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"The abolishment of pain in surgery is a chimera. It is absurd to go on seeking it...knife and pain are two words in surgery that must forever be associated in the consciousness of the patient."
Dr. Alfred Velpeau, French surgeon ; 1839
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| Number | Title | Issue Date |
| 7381733 | Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases The present invention relates to the use of tropane derivatives having dopamine reuptake inhibitor activity for the treatment of diseases associated with reduced blood flow to the brain or with instances of a temporary break in blood supply to the brain, such as isc... | 06/03/2008 |
| 7333095 | Illumination for optical touch panel An optical touch panel including a support defining a generally planar surface, an optical illumination assembly arranged along and above at least part of a periphery of the support to define a detection region, at least one light detector, arranged to detect change... | 02/19/2008 |
| 7186731 | 2-cyanopyrrolidinecarboxamide compound A compound of the formula (I) or a pharmaceutically acceptable salt thereof: [wherein X1 and X2 each is independently lower alkylene; X | 03/06/2007 |
| 7105678 | Boat tropanes Radiopharmaceutical compounds are disclosed. A tropane compound is linked through the N atom at the 8-position to a chelating ligand capable of complexing technetium or rhenium to produce a neutral labeled complex that selectively binds to the dopamine transporter o... | 09/12/2006 |
| 6964972 | 8-Azabicyclo(3,2,1)oct-2 ene and octane derivatives as cholinergic ligands at nicotinic ACh receptors The invention disclosed herein relates to novel a 8-azabicyclo[3.2.1]oct-2-ene compound of Formula II, wherein R is hydrogen, methyl, ethyl or benzyl; and R1 is 3-thienyl, 2-thienyl... | 11/15/2005 |
| 6843979 | 4-haloethenylphenyl tropane:serotonin transporter imaging agents A series of compounds in the 4-fluoroalkyl-3-halophenyl nortropanes and 4-haloethenylphenyl tropane families are described as diagnostic and therapeutic agents for diseases associated with serotonin transporter dysfunction. These compounds bind to serotonin transpor... | 01/18/2005 |
| 6815452 | Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments Fluorenecarboxylic acid esters of general formula 1 wherein X− and the groups A, R, R1, R2, R3, R3′, R4, and R4′ have the meanings give... | 11/09/2004 |
| 6706880 | Cocaine receptor binding ligands The invention relates to novel compounds which show high affinity for cocaine receptors in the brain, particularly dopamine and serotonin transporter sites. The compounds may be used as imaging or pharmaceutical agents, in the diagnosis and treatment of drug addicti... | 03/16/2004 |
| 6670375 | Tropane analogs and methods for inhibition of monoamine transport New tropane analogs that bind to monoamine transporters are described, particularly, 8-aza, 8carbo and 8-oxo tropanes having 6- or 7-substituents. The compounds of the present invention can be racemic, pure R-enantiomers, or pure S-enantiomers. Certain pr... | 12/30/2003 |
| 6645977 | 8-azabicyclo(3,2,1)oct-2-ene and octane derivatives as cholinergic ligands at nicotinic ACh receptors The present invention discloses compounds of formula (1) any of its enantiomers or any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein - - - - is a single or a double bond; R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, #... | 11/11/2003 |
| 6537522 | Neuroprobes for mapping monoamine reuptake sites Iodinated neuroprobes for mapping monoamine reuptake sites in the brain, and particularly iodinated neuroprobes that can also serve as radiotracers for use in single-photon emission computed tomography (SPECT) and positron emission tomography (PET) for im... | 03/25/2003 |
| 6531483 | Cocaine receptor binding ligands The invention relates to novel compounds which show high affinity for cocaine receptors in the brain, particularly dopamine and serotonin transporter sites. The compounds may be used as imaging or pharmaceutical agents, in the diagnosis and treatment of d... | 03/11/2003 |
| 6399042 | 4-fluoroalkyl-3-halophenyl nortropanes A series of compounds in the 4-fluoroalkyl-3-halophenyl nortropanes family are described as diagnostic and therapeutic agents for diseases associated with serotonin transporter dysfunction. These compounds bind to serotonin transporter protein with high a... | 06/04/2002 |
| 6383490 | Anti-cocaine vaccine An anti-cocaine vaccine employs a cocaine hapten conjugated to a carrier protein. The anti-cocaine vaccine elicits an immune response which reduces the psychoactive effects of cocaine consumption by the production of anti-cocaine polyclonal antibodies. Th... | 05/07/2002 |
| 6358492 | Dopamine transporter imaging ligand The 3 isomer of RTI-55, RTI-352, is an effective in vivo binding ligand that reflects greater selectivity for the dopamine transporter than is observed with RTI-55. In addition, there is also a more rapid achievement of apparent equilibrium in the ... | 03/19/2002 |
| 6350758 | Tropane derivatives and method for their synthesis A compound of formula (I) wherein R1 -R6 have any of the values defined in the specification are described, as well as pharmaceutical compositions comprising a compound of formula (I), and methods for preparing and using compounds of... | 02/26/2002 |
| 6344179 | Fluoralkenyl nortropanes Provided are compounds of the following formula: ##STR1## wherein R is C2-C6 mono- or multi-unsaturated hydrocarbon having one or more ethylene, acetylene or allene groups, A is 18 or 19, and X is H or halogen. The compounds of the invention bind to dopam... | 02/05/2002 |
| 6329520 | Cocaine receptor binding ligands The invention relates to novel compounds which show high affinity for cocaine receptors in the brain, particularly dopamine and serotonin transporter sites. The compounds may be used as imaging or pharmaceutical agents, in the diagnosis and treatment of d... | 12/11/2001 |
| 6316624 | Process for the preparation of substituted 8-azabicyclo[3,2,1]octanes A process for preparing a compound of formula (IV) wherein R1 is C1-4 alkyl, C1-4 haloalkyl, benzyl, C3-6 alkenyl or C3-6 alkyny, (provided that the -carbon atom of R1 is neither uns... | 11/13/2001 |
| 6241963 | Dopamine and serotonin transporter ligands and imaging agents This invention presents a series novel tropane-based derivatives complexed with either technetium or rhenium that are specific for central nervous system receptors, in particular, dopamine or serotonin receptors. The compounds of the invention have utilit... | 06/05/2001 |
| 6221879 | 8-azabicyclo[3.2.1] octane-3-methanamine derivatives as ligands of D2 and D3 dopamine and 5HT1A and 5HT2 serotonin receptors Compounds of general formula (I) ##STR1## in which U represents a group of general formula (A) or (B) ##STR2## in which formulae V represents a hydrogen or halogen atom, a (C1 -C3)alkyl group or one or two (C1 -C3 | 04/24/2001 |
| 6180083 | Tropane derivatives useable in particular for in vivo detection of dopamine transporters The present invention relates to tropane derivatives having particular use for the in vivo detection of dopamine transporters. These derivatives meet the formula ##STR1## in which R1 is I or Sn (R3)3, R2 is for example the meth... | 01/30/2001 |
| 6171576 | Dopamine transporter imaging agent Radiopharmaceutical compounds are disclosed. A tropane compound is linked through the N atom at the 8-position to a chelating ligand capable of complexing technetium or rhenium to produce a neutral labeled complex that selectively binds to the dopamine tr... | 01/09/2001 |
| 6123917 | Method for making cocaine receptor binding ligands and intermediates therefor An improved method for preparation of cocaine receptor binding ligands is provided. The method calls for the preparation of the silylaryl intermediate prepared from phenyl trimethylsilane and a anhydroecgonine methyl ester appropriately substituted. The i... | 09/26/2000 |
| 6054127 | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo are disclosed. Methods of preparing the hapten-carrier conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition... | 04/25/2000 |
| 6054465 | Hemoregulatory compounds The present invention relates to novel compounds of the Formula I which have hemoregulatory activities and can be used to stimulate hematopoiesis and for the treatment of viral fungal and bacterial infectious diseases.... | 04/25/2000 |
| 6013242 | Tropane derivatives with selective binding to the serotonin reuptake transporters for treatment of mental illness and as intermediates in the formation of imaging diagnostic agents for depression Biologically active derivatives of the tropane ring system are provided which selectively bind either to the 5-HT or DA reuptake site, leading to compounds which have use for the treatment of clinical depression, attention deficit disorder, obesity and co... | 01/11/2000 |
| 5990312 | Method for the preparation of esters of anhydroecgonine The present invention discloses compounds of the formula any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein R, R3, and R4 each have the meanings set forth in the specification. The compounds possess valuable pharm... | 11/23/1999 |
| 5980860 | Dopamine and serotonin transporter ligands and imaging agents This invention presents a series of novel tropane-based derivatives complexed with either technetium or rhenium that are specific for central nervous system receptors, in particular, dopamine or serotonin receptors. The compounds of the invention have uti... | 11/09/1999 |
| 5958945 | Naphthamide derivatives of 3-beta-amino azabicyclo octane or nonane as neuroleptic agents The invention pertains to novel azabicyclo-naphthalene-carboxamide derivatives, a method for preparing same and the use thereof as a medicament. The compounds of the invention are of formula (I). ##STR1##... | 09/28/1999 |
| 5935953 | Methods for controlling invertebrate pests using cocaine receptor binding ligands The invention relates to a method of controlling an invertebrate pest, comprising contacting the pest with a pest-controlling amount of an agent having substantial inhibitory activity toward a phenylethanolamine reuptake transporter as determined by radio... | 08/10/1999 |
| 5888475 | Labeled cocaine analogs Novel methods for positron emission tomography or single photon emission spectroscopy using tracer compounds having the structure: ##STR1## where X in ଲ configuration is phenyl, naphthyl; 2,3 or 4-iodophenyl; 2,3 or 4-(trimethylsilyl)phenyl; 3,... | 03/30/1999 |
| 5876727 | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo are disclosed. Methods of preparing the hapten-carrier conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition... | 03/02/1999 |
| 5864038 | Labeled cocaine analogs Novel compounds having the structure: ##STR1## where X in ଲ configuration is phenyl, naphthyl; 2,3 or 4-iodophenyl; 2,3 or 4-(trimethylsilyl)phenyl; 3,4,5 or 6-iodonaphthyl; 3,4,5 or 6-(trimethylsilyl)naphthyl; 2,3 or 4-(trialkylstannyl)phenyl;... | 01/26/1999 |
| 5834484 | Cocaine analogs Cocaine analogs are disclosed. The analogs, certain 6-alkyl substituted tropane derivatives, bind to the cocaine binding site on dopamine transporter, without interfering with the dopamine receptor. The craving for cocaine is thereby blocked. The analogs ... | 11/10/1998 |
| 5821249 | Anhydroecogonine compounds and their use as anticholinergic agents Methylecgonidine (MEG; anhydroecgonine methylester), is produced when cocaine base ("crack") is heated. MEG alone and in combination with cocaine was tested for action on isolated tracheal rings stimulated to contact with acetylcholine. At micromolar conc... | 10/13/1998 |
| 5736123 | Cocaine receptor binding ligands Novel compounds useful as intermediates in the synthesis of compounds having high affinity for specific cocaine receptors in the brain have the formula ##STR1## wherein R is (CH2)n CH2 Y, and wherein Y is H or F, X is... | 04/07/1998 |
| 5736556 | Tropane-2-aldoxime derivatives as nevro transmitter reuptake inhibitors The present invention discloses compounds of the formula, ##STR1## any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein R, R3, and R4 each have the meanings set forth in the specification. The compounds po... | 04/07/1998 |
| 5591854 | Enantioselective synthesis of seven-membered carbocycles and tropanes A process of enantioselective synthesis of seven-membered carbocycles in the presence of di-rhodium(II) tetracarboxylate catalysts.... | 01/07/1997 |
| 5585492 | LTA4 Hydrolase inhibitors The present invention provides compounds of the formula Ar1 --Q--Ar2 --Y--R--Z and pharmaceutically acceptable salts thereof wherein Ar1 and Ar2 are optionally substituted aryl moieties, Z is an optionally subst... | 12/17/1996 |
