Class 544/80 - Ring nitrogen in the polycyclo ring system

Subclass of Class 544 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which a nitrogen containing hetero ring is
No. of patents: 121
Last issue date: 08/12/2008

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Number	Title	Issue Date
7410990	Heterocyclic compounds This invention features a compound of formula (I): R1 is aryl or heteroaryl; each of R2 and R4, independently, is H, halogen, CN, alkyl, ORa, or NRaRb; R	08/12/2008
7312209	Acridone inhibitors of IMPDH enzyme Compounds having the formula (I), wherein R3 is selected from H, OH and NH2; R30 is selected from ═O and ═S; W is —C(═O)—, —S(═O)—, or —S(O)2—; or W...	12/25/2007
7074929	Certain alkylene diamine-substituted heterocycles This invention relates to novel compounds, compositions, and methods for the treatment of physiological disorders associated with an excess of neuropeptide Y. The novel compounds encompassed by the present invention are those of the formula II, IV, V, VII–IX and X...	07/11/2006
6949521	Therapeutic azide compounds Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and hydroxy substituents are converted in vivo to the corresponding drugs...	09/27/2005
6653307	1-aryl-4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents The present invention provides compounds of formula I ##STR1## which are useful as antiviral agents, in particular, as agents against viruses of the herpes family....	11/25/2003
6613772	Substituted 2-aryl-4-amino-chinazolines, method for the production and use thereof as medicaments Compounds of the formula I ##STR1## in which R1, R2, R3 and Ar have the meanings indicated in the claims, are suitable for the production of pharmaceuticals, for example for the prophylaxis and therapy of cardiovascular di...	09/02/2003
6583146	Thiazolopyrimidine compounds, its production and use Compounds represented by general formula (I): ##STR1## and salts thereof, exhibiting excellent adenosine A3 receptor antagonism: wherein A is an optionally substituted benzene ring; B may be further substituted; and R1 is an optional...	06/24/2003
6579885	Aryl and heteroaryl substituted tetrahydroisoquinolines and use thereof Provided herein are compounds of the formula (I): ##STR1## wherein R1 -R8 are as described herein, R4 being aryl or heteroaryl Such compounds are particularly useful in the treatment of a disorder which is created by or is...	06/17/2003
6559143	Oxabispidine compounds useful in the treatment of cardiac arrhyythmias There is provided compounds of formula I, ##STR1## wherein R1, R2, R3, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the trea...	05/06/2003
6506762	Certain alkylene diamine-substituted heterocycles The present invention also provides a general method to whereby mono-, bi-, or tricyclic heterocycles may be modified to obtain potent antagonists at the NPY1 receptor. The present invention provides novel, potent, non-peptidic antagonists of N...	01/14/2003
6479499	2-phenyl-4-quinazolinone compounds, 2-phenyl-4-alkoxy-quinazoline compounds and their pharmaceutical compositions Two series of 6,7,2',3',4',5'-substituted 2-phenyl-4-quinazolinones and 6,2',3',4',5'-substituted 2,3-dihydro-2-phenyl-4-quinazolinones are synthesized and evaluated for cytotoxicity against a panel of human tumor cell lines, such as epidermoid carcinoma ...	11/12/2002
6407103	Indeno [1,2-c] pyrazol-4-ones and their uses The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): ##STR1## that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and t...	06/18/2002
6271212	Prodrug azide compositions and compounds Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and hydroxy substituents are converted in vivo to the correspo...	08/07/2001
6124306	Thioalkyl alpha substituted pyrimidine compounds The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula I ##STR1## and pyrimidine-thioalkyl and alkylethers of Formula I, where R4 is selected from the group consisting of --H or --NR15 R16...	09/26/2000
5948784	Quinazoline derivatives Disclosed are quinazoline derivatives represented by formula (I): wherein R1 represents hydrogen, lower alkyl, alkenyl, or aralkyl; R2, R3, R4, and R5 represent hydrogen, lower alkyl, lower alkoxy, lo...	09/07/1999
5880125	4-spiroindoline piperidines promote release of growth hormone The present invention is directed to certain novel compounds identified as 4-spiroindoline piperidines of the general structural formula: ##STR1## wherein R1, R1a, R2a, R3a, R3b, R4, R...	03/09/1999
5744602	Certain imidazoquinoxalines; a new class of GABA brain receptor ligands The invention encompasses compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4, and X are variables; and W is phenyl optionally substituted with straight or...	04/28/1998
5616537	Condensed heterocyclic derivatives and herbicides A condensed heterocyclic derivative of the formula (I): ##STR1## (wherein R is a hydroxyl group, R3 or R4 is an alkoxy group, W is an oxygen atom, Yn is a hydrogen atom, Z is a methine group, and A is a 5- or 6-membered heterocy...	04/01/1997
5478825	5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives The disclosed compounds have the formula ##STR1## wherein Q is a 6-membered saturated heterocyclic group or a group S(O)pR3, wherein p is 0, 1, or 2, and R3 is alkyl, alkenyl, or phenyl-, which may have halogen or nitro substitu...	12/26/1995
5330987	Substituted pyridopyrimidinones and related heterocycles as angiotensin II antagonists Novel substituted pyridopyrimidinones of formula (I), which are useful as angiotensin II antagonists, are disclosed. ##STR1##...	07/19/1994
5326744	Glycol aldehyde and lactic acid derivatives and the preparation and use thereof Glycol aldehyde and lactic acid derivatives and their sulfur analogs of the formula I ##STR1## where R1 to R3 have the meanings given in the specification, X is oxygen, sulfur or a single bond, and Y is a C2 -C4	07/05/1994
5266699	NIR dyes, methods of preparing them and their use The compounds of the formula I ##STR1## in which Y and Y1 are each, independently of one another, O, S, NH or N-alkyl, N-cycloalkyl, N-phenyl or N-benzyl, or Y and Y1 are together N-alkylene-N, R and R1 are each, independe...	11/30/1993
5250533	Fungicidal pyridinylpyrimidines Fungicidal pyridinylpyrimidines of the formula ##STR1## in which R1 represents hydrogen, halogen, alkoxy, alkylthio, halogenoalkyl, amino or dialkylamino, where, in the case of dialkylamino, the two radicals may, together with the nitrogen...	10/05/1993
5250530	Aminopyrimidine derivatives, and their use as fungicides Aminopyrimidine derivatives, their preparation, and agents containing them, and their use as fungicides comprising ##STR1## in which R1 is alkyl, alkoxyalkyl, alkylthioalkyl, cycloalkyl, alkenyl, alkynyl, cycloalkylalkyl, substituted amino...	10/05/1993
5223505	Pyrimidine derivatives This invention concerns novel aminopyrimidinium salts of the formula I: ##STR1## in which R1 is alkyl, alkenyl, cycloalkyl, phenyl, phenylalkyl or cycloalkyl-alkyl; one of R2 and R6 is a basic group selected from amin...	06/29/1993
5217972	Quinolonecarboxylic acid derivatives and their use as antiviral agents New quinolone-carboxylic acids of the general formula (I) ##STR1## wherein the definitions for R1 -R9 are given in the description, a process for their preparation and their use as medicaments, in particular as antiviral agents....	06/08/1993
5175287	Process for preparing 1,2,4-benzotriazine oxides A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosensitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitize hypoxic tumor cells. Some are additionally disclosed...	12/29/1992
5166344	Process for the preparation of imidazoquinoxalinones This invention relates to novel imidazoquinoxalinones and their aza analogs and to a process for their preparation. The compounds of this invention have been found to have inodilatory, vasodilatory, venodilatory and other pharmacologic effects....	11/24/1992
5162325	Angiotensin II antagonists incorporating a substituted benzyl element Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. ##STR1##...	11/10/1992
5130430	2-substituted imidazoquinoxaline diones, a new class of GABA brain receptor ligands The invention encompasses compounds of the formula: ##STR1## and the pharmaceutically acceptable non-toxic salts thereof wherein R1, R2, R3, and R4 represent organic or inorganic substituents; X represents ...	07/14/1992
5106847	Excitatory amino acid antagonists, compositions and use The present invention is directed a new group of indole derivatives that are NMDA antagonists....	04/21/1992
5071996	Benzheterocyclic compounds Novel hydroxy-benzoheterocyclic-substituted 3-oxopentane derivatives are produced by reaction of a hydroxy-containing ortho-phenylene amine compound and the source of a five-carbon keto-containing moiety selected from 4-oxoheptanedioic acid compounds or 1...	12/10/1991
5071888	Carbazole photoinitiators for the photopolymerization of unsaturated compounds Photopolymerizable prepolymer compositions are provided comprising an unsaturated compound having at least one ethylenic double bond that is photopolymerizable to form a polymer, and a photoinitiator having one of the formulae: ##STR1##...	12/10/1991
5064833	Substituted quinazoline derivatives for use in gastrointestinal diseases 2,4-diaminoquinazoline compounds are inhibitors of the H+ K+ ATPase enzyme and useful for the treatment of diseases of the stomach based on excessive gastric acid secretion. A compound of the invention is 2-[2-methyl-4-fluorophenyl)a...	11/12/1991
5055465	Imidazoquinoxalinones, their aza analogs and process for their preparation This invention relates to novel imidazoquinoxalinones and their aza analogs and to a process for their preparation. The compounds of this invention have been found to have inodilatory, vasodilatory, venodilatory and other pharmacologic effects....	10/08/1991
5004813	Chromogenic phthalides and azaphthalides Chromogenic phthalides and azaphthalides of the formula ##STR1## in which V1 and V2 are each, independently of the other, hydrogen, halogen, lower alkyl, lower alkoxy, (lower alkoxy)carbonyl or --NR1 R2, at...	04/02/1991
4970308	Di(bis-(indolyl)ethylenyl)tetrahalophtalides Chromogenic di-[bis-(indolyl)ethylenyl] tetrahalophthalides are disclosed of the formula ##STR1## wherein each X1, X2, X3, and X4 is independently selected from chlorine or bromine; wherein each of R1	11/13/1990
4960784	Insecticidal substituted indazoles Certain substituted indazoles, including all geometric and stereoisomers thereof, agricultural compositions containing the indazoles and use of the indazoles as insecticides....	10/02/1990
4950668	Pyrazole derivative, insecticidal or miticidal composition containing the same as the effective ingredient A novel pyrazole derivative and an insecticidal or miticidal composition containing the derivative as the effective ingredient are disclosed. The pyrazole derivative of the present invention has an excellent controlling effect also against harmful insects and ...	08/21/1990
4939140	Heterocyclic oxophthalazinyl acetic acids A heterocyclic oxophthalazinyl acetic acid having aldose reductast inhibitory activity of the formula ##STR1## wherein X is oxygen or sulfur; Z is a covalent bond, O, S, NH or CH2 or CHR5 Z is vinyl; R1 is hydroxy, or...	07/03/1990

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Class 544/80 - Ring nitrogen in the polycyclo ring system