Did You Know...
...that a workman who left the soap mixing machine on too long was responsible for making Ivory Soap? He was so embarrassed by his mistake that he threw the mess in a stream. Imagine his dismay when the evidence of his error floated to the surface! Result: Ivory soap, the soap that floats.
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| Number | Title | Issue Date |
| 8153799 | Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists The invention relates to novel benzothiophene-, benzofuran-, and indole ureas and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning, and/or memory. ... | 04/10/2012 |
| 8134003 | Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of ... | 03/13/2012 |
| 7977485 | 2-heteroaryl carboxamides The invention relates to novel 2-heteroaryl carboxamides and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory. ... | 07/12/2011 |
| 7737280 | Processes for preparing palonosetron salts The present invention provides processes for preparing Palonosetron salts, especially, the hydrochloride salt and intermediates used to prepare Palonosetron salts. ... | 06/15/2010 |
| 7732610 | Heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-bacterial agents The invention relates to new heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a process for the preparation of these compounds as well as their use as medica... | 06/08/2010 |
| 7667040 | Azacyclic ethynyl derivatives Azacyclic ethynyl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the tr... | 02/23/2010 |
| 7619089 | Derivatives of -heterocyclylmethylbenzamides, preparation method thereof and application of same in therapeutics The invention relates to compositions comprising a compound having general formula (I): Wherein R, R1, R2, X and n are as described herein. Also disclosed and claimed in certain of the embodiments herein are the methods of ... | 11/17/2009 |
| 7498440 | Muscarinic acetylcholine receptor antagonists Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided. ... | 03/03/2009 |
| 7495102 | Azaindole inhibitors of aurora kinases The present invention relates to a compound represented by Formula (I): and pharmaceutically acceptable salts. Compounds of the present invention inhibit Aurora kinase, making them especially suitable for the treatment of a... | 02/24/2009 |
| 7488827 | Muscarinic acetylcholine receptor antagonists Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided. ... | 02/10/2009 |
| 7361668 | Quinuclidine derivatives processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors The invention concerns quinuclidine derivatives of formula I or II wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention show high affinities for m3 and/or m2 muscarinic receptors and ar... | 04/22/2008 |
| 7358359 | Antibacterial agents Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacteria... | 04/15/2008 |
| 7354930 | N-biarylamides The invention relates to N-biarylamides useful for the prophylaxis and/or treatment of impairments of perception, concentration, learning and/or memory, and to processes for preparing them, and pharmaceutical compositions containing them. ... | 04/08/2008 |
| 7342028 | Medical use for tachykinin antagonists The present invention relates to the use of tachykinin antagonists, including substance P antagonists and other neurokinin antagonists, in the treatment of emesis. Also described are novel tachykinin antagonists of formula (I), processes for their preparation, pharm... | 03/11/2008 |
| 7332507 | 3-substituted quinuclidines and their use This invention relates to novel 3-substituted quinuclidine derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds ... | 02/19/2008 |
| 7309699 | 3-Quinuclidinyl amino-substituted biaryl derivatives Compounds of formula (I) wherein A is N or N+—O−; n is 0, 1, or 2; Y is O, S, —NH—, and —N-alkyl-; Ar1 is both 6-membered aromatic rings; Ar2 is 5- or 6-membe... | 12/18/2007 |
| 7288656 | Derivatives of N-heterocyclylmethylbenzamides, preparation method thereof and application of same in therapeutics The invention relates to a compound having general formula (I): Wherein R, R1, R2, X and n are as described herein. Also disclosed and claimed in certain of the embodiments herein are the methods of preparation o... | 10/30/2007 |
| 7282588 | Azaindole inhibitors of aurora kinases The present invention relates to a compound represented by Formula (I): and pharmaceutically acceptable salts. Compounds of the present invention inhibit Aurora kinase, making them especially suitable for the tre... | 10/16/2007 |
| 7256288 | Heteroaryl carboxylic acid amides The invention relates to novel heteroaryl carboxamides, a process for their preparation, and pharmaceutical compositions containing them. These materials are useful for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learnin... | 08/14/2007 |
| 7247728 | Bicyclic N-arylamides This application relates to bicyclic N-aryl amides of the formula R1 is a 1-aza-bicyclo[3.2.1]octyl group, a 1-aza-bicyclo[2.2.2]oct-3-yl; R2 is an optiona... | 07/24/2007 |
| 7241773 | 3-quinuclidinyl heteroatom bridged biaryl derivatives Compounds of formula: or pharmaceutically acceptable salts, esters, amides, or prodrugs thereof, wherein: A and G are each independently N or N+—O−; m and n are each independently 0, 1, ... | 07/10/2007 |
| 7241787 | Substituted N-cycloexylimidazolinones, process for their preparation and their use as medicaments The invention relates to substituted N-cyclohexylheterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof, to processes for their preparation and to their use as medicaments. Compounds of the formula I, | 07/10/2007 |
| 7214688 | Compounds Compounds of formula I: wherein A, D, Ar1, E and Ar2 are as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, ... | 05/08/2007 |
| 7214686 | Pharmaceutical compositions and methods for effecting dopamine release Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e.g., Parkinsonism, Parkinson's Disease, Tourette's Syndrome, attent... | 05/08/2007 |
| 7176236 | Water-soluble etoposide analogs and methods of use thereof Etoposide analogs with improved water-solubility such as 4′-O-Demethyl-4′-(N′,N′-dimethyl-glycyl)-4β-(4″-nitroanilino)-4-desoxy-podophyllotoxin (8) and 4′-O-Demethyl-4′-(N′,N′-dimethyl-glycyl)-4β-(4″-fluoroanilino)-4-desoxy-podophyllotoxin (9) ... | 02/13/2007 |
| 7176198 | 1-pyrazole and 1-pyrrole-azabicyclic compounds for the treatment of disease The invention provides compounds of Formula I: wherein Azabicyclo is where the variables have the definitions discussed herein. These compounds may be in the... | 02/13/2007 |
| 7160876 | Fused bicycloheterocycle substituted quinuclidine derivatives Compounds of formula (I) wherein n is 0, 1, or 2; X is O, S, —NH—, and —N-alkyl-; Ar1 is a 6-membered aromatic ring; and Ar2 is a fused bicycloheterocycle. The compounds are useful in ... | 01/09/2007 |
| 7138410 | Aza-bicyclic N-biarylamides with affinity for the α7 nicotinic acetylcholine receptor The invention relates to novel 1-aza-bicyclic N-biarylamides, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning ability and memory. ... | 11/21/2006 |
| 7122558 | Quinuclidine derivatives and medicinal compositions containing the same A compound of formula (I), wherein B is a phenyl ring, a 5 to 10 membered heteroaromatic group containing one or more heteroatoms, or a naphthalenyl, 5,6,7,8-tetrahydronaphthalenyl, benzo[1,3]dioxolyl, or biphenyl group; R1, R2 and R3 | 10/17/2006 |
| 7115629 | Carbamates derived from arylalkylamines The invention relates to carbamates having general structure (I), wherein: R1, R2 and R3 are H, OH, SH, CN, F, Cl, Br, I, (C1–C4)-alkylthio, (C1–C4)-alkoxyl, (C1–C4)-alkoxyl substituted by one o... | 10/03/2006 |
| 7115768 | Multicyclic compounds which inhibit leukocyte adhesion mediated by VLA-4 Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, su... | 10/03/2006 |
| 7112592 | Azabicyclic compounds, preparation thereof and use as medicines, in particular as antibacterial agents The invention relates to new heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a process for the preparation of these compounds as well as their us... | 09/26/2006 |
| 7112593 | N-aryl-substituted cyclic amine derivative and medicine containing the same as active ingredient An excellent squalene synthase inhibitor is provided. Specifically, what is provided is a compound (I) represented by the following formula, a salt thereof or a hydrate of them. In formula (I), R1 represents an optionally substituted vinyl group or an aro... | 09/26/2006 |
| 7101896 | Pharmaceutical compositions and methods for use The present invention relates to aryl olefinic azacyclic compounds and aryl acetylenic azacyclic compounds, including pyridyl olefinic cycloalkylamines and pyridyl acetylenic cycloalkylamines. The present invention also relates to prodrug derivatives of the compound... | 09/05/2006 |
| 7097919 | Polymeric fluorescent substance, process for producing the same, and organic electroluminescent element A polymeric fluorescent substance has a prolonged service life and high luminescence brightness. The substance also has excellent thermal stability and good practicality. The polymeric fluorescent substance is adapted for emission of visible fluorescence in a solid ... | 08/29/2006 |
| 7087750 | Compounds, their use and preparation The invention provides 2, 3-, 4- or 5-substituted-N1-(arylsulfonyl)indole and (heteroaryl)indole compounds of the general formula (I): in which Ar, R2, R3, R4 and R5 ar... | 08/08/2006 |
| 7078412 | Quinuclidine derivatives and medicinal compositions containing the same The invention provides 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2] octane in salt form, pharmaceutical compositions comprising it, and methods of using it for treatment of respiratory disorders, alone or in combination with ot... | 07/18/2006 |
| 7067515 | Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease The invention provides compounds of Formula I: where in W is These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or... | 06/27/2006 |
| RE39128 | Pleuromutilin derivatives as antimicrobials The present invention relates to pleuromutilin derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medical therapy, particularly antibacterial therapy. ... | 06/13/2006 |
| 7045530 | Spirocyclic quinuclidinic ether derivatives Compounds of formula (I) wherein n1 is 0, 1, or 2; n2 is 0, 1, or 2; X is a bond, O, S, or NR1; and Ar1 is a 5-membered aromatic ring, 6-membered aromatic ring, or a fused bicycloheterocycle... | 05/16/2006 |
