Class 546/138 - Quinolizines (including hydrogenated)

Subclass of Class 546 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the bicyclo ring system has the following
No. of patents: 115
Last issue date: 08/19/2008

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Number	Title	Issue Date
7414056	Pyrazole-amide compounds useful as kinase inhibitors The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where G, X, R1, R2, R3, R4, R5, R6	08/19/2008
7390810	Pyrazole-amine compounds useful as kinase inhibitors The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where G, X, R1, R2, R3, R4, R5, R6	06/24/2008
7223773	4-oxoquinolizine antibacterial agent having 2-pyridone skeleton as partial structure The present invention provides a 4-oxoquinolizine antibacterial agent having a 2-pyridone skeleton as a partial structure and also having a strong antibacterial effect on gram-positive bacteria, gram-negative bacteria or anaerobic bacteria. The compound having the f...	05/29/2007
7148008	Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease Methods are disclosed for predicting the efficacy of a drug for treating an inflammatory disease in a human patient, including: obtaining a sample of cells from the patient; obtaining a gene expression profile of the sample in the absence and presence of in vitro mo...	12/12/2006
7125863	Inhibitors of dipeptidyl peptidase IV Compounds according to formula (1), wherein R1 is H or CN, X1 is S, O, SO2 or CH2, X2 is CO, CH2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The compounds of t...	10/24/2006
7091352	Compounds substituted with bicyclic amino groups Compounds of the formula (I) below, or pharmacologically acceptable salts, esters or other derivatives thereof: wherein A is furan, thiophene, pyrazole, imidazole, isoxazole or isothiazole; R1 is a sub...	08/15/2006
6962917	Aminopiperidine quinolines and their azaisosteric analogues with antibacterical activity Aminopiperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man. ...	11/08/2005
6919371	2,6-substituted chroman derivatives useful as beta-3 adrenoreceptor agonists This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions. ...	07/19/2005
6900224	Antimicrobial quinolones, their compositions and uses Compounds of the following formula: are effective antimicrobial agents. ...	05/31/2005
6900322	Method for stereochemically controlled production of isomerically pure highly substituted azacyclic compounds A method for stereochemically controlled production of azacyclic compounds of general formula (I) in which the substituents have the meanings given in the specification. The invention also relates to intermediate produ...	05/31/2005
6884806	Bicyclic lactam derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) The present application describes novel bicyclic lactam derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein A, B, C, D, R1, and R2 are defined in the present speci...	04/26/2005
6841559	Pyridinones to treat and prevent bacterial infections Novel pyridinones and their derivatives which are effective in treating or preventing Gram-negative bacterial infections are provided. The pyridinones are stable and easily derivatized; the methods by which these derivatizations occur is described. Two regioselectiv...	01/11/2005
6762181	Aminomethylpyrrolidine derivatives having aromatic substituents This invention provides a quinolone derivative having potent antibacterial activity against various bacteria including drug-resistant strains which is a compound of the following formula wherein R1 is an optionally substituted aromatic group, a salt of th...	07/13/2004
6743817	Substituted fused pyrroleimines and pyrazoleimines Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R1 and R2 are defined herein. These compounds are highly selective agonists, antagonists...	06/01/2004
6632825	Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis Compounds of the formula: ##STR1## where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containi...	10/14/2003
6630488	Quinolizinones as integrin inhibitors The present invention is directed towards novel compounds that are effective inhibitors of integrins, particularly ଱IIbଲ.sub.3 or ଱v integrins such as ଱vଲ.sub.3 and ଱vଲ.sub.5....	10/07/2003
6608079	Indole derivatives and their use as 5-HT1F agonists The present invention relates to a compound of formula (I), or a pharmaceutical acid addition salt thereof, which are useful for activating 5-HT1F receptors and inhibiting neuronal protein extravasation in a mammal. ##STR1##...	08/19/2003
6602882	Quinoline derivatives and their use as antibacterial agents Piperidine derivatives and pharmaceutical derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man....	08/05/2003
6569871	Substituted imidazole compounds Novel 1,4,5 substituted imidazole compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors....	05/27/2003
6562809	3-bicycloindole compounds Described herein are compounds selective for a 5-HT1D receptor, which have the general formula: ##STR1##...	05/13/2003
6525066	4-oxoquinolizine antimicrobial having 2-pyridone skeleton as partial structure A compound represented by the following Formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein R1 represents a hydrogen atom or a carboxyl-protecting group, R2 represents a hydrogen atom, a halogen atom, a lower alkyl...	02/25/2003
6518266	1- Aryl-3-thioalkyl pyrazoles, the synthesis thereof and the use thereof as insecticides The present invention is directed to novel pyrazole derivatives and their use as pesticidal agents. The pyrazole derivatives have Formula I: ##STR1## or a salt thereof, where R1 represents R5 O, R5 SO2, R5...	02/11/2003
6509349	Antimicrobial 2-pyridones, their compositions and uses Compounds having the general structure: ##STR1## are effective antimicrobial agents....	01/21/2003
6458950	Compounds and pharmaceutical compositions containing the same A compound shown by the formula II, wherein Het is a mono- or polycyclic heterocyclic group comprising one or more hetero atoms selected from the group consisting of N, O and S which may be the same or different from each other; R1 is hydrogen,...	10/01/2002
6294560	Synthesis of clasto-lactacystin ଲ-lactone and analogs thereof The present invention is directed to an improved synthesis of clasto-lactacystin-ଲ-lactone, and analogs thereof, that proceeds in fewer steps and in much greater overall yield than syntheses described in the prior art. The synthetic pathway relies u...	09/25/2001
6251893	Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity Described herein are compounds with affinity for the 5-HT6 receptor, which have the general formula: ##STR1## wherein R1, R2, R3 and R4 are independently selected from the group consisting of H, halo,...	06/26/2001
6235751	Quinolizine carboxylic acid derivatives A quinolizine carboxylic acid derivative of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein R1 and R2 have the same meanings the as defined in the specification....	05/22/2001
6177445	Substituted isoquinolines as ultra short acting neuromuscular blockers Ultra short acting neuromuscular blocking agents of Formula (I) which are useful as skeletal muscle relaxants during emergency intubation procedures, routine surgery and post-operative settings are disclosed, wherein q and t are independently from 0 to 4;...	01/23/2001
6169181	Compounds useful to treat retroviral infections The present invention relates to compounds of formula I and II which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl[b]pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian c...	01/02/2001
6133290	5-HT_1F agonists The present invention relates to a compound of formula I: ##STR1## or a pharmaceutical acid addition salt thereof; which are useful for activating 5-HT1F receptors and inhibiting neuronal protein extravasation in a mammal....	10/17/2000
6121281	Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use Compounds of formula (3), and pharmaceutically acceptable salts and derivatives thereof, in which R1 is vinyl or ethyl; and R2 is a group R3, R4 CH2 --, or R5 R6 C.dbd.CH--; wherein ...	09/19/2000
6025371	Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones The invention provides chemistry libraries containing fused 2,4-pyrimidinediones. The invention also provides methods for the construction of fused 2,4-pyrimidinedione containing libraries. The invention further provides methods for the identification of ...	02/15/2000
5977133	Pyridone antibiotic with improved safety profile Antibacterial compounds having the formula ##STR1## and the pharmaceutically acceptable salts, esters and amides thereof, as well as pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infection...	11/02/1999
5955491	Method for treating osteoporosis The present invention provides a cathepsin L inhibitor containing a compound of the formula: ##STR1## wherein R1 is a hydrogen atom or an arylalkyl, heterocyclic-alkyl or lower alkyl group which may be substituted; R2 and R...	09/21/1999
5874427	Substituted heteroaromatic 5-HT_1F agonists This invention provides novel 5-HT1F agonists of the Formula ##STR1## in which X, Y, E, R, A, B, and n are as defined in the specification, which are useful for the treatment of migraine and associated disorders....	02/23/1999
5872117	1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same This invention relates to a 1,2-ethanediol derivative and a salt thereof, a process for producing the same, and a cerebral function-improving agent comprising the same. The cerebral function-improving agent of this invention is useful for treating cerebro...	02/16/1999
5844102	Glycohydrolase inhibitors, their preparation and use thereof A compound of the formula ##STR1## wherein n, m, and p, which may be the same or different, are a number between 0 and 5; q is a number between 0 and 10; R1, R2 R3 R4 and R5, which may be the sam...	12/01/1998
5834499	5-HT₃ receptor agonist, novel thiazole derivative and intermediate thereof A 5-HT3 receptor against containing a thiazole derivative as the effective ingredient is provided and is represented by the Formula (I): ##STR1## wherein the A ring is substituted or unsubstituted and represents a benzene or a heterocyclic...	11/10/1998
5789591	Process for preparing 1-substituted 8-chloro-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid ethyl ester compounds A process for preparing a compound having the formula: ##STR1## wherein R is selected from the group consisting of C3 -C6 -cycloalkyl, C3 -C6 -cycloalkylmethyl, C1 -C6 -alkyl, allyl an...	08/04/1998
5786372	Heteroaryl compounds used as pharmaceuticals Compounds of formula (I), or pharmaceutically acceptable salts thereof are provided: ##STR1## in which X1 --(CH2)x --X2 forms a 5-7 membered ring wherein: X1 is O or S; X2 is O, S or N...	07/28/1998

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Class 546/138 - Quinolizines (including hydrogenated)