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| Number | Title | Issue Date |
| 8183377 | Process for the preparation of imidazopyridines A process for the preparation of imidazopyridines of formula (I), comprising reacting 6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine with oxalyl chloride, followed by conversion of the chloride to oxoacetic acid, and further to compound of Formula (I). | 05/22/2012 |
| 8163919 | Imidazopyridinyl benzamide mitotic kinesin inhibitors Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed. ... | 04/24/2012 |
| 8063219 | Nitrogenous heterocyclic compounds, preparation thereof and use thereof as antibacterial medicaments The invention concerns nitrogenated heterocyclic compounds, their preparation and use as antibacterial drugs, compounds of general formula (I) wherein R1 represents a (CH2)n-NHR2 or (CH... | 11/22/2011 |
| 8063218 | Imidazopyridine inhibitors of IAP The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein Q, X1, X2, Y, Z R1, R2, R3, R3′... | 11/22/2011 |
| 8030492 | Compositions to effect neuronal growth Compositions containing neurogenic agents for inhibition of neuron death and inducing proliferation of neural cells are disclosed. ... | 10/04/2011 |
| 7700773 | 4-cyano, 4-amino, and 4-aminomethyl derivatives of pyrazolo[1,5-a]pyridines, pyrazolo[1,5-c]pyrimidines and 2H-indazole compounds and 5-cyano, 5-amino, and 5-aminomethyl derivatives of imidazo[1,2-a]pyridines, and imidazo[1,5-a]pyrazines as cyclin dependent kinase inhibitors In its many embodiments, the present invention provides a novel class of 4-cyano, 4-amino, and 4-aminomethyl derivatives of pyrazolo[1,5-a]pyridine, pyrazolo[1,5-c]pyrimidine, and 2H-Indazole compounds and 5-cyano, 5-amino, and 5-aminomethyl derivatives of imidazo[1... | 04/20/2010 |
| 7622584 | Imidazopyridine-based compound and organic light emitting diode including organic layer comprising the imidazopyridine-based compound Imidazopyridine-based compounds and organic light emitting diodes (OLEDs) including organic layers including the imidazopyridine-based compounds are provided. The organic light emitting diodes including organic layers having the imidazopyridine-based compounds have ... | 11/24/2009 |
| 7432278 | Dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents A method for treating a microbial infection, including an infection from a protozoan pathogen, such as Trypanosoma brucei rhodesiense and Plasmodium falciparum, in a subject in need thereof by administering to the subject an effective amount of a dicat... | 10/07/2008 |
| 7417053 | Pyrazolo[1,5-a]pyridine derivatives or pharmaceutically acceptable salts thereof A pyrazolo[1,5-a]pyridine derivative represented by formula (I) and salt thereof exhibit excellent MAPKAP-K2 inhibitory activity. Accordingly, medicines comprising this compound as an active ingredient are expected to be valuable for treating or preventing diseases ... | 08/26/2008 |
| 7417041 | Imidazopyrimidines as transforming growth factor (TGF) inhibitors Novel fused heteroaromatic compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of tran... | 08/26/2008 |
| 7399769 | Aryl-isoxazol-4-yl-imidazo[1,5-a]pyridine derivatives The present invention is concerned with aryl-isoxazol-4-yl-imidazo[1,5-a]pyridine derivatives of formula wherein: R1, R2, and R3 are as defined herein and pharmaceutically acceptab... | 07/15/2008 |
| 7385056 | Synthesis of heteroaryl acetamides An improved process for the preparation of a heteroaryl acetamide from a heteroaryl α-hydroxyacetamide is provied. The process comprises directly hydrogenating the heteroaryl α-hydroxyacetamide in the presence of a strong acid, a halide and a catalyst. In one embo... | 06/10/2008 |
| 7371871 | Inhibitors of glutaminyl cyclase The present invention relates to compounds that act as inhibitors of QC including those represented by the general formulae 1 to 9: and combinations thereof for the treatment of neuronal disorders, especially Alzheimer's di... | 05/13/2008 |
| 7365066 | Pyrazolopyridine derivatives as pharmaceutical agents Novel pyrazolopyridine derivative compounds are disclosed and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors useful in the treatment of cancer and other disease states influenced by TGF beta. ... | 04/29/2008 |
| 7358261 | Heteroaryl alkylamide derivatives useful as bradykinin receptor modulators This invention is directed towards novel alkylamide derivatives as bradykinin receptor antagonists useful for the treatment of bradykinin modulated disorders such as pain, inflammation, asthma and allergy. Furthermore, the present invention is directed to novel alky... | 04/15/2008 |
| 7348324 | Cyclic amine compounds as CCR5 antagonists A compound of formula (I) (wherein R1 is a hydrogen atom, a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, R2 is a hydrocarbon group which may be substituted, a non-aromatic heterocyclic ... | 03/25/2008 |
| 7348432 | Pyridine imidazoles and aza-indoles as progesterone receptor modulators The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders mediated by one or more estrogen receptors. The compounds of the invention are useful in... | 03/25/2008 |
| 7345050 | Pyrimidine compounds The present invention relates to new compounds of the formula (I) a process for their preparation, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy, as well as intermediates used in the p... | 03/18/2008 |
| 7345055 | Substituted C-imidazo [1,2-α] pyridin-3-yl-methylamines Novel C-imidazo[1,2-α]pyridin-3-yl-methylamine compounds corresponding to formula I, wherein R1-R6 have the meanings provided in the description. Pharmaceutical compositions containing these compounds... | 03/18/2008 |
| 7342025 | Substituted -imidazo[1,2-a]pyridin-3-yl-methylamines Substituted C-imidazo [1,2-a]pyridine-3-yl methylamines and physiologically acceptable salts thereof, a method for the production thereof, pharmaceutical compositions containing these compounds, and pharmaceutical uses thereof, e.g., as NO synthase inhibitors. ... | 03/11/2008 |
| 7326718 | 8-Substituted imidazopyridines The present invention relates to 8-substituted imidazopyridines of a certain formula (1) in which the substitutents and symbols have the meanings indicated in the description. The compounds have gastric secretion... | 02/05/2008 |
| 7326784 | Intermediates for the preparation of tricyclic dihydropyrano-imidazo-pyridines derivatives The invention relates to compounds of the formula 1, in which R1, R2, R3, Arom and PG have the meanings as indicated in the description. These compounds are valuable intermediates for the preparation of pharmaceu... | 02/05/2008 |
| 7323569 | 7-phenylpyrazolopyridine compounds A compound represented by the formula: [wherein R1 is methoxy, methylthio, ethyl, etc.; R5 and R6 are each independently cyclopropylmethyl, (4-tetrahydropyranyl)methyl, etc.; and ... | 01/29/2008 |
| 7314940 | Jun kinase inhibitors The present invention provides novel compounds of formula I and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particula... | 01/01/2008 |
| 7300470 | Dye composition comprising 2-chloro-6-methyl-3-aminophenol, at least two oxidation bases chosen from para-phenylenediamine derivatives and at least one associative thickening polymer The present disclosure relates to a composition for oxidation dyeing keratin fibers, for instance, human keratin fibers such as the hair, comprising 2-chloro-6-methyl-3-aminophenol as a coupler, para-phenylenediamine or para-tolylenediamine as at least one first oxi... | 11/27/2007 |
| 7285551 | Fused-ring compounds and use thereof as drugs The present invention provides a fused ring compound of the following formula [I] wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, and a therapeutic agent for he... | 10/23/2007 |
| 7285666 | Pyrazolo[1,5-a] pyridines and medicines containing the same Compounds represented by the general formula: [wherein R1 represents methoxy, ethyl, methylthio, etc., R2, R3 and R4 each represent hydrogen, a halogen, etc., R5 | 10/23/2007 |
| 7279580 | Imidazo-pyridine derivatives as ligands for GABA receptors A class of 8-fluoro-3-phenylimidazo[1,2-α]pyridine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group, or by a pyrrolidinonyl group, which is directly attached or bridged by an oxygen atom or by a ... | 10/09/2007 |
| 7276087 | Dye composition comprising 2-chloro-6-methyl-3-aminophenol as coupler, para-aminophenol and 3-methyl-4-aminophenol as oxidation bases and at least one associative thickening polymer The present disclosure relates to a composition for oxidation dyeing keratin fibers, for instance human keratin fibers such as the hair, comprising 2-chloro-6-methyl-3-aminophenol as at least one coupler, para-aminophenol as at least one first oxidation base, 3-meth... | 10/02/2007 |
| 7271178 | Heterocyclic inhibitors of MEK and methods of use thereof Disclosed are compounds of the Formula V and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9, R10, R11 | 09/18/2007 |
| 7265127 | βadrenergic agonists The present invention relates to 2-imidazo[1,2-a]pyridine group containing β3 adrenergic receptor agonists or pharmaceutical salts thereof. ... | 09/04/2007 |
| 7259263 | Method of synthesis of azole-containing amino acids The invention relates to methods of synthesizing 2-substituted azole compunds of formula (I): The invention is also relates to compounds of formula (I) and to intermediate compounds in the synthesis method. ... | 08/21/2007 |
| 7256293 | Imidazopyridine intermediates The invention relates to compounds of the formula 1, in which the substituents and symbols have the meanings indicated in the description. The compounds are valuable intermediates for the preparation of pharmaceu... | 08/14/2007 |
| 7241772 | βadrenergic agonists The present invention relates to 2-imidazo[1,5-a]pyridine containing β3 adrenergic receptor agonists or pharmaceutical salts thereof. ... | 07/10/2007 |
| 7238808 | Acetylenyl-pyrazolo-pyrimidine derivatives The present invention relates to compounds of formula (I): wherein R1 to R3, A, M, L, E, G, and J are as defined in the description and claims. The invention also relates to a process for th... | 07/03/2007 |
| 7230099 | Heterocyclic inhibitors of MEK and methods of use thereof Disclosed are compounds of the Formula and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9 and R10, W and Y are... | 06/12/2007 |
| 7226926 | 8-fluoroimidazo 1,2-a pyridine derivatives as ligands for GABA receptors A class of 8-fluoroimidazo[1,2-α]pyridine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, being selective ligands for GABAA receptors, in particular having high affinity for the Î... | 06/05/2007 |
| 7223866 | Imidazo[1,5-a]pyridine derivatives and methods for treating aldosterone mediated diseases Compounds of the formula (I) provide pharmacological agents which are inhibitors of the P450 enzyme, aldosterone synthase, and thus may be employed for the treatment of aldosterone mediated conditions. Accordingl... | 05/29/2007 |
| 7220756 | N-sulfonylheterocyclopyrrolyl-alkylamine compounds as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a CNS disorder relating to or affected by the 5-HT6 receptor ... | 05/22/2007 |
| 7214677 | Benzamide, heteroarylamide and reverse amides The present invention relates to novel to P2X7 inhibitors of formula I and to processes for their preparation, intermediates useful in their preparation, pharmaceutical compositions containing them, an... | 05/08/2007 |
