Did You Know...
...that in 1800 ether was first used by partyers as a fun diversion? Sniffing the gas led to hilarious and raucous laughter as people watched each other become more and more intoxicated and silly. Several doctors independently realized the value ether would have to anesthetize surgery patients. Of those who claimed rights to the "discovery," none had a happy ending. One had a seizure and died defending his rights. Another spent his life in an asylum because he had been denied acclaim. A third became addicted to chloroform and, in a New York City jail, he soaked a cloth in the drug, severed an artery and bled to death.
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| Number | Title | Issue Date |
| 7326703 | (1,10B-Dihydro-2-(aminocarbonyl-phenyl)-5H-pyrazolo[1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as HIV viral replication inhibitors The present invention realtes to 5H-pyrazolo[1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as inhibitors of the viral replication of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnost... | 02/05/2008 |
| 7112674 | Organic electroluminescent device based on 2,5-diaminoterephthalic acid derivatives The invention relates to an organic electroluminescent device which contains 2,5-diaminoterephthalic acid derivatives of formula 1a as emitter substances in one or several emitter layers in a pure or doped manner. The ring A is a triple unsaturated benzene ring wher... | 09/26/2006 |
| 7008941 | Reverse-turn mimetics and methods relating thereto Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: wherein A, B, X, R1 | 03/07/2006 |
| 6794391 | Derivatives of pyrimido[6.1-a]isoquinolin-4-one The invention provides compounds or salts thereof of the general formula (I): wherein each of R1 and R2 independently represents a C1-6 alkyl or C2-7 acyl group; X represents O... | 09/21/2004 |
| 6777404 | Use of corticotropin releasing factor antagonists and related compositions The present invention relates to compositions and methods of achieving a therapeutic effect including, the treatment or prevention of Syndrome X in an animal, preferably a mammal including a human subject or a companion animal, using a corticotropin releasing factor... | 08/17/2004 |
| 6743852 | Benzoxazines, thermosetting resins comprised thereof, and methods for use thereof In accordance with the present invention, there are provided novel benzoxazine compounds and thermosetting resin compositions prepared therefrom. Invention compositions are particularly useful for increasing adhesion at interfaces within microelectronic packages. In... | 06/01/2004 |
| 6730677 | Benzofurazan compounds which enhance AMPA receptor activity Compounds of general structural formula (1) are shown to have AMPA receptor enhancing properties. The compounds are useful for such therapeutic purposes as facilitating the learning of behaviors dependent upon AMPA receptors, and in treating conditions, such ... | 05/04/2004 |
| 6514984 | Treatment for alzheimer's disease A method is disclosed for the prevention and treatment of Alzheimer's disease by administering to a human in need thereof an effective amount of a substituted tricyclic sPLA2 inhibitor.... | 02/04/2003 |
| 6384045 | Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxypyrone synthetic method is a simple con... | 05/07/2002 |
| 6358947 | Tetracyclic progesterone receptor modulator compounds and methods Nonsteroidal compounds that are high affinity, high selectivity modulators for progesterone receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and composition... | 03/19/2002 |
| 6303780 | 4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as HIV reverse transcriptase inhibitors and intermediates and processes for making the same The present invention relates to benzoxazinones of formula I: ##STR1## or stereoisomeric forms or mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions ... | 10/16/2001 |
| 6153126 | Photochromic six-membered heterocyclilc-fused naphthopyrans Described are novel photochromic six-membered heterocyclic-fused naphthopyran compounds, examples of which are naphthopyran compounds having an oxazino group fused to one side of the naphtho portion of the naphthopyran and having certain substituents at t... | 11/28/2000 |
| 6124278 | Acylbenzoxazines for enhancing synaptic response Compounds based on the benzoxazine ring system that are remarkably more potent than corresponding benzoyl piperidines for enhancing synaptic responses mediated by AMPA receptors are disclosed, as are methods for the preparation thereof, and methods for th... | 09/26/2000 |
| 6121278 | Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity A compound of formula I: ##STR1## or a pharmaceutically acceptable salt, hydrate, ester, solvate, prodrug, metabolite, stereoisomer, or mixtures thereof, wherein: Y represents the atoms necessary to form a fused 5- to 6-membered, aromatic or non-arom... | 09/19/2000 |
| 6069114 | 2-amino-4-bicycloamino-1,3,5-Triazines, their preparation, and their use as herbicide and plant growth regulators Compounds of the formula (I) and their salts ##STR1## in which R1 to R6, Y1, to Y2, Y3, m and n are as defined in claim 1 are suitable as herbicides and plant growth regulators. They can be prepa... | 05/30/2000 |
| 5985871 | Benzoxazine compounds for enhancing synaptic response Compounds having a certain benzoxazine ring system and their precursors are disclosed which are useful for enhancing synaptic responses mediated by AMPA receptors. Also disclosed are methods for preparing such compounds, and methods for their use in treat... | 11/16/1999 |
| 5962447 | Benzoxazines for enhancing synaptic response Compounds based on the benzoxazine ring system are disclosed for use in enhancing synaptic responses mediated by AMPA receptors. The compounds are effective in the treatment of subjects suffering from impaired nervous or intellectual functioning due to de... | 10/05/1999 |
| 5958970 | Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxyprone synthetic method is a simple cond... | 09/28/1999 |
| 5932573 | Substituted quinolines and isoquinolines as calcium channel blockers, their preparation and the use thereof The present invention relates to novel substituted quinolines and isoquinolines and derivatives thereof useful in the treatment of neurological disorders. Methods of preparing the compounds, intermediates useful in the preparation and pharmaceutical compo... | 08/03/1999 |
| 5801243 | Photochromic compounds (7) Disclosed are photochromic oxazine compounds, yielded by means of condensation of an aldehyde bearing in the -position to the aldehyde group a halogen or hydroxy group (reacting agent 1), with (substituted) ortho-aminohydroxy aromatic compounds (re... | 09/01/1998 |
| 5482936 | Imidazo[4,5-C]quinoline amines Compounds and pharmaceutically acceptable salts thereof formally derived by bridging the 1- and 2-positions of 1H-imidazo[4,5-c]quinolin-4-amines. Also, methods of using such compounds and pharmaceutical formulations containing such compounds. Said compou... | 01/09/1996 |
| 5380718 | Arthropodicidal fused tetrahydropyridazines Arthropodicidal tetrahydropyridazines of Formulae I and II, ##STR1## wherein Q,X,X1 Y, and G are as defined in the text, compositions containing them and their use in the control of arthropods.... | 01/10/1995 |
| 5362872 | Chromogenic lactams The invention relates to chromogenic lactams, to their preparation and to the use thereof in pressure-sensitive or heat-sensitive recording materials. The novel lactams have the general formula I ##STR1## wherein the ring A is an aromatic or heteroar... | 11/08/1994 |
| 5270308 | 1,3-benzoxazine derivatives, their production and use A new compound of the formula: ##STR1## wherein ##STR2## is an optionally substituted benzene ring; R1 is a carbocyclic or heterocyclic group which is linked to the 4-position of the 1,3-benzoxazine ring through a carbon-carbon b... | 12/14/1993 |
| 5217968 | N-alkylbenzo(b)thieno [3,2-b]oxazin-2,4-diones N-Alkenylbenzo[b]thieno[3,2-b]oxazin-2,4-diones, pro-drugs of cyclooxygenase and 5-lipoxygenase inhibitory N-alkenyl-3-hydroxybenzo[b]thiophene-2-carboxamide derivatives; pharmaceutical compositions comprising one or more of said pro-drugs and a phar... | 06/08/1993 |
| 5212186 | Cardioactive pyrrolobenzimidazoles Compounds for the treatment of cardiac insufficiency, an arterial thrombo embolism, an arterial occlusive disease, psoriasis, neurodermatitis, asthma, platelet aggregation and hypertension, of the formula ##STR1## in which R1 is hydrogen, ... | 05/18/1993 |
| 5095103 | Polycyclic aromatic azacyclic compounds useful in dyeing Heterocyclic compounds of the formula ##STR1## with the substituent meanings given in the description, and derivatives thereof are suitable for dyeing and pigmenting the most diverse substrates.... | 03/10/1992 |
| 4980468 | Polyheterobicyclotridecane compounds 3-7-Diheterabicyclo[3.3.1]nonanes and derivatives thereof are disclosed. Their method of preparation and use as antiarrhythmic agents is given.... | 12/25/1990 |
| 4937329 | Production of 2,3'-anhydro-2'-deoxyuridine derivatives A process for the production of a 5-substituted derivative of a 2,3'-anhydro-2'-deoxyuridine preferably corresponding to the following general formula: ##STR1## wherein R1 represents H, alkyl, aryl, halogeno or CF3 ; charac... | 06/26/1990 |
| 4835270 | Chromogenic 3,1-benzoxazines Compounds of the formula ##STR1## wherein Z1 denotes hydrogen, alkyl, cycloalkyl or ##STR2## R1 denotes hydrogen, alkyl, cycloalkyl, aralkyl, aryl, heteroalkyl or heteryl, X1, X2 and X3 deno... | 05/30/1989 |
| 4831141 | Chromogenic 3,1-benzoxazines The invention relates to chromogenic 3,1-benzoxazines of the formula ##STR1## wherein X1 denotes hydrogen, C1 -C4 -alkyl, chlorine or OY1, X2 denotes NY2 Y3, X3 denote... | 05/16/1989 |
| 4831027 | Imidazo-benzoxazinones, the preparation thereof and pharmaceutical compositions containing these compounds The invention relates to new imidazo-benzoxazinones of formula ##STR1## wherein the substituents are defined herein below, which compounds are useful in the treatment of cardiovascular disorders.... | 05/16/1989 |
| 4760063 | Thienooxazinones, processes for their preparation, and their use as growth promoters Novel thienooxazines of the formula ##STR1## in which R1 and R2, together with the adjacent C atoms, represent an optionally substituted thiophene ring, R3 represents hydrogen, optionally substituted alkyl, cycloalkyl, ... | 07/26/1988 |
| 4754034 | Chromogenic 4,4-diaryldihydroquinazolones 4,4-diaryldihydroquinazolones of the formula ##STR1## wherein X1, X2 and X3, independently of one another, denote hydrogen, halogen, alkyl, aryl, alkanoylamino, aroylamino, heteryl, NY1 Y2, OY | 06/28/1988 |
| 4727140 | Chromogenic 4,4-diaryl-2-oxobenzo-3,1-oxazines 4,4-Diaryl-2-oxobenzo-3,1-oxazines of the general formula ##STR1## wherein X1, X2 and X3, independently of one another, denote hydrogen, halogen, alkyl, aryl, alkanoylamino, aroylamino, heteryl, NY1 Y2... | 02/23/1988 |
| 4723987 | Herbicidal sulfonamides Sulfonamides such as N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-1,3-dihydro-6-methyl-3-oxof uro[3,4-c]pyridine-4-sulfonamide are useful as herbicides and plant growth regulants.... | 02/09/1988 |
| 4695633 | Chromogenic 4,4-diaryl-dihydroquinazolones, their preparation and their use Chromogenic 4,4-diaryl-dihydroquinazolones of the formula ##STR1## wherein X1, X2 and X3 independently of one another represent hydrogen, halogen, alkyl, aryl, alkanoylamino, aroylamino, NY1 Y2, ... | 09/22/1987 |
| 4617392 | 4-alkyl-5,6-methylenedioxy-2-1[H]-quinazolinones useful as cardiotonic agents 4-Alkyl-5,6-, 6,7-methylenedioxy-2-1[H]-quinazolinones are prepared from 2,3-methylenedioxyacetophenones. The 4-alkyl-5,6-, 6,7-methylenedioxy-2-1[H]-quinazolinones are active as cardiotonic agents.... | 10/14/1986 |
| 4525588 | Chromogenic naphtholactams The invention relates to chromogenic naphtholactams of the general formula ##STR1## wherein Q is the radical of a couplable compound, X is oxygen or ##STR2## wherein R is hydrogen, lower alkyl or aryl, and W is alkylene, cycloalkylene or a 6-mem... | 06/25/1985 |
| 4412071 | Antiatherosclerotic compositions The present invention provides novel antiatherosclerotic furobenzoxazinones, e.g., 4,9-dimethoxy-4H-furo[3,2-g][1,3]benzoxazin-4-ones. These compounds are structurally and pharmacologically related to khellin and are useful antiatherosclerotic agents... | 10/25/1983 |
