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...When G.G. Hubbard learned of his future son-in-law's invention, he called it "only a toy." His daughter was engaged to a young man named Alexander Graham Bell.
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| Number | Title | Issue Date |
| 8188281 | Azaindoles useful as inhibitors of JAK and other protein kinases The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. ... | 05/29/2012 |
| 8163917 | Azaindoles useful as inhibitors of Janus kinases The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatm... | 04/24/2012 |
| 8148529 | Pyrrolo[3,2-C] pyridine derivatives and processes for the preparation thereof The present invention provides novel pyrrolo[3,2-c]pyridine derivatives or pharmaceutically acceptable salts thereof, processes for the preparation thereof, and compositions comprising the same. The pyrrolo[3,2-c]pyridine derivatives or pharmaceutically acceptable s... | 04/03/2012 |
| 8067599 | Imidazo [4,5-B] pyridine and pyrrolo [2,3-B] pyridine protein kinase inhibitors Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments cont... | 11/29/2011 |
| 7977484 | Crystalline form of cyano-1-cyclopropy1-7-1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid The present invention relates to the trihydrate of pradofloxacin, to a process for its preparation and to antibacterial compositions comprising them. ... | 07/12/2011 |
| 7968718 | Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and proce... | 06/28/2011 |
| 7964728 | Azaindole derivatives with a combination of partial nicotinic acetyl-choline receptor agonism and dopamine reuptake inhibition Azaindole derivatives of formula (I): wherein the symbols have the meanings given in the specification, are described. These compounds have a combination of partial nicotinic acetylcholine receptor agonism and dopamine reup... | 06/21/2011 |
| 7932389 | Octahydropyrrolo[2,3C]pyridine derivatives and pharmaceutical use thereof The present invention is related to octahydropyrrolo[2,3,c]pyridine derivatives of Formula (I) and use thereof in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, can... | 04/26/2011 |
| 7906648 | Pyrrolo-pyridine kinase modulators The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity. ... | 03/15/2011 |
| 7897771 | Fused heterocyclic compounds Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases. ... | 03/01/2011 |
| 7888508 | Pyrrolo[2,3-B]pyridine derivatives active as kinase inhibitors Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or ass... | 02/15/2011 |
| 7880004 | Met kinase inhibitors The invention is directed to compounds that are useful for the treatment of cancer having the following Formula: ... | 02/01/2011 |
| 7812166 | Kinase inhibitors Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using th... | 10/12/2010 |
| 7803944 | Viral polymerase inhibitors An isomer, enantiomer, diastereoisomer, or tautomer of a compound, represented by formula I: wherein: A is O, S, NR1, or CR1, wherein R1 is defined herein; — repr... | 09/28/2010 |
| 7767816 | Azaindoles useful as inhibitors of janus kinases The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatm... | 08/03/2010 |
| 7728140 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors and pharmaceutical compositions comprising them Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or ass... | 06/01/2010 |
| 7709644 | Process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane The present invention relates to a process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane with the aid of continuous countercurrent chromatography, which is also described as SMB chromatography (SMB=simulated moving bed).... | 05/04/2010 |
| 7709645 | Pyrrolo-pyridine kinase modulators The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity. ... | 05/04/2010 |
| 7692015 | Economical process for preparing (S, S)-2, 8-diazabicyclo[4.3.0]nonane and its enantiomer The present invention relates to a novel and economical process for preparing (S,S)-2,8-diazabicyclo[4.3.0]nonane, a valuable intermediate used for constructing quinolone and naphthyridine derivatives having antibacterial effectiveness, e.g. moxifloxacin and its ena... | 04/06/2010 |
| 7678909 | Dipeptidyl peptidase inhibitors Compounds are provided which may be used to inhibit DPP-IV comprising the formula: wherein the substituents are as described in the specification and claims. ... | 03/16/2010 |
| 7626027 | Substituted 1H-pyrrolo[2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase Iε The present invention discloses and claims compounds of formula (I) wherein M is N, and K and L are each C with the remaining substituents further defined herein. These compounds are effective as inhibitors of human casein ... | 12/01/2009 |
| 7622583 | Heteroaryl sulfonamides and CCR2 Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in... | 11/24/2009 |
| 7605266 | Azaindole inhibitors of Aurora kinases The present invention relates to a compound represented by Formula (I): and pharmaceutically acceptable salts. Compounds of the present invention inhibit Aurora kinase, making them especially suitable for the treatment of a... | 10/20/2009 |
| 7601839 | Pyrrolo-pyridine kinase modulators The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity. ... | 10/13/2009 |
| 7598383 | Heterocyclic inhibitors of MEK and methods of use thereof Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the spe... | 10/06/2009 |
| 7589206 | Pyrrolopyridine derivatives The present invention relates to novel pyrrolopyridine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in a... | 09/15/2009 |
| 7579470 | Fused heterocyclic compounds Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases. ... | 08/25/2009 |
| 7579469 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, and X are as defined herein for Formula (IA) and Formula (IB), or a tautomer, prodrug, solvate, or s... | 08/25/2009 |
| 7566784 | Bicyclic heterocycles as kinase inhibitors The compounds of the instant invention can be used as anticancer agents. More specifically, the invention comprises a compound having Formula I or II, ... | 07/28/2009 |
| 7553966 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof Compounds of Formula (IA) and Formula (IB) wherein R1, R2, R3, R4, R5, and R6 are as defined herein for Formula (IA) or Formula (IB), or a tautomer, prodrug,... | 06/30/2009 |
| 7541464 | 7-azaindoles, pharmaceutical compositions and their therapeutic applications The present invention relates generally to compounds and compositions for the treatment of metabolic diseases and specifically, the present invention relates to compounds that therapeutically modulation and control lipid and/or carbohydrate metabolism and are thus s... | 06/02/2009 |
| 7521557 | Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods Compounds are provided having the formula (I) wherein R, X, Y, Z, A and n are as defined herein, which are inhibitors of dipeptidyl peptidase IV and thus are useful in treating diabetes and related diseases. ... | 04/21/2009 |
| 7507826 | Azaindoles useful as inhibitors of JAK and other protein kinases The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. ... | 03/24/2009 |
| 7504509 | Compounds and methods for development of Ret modulators Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for ex... | 03/17/2009 |
| 7488826 | Substituted pyrroline kinase inhibitors The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors and methods for treating or ameliorating a kinase or dual-kinase mediated disorder. ... | 02/10/2009 |
| 7456286 | Bicyclic heteroaromatic compounds as kinase inhibitors A series of 5-6 fused ring bicyclic heteroaromatic derivatives, based in particular on the 5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine ring system, being inhibitors of p38 kinase, are accordingly of use in medicine, for example in the treatment and/or prevention of ... | 11/25/2008 |
| 7446199 | Compositions useful as inhibitors of protein kinases The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, ... | 11/04/2008 |
| 7439246 | Fused heterocyclic kinase inhibitors In general, the instant invention comprises compounds of Formulas I and II including pharmaceutically acceptable salts thereof. The compounds of the invention are useful as protein kinase inhibitors and therefore are useful... | 10/21/2008 |
| 7432375 | JNK inhibitors The present invention provides novel compounds of formula (I) and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegener... | 10/07/2008 |
| 7427682 | Indole derivatives as selective androgen receptor modulators (SARMS) The present invention is directed to novel insole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor. ... | 09/23/2008 |
