Class 546/119 - Two of the ring nitrogens are bonded directly to each other

Subclass of Class 546 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein two of the ring nitrogens are bonded directly
No. of patents: 240
Last issue date: 09/13/2011

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Number	Title	Issue Date
8017781	Azaindazoles useful as inhibitors of kinases The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, o...	09/13/2011
7968719	Indazole derivatives as inhibitors of hormone sensitive lipase The present invention relates to indazole derivatives of the general formulae I or II having the meanings indicated in the description, to the pharmaceutically useful salts thereof and the use thereof as drugs. ...	06/28/2011
7842809	Pyrazolopyridines and salts thereof, a pharmaceutical composition comprising said compounds, a method of preparing same and use of same The invention relates to pyrazolopyridines according to the general formula (I): and salts thereof, to pharmaceutical compositions comprising said pyrazolopyridines and to a method of preparing said pyrazolopyridines as wel...	11/30/2010
7732609	5-(arylsulfonyl)-pyrazolopiperidines The invention provides N-cyclic sulfonamido compounds of Formula I wherein A, B, R1, R1a, R2, R2a, R3 and R3a are as described in the specification. Compound...	06/08/2010
7452993	Fused ring heterocycle kinase modulators The present invention provides novel fused ring heterocycle kinase modulators and methods of using the novel fused ring heterocycle kinase modulators to treat diseases mediated by kinase activity. ...	11/18/2008
7435820	Substituted tetrahydro-1-pyrazolo [3,4-]pyridines compositions comprising them, and use Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology...	10/14/2008
7435731	Substituted pyrazolo[3,4-d]pyrimadines and methods of using the same Compounds of the formula Ia or Ib: wherein A, B, X, Y, Z, W, k, R1, R2, R3, R4 and R5 are those defined herein, and compositions comprising the same. The present invent...	10/14/2008
7432266	Phosphodiesterase 4 inhibitors Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs. ...	10/07/2008
7417041	Imidazopyrimidines as transforming growth factor (TGF) inhibitors Novel fused heteroaromatic compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of tran...	08/26/2008
7402680	Fused heterocyclic compounds Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases. ...	07/22/2008
7381732	Pyrazolobenzamides and derivatives as factor Xa inhibitors The present application describes pyrazolobenzamides and derivatives thereof of Formula I: P4-P-M-M4I or pharmaceutically acceptable salt forms thereof. Compounds of the present invention are useful as inhibitors of trypsin-...	06/03/2008
7375113	Nitrogenous fused-ring derivatives, medicinal compositions containing the derivatives, and use thereof as drugs The present invention provides nitrogen-containing fused-ring derivatives represented by the following general formula, or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT and are useful as ...	05/20/2008
7371761	Lactam-containing compounds and derivatives thereof as factor Xa inhibitors The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4-P-M-M4I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or het...	05/13/2008
7351831	Process for asymmetric intramolecular [3+2] cyclo-addition of hydrazones An intramolecular [3+2] cycloaddition reaction of a hydrazone is carried out under a mild condition with a high stereoselectivity and yield by reacting a hydrazone derivative in the presence of an asymmetric catalyst system obtained by mixing a zirconium alkoxide re...	04/01/2008
7332506	Substituted-3-indolyl-4-piperidino-alkyl heterocycles for the treatment of depression A compound represented by the formula I: wherein A represents the following heterocycles: and R1-9 are as defined herein, a composition containing...	02/19/2008
7321040	Triazolo-pyridines as anti-inflammatory compounds The present invention relates to novel triazolo-pyridines of the formula wherein X is >CH2, >NH, sulfur, >S═O, >SO2 or oxygen; wherein said >CH2 and >NH may optionally be substi...	01/22/2008
7309703	Substituted pyrazoles Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described. ...	12/18/2007
7300944	Pyrazolo[3,4-b]pyridin-6-ones as GSK-3 inhibitors The present invention provides compounds of formula (I) the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers, and prodrugs, wherein R1, R	11/27/2007
7300943	GSK-3 inhibitors The invention provides compounds of formula (I) the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers, and prodrugs, wherein R1, R2	11/27/2007
7268146	Ring fused pyrazole derivatives as CRF antagonists This invention relates to compounds which are generally CRF-1 receptor antagonists and which are represented by Formula I or Formula II: wherein Ar is optionally substituted aryl or heteroaryl, R1-R	09/11/2007
7259171	Di and trifluoro-triazolo-pyridines anti-inflammatory compounds The present invention relates to novel triazolo-pyridines of the formula I wherein R1 is fluoro; s is an integer from two to three; R2 is (C3-C6)cycloalkyl ...	08/21/2007
7241758	Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds of the formula (I) wherein G, X, Ar, L and Q are defined herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory disease...	07/10/2007
7238683	Fused phenylalanine derivatives as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes The present invention is directed to fused phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-RV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is in...	07/03/2007
7226930	Phosphodiesterase 4 inhibitors Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs. ...	06/05/2007
RE39663	Electron-deficient nitrogen heterocycle-substituted fluorescein dyes The invention provides compositions electron-deficient nitrogen heterocycle-substituted fluorescein dyes and methods in which the dyes are conjugated to substrates and used as detection labels in molecular biology experiments. The electron-deficient nitrogen heteroc...	05/29/2007
7223772	Pyrazolopyridine derivatives as selective cox-2 inhibitors The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof wherein: R0 and R1 are independently selected from the gr...	05/29/2007
7189733	Compositions and methods for inhibiting TGF-β This invention provides compounds that are useful for treating patients having a TGF-β-mediated disease, particularly an ALK5-mediated disease. The compounds are represented by formula I: wherein: a-b is CH...	03/13/2007
7186716	3-Pyrrol-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors Compounds of Formula I are useful as mediators of protein kinases and have activity as cell proliferation inhibitors: where X, R1–R7 and R9 are as defined herein. ...	03/06/2007
7166596	Heterocyclic aromatic compounds useful as growth hormone secretagogues Novel heterocyclic aromatic compounds are provided that are useful in stimulating endogenous production or release of growth hormone, said compounds having the general structure of formula I wherein R1...	01/23/2007
7153960	Synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds are useful as factor Xa inhibi...	12/26/2006
7151104	Pyrazolopyridines as cyclin dependent kinase inhibitors In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyridine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of p...	12/19/2006
7145012	Cannabinoid receptor ligands and uses thereof Compounds of Formula (I) and (II) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein ...	12/05/2006
7132426	Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto The present invention relates to certain fused aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or trea...	11/07/2006
7115627	Glycinamides as factor Xa inhibitors The present application describes glycinamidic compounds and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa. ...	10/03/2006
7109340	Substituted tetrahydro-1H-pyrazolo [3,4-c] pyridines, compositions comprising them, and use Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology...	09/19/2006
7105533	Fused heterobicyclo substituted phenyl metabotropic glutamate-5 modulators Phenyl compounds substituted with a fused-heterobicyclo moiety, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, and panic, as well as in the treatment of pain and other disease...	09/12/2006
7087603	Pyrazole compounds useful as protein kinase inhibitors This invention describes novel pyrazole compounds of formula IV: wherein Z1 or Z2 is nitrogen, Q is —S—, —O—, —N(R4)—, —C(R6′)2—, 1,2-cyclo...	08/08/2006
7081466	2-aroylimidazole compounds for treating cancer Disclosed is a compound represented by Structural Formula (I): R1 is a substituted or unsubstituted 2-imidazolyl group which is optionally fused to a substituted or unsubstitut...	07/25/2006
7074928	Polymorphs of clopidogrel hydrogensulfate Provided are new crystalline Forms III, IV, V and VI of clopidogrel hydrogensulfate and the amorphous form of clopidogrel hydrogensulfate, as well as their pharmaceutical compositions, and method of treatments with such compositions. Also provided are novel processe...	07/11/2006
7074929	Certain alkylene diamine-substituted heterocycles This invention relates to novel compounds, compositions, and methods for the treatment of physiological disorders associated with an excess of neuropeptide Y. The novel compounds encompassed by the present invention are those of the formula II, IV, V, VII–IX and X...	07/11/2006

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Class 546/119 - Two of the ring nitrogens are bonded directly to each other