Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 8080663 | Process for the preparation of 2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine An industrially acceptable process for the preparation of 2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine. The cis-isomer of 2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine is known generally as Cevimeline. ... | 12/20/2011 |
| 8044205 | Process for manufacturing 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide This present disclosure relates to a process for manufacturing 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide by reacting 2-hydroxy-2,2-dithien-2-ylacetic acid 1-azabicyclo[2.2.2]oct-3(R)yl ester and 3-phenoxypropyl... | 10/25/2011 |
| 7741489 | Process for the synthesis of solifenacin The present invention provides an improved synthetic strategy for the preparation of solifenacin and pharmaceutically acceptable salts thereof. ... | 06/22/2010 |
| 7705152 | Alcohol oxidation catalyst and its preparation process An alcohol oxidation catalyst which is an organic oxidation catalyst to oxidize an alcohol, which contains azabicyclo[3.3.1]nonane N-oxyl represented by the following formula (1) having an N-oxyl group incorporated in a bicycle[3.3.1]nonane skeleton: | 04/27/2010 |
| 7687630 | Method for producing optically active quinuclidinols having one or more substituted groups at the 2-position The invention provides a method for producing optically active 3-quinuclidinols having one or more substituted groups at the 2-position; wherein 3-quinuclidinones having one or more substituted groups at the 2-position are reacted with compounds providing hydrogen i... | 03/30/2010 |
| 7629466 | Synthetic methods and intermediates for steroisomeric compounds useful for the treatment of gastrointestinal and central nervous system disorders The subject invention provides methods and/or processes for making stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective t... | 12/08/2009 |
| 7521559 | Quinuclidine compounds having quaternary ammonium group, its preparation method and use as blocking agents of acetylcholine The invention relates to the quinuclidine compounds of formula I having quaternary ammonium group, its preparation, and the pharmaceutical composition comprising an effective amount of the compound of formula I. The compound and the composition are used to prevent a... | 04/21/2009 |
| 7462722 | Process for producing optically active-3-quinuclidinols An object of the present invention is to provide a process for producing optically active 3-quinuclidinol having high optical purity or the salt thereof at high yield. The invention relates to a process for producing optically active 3-quinuclidinol or the sa... | 12/09/2008 |
| 7435742 | Quinuclidine derivatives and pharmaceutical compositions containing the same Carbamates of formula (I) or pharmaceutically acceptable salts thereof, including quaternary ammonium salts of formula (II) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as antagonists... | 10/14/2008 |
| 7432280 | 3-aminopiperidines and 3-aminoquinuclidines as inhibitors of monoamine uptake The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, which are useful for the inhibition of the uptake of one or more physiologically active monoamines (serotonin, norepinep... | 10/07/2008 |
| 7361668 | Quinuclidine derivatives processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors The invention concerns quinuclidine derivatives of formula I or II wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention show high affinities for m3 and/or m2 muscarinic receptors and ar... | 04/22/2008 |
| 7358260 | Quinuclidine derivatives and medicinal compositions containing the same The invention provides 1-phenethyl-3 (R)-(9[H]-xanthene-9-carbonyloxy)-1 -azoniabicyclo[2.2.2]octane in salt form, pharmaceutical compositions comprising it, and methods of using it for treatment of respiratory disorders. ... | 04/15/2008 |
| 7335668 | Pharmaceutical composition for therapy of interstitial cystitis A depressant of capsaicin-sensitive sensory nerve, containing quinuclidin-3′-yl 1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate or a salt thereof as an active ingredient, specifically a therapeutic drug of interstitial cystitis, hypersensitive disorder of th... | 02/26/2008 |
| 7326787 | Synthetic methods and intermediates for stereoisomeric compounds useful for the treatment of gastrointestinal and central nervous system disorders The subject invention provides methods and/or processes for making stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and ... | 02/05/2008 |
| 7312231 | Quinuclidine carbamate derivatives and their use as M3 antagonists A compound which is a carbamate of formula: wherein R1 represents R2 represents a benzyl, phenethyl, furan-2-ylmethyl, furan-3-ylmethyl, thiophen-2-ylmethyl ... | 12/25/2007 |
| 7214687 | Quinuclidine derivatives and medicinal compositions containing the same The invention provides 3 (R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1 -azoniabicyclo[2.2.2]octane in salt form, pharmaceutical compositions comprising it, and methods of using it for treatment of respiratory disorders, in association with phosphodie... | 05/08/2007 |
| 7214686 | Pharmaceutical compositions and methods for effecting dopamine release Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e.g., Parkinsonism, Parkinson's Disease, Tourette's Syndrome, attent... | 05/08/2007 |
| 7208501 | Quinuclidine carbamate derivatives and their use as M3 antagonists A compound which is a carbamate of formula: wherein R1 represents R2 represents a benzyl, phenethyl, furan-2-ylmethyl, furan-3-ylmethyl, thiophen-2-ylmethyl ... | 04/24/2007 |
| 7196098 | Quinuclidine derivatives and medicinal compositions containing the same The invention provides 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane in salt form, pharmaceutical compositions comprising it, and methods of using it for treatment of respiratory disorders, in association with steroids. | 03/27/2007 |
| 7176219 | Salts of quinuclidine derivative There is provided an acid addition salt of (−)-(3R)-quinuclidin-3-yl(1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate with an acid selected from the group consisting of (−)-(2S,3S)-tartaric acid, (+)-(2S,3S)-di-O-benzoyltartaric acid, (+)-(2S,3S)-di-O-(... | 02/13/2007 |
| 7176218 | Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders The subject invention provides stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastr... | 02/13/2007 |
| 7164024 | Benzimidazolone derivatives This invention relates to benzimidazolone derivatives, represented by compounds of a general formula [I] [in which R1 and R2 stand for, e.g., hydrogen atoms; R3... | 01/16/2007 |
| 7160876 | Fused bicycloheterocycle substituted quinuclidine derivatives Compounds of formula (I) wherein n is 0, 1, or 2; X is O, S, —NH—, and —N-alkyl-; Ar1 is a 6-membered aromatic ring; and Ar2 is a fused bicycloheterocycle. The compounds are useful in ... | 01/09/2007 |
| 7115629 | Carbamates derived from arylalkylamines The invention relates to carbamates having general structure (I), wherein: R1, R2 and R3 are H, OH, SH, CN, F, Cl, Br, I, (C1–C4)-alkylthio, (C1–C4)-alkoxyl, (C1–C4)-alkoxyl substituted by one o... | 10/03/2006 |
| 7112593 | N-aryl-substituted cyclic amine derivative and medicine containing the same as active ingredient An excellent squalene synthase inhibitor is provided. Specifically, what is provided is a compound (I) represented by the following formula, a salt thereof or a hydrate of them. In formula (I), R1 represents an optionally substituted vinyl group or an aro... | 09/26/2006 |
| 7109210 | Quinuclidine derivatives and medicinal compositions containing the same Compounds of the formula wherein: {circle around (C)} is phenyl, C4 to C9 heteroaromatic, naphthalenyl, 5,6,7,8-tetrahydronaphthalenyl or biphenyl; R1, R2 and R | 09/19/2006 |
| 7078412 | Quinuclidine derivatives and medicinal compositions containing the same The invention provides 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2] octane in salt form, pharmaceutical compositions comprising it, and methods of using it for treatment of respiratory disorders, alone or in combination with ot... | 07/18/2006 |
| 7008951 | Mixtures or organic compounds for the treatment of airway diseases A medicament comprising, separately or together, (A) a compound of formula (I) in free or pharmaceutically acceptable salt or solvate form and (B) a corticosteroid, for simultaneous, sequential or separate administration in the treatment of an inflammatory or obstru... | 03/07/2006 |
| 6949539 | Admantane derivatives The invention provides compounds of general formula (I) in which m, A, R1 and Ar have the meanings defined in the specification; a process for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compo... | 09/27/2005 |
| 6916828 | Carbamates derivatived from arylakylamines The invention relates to carbamates having general structure (I), wherein: R1, R2 and R3 are H, OH, SH, CN, F, Cl, Br, I, (C1-C4)-alkylthio, (C1-C4)-alkoxyl, (C1-C4)-alkoxyl substituted by one or seve... | 07/12/2005 |
| 6911523 | Method to decrease the aldehyde content of polyesters A method to decrease an aldehyde content of a polyester. The method comprises incorporating an effective amount of an additive that is capable of catalyzing a hydride-transfer reaction between an organic donor molecule and an aldehyde in the polyester. ... | 06/28/2005 |
| 6821962 | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and /or p56lck tyrosine kinases This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56lck tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a pati... | 11/23/2004 |
| 6624173 | Pharmaceutical compositions for treating and/or preventing CNS disorders Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e.g., Parkinsonism, Parkinson's Disease, Tourette's Syndr... | 09/23/2003 |
| 6599917 | Quinuclidine compounds and drugs containing the same as the active ingredient The present invention provides an excellent squalene synthesizing enzyme inhibitor. Specifically, it provides a compound (I) represented by the following formula, a salt thereof or a hydrate of them. ##STR1## In which R1 represents (1) hydrogen... | 07/29/2003 |
| 6525065 | Pharmaceutical compositions and methods for effecting dopamine release Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e.g., Parkinsonism, Parkinson's Disease, Tourette's Syndr... | 02/25/2003 |
| 6426415 | Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity A compound of formula I: ##STR1## or a pharmaceutically acceptable salt, prodrug, metabolite, optical isomer or stereoisomer thereof, wherein: R1, when present, is hydrogen or lower alkyl; R2 is lower alkyl, aryl, aralkyl, lower alkanoyl,... | 07/30/2002 |
| 6335447 | Quinolonecarboxylic acid derivatives or salts thereof Novel quinolonecarboxylic acid derivatives of general formula (1) or salts thereof which have potent antibacterial effects on gram-positive bacteria in particular Propionibacterium acnes ##STR1## (wherein R1 represents a hydrogen atom or a carb... | 01/01/2002 |
| 6316389 | Dihydrobenzene pesticides Compounds of the formula I ##STR1## in which: where: X is CH or N; Y is O; S, S.dbd.O or NR5 ; Z is OR2, SR2, N(R3)R4 ; or Y and Z together form 5- to 7-membered ring which contains, 2 or 3 hetero atoms O ... | 11/13/2001 |
| 6313346 | Catalyst compositions for the production of polyurethanes A composition having the formula: ##STR1## wherein R is a linear alkyl, branched alkyl, cycloalkyl, polycyclic alkyl, alkylaminoalkyl, or alkyloxyalkyl group having 1 to 20 carbon atoms and at least one primary, secondary, or tertiary amino functional gro... | 11/06/2001 |
| 6255479 | Process for the preparation of -oxolactams A method for preparing an -oxolactam comprising, reacting a corresponding -diazolactam with an oxygen donor, in the presence of a transition metal catalyst, to yield the corresponding -oxolactam.... | 07/03/2001 |
