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| Number | Title | Issue Date |
| 8178678 | -quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of c... | 05/15/2012 |
| 8158795 | Process for the purification of neuromuscular blocking agents A process for the preparation of neuromuscular blocking agents with isoquinoline structure, such as atracurium besylate, doxacurium chloride, mivacurium chloride and gantacurium chloride, by chromatographic purification of their mixtures of isomers using a silica mo... | 04/17/2012 |
| 7872137 | Process for the preparation of mivacurium chloride A process for preparing the [R—[R*,R*-(E)]]-2,2′-(1,8-dioxo-4-octene-1,8-diyl) bis(oxy-3,1-propanediyl)bis(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl) methyl]isoquinolinium) dichloride, commonly known as mivacurium chloride, useful as s... | 01/18/2011 |
| 7872138 | Process for the preparation of substituted-1,2,3,4-tetrahydroisoquinoline derivatives The present invention is directed to a process for the synthesis of substituted-1,2,3,4-tetrahydroisoquinoline derivatives, useful as intermediates in the synthesis of pharmaceutical agents. ... | 01/18/2011 |
| 7371755 | Antiviral agents This invention relates to a compound capable of binding to a picornavirus capsid comprising two or more capsid binding moieties. ... | 05/13/2008 |
| 7268142 | Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline The invention pertains to substituted quinazoline and isoquinoline compounds that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE-10. The invention also relates to in... | 09/11/2007 |
| 7166617 | Cyclic amide derivatives Novel compounds represented by the following formula (I) that act as a ligand to sigma receptor/binding cite and a medicament comprising the same as an active ingredient: wherein X represents an alkyl group, an a... | 01/23/2007 |
| 7157463 | Substituted piperidines/piperazines as melanocortin receptor agonists The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction ... | 01/02/2007 |
| 6972304 | Aqueous ink compositions Disclosed is an aqueous ink composition comprising an aqueous liquid vehicle, a colorant, and an additive wherein, when the ink has been applied to a recording substrate in an image pattern and a substantial amount of the aqueous liquid vehicle has either evaporated... | 12/06/2005 |
| 6800645 | Substituted azabicyclic compounds This invention is directed to physiologically active compounds of formula (I) wherein represents a bicyclic ring system, of about 10 to about 13 ring members, in which the ri... | 10/05/2004 |
| 6686351 | Compounds and methods for modulation of estrogen receptors Compounds that modulate the estrogen receptor (ER) are disclosed, as well as pharmaceutical compositions containing the same. In a specific embodiment, the compounds are selective modulators for ER-ଲ over ER-. Methods are disclosed for modula... | 02/03/2004 |
| 6645957 | Cyclic amide compound The invention relates to compounds represented by the following general formula (1): ##STR1## wherein A is an aromatic compound which may be substituted, or the like, B is a nitrogen atom or CH, X is a lower alkylene group which may be substituted, o... | 11/11/2003 |
| 6627641 | Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof The present invention provides antimalarial pharmaceutical compositions containing antimalarial naphthylisoquinoline alkaloids or antimalarial derivatives thereof, useful new antimalarial naphthylisoquinoline alkaloid derivatives, methods for obtaining su... | 09/30/2003 |
| 6617335 | Preparation and drug composition of bis-benzyl-isoquinoline class alkaloids This invention relates to the preparation of bis-isoquinoline derivatives of general formula (I) and salts thereof, which possesses multi-drug resistance (MDR) reversal activities. Drug compositions and formulations comprising bis-isoquinoline derivatives... | 09/09/2003 |
| 6593322 | Compounds and methods for modulation of estrogen receptors Compounds that modulate the estrogen receptor (ER) are disclosed, as well as pharmaceutical compositions containing the same. In a specific embodiment, the compounds are selective for ER-ଲ over ER-. Methods are disclosed for modulating ER-&#x... | 07/15/2003 |
| 6576642 | Diamide compounds and compositions containing the same Compounds having the formula (1): ##STR1## wherein A is a phenyl, naphthyl, dihydronaphthyindeny, pyridyl, indolyl,isoindolyl, quinolyl or isoquinolyl group which are optionally substituted; X is optionally substituted alicyclic, aromatic, imino or h... | 06/10/2003 |
| 6436923 | Compounds and methods for modulation of estrogen receptors Compounds that modulate the estrogen receptor (ER) are disclosed, as well as pharmaceutical compositions containing the same. In a specific embodiment, the compounds are selective modulators for ER-ଲ over ER-. Methods are disclosed for modula... | 08/20/2002 |
| 6433177 | Process for the preparation of (S)-N-tert-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide It is here described a new process for the synthesis of (S)-N-tertbutyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide wherein the N-carboxy anhydride of formula ##STR1## is treated with tert-butylamine in an organic inert solvent, preferably toluene, ... | 08/13/2002 |
| 6384028 | N-acylpiperidinylcarbonylaminocarboxylic acids and their use as glycoprotein IIb/IIIa antagonists and fibrinogen-blood platelets binding inhibitors ଲ-alanine compounds or a pharmaceutically acceptable salt thereof, which is useful as a glycoprotein IIB/IIIa antagonist, inhibitor of blood platelet aggregation and inhibitor of the binding of fibrinogen to blood platelet; a composition containing ... | 05/07/2002 |
| 6331630 | Dimeric arylisoquinoline alkaloids and derivatives thereof The present invention provides new naphthylisoquinoline derivatives. In particular, the present invention furthermore provides novel dimeric arylisoquinoline alkaloids comprised of coupled first and second arylisoquinoline monomers. Monomeric and dimeric ... | 12/18/2001 |
| 6274594 | Isoquinoline derivatives and their therapeutical use Novel isoquinoline derivatives and methods of using them to treat various neurological indications are disclosed.... | 08/14/2001 |
| 6242450 | 5-HT1F antagonists This invention provides 5-HT1f antagonists of Formula I: ##STR1## where AR1, AR2, R, and R' are as defined in the specification.... | 06/05/2001 |
| 6187789 | Substituted isoquinolines as ultra short acting neuromuscular blockers Ultrashort acting neuromuscular blocking agents of Formula (I) which are useful as skeletal muscle relaxants during emergency intubation procedures, routine surgery and post-operative settings are disclosed, wherein: X is a halogen; h is from 1 to 2; Y is... | 02/13/2001 |
| 6177445 | Substituted isoquinolines as ultra short acting neuromuscular blockers Ultra short acting neuromuscular blocking agents of Formula (I) which are useful as skeletal muscle relaxants during emergency intubation procedures, routine surgery and post-operative settings are disclosed, wherein q and t are independently from 0 to 4;... | 01/23/2001 |
| 6174901 | Substituted pyridine and pyridazine compounds and methods of use Selected novel substituted pyridine and pyridazine compounds are effective for prophylaxis and treatment of diseases, such as TNF-, IL-1ଲ, IL-6 and/or IL-8 mediated diseases, and other maladies, such as cancer, pain and diabetes. The inventio... | 01/16/2001 |
| 6156767 | Antagonists of gonadotropin releasing hormone There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both m... | 12/05/2000 |
| 6080839 | Labeling reactants and their use The invention relates to a novel labeling reactant, suitable for labeling of a biospecific binding reactant using solid-phase synthesis. The invention further concerns new labeling methods. The novel labeling reactant has the formula (I) ##STR1## ... | 06/27/2000 |
| 6048867 | Biologically active rupununines A method of therapy wherein there is administered to a person in need of such therapy a pharmacologically effective amount of a rupununine having the formula: ##STR1##... | 04/11/2000 |
| 5965730 | Pyridine derivatives A pyridine derivative of the formula (I): ##STR1## wherein A is group of the following formulae: ##STR2## (R1 and R2 are each H, or protected or unprotected OH, R31, R41 and R42 are protecte... | 10/12/1999 |
| 5863929 | Anticoagulant agents This invention relates to a compound of the Formula I X--C(O)--Y--G--R I (wherein X, Y, G and R have the values defined in the description), or a pharmaceutically acceptable salt thereof, processes and intermediates for ... | 01/26/1999 |
| 5789594 | Dimeric naphthylisoquinoline alkaloids and synthesis methods thereof The present invention provides methods of preparing dimeric naphthylisoquinoline alkaloids by coupling together two monomeric naphthylisoquinoline alkaloids, each of which may be the same or different, and one, both, or neither of which may possess a C-8'... | 08/04/1998 |
| 5786482 | Dimeric arylisoquinoline alkaloids and synthesis method thereof The present invention provides a method of preparing dimeric arylisoquinoline alkaloids by coupling two isoquinoline building blocks, which may be the same or different, together with a symmetrical or nonsymmetrical biaryl building block to form homodimer... | 07/28/1998 |
| 5760029 | Spirocycle integrin inhibitors This invention relates to novel heterocycles, including (S)-2-phenylsulfonylamino-3-8-(2-pyridinylaminomethyl)-!-1-oxa-2-azaspi ro-4,5!-dec-2-en-3-yl!carbonylamino! propionic acid, which are useful as antagonists of the v ଲ | 06/02/1998 |
| 5741789 | Compounds having effects on serotonin-related systems A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1A receptor. The compounds are particularly useful for alleviating the sym... | 04/21/1998 |
| 5733931 | Cyclohexanediurea derivative and process for its production The present invention provides a cyclohexanediurea derivative, inclusive of its salt, represented by the following formula (I): ##STR1## wherein R1 and R2 are the same or different and they each represent a straight-chain or bra... | 03/31/1998 |
| 5684154 | Process for the preparation and isolation of atracurium besylate A process of producing atracurium besylate that substantially reduces the level of impurities in the final product and avoids the repeated use of ether is provided. In accordance with such a process, N, N'-4,10-dioxa-3,11-dioxotridecylene-1,13-bis-tetrahy... | 11/04/1997 |
| 5654432 | Process of preparing michellamine compounds The present invention provides new antiviral compounds, i.e., michellamines and derivatives and pharmacologically acceptable salts thereof, methods for isolating such antiviral compounds from a plant species of the genus Ancistrocladus, antiviral composit... | 08/05/1997 |
| 5637708 | Structure based design of capsid stabilizing or antiviral agents Agents having the structure, U--CH2 --V--CH2 --W, and agents having the structure, U--CH2 --V--CH2 --W--X--Y--Z, where U, W, and Z are double fused aromatic rings, V is a single six-membered aromatic ring with a hydroxyl ... | 06/10/1997 |
| 5629430 | Trifluoromethylpyrroloindolecarboxylic acid ester and process for production thereof Trifluoromethylpyrroloindolecarboxylic acid ester derivatives, and optical isomers and pharmaceutically acceptable salts thereof are provided which are represented by the general formula (1): ##STR1## or the general formula (2): ##STR2## Th... | 05/13/1997 |
| 5602168 | 1-(N'-(arylalkylaminoalkyl)) aminoisoindoles; dopamine receptor subtype specific ligands Disclosed are compounds of the formula ##STR1## or the pharmaceutically acceptable salts thereof wherein the 6-membered A ring may be optionally substituted with up to four groups independently selected from halogen, hydroxy, lower alkyl, or lower al... | 02/11/1997 |
