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| Number | Title | Issue Date |
| 8168783 | Chemokine receptor antagonists and use thereof A compound represented by general formula (I): a salt thereof, a solvate thereof, or a prodrug thereof wherein all symbols are as defined in the specification has an antagonistic activity against CXCR4 and is therefore usef... | 05/01/2012 |
| 8138334 | Substituted oxa-diaza-spiro-[5.5]-undecanone derivatives and their use as neurokinin antagonists This invention concerns substituted oxa-diaza-spiro-[5.5]-undecanone derivatives having neurokinin antagonistic activity, in particular an NK1 antagonistic activity, an NK3 antagonistic activity, a combined NK1/NK2 antagon... | 03/20/2012 |
| 7557206 | Photochromic compounds Various non-limiting embodiments disclosed herein relate generally to photochromic compounds, which may be thermally reversible or non-thermally reversible, and articles made therefrom. Other non-limiting embodiments relate to photochromic-dichroic compounds, which ... | 07/07/2009 |
| 7432259 | Spiro-piperidine derivatives Present invention is concerned with novel indol-2-yl-carbonyl-spiro-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them. The active compounds of the present invention are useful in the treatment of anxie... | 10/07/2008 |
| 7423146 | Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones A process for making a compound of formula 1 or a salt thereof, wherein: R1 and R2 are each independently H, halogen, or C1-4-alkyl, or R1 and R2 together ... | 09/09/2008 |
| 7419969 | HIV integrase inhibitors: cyclic pyrimidinone compounds The invention encompasses a series of pyrimidinone compounds which inhibit HIV integrase and thereby prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses intermediates us... | 09/02/2008 |
| 7375104 | Long acting beta-2-agonists and their use as medicaments A compound of formula 1′ wherein: V is —CH2—, —NH—, or —O—; Ra and Rb are each independently hydrogen, C1-4-alkyl, or halogen-C1-4 | 05/20/2008 |
| 7368072 | Photochromic contact lenses and methods of manufacturing Described are contact lenses having photochromic materials within the central or pupillary area of the lens and methods for manufacturing such lenses. In one method, a photochromic amount of at least one photochromic material is added to the pupillary region of a ca... | 05/06/2008 |
| 7358246 | Thioamide derivatives as progesterone receptor modulators Thioamide compounds, and specifically, thioamide pyrrole compounds, and preparation thereof are provided. These thioamide compounds can be used as progesterone receptor modulators, in contraception, and in the treatment of progesterone-related maladies. ... | 04/15/2008 |
| 7351707 | Spiroazacyclic compounds as monoamine receptor modulators The present invention relates to optionally substituted 1-oxa-4,9-diaza-spiro[5.5]undecan-3-one compounds as monoamine receptor modulators; compositions comprising the same; methods of inhibiting an activity of a monoamine receptor with said compounds; methods of tr... | 04/01/2008 |
| 7351706 | Indol-3-yl-carbonyl-spiro-piperidine derivatives This invention relates to indol-3-yl-carbonyl-spiro-piperidine derivatives which act as V1a receptor antagonists and which are represented by Formula I: wherein the spiropiperidine-head group A and the residues R1 | 04/01/2008 |
| 7342112 | Photochromic compounds Various non-limiting embodiments disclosed herein relate generally to photochromic compounds, which may be thermally reversible or non-thermally reversible, and articles made therefrom. Other non-limiting embodiments relate to photochromic-dichroic compounds, which ... | 03/11/2008 |
| 7332500 | Heterocyclic antiviral compounds This invention relates to piperidine derivatives of formulae Ia and Ib with substituents as defined herein useful in the treatment of a variety of disorders, including those in which the modulation of CCR5 receptors is implicated. More particularly, the present inve... | 02/19/2008 |
| 7320826 | Photochromic articles with reduced temperature dependency and methods for preparation Described are photochromic articles that include a substrate, a temperature dependent reducing amount of at least one organic photochromic material (b) that changes from more absorbing to less absorbing of radiation in its activating spectral absorbance as the tempe... | 01/22/2008 |
| 7288539 | Spiroazacyclic compounds as monoamine receptor modulators The present invention relates to optionally substituted 1-oxa-4,9-diaza-spiro[5.5]undecan-3-one compounds as monoamine receptor modulators; compositions comprising the same; methods of inhibiting an activity of a monoamine receptor with said compounds; methods of tr... | 10/30/2007 |
| 7279582 | Retroviral protease inhibiting compounds A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed. ... | 10/09/2007 |
| 7273859 | HIV integrase inhibitors: cyclic pyrimidinone compounds The invention encompasses a series of pyrimidinone compounds which inhibit HIV integrase and thereby prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses intermediates us... | 09/25/2007 |
| 7262294 | Photochromatic pyrano-1,3-oxazinonaphthalene derivatives Photochromatic compounds belonging to the groups of chromenes and spiro-pyrans having general formula (I) ... | 08/28/2007 |
| 7262295 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles Described are photochromic materials of indeno [2′,3′:3,4]naphtho[1,2-b]pyran structure, characterized in that they have a nitrogen or sulfur containing substituent at the 11-position ring atom, are substantially free of spiro-substituents at the 13-position and... | 08/28/2007 |
| 7261844 | Photochromic contact lens having excellent discoloring characteristic A photochromic contact lens having a period of time for discoloring the contact lens from a colored state to the uncolored state shortened, wherein the photochromic contact lens is made of an oxygen-permeable polymer material having a second-order transition point o... | 08/28/2007 |
| 7261843 | Photochromic optical article Describes a photochromic article, e.g., an ophthalmic photochromic plastic article, such as a lens, in which the article includes (1) a rigid substrate, e.g., a transparent substrate such as a glass or organic polymeric substrate, as for example, a thermoset or ther... | 08/28/2007 |
| 7247625 | 6-amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators Compounds having the structure of formula I are provided. In formula I, R1 is H, OH, substituted or unsubstituted C1 to C3 alkyl, C1 to C3 perfluoroalkyl, or COR6; R6 is H, substituted or u... | 07/24/2007 |
| 7247262 | Photochromic compositions and light transmissible articles The invention related to a photochromic polymeric composition comprising a polymer matrix and a photochromic compound which is an adduct comprising a photochromic moiety and at least one pendant oligomer group to provide a rate of fade of the photochromic polymeric ... | 07/24/2007 |
| 7229740 | Reimageable paper An image forming medium includes a substrate and an imaging layer including a photochromic material and a polymer binder coated on the substrate, where the photochromic material exhibits a reversible homogeneous-heterogeneous transition between a colorless state and... | 06/12/2007 |
| 7214754 | Polymerizable polyol (allyl carbonate) compositions A polymerizable composition is described, which composition comprises a major amount of a polyol(allyl carbonate) monomer, e.g., diethylene glycol bis(allyl carbonate) monomer, and a minor amount of a radically polymerizable second monomer represented by the general... | 05/08/2007 |
| 7208490 | Tricyclic tetrahydroquinoline antibacterial agents The invention includes tetrahydroquinoline and related compounds of formula I, and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens ... | 04/24/2007 |
| 7205296 | Substituted 2H-1,3-benzoxazin-4(3H)-ones Substituted benzoxazin-4(3H)-ones are provided which are useful for treating thrombosis and for reducing the likelihood and/or severity of a secondary ischemic event in a patient. ... | 04/17/2007 |
| 7183238 | [1,2]-oxazine-3,5-diones The present invention relates to novel [1,2]-oxazine-3,5-dione derivatives of the formula (I) in which W, X, Y, Z, G, D, A and B are as defined in the disclosure, to a pl... | 02/27/2007 |
| 7166357 | Photochromic articles that activate behind ultraviolet radiation blocking transparencies and methods for preparation Described are photochromic articles that include a substrate and a photochromic amount of at least one organic photochromic material (b) represented by graphic formula XIII adapted to change from an unactivated state to an activated state by exposure to radiation su... | 01/23/2007 |
| 7147889 | Organic photochromic compositions of improved kinetic performance Described are imbibition compositions that incorporate kinetic enhancing additive(s) into photochromic polymeric host material. Kinetic enhancing additives include organic polyol(s), epoxy-containing compound(s) or a mixture thereof that improves the performance of ... | 12/12/2006 |
| 7144969 | Impact resistant polyureaurethane and polyureaurethane prepolymer having low NCO/OH ratio The present invention relates to a polyureaurethane wherein the prepolymer comprising said polyureaurethane has a NCO to OH equivalent ratio of from 2.0 to less than 2.5. In an embodiment, the polyureaurethane prepolymer comprises a polyisocyanate and at least one O... | 12/05/2006 |
| 7135465 | Sustained release beadlets containing stavudine Extended dosage forms of stavudine are provided comprising beadlets formed by extrusion-spheronization and coated with a seal coating. The beadlets are also coated with a modified release coating such that a hard gelatin capsule containing such beadlets will provide... | 11/14/2006 |
| 7122662 | Tricyclic compound having spiro union This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which e... | 10/17/2006 |
| 7115601 | HIV integrase inhibitors Compounds of the present disclosure are spirocycle-substituted pyrimidinecarboxamides. Also disclosed are pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating HIV infection and AIDS. ... | 10/03/2006 |
| 7097303 | Polarizing devices and methods of making the same Certain, non-limiting embodiments of the disclosure provide ophthalmic elements and devices comprising an at least partial coating adapted to polarize at least transmitted radiation on at least a portion of at least one exterior surface of an ophthalmic element or s... | 08/29/2006 |
| 7098290 | Method of preparing an optical polymerizate The present invention is directed to a novel method of preparing a polymerizate, which includes the step of polymerizing a two-component composition, which includes: a first component containing at least one polycyanate reactant having at least two functional groups... | 08/29/2006 |
| 7097304 | Polarizing devices and methods of making the same Certain, non-limiting embodiments of the disclosure provide ophthalmic elements and devices comprising an at least partial coating adapted to polarize at least transmitted radiation on at least a portion of at least one exterior surface of an ophthalmic element or s... | 08/29/2006 |
| 7094368 | Pyrano-quinolines, pyrano-quinolinones, combinations thereof, photochromic compositions and articles Described are compositions of at least one material represented by a pyrano[3,2-c]quinoline structure, a pyrano[3,2-c]quinolinone structure or mixtures thereof. The pyrano[3,2-c]quinoline structure is characterized by having a nitrogen atom at the 6-position ring at... | 08/22/2006 |
| 7091198 | 2,5-disubstituted pyrimidine derivatives The present invention relates to novel 2,5-disubstituted pyrimidine derivatives which stimulate soluble guanylate cyclase, to processes for the preparation thereof, and to the use thereof for producing medicaments, in particular medicaments for the treatment of cent... | 08/15/2006 |
| 7087698 | Method of preparing an optical polymerizate The present invention is directed to a novel method of preparing a polymerizate, which includes the step of polymerizing a two-component composition, which includes: a first component containing at least one polycyanate reactant having at least two functional groups... | 08/08/2006 |
