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| Number | Title | Issue Date |
| 8163918 | Azaindazole compounds as CCR1 receptor antagonists Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. | 04/24/2012 |
| 7579472 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds can be useful as factor Xa inhibitors. | 08/25/2009 |
| 7435821 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds can be useful as factor Xa inhibitors. ... | 10/14/2008 |
| 7435820 | Substituted tetrahydro-1-pyrazolo [3,4-]pyridines compositions comprising them, and use Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology... | 10/14/2008 |
| 7417041 | Imidazopyrimidines as transforming growth factor (TGF) inhibitors Novel fused heteroaromatic compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of tran... | 08/26/2008 |
| 7396932 | Process for preparing 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds can be useful as factor Xa inhibitors. | 07/08/2008 |
| 7388096 | Crystalline forms of a factor Xa inhibitor The instant invention provides crystalline forms of 1-(3-chlorophenyl)-7-oxo-6-[4-(2-oxo-1 (2H)pyridinyl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide and its solvates thereof; processes for the production of such crystalline forms; pharmaceuti... | 06/17/2008 |
| 7371864 | Crystalline forms of a factor Xa inhibitor The instant invention provides crystalline forms of 3-(1-hydroxy-1-methyl-ethyl)-1-(4-methoxy-phenyl)-6-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one and its solvates thereof; processes for the production of such crystalline form... | 05/13/2008 |
| 7371761 | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4-P-M-M4I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or het... | 05/13/2008 |
| 7354929 | Cannabinoid receptor ligands and uses thereof Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein ... | 04/08/2008 |
| 7348324 | Cyclic amine compounds as CCR5 antagonists A compound of formula (I) (wherein R1 is a hydrogen atom, a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, R2 is a hydrocarbon group which may be substituted, a non-aromatic heterocyclic ... | 03/25/2008 |
| 7332506 | Substituted-3-indolyl-4-piperidino-alkyl heterocycles for the treatment of depression A compound represented by the formula I: wherein A represents the following heterocycles: and R1-9 are as defined herein, a composition containing... | 02/19/2008 |
| 7304157 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds can be useful as factor Xa inh... | 12/04/2007 |
| 7265128 | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the ... | 09/04/2007 |
| 7241767 | Quinazoline(di)ones for invertebrate pest control Compounds of Formula I including all geometric and stereoisomers, N-oxides, and agriculturally suitable salts thereof, are disclosed which are useful as invertebrate pest control agents, (I) wherein A, B, J, K, L and R3 are as defined in the disclosure. A... | 07/10/2007 |
| 7166596 | Heterocyclic aromatic compounds useful as growth hormone secretagogues Novel heterocyclic aromatic compounds are provided that are useful in stimulating endogenous production or release of growth hormone, said compounds having the general structure of formula I wherein R1... | 01/23/2007 |
| 7148235 | Substituted-3-indolyl-4-piperidino-alkyl heterocycles for the treatment of depression A compound represented by the formula I: wherein A represents the following heterocycles: and R1-9 are as defined herein, a composition containing... | 12/12/2006 |
| 7135469 | Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors The present application describes linear chain substituted monocyclic and bicyclic compounds and derivatives thereof of Formula I: P4-P-M-M4I or pharmaceutically acceptable salt forms thereof, P-M are rings substituted by a ... | 11/14/2006 |
| 7122557 | Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors The present application describes sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds and derivatives thereof of Formula I: P4-P-M-M4I or pharmaceutically acceptable salt forms thereof, wherein M is a r... | 10/17/2006 |
| 7115627 | Glycinamides as factor Xa inhibitors The present application describes glycinamidic compounds and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa. ... | 10/03/2006 |
| 7074928 | Polymorphs of clopidogrel hydrogensulfate Provided are new crystalline Forms III, IV, V and VI of clopidogrel hydrogensulfate and the amorphous form of clopidogrel hydrogensulfate, as well as their pharmaceutical compositions, and method of treatments with such compositions. Also provided are novel processe... | 07/11/2006 |
| 7041675 | Heterocyclic compounds and their use as PARP inhibitors The invention relates to compounds of the formula I and the tautomeric forms, possible enantiomeric and diasteromeric forms thereof, and prodrugs thereof, and use thereof as PARP inhibitors. ... | 05/09/2006 |
| 6992086 | Antagonists of MCP-1 function and methods of use thereof The present invention relates to chemical compounds, pharmaceutical compositions comprising said compounds, uses of said compounds and compositions, methods of treatment employing said compounds and compositions, and processes for preparing said compounds. Specifica... | 01/31/2006 |
| 6989391 | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4—P-M-M4 I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycl... | 01/24/2006 |
| 6977262 | Dihydropyrazolopyridine compounds and pharmaceutical use thereof The present invention provides dihydropyrazolopyridine compounds represented by the formula (I): wherein each symbol is as defined in the specification, optically active forms thereof, and pharmaceutically acceptable s... | 12/20/2005 |
| 6967208 | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors The present application describes lactam-containing compounds and derivatives thereof of Formula I: or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocy... | 11/22/2005 |
| 6962926 | Antagonist of MCP-1 function, and compositions and methods of use thereof Compounds of formula A and formula B: and their pharmaceutically acceptable salts, compositions comprising them, methods for their use, and their use in the preparation of medicaments. The compounds are antagonists of ... | 11/08/2005 |
| 6946473 | Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors Compounds of the formula which are useful in disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative c... | 09/20/2005 |
| 6939870 | Substituted-3-indolyl-4-piperidino-alkyl heterocycles for the treatment of depression A compound represented by the formula I: wherein A represents the following heterocycles: and R1-9 are as defined herein, a composition containing this compoun... | 09/06/2005 |
| 6919451 | Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds are useful as factor Xa inhibitors. ... | 07/19/2005 |
| 6867208 | Vitronectin receptor antagonists, their preparation and their use The present invention relates to compounds of the formula I A—B—D—E—F—G (I) in which A, B, D, E, F and G have the meanings given in the patent claims, to their preparation and to their use as medicaments. The compounds of the inven... | 03/15/2005 |
| 6867202 | Treatment of insulin resistance This invention is directed to methods of treating insulin resistance in a mammal which comprise administering an effective amount of a compound of formula I, where the variables are defined in the specification, or the... | 03/15/2005 |
| 6855708 | N-arylsulfonyl aza-bicyclic derivatives as potent cell adhesion inhibitors Compounds of Formula I are antagonists of VLA-4 and/or alpha4/beta7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable f... | 02/15/2005 |
| 6852734 | Indole derivatives exhibiting chymase-inhibitory activities and process for preparation thereof According to this invention, there is provided an indole derivative having the general formula (I) wherein A is an oxygen atom or a nitrogen atom which nitrogen atom is optionally substituted with an alkyl group, and (... | 02/08/2005 |
| 6849620 | N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease The invention provides compounds of Formula I: wherein Azabicyclo is W0 is a bicyclic moiety and is | 02/01/2005 |
| 6706730 | 1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-ones as factor Xa inhibitors The present application describes 1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-ones of Formula I or pharmaceutically acceptable salt forms thereof: wherein ring R is 3-amido or 4-methoxy, R1 is trifluoromethyl... | 03/16/2004 |
| 6693116 | Adenosine receptor ligands The present application relates to compounds of the formula ##STR1## wherein R1 is hydrogen, halogen or lower alkoxy; R2 is hydrogen or is --C(O)-lower alkyl or --C(O)-phenyl, wherein the phenyl ring is unsubstituted or substitute... | 02/17/2004 |
| 6689790 | Substituted triazolopyridine compounds A compound of formula ##STR1## wherein R1 is --NR'R", wherein R' and R" are independently selected from the group consisting of lower alkyl, --(CH2)n --C(O)NRa Rb, --(CH2)n,-hete... | 02/10/2004 |
| 6686359 | Growth hormone secretagogues This invention is directed to compounds of the formula ##STR1## and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the specification, which are growth hormone secretogogues and which increase the level of endogenou... | 02/03/2004 |
| 6677365 | Antagonists of MCP-1 function and methods of use thereof Chemical compounds which are antagonists of Monocyte Chemoattractant Protein-1 (MCP-1) function, pharmaceutical compositions comprising these compounds, methods of treatment employing these compounds and compositions, and processes for preparing these com... | 01/13/2004 |
