"The abolishment of pain in surgery is a chimera. It is absurd to go on seeking it...knife and pain are two words in surgery that must forever be associated in the consciousness of the patient."
Dr. Alfred Velpeau, French surgeon ; 1839
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| Number | Title | Issue Date |
| 7041669 | 1,4-benzofused urea compounds useful in treating cytokine mediated diseases Disclosed are 1,4-disubstituted benzo-fused urea compounds of formula (I): wherein Ar, X, A, L, and Q of formula(I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes an... | 05/09/2006 |
| 6319921 | Aromatic heterocyclic compound as antiinflammatory agents Disclosed are novel aromatic heterocyclic compounds of the formula (I) wherein Ar1, Ar2, L, Q and X are described herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involvin... | 11/20/2001 |
| 6130101 | Sulfonated xanthene derivatives The present invention describes xanthene dyes, including rhodamines, rhodols and fluoresceins that are substituted one or more times by a sulfonic acid or a salt of a sulfonic acid. The dyes of the invention, including chemically reactive dyes and dye-con... | 10/10/2000 |
| 5476934 | Nitrogen-containing perfluoroalkanoyl peroxide and method for production thereof A nitrogen-containing perfluoroalkanoyl peroxide is provided which is represented by the formula: ##STR1## wherein Rf1 and Rf2 independently stand for an alkyl group of 1 to 5 carbon atoms, provided that Rf1 and Rf | 12/19/1995 |
| 5436243 | Aminoanthraquinone derivatives to combat multidrug resistance Potentiating agents inhibit the development of multidrug resistance, reduce drug-resistance in drug-resistant tumors, or sensitize tumors to antineoplastic drugs, thereby potentiating the effect of antineoplastic agents. The potentiating agents are aminoa... | 07/25/1995 |
| 5399558 | Isoflavonoid antibacterial compounds, compositions and use Methods, compounds and compositions are provided for inhibiting the growth of mycobacteria and gram-positive organisms in vitro and of treatment of mycobacterial and gram-positive infections in vivo using compounds of the formula (I) or (II): ##STR1#... | 03/21/1995 |
| 5304548 | Bivalent ligands effective for blocking ACAT enzyme for lowering plasma triglycerides and for elevating HDL cholesterol Bivalent ligand compounds synthesized from a tether composition joining two heterocyclic groups comprising furochromones, furobenzoxazinones, and benzobisdifurans. These compounds show pharmacological activity in blocking ACAT enzymes which are major regu... | 04/19/1994 |
| 5208339 | Nitrogen-containing perfluoroalkanoyl peroxide and method for production thereof A nitrogen-containing perfluoroalkanoyl peroxide is provided which is represented by the formula: ##STR1## wherein Rf1 and Rf2 independently stand for an alkyl group of 1 to 5 carbon atoms, provided that Rf1 and Rf | 05/04/1993 |
| 5189188 | Bis(triarylmethane) compounds Compounds of the general formula ##STR1## in which the symbols have the meaning given in the description, are highly suitable as color formers in recording materials based on acid developers. They give deep blue, green-blue, green, violet or red shad... | 02/23/1993 |
| 5093336 | 6- and 7-deoxyforskolin and derivatives thereof Novel forskolin derivatives, intermediates and processes for the preparation thereof, and methods for treating cardiac failure and memory deficit utilizing compounds or compositions thereof are disclosed.... | 03/03/1992 |
| 5004813 | Chromogenic phthalides and azaphthalides Chromogenic phthalides and azaphthalides of the formula ##STR1## in which V1 and V2 are each, independently of the other, hydrogen, halogen, lower alkyl, lower alkoxy, (lower alkoxy)carbonyl or --NR1 R2, at... | 04/02/1991 |
| 4888433 | Process for the preparation of optically active alpha-arylalkanoic acids and novel intermediates thereof A new enantioselective process is described for preparing optically active alpha-arylalkanoic acids by: (a) halogenation on the aliphatic carbon atom alpha to the ketal group, of ketals of formula ##STR1## in which Ar represents an aryl, optionally ... | 12/19/1989 |
| 4876357 | Chromogenic phthalides and azaphthalides Chromogenic phthalides and azaphthalides of the formula ##STR1## in which V1 and V2 are each, independently of the other, hydrogen, halogen, lower alkyl, lower alkoxy, (lower alkoxy)carbonyl or --NR1 R2, at... | 10/24/1989 |
| 4855464 | Optically active ketals, processes for their preparation and their use in the synthesis of alpha-arylalkanoic acids Compounds of formula ##STR1## wherein Ar represents an optionally substituted aryl group; R represents a C1 -C4 alkyl; R1 and R2, equal to or different from each other, represent hydroxy, O- M+ | 08/08/1989 |
| 4833246 | Novel pyrazolone dye A novel pyrazolone dye represented by the following formula (I), which can be effectively used as a filter dye, an irradiation inhibiting dye, an antihalation dye or the like in a photographic light-sensitive material: ##STR1## wherein R1 ... | 05/23/1989 |
| 4804394 | Benzoxazines and use as herbicides Novel benzoxazines of the formula (I) ##STR1## wherein X is hydrogen or halogen, R1 is hydrogen or C1 -C2 -alkyl, R2 is cyano, trimethylsilyl, trimethylsilylmethoxycarbonyl, C1 -C4 -alkylth... | 02/14/1989 |
| 4797413 | Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use Aromatic sulfonamides with a saturated heterocycle fused thereto are carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure.... | 01/10/1989 |
| 4788187 | Benzocyclobutene aminoalkylene ethers and thioethers, pharmaceutical composition and use A class of benzocyclobutene aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of g... | 11/29/1988 |
| 4766211 | Chromogenic quinazolines Chromogenic quinazolines of formula ##STR1## wherein R is an aryl radical or a heterocyclic radical, Z1 is oxygen or sulfur, Z2 is oxygen, sulfur or ##STR2## R' is hydrogen, alkyl which is unsubstituted or substituted by halogen... | 08/23/1988 |
| 4753934 | Acrylic acid heterocyclic amides, fungicidal compositions and use Compounds of the formula ##STR1## wherein A, B, R1, X and Q are substituents of various types, and acid addition salts thereof. The compounds are useful as fungicides.... | 06/28/1988 |
| 4741765 | Herbicidal sulfonamides Benzenesulfonamide compounds such as N-[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-1,4-dihydro-3-methyl-4 -oxo-1-phenyl-indeno[1,2-C]pyrazole-5-sulfonamide and N-[(4-methoxy-6-methyl-pyrimidin-2-yl)aminocarbonyl]-1,4-dihydro-3-methyl- 4-oxo-1-phe... | 05/03/1988 |
| 4737508 | 1-aryl-1-(1H-azol-1-ylalkyl)-1,3-dihydroisobenzofurans, related derivatives and pharmaceutical compositions thereof useful as antifungals Novel compounds including 1-aryl-1-(1H-imidazol-1-ylmethyl)-1,3-dihydroisobenzofurans such as 1-(4-chlorophenyl)-1-(1H-imidazol-1-ylmethyl)-1,3-dihydroisobenzofuran, and 1-aryl-1-(1H-1,2,4-trizazol-1-ylmethyl)-1,3-dihydroisobenzofurans are disclosed.... | 04/12/1988 |
| 4734507 | Optically active ketals, processes for their preparation and their use in the synthesis of alpha-arylalkanoic acids Compounds of formula ##STR1## wherein Ar represents an optionally substituted aryl group; R represents a C1 -C4 alkyl; R1 and R2, equal to or different from each other, represent hydroxy, O- M+ | 03/29/1988 |
| 4661483 | Antihypercholesterolemic lactone compounds, compositions and use Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) and (II): ##STR1## and pharmaceutically acceptable sal... | 04/28/1987 |
| 4639443 | Labdane compounds, pharmaceutical compositions and use Novel labdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure utilizing compounds or compositions thereof are disclosed.... | 01/27/1987 |
| 4639442 | Benzocyclobutene aminoalkylene ethers and thioethers, pharmaceutical compositions and use A class of benzocyclobutene aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of g... | 01/27/1987 |
| 4638001 | Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of... | 01/20/1987 |
| 4617314 | Benzofuran- and benzopyran-carboxamide derivatives Benzofuran- and benzopyran-carboxamide derivatives of the formula: ##STR1## wherein l is 1 or 2; X is hydrogen atom, amino group or halogen atom; Y is --S(O)m --R3 wherein R3 is lower alkyl group and m is 0, 1 or 2, o... | 10/14/1986 |
| 4602087 | Distyrylbiphenyls The distyrylbiphenyls of the formula ##STR1## in which X and X' independently of one another are a direct bond, oxygen, sulfur, --O--C1-3 -alkylene-CON(R4)--CON(R4)--, --O--C1-3 alkylene-COO--, OCO or --COO... | 07/22/1986 |
| 4540519 | 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof This disclosure describes symmetrical 1,4-bis-(substituted-amino)-5,8-hydroxyanthraquinones useful as chelating agents and for inducing regression and/or palliation of cancer diseases in mammals.... | 09/10/1985 |
| 4419354 | 9,10-Bis(aminoalkoxy)anthracenes This disclosure describes certain substituted 9,10-bis(2-aminoethoxy)anthracenes which are useful as modulators of the immune response system in warm-blooded animals and for inducing the regression of tumors in such animals.... | 12/06/1983 |
| 4385182 | Thioxanthonecarboxylic acids and thioxanthonecarboxylic acid derivatives Novel thioxanthonecarboxylic acids and thioxanthonecarboxylic acid derivatives of the formula I ##STR1## in which Y is --COOH, --CO-halogen, --CN or a carboxylic acid ester, thioester or amide group and X, Z and W are as defined in the patent cl... | 05/24/1983 |
| 4375469 | Oxaza heterocycle-anthraquinones, pharmaceutical compositions thereof and method of use thereof Novel 1,4-di(substituted amino)-5,8-dihydroxyanthraquinones wherein the substituents are alkylamino alcohol and/or alkyl cyclicamide and their pharmacologically acceptable acid-addition salts useful as antitumor and chelating agents are described.... | 03/01/1983 |
| 4350812 | Antiarrhythmic tetrahydronaphthalene derivatives Compounds are provided having the structure ##STR1## wherein R1 and R2 may be the same or different and are hydrogen, lower alkyl, lower alkenyl, or hydroxylower alkyl, or R1 and R2 together with the nitrog... | 09/21/1982 |
| 4342756 | Aminocyclopentane alkenoic acids and esters and pharmaceutical compositions Compounds are described of the formula ##STR1## (and their salts and solvates) in which: X is cis or trans --CH.dbd.CH--; R1 is C1-7 alkyl terminated by --COOR3 where R3 is H, C1-6 alkyl or C7-10... | 08/03/1982 |
| 4323691 | Hydroxyaminomethyl derivatives of benzoyl di-substituted -phenoxyalkanoyl esters Described are compounds of the formula ##STR1## wherein ##STR2## wherein Z is hydrogen or loweralkyl, R5 and R6 may be the same or different and are hydrogen, loweralkyl or together are alkylene of 4 or 5 carbon atoms,... | 04/06/1982 |
| 4302453 | Antiarrhythmic tetrahydronaphthalene derivatives Compounds are provided having the structure ##STR1## wherein R1 and R2 may be the same or different and are hydrogen, lower alkyl, lower alkenyl, or hydroxy-lower alkyl, or R1 and R2 together with the nitro... | 11/24/1981 |
| 4269978 | Thiazolylphthalide compounds Thiazolylphthalide compounds of the general formula ##STR1## wherein A represents a p-aminophenyl readical of formula ##STR2## or a 3-indolyl radical of formula ##STR3## or a 2-thiazolyl radical of formula ##STR4## each of R1... | 05/26/1981 |
| 4258181 | Substituted 9,10-anthracenebishydrazones This disclosure describes anthracene-9,10-bis-carbonyl-hydrazones and derivatives thereof useful as antibacterial agents, for inhibiting the growth of transplanted mouse tumors, and for inducing the regression and/or palliation of leukemia and related can... | 03/24/1981 |
| 4241207 | Organonitrogen derivatives of 2-benzopyranone Novel 2-benzopyranone compounds of the formula ##STR1## wherein X is a 3,4,5-trimethoxybenzoyl group or a 3,4,5-trimethoxycinnamoyl group; and each R individually is selected from the group consisting of alkylamino and dialkylamino in which one carbo... | 12/23/1980 |