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| Number | Title | Issue Date |
| 7915405 | 2,4-disubstituted-5-aminocarbonyl-1,3-thiazole derivatives for therapeutic agent of antiinflammatory disease, method thereof for preparation, therapeutic agent for antiinflammatory disease induced by SPC activity containing the same Disclosed herein are 2,4-disubstituted-5-aminocarbonyl-1,3-thiazole derivatives, a preparation method thereof, and a therapeutic agent for treating inflammatory diseases induced by SPC, which contains the derivative as an active ingredient. The anti-inflammatory eff... | 03/29/2011 |
| 7365067 | Indanol derivative The present invention provides a compound having the following general formula (I) which is useful as a neurokinin receptor antagonist: (wherein, R1, R2: optionally s... | 04/29/2008 |
| 7314862 | Antitumor agent The present invention relates to an antitumor agent containing a histone deacetylase inhibitor and a topoisomerase II inhibitor in combination. This combination has been found to exhibit a synergistic anticancer or antitumor effect compared to administration of eith... | 01/01/2008 |
| 7173024 | Compounds having prolyl oligopeptidase inhibitory activity, methods for their preparation and their use Compounds of the formula (I), wherein the symbol aa means a residue of an α-amino acid. The invention is also directed to a method for the preparation of the compounds of formula (I), as well as their use as pro... | 02/06/2007 |
| 7109186 | HIV integrase inhibitors The present invention describes novel compounds of Formula I which inhibit HIV integrase. The invention also describes compositions and treatments of AIDS or ARC by using these compounds ... | 09/19/2006 |
| 6844347 | Substituted 4-amino-2aryl-pyrimidines, their production and use and pharmaceutical preparations containing same The invention relates to compounds of formula I, in which R1, R2, R3 and R4 have the meanings given in the claims. Said compounds are valuable active ingredients for the trea... | 01/18/2005 |
| 6833364 | Substituted pyrazole derivatives The present invention relates to novel substituted pyrazole derivatives of the general formula (I) in which the substituents R1, R2, R3, A, X and Y are each as defined, and to processes... | 12/21/2004 |
| 6730681 | Triazolo-pyrimidine derivatives as ligands for gaba receptors A class of substituted or 6,7-ring fused [1, 2, 3]triazolo[1,5-α]-pyrimidine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position and an amino moiety at the 5-position, are selective ligands for GABAA... | 05/04/2004 |
| 6720319 | Compounds useful as reversible inhibitors of cysteine proteases Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R2, R3, R4, R5, R6, R7, R8, Het and X are defined herein. The compounds are... | 04/13/2004 |
| 6683181 | Pyrroloquinolones as antiviral agents The present invention provides a compound of formula I ##STR1## which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.... | 01/27/2004 |
| 6608052 | Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds of the formula(I) wherein G, E, W, Ar, X, Y and Z. The compounds are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceut... | 08/19/2003 |
| 6579982 | Pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula ##STR1## wherein X, Y, Ar1, Z, R1, R2 and R3 are as defined in the specification, and to pharmaceutical compos... | 06/17/2003 |
| 6566359 | 2,4,6-trimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid esters as neuroprotective drugs A new series of derivatives of 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid and their synthesis have been discovered. Surprisingly, by modifying the substituent of the 3-carboxylic acid group, new compounds were produced with high activi... | 05/20/2003 |
| 6525049 | Pyrroloquinolones as antiviral agents The present invention provides a compound of formula I ##STR1## which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.... | 02/25/2003 |
| 6476024 | Pyridazine derivatives and related composition Ultraviolet absorbents and photostabilizers have an excellent absorption ability in a wide range of ultraviolet rays, and also have high stability and high safety. The ultraviolet absorbent and photostabilizer include a pyridazine derivative of the formul... | 11/05/2002 |
| 6458950 | Compounds and pharmaceutical compositions containing the same A compound shown by the formula II, wherein Het is a mono- or polycyclic heterocyclic group comprising one or more hetero atoms selected from the group consisting of N, O and S which may be the same or different from each other; R1 is hydrogen,... | 10/01/2002 |
| 6455520 | Benzamide derivatives and their use as cytokine inhibitors The invention concerns amide derivatives of formula (I) ##STR1## wherein R3 is (1-6C)alkyl or halogeno; m is 0-3, p is 0-2 and q is 0-4; each of R1 and R2 is a group such as hydroxy, halogeno, trifluoromethyl and cyano; R | 09/24/2002 |
| 6432949 | Amide derivatives useful as inhibitors of the production of cytokines ##STR1## The invention concerns amide derivatives of formula (I) wherein R3 is (1-6C)alkyl or halogeno; Q1 is heteroaryl which is optionally substituted with 1, 2, 3, or 4 substituents such as hydroxy, halogeno, trifluoromethyl, (1-6... | 08/13/2002 |
| 6395896 | Pyridazine derivatives, manufacturing method and related composition Ultraviolet absorbents and photostabilizers have an excellent absorption ability in a wide range of ultraviolet rays, and also have high stability and high safety. The ultraviolet absorbent and photostabilizer include a pyridazine derivative of the formul... | 05/28/2002 |
| 6339089 | Pyrimidine nucleus-containing compound and a medicament containing the same for a blood oxygen partial pressure amelioration, and a method for preparing the same A pyrimidine nucleus-containing compound represented by the formula (I): ##STR1## wherein ring A represents the ring of the formula (a): ##STR2## in which R1 is a nitro group, an amino group, a substituted amino group or a halogen atom, or the ... | 01/15/2002 |
| 6159980 | Pyrazinones and triazinones and their derivatives thereof Corticotropin releasing factor (CRF) antagonists of Formula (I) ##STR1## and their use in treating psychiatric disorders and neurological diseases including major depression, anxiety-related disorders, post-traumatic stress disorders, supranuclear pa... | 12/12/2000 |
| 6150527 | Synthetic multimerizing agents New compounds are disclosed for multimerizing immunophilins and proteins containing immunophilin or immunophilin-related domains. The compounds are of the formula M-L-Q where M is a synthetic ligand for an FKBP protein... | 11/21/2000 |
| 6133456 | Synthetic multimerizing agents New compounds are disclosed for multimerizing immunophilins and proteins containing immunophilin or immunophilin-related domains. The compounds are of the formula M1 --L--M2 where M1 and M2 are independently moieties... | 10/17/2000 |
| 6011154 | Substituted heterocyclic compounds, method of preparing them and pharmaceutical compositions in which they are present The invention relates to compounds of the formula ##STR1## in which: A is a divalent radical selected from: A1) --O--CO-- A2) --CH2 --O--CO-- A3) --O--CH2 --CO-- A4) --O--CH2 --CH | 01/04/2000 |
| 6004965 | Sulfonamides Compounds of the formula: ##STR1## where A, B, R1 -R8 are as described herein are endothelin inhibitors that can be used in treating diseases associated with endothelin, such as high blood pressure. Chemical synthesis of these ... | 12/21/1999 |
| 5965556 | Pyrrolidine derivatives The invention relates to novel pyrrolidine derivatives represented by formula (1): ##STR1## wherein: R1 represents (1) a lower alkyl group having 1 to 6 carbon atoms, or (2) a 3- to 15-membered mono- or fused cyclic hydrocarbon group which may c... | 10/12/1999 |
| 5948778 | Difluoro statone antiviral analogs This invention relates to novel statone antiviral analogs, to the processes and intermediates useful for their preparation and to their use as antiviral agents.... | 09/07/1999 |
| 5856484 | Sulfonylaminopyrimidine carboxylic acid derivatives having endothelin inhibiting activity Compounds of formula I: ##STR1## are disclosed. The compounds inhibit the binding of endothelin to its receptors.... | 01/05/1999 |
| 5854179 | Sulfur-substituted phenylsulfonylureas, processes for their preparation and their use as herbicides and plant growth regulators Sulfur-substituted phenylsulfonylureas; processes for their preparation and their use as herbicides and plant growth regulators Compounds of the formula (I) and salts thereof ##STR1## in which R*, R1, R2, R3, X, Y, Z, W, n... | 12/29/1998 |
| 5837708 | Sulphonamides Compounds of the formula ##STR1## wherein the variables are hereinbelow defined. The compounds of formula I are inhibitors for endothelin receptors. They can be used for the treatment of disorders which are associated with endothelin activities, ... | 11/17/1998 |
| 5831094 | Difluoro statone antiviral analogs The present invention relates to difluorostatone derivatives useful as antiviral agents.... | 11/03/1998 |
| 5780466 | Substituted heterocyclic compounds method of preparing them and pharmaceutical compositions in which they are present The invention relates to compounds of the formula ##STR1## in which: A is a divalent radical selected from: A1) --O--CO-- A2) --CH2 --O--CO-- A3) --O--CH2 --CO-- A4) --O--CH2 --CH | 07/14/1998 |
| 5719104 | Herbicidal bicyclic and tricyclic imides Bicyclic imides of formulae (I) and (II) and their agriculturally-suitable salts, are disclosed which are useful for controlling undesirable vegatation, wherein G is O or S; n and m are each independently 0; 1; 2; or 3; provided that m+n is 2 or 3; q is 1... | 02/17/1998 |
| 5696259 | 2,4-diamino-5-iodopyrimidines useful as pesticide intermediates This invention describes 2,4-diamino-5-iodopyrimidines II where R, R1, R2, and R3 are independently selected from hydrogen, alkyl, cycloalkyl, alkoxyalkyl, alkoxyalkoxyalkyl, and arylalkyl; or, R1 and R2, and R3 and R, each independently, when taken toget... | 12/09/1997 |
| 5658854 | Acylated aminophenylsulfonylureas; preparation and use as herbicides and plant growth regulators Acylated aminophenylureas, preparation and use as herbicides and plant growth regulators The compounds of the formula I or their salts ##STR1## in which G is a radical G1, G2 or G3 ##STR2## R1 is H or alkyl, R2 is COOH, CSO... | 08/19/1997 |
| 5641777 | Substituted heterocyclic compounds and pharmaceutical compositions in which they are present The invention relates to neurokinin receptor antagonist compounds of the formula ##STR1## in which: A is a divalent radical selected from: A1) --O--CO-- A2) --CH2 --O--CO-- A3) --O--CH2 --CO-- A4... | 06/24/1997 |
| 5616537 | Condensed heterocyclic derivatives and herbicides A condensed heterocyclic derivative of the formula (I): ##STR1## (wherein R is a hydroxyl group, R3 or R4 is an alkoxy group, W is an oxygen atom, Yn is a hydrogen atom, Z is a methine group, and A is a 5- or 6-membered heterocy... | 04/01/1997 |
| 5612337 | Substituted morpholine derivatives and their use as therapeutic agents The present invention relates to compounds of formula (I), wherein R1 is hydrogen, halogen, C1-6 C alkyl, C1-6 alkoxy, CF3, NO2, CN, SRa, SORa, SO2 Ra, CO2 | 03/18/1997 |
| 5556985 | Pyrazolonoxonol compounds A novel pyrazolonoxonol compound represented by formula (A) and a silver halide photographic material comprising such a pyrazolonoxonol compound: ##STR1## wherein R1 and R2 each represents a hydrogen atom, an alkyl group or an a... | 09/17/1996 |
| 5541186 | Sulfonylaminopyrimidines A compound of the formula ##STR1## wherein R1 to R, Ra, Rb X, Y, Z, m and n have the significance given in the description, can be used as medicaments, especially for the treatment and prophylaxix of conditions which ... | 07/30/1996 |
