Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 7371750 | Compounds and compositions as protein kinase inhibitors The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or d... | 05/13/2008 |
| 7321828 | System of components for preparing oligonucleotides Interative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is prov... | 01/22/2008 |
| 7276506 | Immunosuppressive effects of pteridine derivatives This invention relates to a group of trisubstituted and tetrasubstituted pteridine derivatives, having the formula: wherein X represents an oxygen atom or a group with the formula NZ and wherein: R1 C | 10/02/2007 |
| 7259155 | Phosphonic diester derivatives The present invention provides a phosphonic acid diester compound represented by General Formula wherein R1, R2, R3 and R4 are the same or different, and represent hydr... | 08/21/2007 |
| 7211381 | β2 andrenergic polymorphism detection Nucleic acid sequences are provided that are useful as amplification primers and hybridization probes for amplifying and detecting target sequence from the β2 adrenergic receptor gene. The primers and probes can be employed in amplification based methods for detect... | 05/01/2007 |
| 7002006 | Protection of nucleosides A process of manufacturing protected nucleosides comprises reacting a nucleoside with a protecting reagent in the presence of a regioselective activator to produce a regioselectively protected nucleoside. In some embodiments of the inventive method, an optionally su... | 02/21/2006 |
| 6958214 | Polymorphic kinase anchor proteins and nucleic acids encoding the same Polymorphic A-kinase anchor proteins (AKAPs) and nucleic acids encoding the proteins are provided herein. Methods of detecting polymorphic AKAPs and nucleic acids encoding the AKAPs, and kits for use in the detection methods are also provided. Further provided herei... | 10/25/2005 |
| 6914148 | Guanidinium functionalized intermediates The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to include a guanidinium group. These oligomers are useful for diagnostic,... | 07/05/2005 |
| 6838238 | Morphatides: novel shape and structure libraries This invention provides a method for identifying one or more complexes from a library of complexes, wherein said complex or complexes are selected for their ability to perform a preselected or desired function on a target molecule or by having a pre-selected structu... | 01/04/2005 |
| 6730676 | Pyrazino-pyridazine derivatives as ligands for GABA receptors A class of pyrazino[2,3-d]pyridazine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 5-position, a substituted alkoxy moiety at the 3-position, and a range of substituents at the 2-position, are selective ligands... | 05/04/2004 |
| 6730681 | Triazolo-pyrimidine derivatives as ligands for gaba receptors A class of substituted or 6,7-ring fused [1, 2, 3]triazolo[1,5-α]-pyrimidine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position and an amino moiety at the 5-position, are selective ligands for GABAA... | 05/04/2004 |
| 6476030 | Pyrazolo-triazine derivatives as ligands for GABA receptors Compounds according to Formula (I): ##STR1## or a salt or prodrug thereof, have good affinity as ligands for the alpha2 and/or alpha3 subunit of the human GABAA receptor and are useful for treatment of disorders of the central nervous system, i... | 11/05/2002 |
| 6277854 | Tricyclic antitumor farnesyl protein transferase inhibitors The invention relates to compounds of the formula ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, Y, A, B, X, a, b, c, d, v, and w are as described herein. The compou... | 08/21/2001 |
| 6124306 | Thioalkyl alpha substituted pyrimidine compounds The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula I ##STR1## and pyrimidine-thioalkyl and alkylethers of Formula I, where R4 is selected from the group consisting of --H or --NR15 R16... | 09/26/2000 |
| 6001832 | [1,2,4]triazolo[4,3-a]quinoxalinone derivatives, their preparation and use The present invention relates to [1,2,4]triazolo[4,3-a]quinoxalinone compounds of the formula ##STR1## wherein R1 is POX'X" or alkyl substituted with COX' or POX'X", and X' and X" independently are hydroxy or alkoxy, and R7 is ... | 12/14/1999 |
| 5880125 | 4-spiroindoline piperidines promote release of growth hormone The present invention is directed to certain novel compounds identified as 4-spiroindoline piperidines of the general structural formula: ##STR1## wherein R1, R1a, R2a, R3a, R3b, R4, R... | 03/09/1999 |
| 5866571 | 9-substituted 2-(2-n-alkoxyphenyl)-purin-6-ones 9-Substituted 2-(2-n-alkoxyphenyl)purin-6-ones are prepared by cyclizing correspondingly substituted imidazoles and derivatizing the purines thus obtained. The 9-substituted 2 -(2-n-alkoxyphenyl)purin-6-ones can be employed as active compounds ... | 02/02/1999 |
| 5618814 | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds The invention relates to trisubstituted pyrimido [5,4-d]-pyrimidines of general formula ##STR1## (wherein Ra, Rb and Rc are defined as in claim 1) and the salts thereof, more particularly for pharmaceutical use the ... | 04/08/1997 |
| 5521063 | Polynucleotide reagent containing chiral subunits and methods of use The present invention describes an assay system wherein target polynucleotide molecules are captured on a support by base-specific binding to support-bound polymers, which are themselves substantially uncharged, and the target polynucleotides can be detec... | 05/28/1996 |
| 5478825 | 5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives The disclosed compounds have the formula ##STR1## wherein Q is a 6-membered saturated heterocyclic group or a group S(O)pR3, wherein p is 0, 1, or 2, and R3 is alkyl, alkenyl, or phenyl-, which may have halogen or nitro substitu... | 12/26/1995 |
| 5235033 | Alpha-morpholino ribonucleoside derivatives and polymers thereof Alpha-morpholino subunits and polymer compositions composed of alpha-morpholino subunits are disclosed. These subunits can be linked together by uncharged linkages, one to three atoms in length, joining the morpholino nitrogen of one subunit to the 5' exo... | 08/10/1993 |
| 5185444 | Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages A polymer composition is disclosed composed of morpholino subunit structures linked together by uncharged, chiral linkages, one-three atoms in length. These chiral linkages join the morpholino nitrogen of one subunit to the 5' exocyclic carbon of an adjac... | 02/09/1993 |
| 5166344 | Process for the preparation of imidazoquinoxalinones This invention relates to novel imidazoquinoxalinones and their aza analogs and to a process for their preparation. The compounds of this invention have been found to have inodilatory, vasodilatory, venodilatory and other pharmacologic effects.... | 11/24/1992 |
| 4908056 | Heterocyclic acyl sulfonamides This invention relates to novel heterocyclic carbonyl sulfonamides which are particularly useful as agricultural chemicals.... | 03/13/1990 |
| 4871736 | Stereoisomeric tricyclic bis(dioxopiperazines) and pharmaceutical compositions Stereoisomeric tricyclic bis(dioxopiperazines) of the formula ##STR1## wherein R is H or ##STR2## and the processes for the synthesis thereof are provided. The compounds are effective as antitumor or antimetastatic drugs.... | 10/03/1989 |
| 4838925 | Heterocyclic acyl sulfonamides This invention relates to novel heterocyclic carbonyl sulfonamides which are particularly useful as agricultural chemicals.... | 06/13/1989 |
| 4831029 | Condensed cyclic triazole derivatives, pharmaceutical compositions and use The invention relates to condensed cyclic triazole derivatives of the general Formula I ##STR1## and pharmaceutically acceptable salts thereof. The compounds of the general Formula I possess useful sedative and tranquillant properties and exhibi... | 05/16/1989 |
| 4788186 | 6-substituted-s-triazolo[3,4-a]phthalazine derivatives The present invention refers to new s-triazolo[3,4-a]phthalazine derivatives, to the process for their preparation and to the pharmaceutical compositions containing them.... | 11/29/1988 |
| 4572910 | Triazolo[1,5-c]pyrimidines substituted by nitrogen-containing heterocyclic rings 1,2,4-Triazolo[1,5-c]pyrimidines substituted at the 5 or 7 positions through a nitrogen atom which is part of a heterocyclic ring have been found to have potent bronchodilator activity. Methods for inducing bronchodilation, pharmaceutical compositions and... | 02/25/1986 |
| 4560685 | 2-Piperazino-pteridines useful as antithrombotics and antimetastatics Compounds of the formula ##STR1## wherein R1 is phenylalkylamino, alkylamino, dialkylamino, piperidino, morpholino, thiomorpholino or 1-oxido-thiomorpholino; R2 is dialkylamino, piperidino, morpholino, thiomorpholino or 1-oxido-... | 12/24/1985 |
| 4444770 | New imidazoazole-alkenoic acid amide compounds, intermediate products for their production, their production, and their medicinal use The invention relates to imidazoazole-alkenoic acid amides of Formula (I) and methods for their production. Also included in the invention are compositions containing said alkenoic acid amides and methods for the use of said alkenoic acid amides and the c... | 04/24/1984 |
| 4331805 | V-Triazolyl-[4,5-d]-pyrimidines New v-Triazolyl-[4,5-d]-pyrimidines of the formula ##STR1## wherein Q and Q1 independently of one another are a secondary or tertiary amino radicals and X, X1 and X2 are certain nonchromophoric substituents, their pre... | 05/25/1982 |
| 4123439 | Chromenoindole compounds A chromenoindole compound of the formula ##STR1## wherein R1 and R2 independently of one another represent hydrogen, alkyl which has at most 12 carbon atoms and is unsubstituted or substituted by halogen, hydroxyl, cyano or lowe... | 10/31/1978 |
| 3950393 | Aminobenzyl-amides and salts thereof Compounds of the formula ##SPC1## Wherein R1 is hydrogen or aliphatic or aromatic carboxylic acyl, R2 is hydrogen, chlorine or bromine, R3 is fluorine, alkyl of 1 to 4 carbon atoms, trifluoromethyl, cyano, carbamoyl, carboxyl, ... | 04/13/1976 |
