electron-deficient nitrogen heterocycle-substituted fluorescein dyes and methods in which the dyes are conjugated to substrates and used as detection labels in molecular biology experiments. The electron-deficient nitrogen heteroc... | 05/29/2007 |
| 7205314 | Compounds for the treatment of dementia related diseases The present invention relates to new compounds of formula (I) wherein Y, P, R1, R2, R3, n, m are defined as in claim 1, a process for their preparation and new intermediates used therein, pharmaceutical composition containing ... | 04/17/2007 |
| 7169927 | Indole-amide derivatives and their use as glycogen phosphorylase inhibitors Heterocyclic amides of formula (1) wherein: is a single or double bond; A is phenylene or heteroarylene; m is 0, 1 or 2; | 01/30/2007 |
| 7163949 | 4-phenyl substituted tetrahydroisoquinolines and use thereof Provided herein are compounds of the formulae IA–IF. These compounds are tetrahydroisoquinolines of the following structure: wherein R1–R8 for compounds of each of the formulae IA, IB, I... | 01/16/2007 |
| 7157456 | Substituted oxazolidinones and their use in the field of blood coagulation The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxi... | 01/02/2007 |
| 7144893 | 4-aryl quinols and analogs thereof as therapeutic agents The present invention pertains to compounds of the formula (1) which are, inter alia, antiproliferative agents, anticancer agents, antimycobacterial agents, antituberculosis agents, and/or thioredoxin/thioredoxin reductase inhibitor: wherein: Q is ═O or ═N—S(... | 12/05/2006 |
| 7141570 | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives The present invention provides antibacterial agents having the formula I described herein. ... | 11/28/2006 |
| 7141588 | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives The present invention provides antibacterial agents having the formulae I, II, and III described herein. ... | 11/28/2006 |
| 7129259 | Halogenated biaryl heterocyclic compounds and methods of making and using the same The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having at least one halogenated hydrocarbon moiety, a biaryl moiet... | 10/31/2006 |
| 7125891 | Tripeptidyl peptidase inhibitors The present invention is concerned with novel compounds of formula (I) which are inhibitors of a membrane tripeptidyl peptidase responsible for the inactivation of endogenous neuropeptides such as cholecystokinis (CCKs). The invention further relates to methods for ... | 10/24/2006 |
| 7115635 | Benzylpiperidine compound The object of the present invention is to provide a compound having a treatment effect based on a chemokine inhibitory activity, which is satisfactory as a pharmaceutical product for oral administration. The present inventors have found that the following ben... | 10/03/2006 |
| RE39265 | Heteroarylpiperidines, and their use as antipsychotics and analgetics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compound... | 09/05/2006 |
| 7094900 | N-Aryl-2-oxazolidinones and their derivatives The present invention provides antibacterial agents of formula I described herein. ... | 08/22/2006 |
| 7074801 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof The present invention discloses compounds and compositions of formula (I): having inhibitory activity on activation of STAT6, wherein X represents quinoline, isoquinoline, quinazoline or imidazopyridine; Y repres... | 07/11/2006 |
| 7067533 | Aminophenoxyacetamide derivatives and pharmaceutical composition containing thereof The present invention relates to an aminophenoxyacetamide derivative of the formula (I): wherein R1 to R4 are, independent from each other, a hydrogen atom or an optionally substituted alkyl... | 06/27/2006 |
| 7015328 | Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted coumarins and quinolines and analogs thereof, represented by the general Formula I: wherein A, B, X, Y, and Z are defined herein. The present invention also relates to t... | 03/21/2006 |
| 6998401 | Aminophenoxyacetic acid derivatives and pharmaceutical composition containing thereof There is provided an aminophenoxyacetic acid derivative of the following formula (I): wherein, R1, R2, R3 and R4 are, independent from each other, alkoxy group, alkyl group or... | 02/14/2006 |
| 6992177 | Saquinavir derivatives useful in immunoassay Analogs of saquinavir functionalized at the quinoline portion of the molecule are described. These include pyridyl analogs (replacing the quinoline ring) with a functional handle out of the ring allowing for elaboration with linkers terminated by a functional group ... | 01/31/2006 |
| 6969726 | Biaryl heterocyclic compounds and methods of making and using the same The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety th... | 11/29/2005 |
| 6962996 | Inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceut... | 11/08/2005 |
| 6951863 | Pyridoarylphenly oxazolidinone antibacterials, and related compositions and methods Pyridoarylphenyl oxazolidinone compounds of the formula: in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents. ... | 10/04/2005 |
| 6949566 | Thiazole and oxazole derivatives A compound of the formula (I): wherein R1 is hydroxy and the like; R2 is optionally substituted lower alkyl and the like; R3 is hydrogen atom and the like; R | 09/27/2005 |
| 6919329 | N-Aryl-2-oxazolidinone-5-carboxamides and their derivatives The present invention provides antibacterial agents having the formulae I, II, and III described herein. ... | 07/19/2005 |
| 6916819 | Benzimidazole and pyridylimidazole derivatives This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I The invention is particularly related to such compounds that bind with ... | 07/12/2005 |
| 6911453 | Substituted 4-phenyltetrahydroisoquinolinium, process for their preparation, their use as a medicament, and medicament containing them The invention relates to compounds of the formula I in which R1 to R9 are as defined herein. In one embodiment, these compounds may be used as antihypertensives, for reducing or preventing ischemia-induced damage, as m... | 06/28/2005 |
| 6900226 | Neuropeptide Y antagonists Quinoline and quinazoline derivatives can be used in the form of pharmaceutical preparations as Neuropeptide Y antagonists for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity. ... | 05/31/2005 |
| 6900325 | Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted coumarins and quinolines and analogs thereof, represented by the general Formula I: wherein A, B, X, Y, and Z are defined herein. The present invention also relates to t... | 05/31/2005 |
