Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 7718576 | Peroxide-based chemiluminescent assays and chemiluminescent compounds used therein A compound is provided having the formula: where C* is an sp2 coordinated carbon atom; A is defined by the formula | 05/18/2010 |
| 7442790 | Caspase inhibitors and uses thereof This invention provides caspase inhibitors of formula I: wherein Z is oxygen or sulfur; R1 is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; between R3 and... | 10/28/2008 |
| 7351807 | Cyanine-sulfenates for dual phototherapy Dye-sulfenate derivatives and their bioconjugates for dual phototherapy of tumors and other lesions. The compounds comprise sulfenates having the formula, t,0080 where E is selected from the group consisting of somatostatin receptor binding molecules, heat se... | 04/01/2008 |
| 7319041 | Applications of acridinium compounds and derivatives in homogeneous assays Chemiluminescent acridinium compounds are used in homogeneous assays to determine the concentration of an analyte in a sample without strong acid or strong base treatment. The chemiluminescent acridinium compounds include acridinium esters with electron donating fun... | 01/15/2008 |
| 7300930 | Therapeutic acridone and acridine compounds The present invention pertains to acridone and acridine compounds of formula (I), wherein either: (a) K is ═O, L is —H, alpha is a single bond, beta is a double bond, gamma is a single bond (acridones); or, (b) K is a 9-substituent, L is absent, alpha is a doubl... | 11/27/2007 |
| 7297555 | Hydrophilic chemiluminescent acridinium labeling reagents In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid, glycine peptides, tetraethylene oxide, and the like, offset the hydropho... | 11/20/2007 |
| 7182912 | Fluid handling apparatus for an automated analyzer An analyzer for performing automated assay testing. The analyzer includes a storage and conveyor system for conveying cuvettes to an incubation or processing conveyor, a storage and selection system for test sample containers, a storage and selection system for reag... | 02/27/2007 |
| 7175961 | Photopatternable molecular circuitry Bistable molecules are provided with at least one photosensitive functional group. As thus constituted, the bistable molecules are photopatternable, thereby allowing fabrication of micrometer-scale and nanometer-scale circuits in discrete areas without relying on a ... | 02/13/2007 |
| 7144683 | Photopatternable molecular circuitry Bistable molecules are provided with at least one photosensitive functional group. As thus constituted, the bistable molecules are photopatternable, thereby allowing fabrication of micrometer-scale and nanometer-scale circuits in discrete areas without relying on a ... | 12/05/2006 |
| 7122671 | Luminescent labelling materials and procedures A compound for use as a chemiluminescent label in immunoassay comprises an aryl acridinium ester linked to an N-succinimidyl moiety. The compound is conveniently linked to a monoclonal antibody or other protein and is used in a two-site immunoassay for the quantitat... | 10/17/2006 |
| 7091358 | Cationic substituted hydrazone dyes The present invention relates to novel cationic dyes of formula (1), (2) or (3) wherein R1 and R2 are each independently of the other a C1–C8alkyl radical or ... | 08/15/2006 |
| 7087395 | Vitamin D assay The present invention features a kit and a method of using the kit for determining a concentration of a vitamin D component. The kit comprises a releasing composition and a detecting composition. The releasing composition comprises an aqueous base component. In one ... | 08/08/2006 |
| 7083986 | Near infrared chemiluminescent acridinium compounds and uses thereof A method for the detection or quantitation of an analyte in a biological sample is disclosed. The method comprises the steps of selecting a biological sample suspected of containing a target analyte and binding the target analyte in the sample to a binding partner c... | 08/01/2006 |
| 7060711 | Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HTreceptor antagonist The present invention relates to derivatives of 4-(Thio- or Selenoxanthene-9-ylidene)-piperidine or acridine and pharmaceutically acceptable salts thereof, use of these compounds as a medicament and for the manufacture of a medicament for treatment of a disease stat... | 06/13/2006 |
| 7041674 | Carbamic acid esters with anticholinergic activity A compound of formula 1 wherein X−, A, R1, R2, R3, and R4 may have the meanings given in the claims and in the specification, processes for preparing them, their... | 05/09/2006 |
| RE39047 | Luminescence by reacting an acridinium ester with superoxide A light emitting method of an acridinium ester, comprising reacting said acridinium ester and a superoxide anion, and a method of detecting a substance to be examined, comprising detecting a light emitted by reacting a superoxide anion with an acridinium ester used ... | 03/28/2006 |
| 6995262 | Use of acylsulfonamido-substituted polymethine dyes as fluorescene dyes and/or markers The invention relates to a novel polymethine dyes containing at least one acylsulfonamido group of the formula (I) in which n, Y, A and R have the meaning given in the claims, and at least one compound of the formulae ... | 02/07/2006 |
| 6994980 | Chemiluminescent compounds and use thereof A novel chemiluminescent compound is provided. In one embodiment, the novel compound is employed in an assay to detect analytes. The assay to detect analytes includes the steps of binding the novel compound to the analyte and detecting the novel compound. ... | 02/07/2006 |
| 6924154 | Hydrophilic chemilumescent acridinium labeling reagents In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid, glycine peptides, tetraethylene oxide, and the like, offset the hydropho... | 08/02/2005 |
| 6924373 | DNA labeling reagents, acridinium-9-carboxamide derivatives and process of preparing DNA labeling compounds The present invention relates to DNA labeling reagents comprising a furocoumarin derivative and a detectable group with or without bound via a binding enhancer, and acridinium-9-carboxamide derivatives for use as chemiluminescent labels. The present invention also r... | 08/02/2005 |
| 6872828 | Compounds for generating chemiluminescence with a peroxidase Novel compounds comprising a C—C double bond substituted at one carbon with two sulfur atom-containing groups are disclosed. The compounds are useful in methods and compositions for generating chemiluminescence rapidly by reaction with a peroxidase enzyme and a pe... | 03/29/2005 |
| 6858733 | Compounds for generating chemiluminescence with a peroxidase Novel compounds comprising a C—C double bond substituted at one carbon with two sulfur atom-containing groups are disclosed. The compounds are useful in methods and compositions for generating chemiluminescence rapidly by reaction with a peroxidase enzyme and a pe... | 02/22/2005 |
| 6858742 | DNA labeling reagents, acridinium-9-carboxamide derivatives and process of preparing DNA labeling compounds The present invention relates to DNA labeling reagents comprising a furocoumarin derivative and a detectable group with or without bound via a binding enhancer, and acridinium-9-carboxamide derivatives for use as chemiluminescent labels. The present invention also r... | 02/22/2005 |
| 6858162 | Single molecule realization of the switch and doide combination Diodes and switches are combined in a single molecular species. Thus, the single molecular species is capable of performing more than one function. A single molecular species having both diode and switch functionalities is provided. The molecular species is represen... | 02/22/2005 |
| 6800656 | Tricyclic compounds and method of treating herpes virus The present invention provides a compound of the formula and pharmaceutically acceptable salts having useful antiviral activity against viruses of the herpes family. Wherein: X=O, (CH2)m, S, ... | 10/05/2004 |
| 6740649 | Cyclic hydroxamic acids as inhibitors of matrix metalloproteinases and/or TNF- α converting enzyme (TACE) The present application describes novel cyclic hydroxamic acids of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms selected fro... | 05/25/2004 |
| 6723851 | Chemiluminescent compounds and use thereof A novel chemiluminescent compound is provided. In one embodiment, the novel compound is employed in an assay to detect analytes. The assay to detect analytes includes the steps of binding the novel compound to the analyte and detecting the novel compound. ... | 04/20/2004 |
| 6706722 | Heteroaryl derivatives and their use as medicaments The invention relates to novel acridine derivatives of formula 1, to their preparation and to their use as medicaments, in particular for treating tumors. ... | 03/16/2004 |
| 6664043 | Acridinium ester labels having hydrophilic modifiers The present invention is generally directed to detectable chemiluminescent acridinium ester labels having hydrophilic modifiers; to compositions, complexes and/or conjugates which include such labels; and to processes for performing bioanalytical assays f... | 12/16/2003 |
| 6630481 | Viologen linked acridine based molecule and process for the preparation thereof The present invention provides a series of novel bifunctional molecules based on viologen linked acridine, bisacridine and bisacridinium salts of the general formula 1 (1a, 1b, 1c and 1d) and or pharmaceutically acceptable derivatives thereof, which can b... | 10/07/2003 |
| 6512119 | Bistable molecular mechanical devices with an appended rotor activated by an electric field for electronic switching, gating and memory applications In accordance with the present invention, nanometer-scale reversible electronic switches are provided that can be assembled to make cross-bar circuits that provide memory, logic, and communications functions. The electronic switches, or crossed-wire devic... | 01/28/2003 |
| 6417005 | Covalently immobilized fluoroionophores as optical ion sensors Fluoroionophores that are functionalised with reactive groups and correspond to the formula I--R1 --F--R2 --G, wherein I is a monovalen residue of an ionophore, wherein F is a divalent residue of a fluorophore, wherein G is a functio... | 07/09/2002 |
| 6417402 | Squaraine based dyes and process for preparation thereof The present invention relates to squaraine dye containing terminal aminoanthracene or acridine groups and to a process for preparation thereof.... | 07/09/2002 |
| 6414152 | Luminescent labelling material and procedures A compound for use as a chemiluminescent label in immunoassay comprises an aryl acridinium ester linked to an N-succinimidyl moiety. The compound is conveniently linked to a monoclonal antibody or other protein and is used in a two-site immunoassay for th... | 07/02/2002 |
| 6413984 | 8-(heterocyclylmethyl)quinoline derivatives for treating urinary incontinence The invention concerns compounds of formula (I) wherein: A represents either a hydrogen atom or a hydroxyl group; B represents a pyrrolidin-2-yl (D) or 2-piperidyl (E), B capable of being substituted by one or two R5 groups; R1 repre... | 07/02/2002 |
| 6410732 | Processing and synthetic intermediates for preparing N-arylacridancarboxylic acid derivatives Synthetic processes and intermediates are disclosed for the preparation of N-arylacridancarboxylic acid derivatives. The derivatives are esters, thioesters, amides and sulfonimides. A key feature of the processes is the preparation of N-aryl substituted i... | 06/25/2002 |
| 6355803 | Near infrared chemiluminescent acridinium compounds and uses thereof This application relates to long-wavelength acridinium compounds having electron-donating groups, which may either be: (a) Part of an extended conjugation system attached by appropriate functional groups to the acridinium nucleus, with coplanarity of the ... | 03/12/2002 |
| 6296787 | Compounds, compositions and methods for generating chemiluminescence with phosphatase enzymes Novel heterocyclic compounds which generate chemiluminescence on reaction with a phosphatase enzyme are provided as well as a process for their preparation and intermediates useful therein. The compounds comprise a nitrogen, oxygen or sulfur-containing he... | 10/02/2001 |
| 6274768 | Acridin derivatives This invention relates to intermediates in the preparation of acridin derivatives of general formula ##STR1## or pharmaceutically acceptable salts thereof, and to a method of producing them.... | 08/14/2001 |
| 6248884 | Extended rhodamine compounds useful as fluorescent labels Extended rhodamine compounds exhibiting favorable fluorescence characteristics having the structure ##STR1## are disclosed. In addition, novel intermediates for synthesis of these dyes are disclosed, such intermediates having the structure ##STR2## I... | 06/19/2001 |
