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| Number | Title | Issue Date |
| 8129532 | Amino(oligo)thiophene dyes, preparation thereof, and optical methods of use Amino(oligo)thiophene dyes useful for studying the electrophysiology of organelles, cells, and tissues are described. Compared to previously known dyes, the amino(oligo)thiophene dyes exhibit improved (faster) response to membrane potential changes, as well as the a... | 03/06/2012 |
| 8106203 | Assay methods using chemiluminescent detection of peroxidase Methods for generating chemiluminescence rapidly by reaction of at least one compound comprising a C—C double bond substituted at one carbon with two sulfur atom-containing groups with a peroxidase enzyme and a peroxide are disclosed. The chemiluminescence thus pr... | 01/31/2012 |
| 7781588 | Acridan monomers and polymers Acridian monomers and polymers are described, as well as their use in organic electronic devices, and materials and methods for fabrication of the same. ... | 08/24/2010 |
| 7388017 | Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease The present invention relates to compounds, methods and pharmaceutical compositions for inhibiting proteases, particularly serine proteases, and more particularly HCV NS3 proteases. The compounds, and the compositions and methods that utilize them, can be used, eith... | 06/17/2008 |
| 7332354 | Compounds for chemiluminescense procedures The present invention relates to a chemical compound comprising a light emitting moiety precursor and a precursor of a leaving group, bound to each other by an amide or by an ester bond and characterized in that the leaving group precursor upon oxidation is converte... | 02/19/2008 |
| 7319041 | Applications of acridinium compounds and derivatives in homogeneous assays Chemiluminescent acridinium compounds are used in homogeneous assays to determine the concentration of an analyte in a sample without strong acid or strong base treatment. The chemiluminescent acridinium compounds include acridinium esters with electron donating fun... | 01/15/2008 |
| 7309615 | High quantum yield acridinium compounds and their uses in improving assay sensitivity The present invention relates to hydrophilic, high quantum yield acridinium compounds. It has been discovered that the placement of electron-donating groups in the acridinium ring system increases the amount of light that is emitted by the corresponding acridinium c... | 12/18/2007 |
| 7300930 | Therapeutic acridone and acridine compounds The present invention pertains to acridone and acridine compounds of formula (I), wherein either: (a) K is ═O, L is —H, alpha is a single bond, beta is a double bond, gamma is a single bond (acridones); or, (b) K is a 9-substituent, L is absent, alpha is a doubl... | 11/27/2007 |
| 7297555 | Hydrophilic chemiluminescent acridinium labeling reagents In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid, glycine peptides, tetraethylene oxide, and the like, offset the hydropho... | 11/20/2007 |
| 7256292 | Fluorescent dye compounds, conjugates and uses thereof The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof. ... | 08/14/2007 |
| 7223865 | Chromogenic compounds, and use thereof as enzyme substrates The present invention relates to novel chromogenic substrates which are used to detect aminopeptidase activity in microorganisms or to determine whether at least one bacterium belongs to the Gram-positive group or to the Gram-negative group according to the color th... | 05/29/2007 |
| 7205311 | Therapeutic acridone and acridine compounds This invention pertains to certain acridone and acridine compounds of the formula which inhibit telomerase, regulate cell proliferation, etc., and/or treat cancer, proliferative conditions, etc.: wherein either: (a) K is ═O, L is —H, alpha single bond, beta is a... | 04/17/2007 |
| 7186568 | Electrochemiluminescence from acridan compounds Methods are disclosed for producing electrochemiluminescence by electrochemically oxidizing an acridan compound at an electrode in the presence of a peroxide. Maintaining a sufficiently positive potential results in continuous oxidation of the acridan compound to an... | 03/06/2007 |
| 7173048 | Indolyl derivatives as liver-X-receptor (LXR) modulators The invention relates to compounds of formula (I): and pharmaceutically acceptable salts and pharmaceutically acceptable esters thereof, wherein R1, R2, R3, R4, R5... | 02/06/2007 |
| 7160896 | Therapeutic acridone and acridine compounds The present invention pertains to acridone and acridine compounds of formula (I), wherein either: (a) K is ═O, L is —H, alpha single bond, beta is a double bond, gamma is a single bond (acridones); or, (b) K is a 9-substituent, L is absent, alpha is a double bon... | 01/09/2007 |
| 7160732 | Fluorescein-based metal sensors, and methods of making and using the same The present invention is directed, in part, to fluorescein-based ligands for detection of metal ions, and methods of making and using the same. ... | 01/09/2007 |
| 7148069 | Method for analysis of compounds with amino group and analytical reagent therefor The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino... | 12/12/2006 |
| 7122671 | Luminescent labelling materials and procedures A compound for use as a chemiluminescent label in immunoassay comprises an aryl acridinium ester linked to an N-succinimidyl moiety. The compound is conveniently linked to a monoclonal antibody or other protein and is used in a two-site immunoassay for the quantitat... | 10/17/2006 |
| 7097995 | Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes A chemiluminescent substrate of a hydrolytic enzyme having the following general Formula I is disclosed, as follows: Lumi-M-PFormula I where “Lumi” is a chemiluminescent moiety capable of producing light (a) by itself, (b) with MP attached an... | 08/29/2006 |
| 7087395 | Vitamin D assay The present invention features a kit and a method of using the kit for determining a concentration of a vitamin D component. The kit comprises a releasing composition and a detecting composition. The releasing composition comprises an aqueous base component. In one ... | 08/08/2006 |
| 7083986 | Near infrared chemiluminescent acridinium compounds and uses thereof A method for the detection or quantitation of an analyte in a biological sample is disclosed. The method comprises the steps of selecting a biological sample suspected of containing a target analyte and binding the target analyte in the sample to a binding partner c... | 08/01/2006 |
| 7060711 | Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HTreceptor antagonist The present invention relates to derivatives of 4-(Thio- or Selenoxanthene-9-ylidene)-piperidine or acridine and pharmaceutically acceptable salts thereof, use of these compounds as a medicament and for the manufacture of a medicament for treatment of a disease stat... | 06/13/2006 |
| 7037642 | Removing compounds from blood products with porous particles immobilized in a matrix Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly po... | 05/02/2006 |
| RE39047 | Luminescence by reacting an acridinium ester with superoxide A light emitting method of an acridinium ester, comprising reacting said acridinium ester and a superoxide anion, and a method of detecting a substance to be examined, comprising detecting a light emitted by reacting a superoxide anion with an acridinium ester used ... | 03/28/2006 |
| 6998493 | Colorant compounds Compounds of the formula wherein M is either (1) a metal ion having a positive charge of +p wherein p is an integer which is at least 2, said metal ion being capable of forming a compound with at least two chromogen moi... | 02/14/2006 |
| 6994980 | Chemiluminescent compounds and use thereof A novel chemiluminescent compound is provided. In one embodiment, the novel compound is employed in an assay to detect analytes. The assay to detect analytes includes the steps of binding the novel compound to the analyte and detecting the novel compound. ... | 02/07/2006 |
| 6989446 | Process for the preparation of 3-aryl-benzofuranones Process for the preparation of compounds of formula I wherein the general symbols are as defined in claim 1, which process comprises reacting a compound of formula V wherein ... | 01/24/2006 |
| 6951713 | Absorbing pathogen-inactivating compounds with porous particles immobilized in a matrix Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition, while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent p... | 10/04/2005 |
| 6924154 | Hydrophilic chemilumescent acridinium labeling reagents In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid, glycine peptides, tetraethylene oxide, and the like, offset the hydropho... | 08/02/2005 |
| 6924373 | DNA labeling reagents, acridinium-9-carboxamide derivatives and process of preparing DNA labeling compounds The present invention relates to DNA labeling reagents comprising a furocoumarin derivative and a detectable group with or without bound via a binding enhancer, and acridinium-9-carboxamide derivatives for use as chemiluminescent labels. The present invention also r... | 08/02/2005 |
| 6916767 | Antioxidant amines based on n-(4aniliophenyl) amides antioxidant amines based on n-(4-anilinophenyl) amides A composition of matter is disclosed wherein the composition comprises an N-aromatic substituted acid amide compound selected from the group consisting of compounds of formula (I) wherein A and B are independently selected alkylene groups; R1 is selected ... | 07/12/2005 |
| 6884802 | 6-heteroarylphenanthridines Compounds of formula 1, in which Het is an unsubstituted or R6- and/or R7-substituted pyrrolyl, furanyl, thiophenyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrimidinyl, pyrazinyl or pyradazinyl radical, or an unsubstitute... | 04/26/2005 |
| 6872828 | Compounds for generating chemiluminescence with a peroxidase Novel compounds comprising a C—C double bond substituted at one carbon with two sulfur atom-containing groups are disclosed. The compounds are useful in methods and compositions for generating chemiluminescence rapidly by reaction with a peroxidase enzyme and a pe... | 03/29/2005 |
| 6858733 | Compounds for generating chemiluminescence with a peroxidase Novel compounds comprising a C—C double bond substituted at one carbon with two sulfur atom-containing groups are disclosed. The compounds are useful in methods and compositions for generating chemiluminescence rapidly by reaction with a peroxidase enzyme and a pe... | 02/22/2005 |
| 6783948 | Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes A chemiluminescent substrate of hydrolytic enzyme having the following general Formula I, as follows: Lumi-M-P Formula I where “Lumi” is a chemiluminescent moiety capable of producing light (a) by itself, (b) with MP attached... | 08/31/2004 |
| 6727098 | Biaryl-type compounds, CD color fixing agent and method for determination of absolute configuration A novel achiral biaryl-type compound and a circular dichroism (CD) color fixing agent are provided. Furthermore, a method for determining an absolute configuration of a chiral compound is carried out by introducing the above achiral biaryl-type compound into the chi... | 04/27/2004 |
| 6723851 | Chemiluminescent compounds and use thereof A novel chemiluminescent compound is provided. In one embodiment, the novel compound is employed in an assay to detect analytes. The assay to detect analytes includes the steps of binding the novel compound to the analyte and detecting the novel compound. ... | 04/20/2004 |
| 6706722 | Heteroaryl derivatives and their use as medicaments The invention relates to novel acridine derivatives of formula 1, to their preparation and to their use as medicaments, in particular for treating tumors. ... | 03/16/2004 |
| 6696569 | Compounds for generating chemiluminescence with a peroxidase Novel compounds comprising a C--C double bond substituted at one carbon with two oxygen or sulfur atom-containing groups are disclosed. The compounds are useful in methods and compositions for generating chemiluminescence by reaction with a peroxidase enz... | 02/24/2004 |
| 6642222 | Pyrano, piperidino, and thiopyrano compounds and methods of use ##STR1## The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.... | 11/04/2003 |
