Class 544/98 - 1,4-Oxazines

Subclass of Class 544 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the six-membered hetero ring has oxygen
No. of patents: 114
Last issue date: 08/04/2009

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Number	Title	Issue Date
7569687	Processes for the synthesis of rocuronium bromide The invention encompasses processes for synthesizing 1-[17β-acetyloxy-3α-hydroxy-2β-(4-morpholinyl)-5α-androstan-16β-yl]-1-(2-propenyl)pyrrolidinium bromide (rocuronium bromide) and intermediates thereof. ...	08/04/2009
7371746	1,2,4-Thiadiazole compounds and pests controlling composition containing the same The present invention relates to a 1,2,4-thiadiazole compound of the formula (I) represented by the formula (1): wherein R1? represents C3-C7 alkynyl and X represents C4-C7 straight alkylene optionally substituted with one to four of R2?, C4-C7 straight alkenylene o...	05/13/2008
7358052	Catalytic amplification of multiplexed assay signals Methods, compositions, kits, and a system are disclosed for detecting one or more analytes in a sample. A mixture comprising the (i) sample, (ii) a first binding reagent comprising a cleavage-inducing moiety and a first binding agent specific for an analyte, and (ii...	04/15/2008
7354733	Method for sorting and separating living cells We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating cell-selective photophoric labels, which photosensitize and chemically reduce a...	04/08/2008
7285568	Biaromatic compounds which activate PPARgamma type receptors and cosmetic/pharmaceutical compositions comprised thereof Novel biaromatic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the field...	10/23/2007
7256191	Materials and methods for the treatment of depression The subject invention provides compounds which are easily metabolized by the metabolic drug detoxification systems. Particularly, fluvoxamine analogs which have been designed to include esters within the structure of the compounds are taught. Also provided are metho...	08/14/2007
7255999	Methods and compositions for analyzing proteins Methods, compositions and kits are disclosed for determining one or more target polypeptides in a sample where the target polypeptides have undergone a post-translational modification. A mixture comprising the sample and a first reagent comprising a cleavage-inducin...	08/14/2007
7229988	Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses The present invention provides novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups and the use of the novel compounds as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen spe...	06/12/2007
7217531	Multiplex analysis using membrane-bound sensitizers The present invention is directed to methods and compositions for determining the presence, absence, and/or amounts of one or more membrane-associated analytes in a sample. In accordance with the invention, binding compounds derivatized with releasable molecular tag...	05/15/2007
7166609	Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases Pyrimidine-4,6-dicarboxylic acid diamides of the formula I are suitable for selectively inhibiting collagenase (MMP 13). The pyrimidine-4,6-dicarboxylic acid diamides can therefore be used for treating degenerati...	01/23/2007
7160735	Tagged microparticle compositions and methods Compositions and methods are disclosed for detecting multiple target analytes in a sample using microparticles having molecular tags attached by cleavable linkages. Generally, an assay mixture is formed comprising a sample and a reagent comprising multiple such micr...	01/09/2007
7135300	Profiling frequencies of receptor heterodimers Methods are provided for detecting formation of oligomeric complexes of molecules on the surface of cell membranes. These methods employ pairs of tagged probes and cleaving probes, each of which binds specificly to a cell surface molecule. The tagged probe includes ...	11/14/2006
7112684	Compounds and methods for fluorescent labeling Dye reagents useful in labeling biological materials are provided along with methods for their use. ...	09/26/2006
7105308	Detecting receptor oligomerization Methods are provided for detecting formation of oligomeric complexes of molecules on the surface of cell membranes. These methods employ pairs of tagged probes and cleaving probes, each of which binds specificly to a cell surface molecule. The tagged probe includes ...	09/12/2006
7045311	Whole cell assay systems for cell surface proteases The activity of a cell surface protease, particularly an ADAM, is determined in a rapid and sensitive assay employing a whole cell system. The assays are effective to identify effector molecules that affect the activity of a cell surface protease directly or indirec...	05/16/2006
7041459	Analyzing phosphorylated proteins Methods, compositions and kits are disclosed for determining one or more target polypeptides in a sample where the target polypeptides have undergone phosphorylation. A mixture comprising the sample and a first reagent comprising a cleavage-inducing moiety and an IM...	05/09/2006
7041668	Substituted benzimidazole compounds and their use for the treatment of cancer The present invention discloses and claims benzimidazole compounds of formula (I): in which A is aryl or heteroaryl; R1 is selected from optionally substituted alkyl, alkoxy, aryl or heteroaryl, NH-lower alky...	05/09/2006
6955874	Kits employing oligonucleotide-binding e-tag probes Kits for the multiplexed detection of known, selected nucleotide target sequences are provided. Detection involves the release of identifying tags as a consequence of target recognition. The kits include sets of electrophoretic tag probes or e-tag probes, capture ag...	10/18/2005
6949347	Multiplex analysis using membrane-bound sensitizers The present invention is directed to methods and compositions for determining the presence, absence, and/or amounts of one or more membrane-associated analytes in a sample. In accordance with the invention, binding compounds derivatized with releasable molecular tag...	09/27/2005
6777403	Method and structure for inhibiting activity of serine elastases Therefore, it is critical that the roles these enzymes play in biological processes outside of extracellular matrix degradation or remodeling be understood in order to assess their potential as targets for therapeutic intervention, and to design safe, conveniently p...	08/17/2004
6743564	Amine compounds, resist compositions and patterning process Amine compounds having a cyano group are useful in resist compositions for preventing a resist film from thinning and also for enhancing the resolution and focus margin of resist. ...	06/01/2004
6730668	6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines The present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula:	05/04/2004
6727244	Mammalian metabolites of a tachykinin receptor antagonist This invention is concerned with mammalian metabolites of the compound 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)-phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methylmorpholine which is a tachykinin receptor antagonist that is useful in the prev...	04/27/2004
6660466	Di-nitrogen heterocycle compositions Compositions comprising novel di-nitrogen heterocycle compounds containing at least one N-meta-substituted alkaryl group are prepared. The compounds of the present invention are useful as antibacterial and as other pharmaceutical agents and as intermediat...	12/09/2003
6624176	Heteroaromatic substituted amides with antagonistic activity to neurokinin 1 receptors The present invention is a heteroaromatic substituted amide showing antagonist activity to neurokinin 1 (NK-1, substance P) receptors....	09/23/2003
6624171	Substituted aza-oxindole derivatives Substituted aza-oxindole derivatives useful as cyclin dependent kinase 11 inhibitors, for preventing/reducing the severity of epithelial cytotoxicity side-effects (e.g., alopecia, plantar-palmar syndrome, mucositis) induced by chemoptherapy and/or radiati...	09/23/2003
6608070	2,3-substituted indole compounds as anti-inflammatory and analgesic agents This invention provides a compound of the following formula: ##STR1## or the pharmaceutically acceptable salts thereof wherein Z is OH, C1-6 alkoxy, --NR2R3 or heterocycle; Q is selected from the following: (a) an optionally substituted phenyl, (b) an opt...	08/19/2003
6576762	Heteroaromatic substituted amides with antagonistic activity to neurokinin 1 receptors The present invention is a heteroaromatic substituted amide showing antagonist activity to neurokinin 1 (NK-1, substance P) receptors....	06/10/2003
6576628	3-aryl-succinamido-hydroxamic acids, methods for producing said acids and medicaments containing the same The invention relates to inhibitors of matrix metalloproteases, more specifically a 3-aryl-succinamido-hydroxamic acid of formula (I) ##STR1## and its salt, ester and derivative thereof, along with methods of producing a compound of formula (I) and pharma...	06/10/2003
6531471	Morpholinone and morpholine derivatives and uses thereof This invention is directed to morpholinone and morpholine derivatives which are selective antagonists for human 򳄚 receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholest...	03/11/2003
6465684	Process for the separation of a mixture of enantiomers A diastereomer complex obtained via a process for the separation of enantiomers is disclosed, wherein separation can be rapidly effected such that enantiomers are obtained with high e.e. values. The process permits the separation of mixtures of enantiomer...	10/15/2002
6444809	Therapeutic heterocycles Compounds of formula I ##STR1## wherein G, J, L, M, m and D have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of as...	09/03/2002
6388127	Process for preparing cyclic thioamides The present invention relates to a process for preparing a compound of the formula ##STR1## wherein b, Y and R3 are defined as above, useful for preparing novel aralkyl and aralkylidene heterocyclic lactams and imides which are selective a...	05/14/2002
6362182	Morpholinone and morpholine derivatives and uses thereof This invention is directed to morpholinone and morpholine derivatives which are selective antagonists for human 򳄚 receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholest...	03/26/2002
6271235	HIV protease inhibitors HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain the...	08/07/2001
6235927	Process for the separation of a mixture of enantiomers A diastereomer complex obtained via a process for the separation of enantiomers is disclosed, wherein separation can be rapidly effected such that enantiomers are obtained with high e.e. values. The process pets the separation of mixtures of enantiomers i...	05/22/2001
6218390	Morpholinone and morpholine derivatives and uses thereof This invention is directed to morpholinone and morpholine derivatives which are selective antagonists for human 򳄚 receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholest...	04/17/2001
6177422	Benzoxazinone dopamine D4 receptor antagonists This invention relates to compounds that are antagonists of dopamine D4 receptors, to methods of treating psychosis and schizophrenia using a compound that is an antagonist of dopamine D4 receptors, and to pharmaceutically acceptable compositions that con...	01/23/2001
6140500	Red-emitting [8,9]benzophenoxazine nucleic acid dyes and methods for their use A new class of red-emitting, fluorescent [8,9]benzophenoxazine dyes are provided that are useful for staining nucleic acids in a variety of contexts, including in solutions, in electrophoretic gels or other matrices, in blotting experiments and in assays ...	10/31/2000
6140326	Morpholinones as light stabilizers The invention relates to new compounds containing 1-8 active groups of the type 3,3,6,6-polysubstituted 2-morpholinone and having the formula F (A'--Z)m --X (F), wherein m is a number from 1 to 8; X is an organic ...	10/31/2000

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Class 544/98 - 1,4-Oxazines